GREMLIN Database
OPUBB - Choline transport system permease protein OpuBB
UniProt: Q45461 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (189)
Sequences: 94131 (56718)
Seq/√Len: 4125.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_Y24_T3.3731.00
124_E128_L3.3611.00
116_K125_Q3.1881.00
101_Y105_R2.7061.00
121_T124_E2.6251.00
115_G125_Q2.5131.00
32_L89_F2.4741.00
122_P125_Q2.3761.00
17_Y20_Y2.3701.00
112_L130_E2.2661.00
123_A127_R2.2601.00
103_G137_V2.2541.00
16_L20_Y2.1601.00
28_I85_I2.1221.00
176_Q179_Y2.0921.00
46_R112_L2.0381.00
112_L125_Q1.9921.00
45_T105_R1.9851.00
111_L133_L1.9681.00
162_G170_I1.9481.00
24_T81_K1.9461.00
112_L116_K1.9281.00
120_M124_E1.9111.00
100_T138_I1.8901.00
18_K167_Y1.7981.00
24_T28_I1.7971.00
17_Y21_E1.7811.00
124_E127_R1.7541.00
196_Y200_V1.7381.00
104_I134_A1.7191.00
84_A156_A1.7171.00
116_K122_P1.7101.00
115_G120_M1.7101.00
30_V142_I1.6881.00
40_L97_L1.6841.00
44_L97_L1.5981.00
35_L39_P1.5571.00
162_G167_Y1.5461.00
96_I145_S1.5431.00
38_V100_T1.5051.00
21_E24_T1.5011.00
109_K112_L1.4781.00
14_E17_Y1.4571.00
143_R198_L1.4451.00
55_I101_Y1.4431.00
37_A96_I1.4401.00
96_I141_G1.4351.00
45_T104_I1.4251.00
41_G100_T1.4231.00
26_S146_T1.4141.00
115_G129_V1.4031.00
166_D170_I1.3601.00
167_Y170_I1.3581.00
29_A149_L1.3561.00
38_V134_A1.3531.00
48_K51_A1.3501.00
38_V126_V1.3491.00
50_G53_T1.2911.00
168_I183_G1.2871.00
104_I130_E1.2791.00
64_L69_I1.2741.00
121_T125_Q1.2611.00
34_V142_I1.2541.00
109_K113_E1.2351.00
140_A144_T1.2251.00
175_Y178_E1.2221.00
49_K52_G1.1991.00
44_L55_I1.1851.00
51_A105_R1.1731.00
153_A157_S1.1591.00
79_V82_V1.1541.00
40_L93_V1.1531.00
163_G166_D1.1401.00
85_I89_F1.1381.00
110_N113_E1.1211.00
41_G45_T1.1191.00
49_K53_T1.1161.00
155_L159_I1.1071.00
45_T101_Y1.1041.00
122_P126_V1.1001.00
107_V133_L1.0991.00
93_V97_L1.0891.00
30_V146_T1.0711.00
39_P43_V1.0631.00
32_L85_I1.0601.00
53_T56_G1.0591.00
112_L122_P1.0521.00
28_I31_I1.0481.00
162_G166_D1.0471.00
131_L138_I1.0441.00
31_I35_L1.0271.00
53_T57_I1.0261.00
82_V86_V1.0141.00
33_G145_S1.0141.00
42_V104_I1.0131.00
28_I32_L1.0051.00
29_A33_G1.0021.00
46_R109_K0.9961.00
162_G165_G0.9911.00
196_Y199_A0.9901.00
41_G104_I0.9841.00
100_T141_G0.9831.00
192_I196_Y0.9821.00
120_M125_Q0.9821.00
43_V54_I0.9681.00
161_G165_G0.9671.00
81_K85_I0.9571.00
135_A139_M0.9471.00
38_V138_I0.9471.00
78_G82_V0.9411.00
125_Q130_E0.9381.00
197_V200_V0.9341.00
29_A88_L0.9281.00
84_A88_L0.9271.00
25_I81_K0.9131.00
165_G168_I0.9111.00
133_L136_P0.9081.00
72_F76_L0.8971.00
125_Q128_L0.8951.00
80_G161_G0.8941.00
193_V197_V0.8851.00
36_V93_V0.8841.00
88_L149_L0.8831.00
36_V89_F0.8731.00
33_G92_S0.8721.00
24_T82_V0.8711.00
73_F87_A0.8701.00
37_A97_L0.8681.00
80_G83_P0.8541.00
48_K52_G0.8511.00
16_L19_T0.8461.00
51_A55_I0.8461.00
52_G56_G0.8401.00
23_I27_L0.8361.00
78_G81_K0.8331.00
81_K161_G0.8271.00
24_T27_L0.8221.00
42_V126_V0.8171.00
100_T134_A0.8161.00
152_W155_L0.8151.00
166_D169_F0.8141.00
99_N141_G0.8121.00
30_V149_L0.8081.00
197_V201_A0.8071.00
44_L101_Y0.8061.00
28_I89_F0.8061.00
19_T23_I0.7991.00
31_I142_I0.7991.00
32_L35_L0.7961.00
156_A163_G0.7901.00
27_L31_I0.7891.00
96_I100_T0.7891.00
178_E181_I0.7881.00
20_Y23_I0.7881.00
66_S91_Y0.7881.00
165_G169_F0.7831.00
120_M128_L0.7811.00
171_G174_L0.7781.00
33_G96_I0.7771.00
167_Y183_G0.7731.00
87_A159_I0.7701.00
134_A137_V0.7661.00
126_V130_E0.7651.00
82_V85_I0.7641.00
163_G167_Y0.7611.00
36_V39_P0.7581.00
52_G55_I0.7511.00
137_V141_G0.7501.00
79_V83_P0.7461.00
22_H150_I0.7411.00
21_E161_G0.7401.00
34_V100_T0.7361.00
163_G168_I0.7331.00
29_A89_F0.7321.00
58_V97_L0.7321.00
188_T192_I0.7301.00
100_T137_V0.7281.00
26_S150_I0.7251.00
19_T164_L0.7211.00
42_V122_P0.7201.00
109_K116_K0.7191.00
46_R122_P0.7161.00
41_G97_L0.7151.00
77_L83_P0.7151.00
127_R131_L0.7131.00
152_W156_A0.7131.00
114_S118_I0.7111.00
126_V131_L0.7031.00
73_F76_L0.7021.00
130_E133_L0.6971.00
22_H164_L0.6921.00
19_T190_L0.6861.00
171_G180_I0.6851.00
103_G134_A0.6851.00
92_S145_S0.6831.00
69_I91_Y0.6821.00
70_L74_I0.6771.00
191_A195_D0.6751.00
177_P181_I0.6741.00
145_S149_L0.6711.00
18_K21_E0.6691.00
170_I173_N0.6681.00
59_N98_R0.6671.00
73_F159_I0.6671.00
127_R130_E0.6651.00
33_G37_A0.6641.00
21_E81_K0.6601.00
13_G17_Y0.6591.00
43_V47_M0.6591.00
35_L38_V0.6581.00
44_L54_I0.6561.00
37_A100_T0.6561.00
47_M122_P0.6501.00
59_N62_Q0.6491.00
181_I184_A0.6481.00
114_S117_G0.6411.00
111_L129_V0.6391.00
69_I73_F0.6381.00
135_A138_I0.6381.00
195_D199_A0.6371.00
47_M51_A0.6341.00
154_T157_S0.6311.00
111_L114_S0.6251.00
29_A85_I0.6221.00
83_P87_A0.6201.00
87_A155_L0.6181.00
17_Y24_T0.6161.00
157_S166_D0.6121.00
25_I84_A0.6041.00
66_S154_T0.6021.00
74_I78_G0.6001.00
30_V34_V0.5991.00
162_G169_F0.5971.00
145_S148_Y0.5921.00
70_L154_T0.5911.00
46_R130_E0.5901.00
179_Y183_G0.5851.00
34_V138_I0.5831.00
57_I61_I0.5821.00
31_I34_V0.5821.00
80_G160_G0.5811.00
108_N111_L0.5811.00
153_A169_F0.5771.00
44_L51_A0.5761.00
138_I142_I0.5691.00
148_Y151_G0.5661.00
26_S30_V0.5661.00
107_V134_A0.5641.00
141_G145_S0.5611.00
113_E116_K0.5591.00
25_I88_L0.5591.00
88_L156_A0.5571.00
50_G54_I0.5561.00
25_I29_A0.5551.00
42_V46_R0.5521.00
190_L193_V0.5511.00
33_G89_F0.5481.00
15_L183_G0.5481.00
41_G101_Y0.5431.00
54_I58_V0.5421.00
125_Q129_V0.5421.00
189_I193_V0.5401.00
62_Q94_L0.5381.00
64_L68_A0.5381.00
14_E18_K0.5371.00
193_V196_Y0.5371.00
100_T104_I0.5351.00
33_G149_L0.5351.00
21_E25_I0.5351.00
44_L58_V0.5321.00
14_E167_Y0.5301.00
40_L43_V0.5271.00
103_G141_G0.5271.00
13_G16_L0.5211.00
190_L194_I0.5151.00
177_P180_I0.5141.00
55_I59_N0.5141.00
69_I90_F0.5121.00
28_I81_K0.5121.00
37_A41_G0.5091.00
34_V38_V0.5091.00
19_T186_P0.5071.00
173_N176_Q0.5031.00
181_I185_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.9263 100 0.246 Contact Map
3d31C 2 0.9078 100 0.254 Contact Map
4tquM 1 0.9447 100 0.293 Contact Map
3rlfF 1 0.9032 100 0.31 Contact Map
4ymuD 2 0.9493 100 0.329 Contact Map
3rlfG 1 0.9724 99.9 0.348 Contact Map
3tuiA 2 0.9263 99.9 0.356 Contact Map
4tquN 1 0.9171 99.9 0.386 Contact Map
4mt1A 3 0.8111 28 0.92 Contact Map
3ne5A 3 0.8664 27.7 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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