GREMLIN Database
OPUBC - Choline-binding protein
UniProt: Q45462 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 306 (277)
Sequences: 3911 (2915)
Seq/√Len: 175.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
282_E288_K4.8641.00
145_K229_G4.6121.00
272_D275_T3.7601.00
157_S236_D3.4801.00
145_K231_K3.1491.00
39_G86_I3.0371.00
143_V153_L3.0321.00
295_K299_E2.9511.00
154_E231_K2.8271.00
147_L151_Y2.8261.00
142_T218_A2.8141.00
282_E296_E2.6351.00
128_K251_E2.4941.00
54_G67_T2.2981.00
275_T279_L2.2881.00
35_T64_K2.2641.00
296_E300_K2.2401.00
141_F215_I2.2051.00
37_K66_T2.1631.00
55_Q295_K2.1381.00
145_K149_D2.1351.00
275_T301_H2.1321.00
169_G213_M2.1281.00
35_T66_T2.0581.00
48_I283_V2.0581.00
288_K296_E2.0511.00
282_E286_N2.0151.00
37_K68_I1.9871.00
226_K278_E1.9711.00
270_K301_H1.9651.00
51_S55_Q1.9491.00
79_Q82_M1.9031.00
38_I88_I1.8871.00
111_D115_A1.8801.00
251_E255_K1.8121.00
61_T263_I1.7711.00
213_M216_V1.7481.00
288_K292_V1.7151.00
131_D265_K1.7061.00
184_D239_F1.7021.00
127_L248_V1.6941.00
283_V293_V1.6861.00
56_L263_I1.6641.00
188_T237_K1.6101.00
154_E158_D1.5981.00
253_V257_H1.5961.00
155_T234_K1.5931.00
155_T236_D1.5781.00
154_E234_K1.5701.00
54_G58_E1.5551.00
126_D251_E1.5411.00
270_K297_Y1.5281.00
205_Y228_Y1.5251.00
114_L118_Q1.5151.00
51_S67_T1.5151.00
144_S147_L1.5101.00
109_D112_K1.5071.00
171_D201_I1.4881.00
186_T192_T1.4791.00
40_A50_A1.4751.00
140_A232_M1.4711.00
56_L267_M1.4621.00
198_P202_G1.4511.00
153_L162_W1.4351.00
55_Q58_E1.4311.00
55_Q59_H1.4231.00
143_V147_L1.4111.00
195_G201_I1.4061.00
159_V163_A1.3961.00
196_T199_M1.3931.00
292_V296_E1.3751.00
144_S211_G1.3671.00
146_E211_G1.3521.00
188_T239_F1.3441.00
78_Q125_Y1.3381.00
289_E292_V1.3381.00
195_G198_P1.3311.00
278_E282_E1.3191.00
281_Y286_N1.3181.00
275_T297_Y1.3091.00
55_Q291_S1.3051.00
15_A18_L1.3011.00
157_S237_K1.2811.00
147_L213_M1.2741.00
274_A277_Q1.2731.00
206_D210_S1.2491.00
205_Y209_K1.2451.00
15_A19_T1.2381.00
155_T159_V1.2331.00
271_I279_L1.2321.00
36_I63_L1.2231.00
138_T220_S1.2081.00
44_S284_D1.1951.00
36_I260_L1.1931.00
87_D250_P1.1861.00
204_V216_V1.1811.00
254_L261_E1.1811.00
52_M297_Y1.1761.00
58_E65_T1.1721.00
181_G184_D1.1681.00
53_L264_I1.1611.00
197_Y200_Q1.1601.00
98_L101_T1.1551.00
160_K163_A1.1491.00
40_A67_T1.1491.00
128_K261_E1.1481.00
151_Y162_W1.1471.00
198_P201_I1.1401.00
199_M202_G1.1381.00
140_A220_S1.1371.00
104_M120_E1.1361.00
42_S70_N1.1361.00
166_L215_I1.1351.00
115_A118_Q1.1351.00
51_S54_G1.1341.00
171_D219_Y1.1221.00
45_E276_M1.1201.00
19_T22_G1.1151.00
80_A86_I1.1121.00
158_D161_K1.0971.00
52_M298_L1.0941.00
54_G65_T1.0851.00
184_D188_T1.0801.00
195_G200_Q1.0791.00
271_I276_M1.0771.00
159_V162_W1.0771.00
140_A156_V1.0711.00
179_G183_Q1.0671.00
250_P256_E1.0661.00
18_L21_S1.0641.00
226_K277_Q1.0621.00
55_Q298_L1.0601.00
218_A224_R1.0521.00
182_Y185_F1.0441.00
16_A19_T1.0410.99
182_Y186_T1.0380.99
50_A67_T1.0310.99
183_Q187_K1.0300.99
195_G199_M1.0270.99
16_A20_L1.0250.99
20_L23_C1.0210.99
129_W246_S1.0150.99
290_P294_A1.0120.99
34_Q257_H1.0110.99
107_E112_K1.0110.99
135_F276_M1.0080.99
281_Y285_G1.0080.99
51_S291_S0.9850.99
78_Q248_V0.9850.99
152_H155_T0.9840.99
173_Y178_K0.9780.99
152_H159_V0.9750.99
78_Q121_F0.9730.99
97_A117_T0.9650.99
78_Q82_M0.9570.99
120_E124_R0.9500.99
102_L120_E0.9460.99
58_E67_T0.9450.99
39_G77_Q0.9390.99
262_G266_K0.9370.99
147_L153_L0.9320.99
53_L263_I0.9320.99
203_L207_A0.9320.99
129_W132_S0.9310.99
288_K293_V0.9270.99
88_I249_V0.9270.99
63_L259_E0.9270.99
41_Q89_A0.9220.99
132_S135_F0.9200.99
136_D273_T0.9190.99
291_S295_K0.9170.99
130_Y249_V0.9170.99
98_L103_R0.9170.99
273_T277_Q0.9140.99
261_E265_K0.9110.99
45_E49_I0.9040.99
196_T200_Q0.9030.99
296_E299_E0.9020.99
196_T201_I0.8980.98
12_L16_A0.8950.98
52_M267_M0.8830.98
57_I61_T0.8780.98
116_L120_E0.8740.98
254_L260_L0.8600.98
116_L119_R0.8590.98
52_M56_L0.8550.98
167_K214_D0.8540.98
52_M294_A0.8470.98
250_P253_V0.8460.98
47_E70_N0.8410.98
52_M55_Q0.8390.98
155_T163_A0.8380.98
47_E290_P0.8340.98
170_V174_W0.8320.98
57_I63_L0.8310.98
14_L17_T0.8290.97
59_H295_K0.8270.97
279_L293_V0.8270.97
204_V217_L0.8140.97
143_V151_Y0.8140.97
249_V253_V0.8120.97
156_V191_M0.8100.97
197_Y201_I0.8090.97
36_I257_H0.8050.97
153_L158_D0.8050.97
112_K115_A0.8010.97
135_F245_C0.7980.97
252_K256_E0.7960.97
144_S214_D0.7940.97
191_M194_G0.7930.97
275_T278_E0.7920.97
163_A191_M0.7910.97
152_H163_A0.7860.97
52_M271_I0.7850.96
211_G214_D0.7810.96
156_V163_A0.7790.96
253_V260_L0.7780.96
98_L102_L0.7770.96
150_Q155_T0.7730.96
260_L263_I0.7720.96
155_T158_D0.7700.96
247_P264_I0.7700.96
167_K195_G0.7690.96
72_G76_V0.7690.96
274_A278_E0.7680.96
130_Y135_F0.7660.96
13_A16_A0.7630.96
220_S232_M0.7620.96
78_Q97_A0.7600.96
156_V159_V0.7560.96
189_Y235_D0.7550.96
141_F240_F0.7550.96
97_A121_F0.7510.95
49_I245_C0.7490.95
185_F239_F0.7480.95
115_A119_R0.7460.95
182_Y240_F0.7450.95
161_K164_P0.7410.95
103_R106_P0.7390.95
100_G103_R0.7380.95
193_F200_Q0.7310.95
127_L130_Y0.7290.95
107_E116_L0.7270.95
57_I62_D0.7250.95
99_T102_L0.7230.94
130_Y247_P0.7210.94
80_A85_E0.7210.94
23_C30_A0.7190.94
38_I67_T0.7180.94
159_V215_I0.7160.94
146_E150_Q0.7150.94
142_T232_M0.7140.94
42_S219_Y0.7130.94
223_G284_D0.7120.94
141_F182_Y0.7110.94
262_G265_K0.7100.94
249_V254_L0.7090.94
40_A46_S0.7050.94
189_Y237_K0.7010.94
99_T105_E0.7000.93
147_L162_W0.7000.93
53_L247_P0.6950.93
133_Y137_N0.6930.93
131_D135_F0.6910.93
30_A33_D0.6910.93
88_I260_L0.6910.93
99_T103_R0.6890.93
190_G237_K0.6880.93
227_S281_Y0.6820.93
117_T121_F0.6810.93
13_A17_T0.6810.93
121_F129_W0.6780.92
52_M279_L0.6770.92
227_S285_G0.6770.92
44_S283_V0.6750.92
147_L166_L0.6740.92
36_I253_V0.6710.92
56_L59_H0.6690.92
34_Q63_L0.6680.92
152_H161_K0.6670.92
156_V233_L0.6670.92
98_L107_E0.6660.92
21_S24_S0.6650.92
147_L150_Q0.6650.92
225_I232_M0.6640.92
149_D231_K0.6630.92
118_Q128_K0.6630.92
167_K194_G0.6610.91
102_L105_E0.6600.91
195_G202_G0.6590.91
41_Q46_S0.6540.91
278_E281_Y0.6530.91
121_F125_Y0.6490.91
143_V215_I0.6470.91
101_T105_E0.6460.90
149_D234_K0.6450.90
37_K65_T0.6450.90
11_G18_L0.6430.90
218_A225_I0.6420.90
167_K197_Y0.6410.90
45_E221_T0.6400.90
260_L264_I0.6350.90
130_Y133_Y0.6310.89
130_Y261_E0.6300.89
154_E161_K0.6290.89
112_K116_L0.6250.89
245_C276_M0.6240.89
12_L15_A0.6220.89
102_L106_P0.6220.89
136_D220_S0.6210.89
81_L250_P0.6210.89
79_Q83_N0.6200.89
98_L113_A0.6200.89
160_K191_M0.6190.88
216_V224_R0.6170.88
150_Q154_E0.6160.88
142_T225_I0.6150.88
56_L298_L0.6150.88
114_L132_S0.6130.88
48_I52_M0.6120.88
106_P113_A0.6110.88
141_F156_V0.6100.88
98_L106_P0.6090.88
169_G207_A0.6040.87
267_M271_I0.6040.87
157_S160_K0.6030.87
175_M198_P0.6030.87
57_I260_L0.6010.87
223_G227_S0.5990.87
218_A232_M0.5970.87
10_I15_A0.5960.87
149_D152_H0.5940.86
263_I267_M0.5930.86
23_C32_A0.5930.86
139_Y243_Y0.5920.86
143_V233_L0.5920.86
259_E262_G0.5920.86
97_A101_T0.5910.86
196_T202_G0.5910.86
174_W178_K0.5890.86
159_V166_L0.5880.86
23_C29_S0.5860.86
11_G15_A0.5850.86
84_G87_D0.5820.85
96_D101_T0.5810.85
96_D102_L0.5800.85
174_W217_L0.5790.85
171_D204_V0.5780.85
43_M173_Y0.5760.85
153_L157_S0.5750.85
81_L89_A0.5730.84
147_L231_K0.5720.84
189_Y236_D0.5720.84
97_A129_W0.5690.84
153_L159_V0.5650.84
142_T230_L0.5640.83
13_A20_L0.5640.83
129_W248_V0.5630.83
23_C27_G0.5610.83
152_H157_S0.5570.83
110_P114_L0.5570.83
171_D217_L0.5560.83
163_A194_G0.5550.82
17_T23_C0.5490.82
220_S273_T0.5470.82
59_H299_E0.5440.81
96_D180_N0.5440.81
53_L95_G0.5430.81
131_D134_G0.5430.81
133_Y245_C0.5430.81
146_E300_K0.5410.81
180_N184_D0.5410.81
117_T120_E0.5380.80
182_Y193_F0.5380.80
37_K84_G0.5360.80
108_K112_K0.5360.80
53_L57_I0.5320.80
171_D199_M0.5320.80
71_L80_A0.5300.80
203_L214_D0.5290.79
77_Q89_A0.5280.79
12_L23_C0.5270.79
184_D187_K0.5260.79
49_I95_G0.5240.79
48_I293_V0.5240.79
53_L267_M0.5230.79
204_V224_R0.5230.79
189_Y193_F0.5210.78
189_Y192_T0.5210.78
108_K113_A0.5190.78
156_V160_K0.5190.78
71_L86_I0.5190.78
61_T260_L0.5180.78
282_E292_V0.5170.78
74_N101_T0.5160.78
150_Q159_V0.5160.78
36_I87_D0.5160.78
39_G71_L0.5150.78
45_E96_D0.5150.78
166_L197_Y0.5140.77
226_K281_Y0.5130.77
105_E116_L0.5130.77
175_M196_T0.5090.77
88_I264_I0.5090.77
149_D155_T0.5060.76
88_I95_G0.5050.76
81_L127_L0.5050.76
209_K230_L0.5040.76
181_G185_F0.5030.76
157_S163_A0.5030.76
162_W166_L0.5030.76
178_K184_D0.5030.76
283_V288_K0.5020.76
111_D114_L0.5020.76
141_F185_F0.5010.76
186_T211_G0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o66A 1 0.8856 100 0.253 Contact Map
4ne4A 1 0.8791 100 0.291 Contact Map
3r6uA 1 0.8824 100 0.312 Contact Map
1sw5A 1 0.8758 100 0.373 Contact Map
1r9lA 1 0.8366 100 0.464 Contact Map
2rinA 1 0.8235 100 0.542 Contact Map
3tmgA 1 0.7974 100 0.579 Contact Map
3l6gA 1 0.7941 100 0.582 Contact Map
2b4lA 1 0.4837 100 0.596 Contact Map
3un6A 1 0.7843 99.7 0.758 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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