GREMLIN Database
OPUBA - Choline transport ATP-binding protein OpuBA
UniProt: Q45460 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 381 (301)
Sequences: 6664 (5656)
Seq/√Len: 326.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_N20_N5.1601.00
4_L7_V3.8551.00
200_I221_D3.8071.00
5_E58_K3.7601.00
16_K19_N3.3341.00
29_E205_R3.2651.00
90_H134_H3.1821.00
45_M192_V3.1351.00
9_K47_M3.0141.00
91_M99_L2.8111.00
9_K55_S2.7091.00
7_V54_P2.4721.00
19_N213_E2.4601.00
308_K311_L2.3671.00
289_D315_V2.3471.00
10_T55_S2.2951.00
25_I31_I2.2931.00
3_T24_K2.2341.00
88_F91_M2.1071.00
6_N22_N2.1041.00
8_S56_A2.0841.00
4_L23_L2.0621.00
45_M158_L2.0371.00
315_V319_D2.0351.00
311_L315_V2.0231.00
32_C203_A2.0211.00
47_M54_P1.9551.00
313_S317_H1.9521.00
289_D292_V1.9371.00
8_S20_N1.8841.00
32_C199_A1.8681.00
31_I207_V1.8391.00
282_D285_L1.7871.00
47_M59_I1.7861.00
4_L48_I1.7161.00
265_A268_T1.6871.00
318_E322_T1.6731.00
131_R135_E1.6661.00
273_I277_R1.6591.00
9_K52_I1.6531.00
26_A29_E1.6511.00
307_K310_N1.6471.00
314_E318_E1.6401.00
219_T222_D1.6291.00
49_N158_L1.6281.00
79_G154_P1.6191.00
272_A276_M1.6111.00
263_I266_D1.6071.00
271_E275_L1.5911.00
91_M95_Q1.5801.00
296_Y299_V1.5751.00
7_V47_M1.5681.00
292_V296_Y1.5591.00
23_L207_V1.5541.00
256_M259_Q1.5381.00
96_N133_P1.5071.00
268_T272_A1.4981.00
133_P144_I1.4911.00
278_Q282_D1.4901.00
319_D322_T1.4881.00
94_Q98_S1.4851.00
317_H321_Y1.4831.00
92_T95_Q1.4821.00
262_T265_A1.4751.00
218_G222_D1.4741.00
261_V265_A1.4721.00
282_D322_T1.4711.00
128_Y131_R1.4621.00
10_T16_K1.4601.00
3_T60_F1.4321.00
274_Q277_R1.4201.00
96_N148_R1.3991.00
269_L272_A1.3921.00
210_K213_E1.3881.00
179_K201_K1.3811.00
46_K52_I1.3771.00
270_S274_Q1.3671.00
310_N314_E1.3361.00
284_L288_N1.3281.00
107_P110_Q1.3211.00
36_P39_C1.3201.00
283_S287_V1.3191.00
89_P134_H1.3101.00
46_K51_L1.3101.00
237_G240_R1.3051.00
11_Y17_A1.2941.00
290_E319_D1.2921.00
116_R126_P1.2861.00
305_C308_K1.2831.00
232_V235_F1.2721.00
91_M96_N1.2661.00
18_V47_M1.2621.00
253_D256_M1.2501.00
87_L96_N1.2471.00
191_F203_A1.2461.00
315_V318_E1.2421.00
178_F189_I1.2371.00
282_D286_V1.2371.00
317_H320_I1.2331.00
258_T262_T1.2331.00
318_E321_Y1.2271.00
47_M55_S1.2271.00
5_E60_F1.2191.00
257_N260_P1.2191.00
281_V284_L1.2101.00
205_R216_Q1.2091.00
312_V315_V1.2051.00
275_L279_E1.2031.00
63_G76_R1.1971.00
8_S16_K1.1881.00
294_Q320_I1.1821.00
301_I304_Q1.1781.00
93_I144_I1.1661.00
314_E317_H1.1661.00
264_T268_T1.1661.00
285_L289_D1.1521.00
5_E22_N1.1381.00
253_D257_N1.1371.00
199_A203_A1.1351.00
31_I190_V1.1331.00
270_S273_I1.1231.00
114_R117_E1.1211.00
258_T261_V1.1211.00
28_G188_T1.1161.00
18_V21_V1.1151.00
311_L314_E1.1131.00
307_K311_L1.1111.00
132_Y135_E1.1061.00
95_Q98_S1.1061.00
13_G16_K1.1031.00
158_L190_V1.1031.00
303_D309_A1.0971.00
181_L187_K1.0921.00
29_E204_D1.0921.00
113_E117_E1.0891.00
225_R228_A1.0861.00
269_L273_I1.0861.00
232_V236_I1.0841.00
316_L319_D1.0791.00
265_A269_L1.0781.00
303_D306_R1.0761.00
100_V148_R1.0761.00
171_R195_D1.0751.00
290_E294_Q1.0721.00
6_N56_A1.0681.00
90_H132_Y1.0671.00
293_L297_V1.0671.00
267_K270_S1.0651.00
316_L320_I1.0641.00
254_Q257_N1.0641.00
302_I309_A1.0631.00
275_L278_Q1.0631.00
308_K312_V1.0621.00
260_P263_I1.0461.00
92_T96_N1.0451.00
176_E180_K1.0401.00
292_V295_G1.0381.00
276_M279_E1.0301.00
279_E283_S1.0261.00
112_K115_A1.0131.00
271_E274_Q1.0081.00
118_L147_L1.0081.00
253_D259_Q1.0071.00
4_L59_I1.0051.00
8_S19_N1.0031.00
262_T266_D0.9971.00
222_D226_N0.9961.00
235_F238_K0.9951.00
208_I227_P0.9951.00
257_N261_V0.9921.00
110_Q113_E0.9911.00
284_L287_V0.9871.00
25_I188_T0.9871.00
108_E111_R0.9821.00
277_R281_V0.9801.00
191_F202_L0.9801.00
88_F96_N0.9761.00
208_I223_I0.9751.00
265_A270_S0.9721.00
313_S316_L0.9681.00
270_S276_M0.9601.00
231_F234_E0.9571.00
191_F199_A0.9541.00
39_C209_L0.9531.00
81_V149_A0.9531.00
79_G149_A0.9401.00
313_S320_I0.9391.00
210_K214_I0.9381.00
294_Q298_D0.9361.00
291_R295_G0.9341.00
93_I133_P0.9321.00
293_L296_Y0.9301.00
64_E76_R0.9281.00
193_T199_A0.9271.00
93_I99_L0.9251.00
267_K274_Q0.9241.00
220_P224_L0.9241.00
293_L312_V0.9231.00
118_L151_A0.9141.00
107_P112_K0.9121.00
81_V142_Q0.9101.00
231_F235_F0.9071.00
101_P104_L0.9071.00
269_L274_Q0.9061.00
274_Q278_Q0.9061.00
305_C309_A0.9031.00
238_K242_I0.8981.00
286_V290_E0.8981.00
251_R254_Q0.8921.00
10_T14_G0.8911.00
306_R309_A0.8911.00
310_N313_S0.8861.00
221_D225_R0.8851.00
49_N80_Y0.8751.00
305_C312_V0.8711.00
252_V256_M0.8711.00
291_R294_Q0.8711.00
9_K18_V0.8711.00
272_A275_L0.8711.00
9_K43_T0.8581.00
258_T263_I0.8471.00
276_M280_R0.8461.00
51_L86_G0.8451.00
295_G298_D0.8441.00
34_I208_I0.8441.00
111_R114_R0.8421.00
263_I269_L0.8381.00
213_E217_V0.8361.00
7_V59_I0.8321.00
264_T267_K0.8291.00
178_F202_L0.8201.00
297_V302_I0.8161.00
197_D201_K0.8151.00
260_P264_T0.8121.00
98_S115_A0.8101.00
77_K152_A0.8071.00
272_A280_R0.8051.00
266_D269_L0.8021.00
168_P172_D0.8021.00
154_P181_L0.8011.00
54_P59_I0.8011.00
223_I227_P0.8001.00
209_L214_I0.8001.00
219_T223_I0.7991.00
289_D296_Y0.7991.00
279_E282_D0.7981.00
193_T198_E0.7981.00
233_E237_G0.7961.00
301_I305_C0.7911.00
192_V195_D0.7911.00
295_G299_V0.7901.00
156_L190_V0.7891.00
221_D224_L0.7861.00
254_Q258_T0.7861.00
259_Q263_I0.7851.00
288_N291_R0.7801.00
93_I136_L0.7781.00
116_R129_V0.7781.00
300_E303_D0.7751.00
281_V285_L0.7741.00
288_N292_V0.7691.00
280_R284_L0.7671.00
280_R283_S0.7631.00
290_E320_I0.7611.00
110_Q114_R0.7570.99
191_F198_E0.7540.99
289_D319_D0.7480.99
213_E216_Q0.7470.99
233_E236_I0.7370.99
266_D270_S0.7360.99
224_L227_P0.7350.99
25_I190_V0.7340.99
286_V289_D0.7330.99
302_I308_K0.7330.99
303_D307_K0.7290.99
92_T132_Y0.7270.99
133_P141_Q0.7240.99
99_L104_L0.7220.99
299_V302_I0.7220.99
116_R120_K0.7220.99
249_V252_V0.7190.99
302_I305_C0.7180.99
297_V313_S0.7150.99
27_K155_P0.7150.99
220_P223_I0.7150.99
107_P111_R0.7090.99
214_I217_V0.6970.99
99_L103_L0.6910.99
224_L228_A0.6910.99
298_D301_I0.6910.99
317_H322_T0.6900.99
239_E242_I0.6890.99
127_E130_D0.6880.99
294_Q316_L0.6870.99
96_N99_L0.6870.99
309_A313_S0.6830.99
117_E121_L0.6820.99
256_M260_P0.6800.99
245_S248_D0.6780.99
268_T275_L0.6780.99
255_I259_Q0.6720.99
94_Q115_A0.6710.99
285_L288_N0.6690.99
78_I156_L0.6680.99
159_M189_I0.6680.99
217_V226_N0.6660.99
280_R287_V0.6640.99
297_V301_I0.6620.99
155_P187_K0.6590.99
7_V18_V0.6590.99
277_R280_R0.6580.99
161_E194_H0.6580.99
157_I187_K0.6530.98
47_M52_I0.6490.98
286_V319_D0.6480.98
120_K126_P0.6470.98
89_P141_Q0.6450.98
306_R310_N0.6420.98
11_Y52_I0.6410.98
289_D293_L0.6400.98
94_Q129_V0.6390.98
97_I100_V0.6380.98
254_Q259_Q0.6370.98
273_I297_V0.6360.98
122_V147_L0.6320.98
2_L156_L0.6270.98
265_A273_I0.6260.98
267_K281_V0.6240.98
237_G241_L0.6220.98
25_I156_L0.6190.98
99_L102_K0.6170.98
138_G143_R0.6130.98
263_I270_S0.6130.98
300_E305_C0.6120.98
2_L61_I0.6120.98
309_A312_V0.6090.98
273_I276_M0.6080.98
11_Y14_G0.6040.97
232_V239_E0.6030.97
242_I245_S0.6000.97
246_S249_V0.5990.97
297_V305_C0.5990.97
312_V316_L0.5980.97
94_Q130_D0.5970.97
108_E112_K0.5960.97
296_Y308_K0.5940.97
97_I104_L0.5940.97
261_V264_T0.5910.97
269_L276_M0.5900.97
252_V259_Q0.5860.97
308_K315_V0.5860.97
109_Q113_E0.5830.97
42_T46_K0.5830.97
175_Q198_E0.5820.97
62_D76_R0.5820.97
98_S102_K0.5810.97
227_P233_E0.5810.97
299_V303_D0.5780.97
290_E297_V0.5770.97
275_L283_S0.5760.97
175_Q201_K0.5750.97
49_N78_I0.5750.97
193_T196_M0.5740.97
145_G150_L0.5720.97
257_N263_I0.5710.97
268_T276_M0.5710.97
10_T56_A0.5700.96
250_E255_I0.5680.96
101_P151_A0.5670.96
267_K271_E0.5650.96
50_R61_I0.5650.96
302_I310_N0.5620.96
164_G196_M0.5610.96
305_C320_I0.5610.96
312_V319_D0.5600.96
210_K215_V0.5590.96
181_L189_I0.5570.96
234_E241_L0.5570.96
165_A171_R0.5560.96
287_V290_E0.5540.96
95_Q130_D0.5540.96
266_D272_A0.5530.96
21_V207_V0.5520.96
304_Q307_K0.5520.96
97_I151_A0.5510.96
256_M262_T0.5500.96
92_T130_D0.5490.96
94_Q99_L0.5490.96
115_A151_A0.5490.96
238_K241_L0.5470.96
94_Q97_I0.5470.96
34_I223_I0.5460.96
220_P232_V0.5450.95
235_F239_E0.5450.95
119_L122_V0.5440.95
218_G223_I0.5430.95
290_E293_L0.5430.95
263_I271_E0.5420.95
195_D198_E0.5410.95
62_D155_P0.5400.95
287_V291_R0.5390.95
17_A39_C0.5390.95
280_R286_V0.5370.95
199_A202_L0.5360.95
313_S321_Y0.5360.95
34_I217_V0.5350.95
305_C310_N0.5350.95
266_D271_E0.5340.95
31_I205_R0.5330.95
205_R217_V0.5330.95
41_K161_E0.5330.95
236_I240_R0.5330.95
313_S322_T0.5320.95
273_I279_E0.5320.95
293_L298_D0.5320.95
261_V269_L0.5310.95
44_T209_L0.5310.95
100_V152_A0.5300.95
253_D258_T0.5290.95
261_V268_T0.5280.95
212_G216_Q0.5240.94
297_V303_D0.5240.94
255_I258_T0.5240.94
267_K273_I0.5240.94
234_E237_G0.5210.94
259_Q262_T0.5200.94
175_Q197_D0.5200.94
37_S164_G0.5170.94
248_D252_V0.5170.94
46_K80_Y0.5170.94
298_D303_D0.5160.94
47_M53_E0.5150.94
50_R53_E0.5140.94
263_I268_T0.5130.94
34_I206_I0.5130.94
44_T48_I0.5120.94
313_S319_D0.5110.94
254_Q263_I0.5100.94
33_F44_T0.5080.93
304_Q320_I0.5070.93
166_L174_L0.5070.93
21_V214_I0.5070.93
109_Q112_K0.5060.93
48_I190_V0.5050.93
100_V103_L0.5040.93
120_K125_G0.5040.93
97_I102_K0.5020.93
81_V145_G0.5020.93
82_I85_I0.5020.93
11_Y43_T0.5010.93
97_I101_P0.5010.93
275_L282_D0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f4cA 1 0.5827 100 0.281 Contact Map
3tuiC 2 0.8793 100 0.281 Contact Map
4ry2A 2 0.6168 100 0.282 Contact Map
4yerA 2 0.7428 100 0.292 Contact Map
4u00A 1 0.6247 100 0.298 Contact Map
4ymuJ 2 0.622 100 0.298 Contact Map
2oljA 2 0.622 100 0.299 Contact Map
4q9hA 1 0.6168 100 0.302 Contact Map
1vplA 2 0.622 100 0.303 Contact Map
1b0uA 2 0.6352 100 0.303 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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