GREMLIN Database
XYND - Arabinoxylan arabinofuranohydrolase
UniProt: Q45071 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 513 (408)
Sequences: 3641 (2803)
Seq/√Len: 138.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_T229_K7.3261.00
59_R92_S6.5641.00
261_T289_S5.7441.00
95_D98_N5.5961.00
141_K159_D5.1831.00
158_A164_P4.6491.00
196_D257_K4.5761.00
325_E353_K4.0141.00
322_F325_E3.6951.00
59_R94_A3.4631.00
261_T287_T3.0741.00
58_G94_A3.0401.00
141_K157_T3.0011.00
227_V292_M2.8091.00
63_Y165_W2.7851.00
446_G450_V2.7781.00
319_V354_L2.7301.00
229_K238_V2.7181.00
242_S292_M2.4391.00
397_T402_A2.3701.00
105_I144_L2.3581.00
291_P295_F2.3571.00
321_N324_N2.3241.00
287_T361_S2.2881.00
88_V144_L2.2781.00
231_G236_S2.2411.00
60_V322_F2.1491.00
446_G449_E2.1461.00
259_N360_G2.1351.00
265_S285_Y2.0901.00
42_L329_V2.0851.00
134_K137_N2.0601.00
228_I237_V2.0321.00
131_I144_L2.0241.00
387_E390_A1.9751.00
433_A437_K1.9691.00
321_N326_W1.9351.00
60_V93_S1.9161.00
468_T473_T1.9141.00
330_Y352_N1.9031.00
63_Y131_I1.8931.00
193_F255_L1.8851.00
110_A167_D1.8831.00
203_Y295_F1.8591.00
231_G234_M1.8141.00
55_T58_G1.8061.00
108_A111_N1.7921.00
290_S295_F1.7711.00
231_G235_T1.7661.00
391_W397_T1.7551.00
92_S100_T1.7361.00
328_V364_E1.6961.00
88_V146_F1.6901.00
408_N422_A1.6821.00
56_Y142_F1.6621.00
357_N361_S1.6551.00
425_N428_F1.6291.00
158_A163_G1.6071.00
92_S162_I1.5801.00
160_S164_P1.5731.00
121_K124_G1.5691.00
466_P469_G1.5521.00
464_N476_E1.5481.00
61_Y162_I1.5451.00
203_Y227_V1.5401.00
447_K450_V1.5021.00
38_N327_Y1.5011.00
258_Y356_H1.4971.00
391_W395_I1.4961.00
394_R397_T1.4871.00
409_N506_D1.4851.00
257_K260_G1.4641.00
381_Y509_Q1.4601.00
391_W396_L1.4571.00
327_Y353_K1.4561.00
370_A373_T1.4561.00
92_S102_H1.4491.00
204_A228_I1.4481.00
466_P472_Q1.4401.00
407_V507_Y1.4391.00
250_F266_Y1.4211.00
126_S146_F1.4031.00
460_V480_A1.3921.00
260_G289_S1.3861.00
265_S283_I1.3851.00
194_V200_G1.3801.00
88_V126_S1.3791.00
288_S295_F1.3691.00
230_L235_T1.3671.00
258_Y360_G1.3611.00
227_V244_I1.3591.00
201_Y292_M1.3561.00
288_S294_P1.3481.00
375_I378_L1.3441.00
399_K402_A1.3351.00
379_N382_N1.3351.00
227_V291_P1.3351.00
443_T446_G1.3341.00
386_A389_F1.3281.00
356_H362_I1.3261.00
155_V235_T1.3241.00
56_Y133_V1.3191.00
197_D257_K1.3181.00
231_G238_V1.3131.00
313_G333_Q1.2981.00
158_A162_I1.2901.00
285_Y362_I1.2891.00
256_H265_S1.2811.00
414_S419_D1.2811.00
137_N198_G1.2801.00
437_K440_V1.2581.00
283_I317_H1.2491.00
229_K239_G1.2471.00
53_A329_V1.2431.00
56_Y59_R1.2421.00
283_I328_V1.2411.00
106_P156_L1.2401.00
193_F262_Y1.2391.00
289_S296_T1.2381.00
468_T472_Q1.2381.00
395_I398_E1.2361.00
408_N412_V1.2261.00
106_P126_S1.2261.00
257_K262_Y1.2251.00
380_P384_V1.2251.00
366_A369_Y1.2231.00
447_K451_R1.2181.00
446_G451_R1.2161.00
54_L142_F1.2141.00
434_R437_K1.1981.00
412_V419_D1.1971.00
384_V389_F1.1961.00
382_N387_E1.1961.00
144_L156_L1.1961.00
382_N390_A1.1951.00
357_N363_Q1.1951.00
426_A429_G1.1871.00
287_T296_T1.1831.00
368_N371_G1.1791.00
384_V387_E1.1791.00
434_R438_A1.1761.00
332_A350_H1.1761.00
160_S165_W1.1690.99
391_W402_A1.1690.99
130_S191_A1.1650.99
203_Y255_L1.1650.99
389_F397_T1.1630.99
89_F104_A1.1620.99
256_H319_V1.1590.99
64_M252_D1.1510.99
195_D257_K1.1490.99
396_L399_K1.1460.99
422_A427_D1.1440.99
462_T476_E1.1400.99
378_L382_N1.1370.99
228_I241_A1.1360.99
203_Y291_P1.1320.99
393_G397_T1.1260.99
387_E391_W1.1240.99
206_G226_R1.1230.99
382_N393_G1.1230.99
466_P474_W1.1230.99
391_W394_R1.1190.99
466_P473_T1.1160.99
255_L295_F1.1150.99
433_A438_A1.0900.99
410_Q414_S1.0850.99
449_E466_P1.0840.99
333_Q343_G1.0840.99
132_A194_V1.0820.99
433_A440_V1.0820.99
424_G428_F1.0780.99
432_G437_K1.0710.99
88_V156_L1.0680.99
285_Y301_F1.0670.99
133_V138_G1.0660.99
233_D236_S1.0650.99
63_Y161_P1.0640.99
448_I451_R1.0640.99
230_L238_V1.0610.99
49_A67_D1.0570.99
93_S96_M1.0560.99
129_P144_L1.0560.99
111_N156_L1.0540.99
389_F393_G1.0540.99
367_A370_A1.0510.99
263_Y285_Y1.0500.99
370_A374_Q1.0500.99
406_P423_V1.0420.99
103_G164_P1.0420.99
411_H421_I1.0410.99
317_H328_V1.0390.99
395_I402_A1.0390.99
406_P508_W1.0370.99
408_N421_I1.0350.99
432_G438_A1.0350.99
396_L402_A1.0330.99
247_P282_E1.0320.99
230_L234_M1.0310.99
381_Y384_V1.0260.99
384_V393_G1.0200.99
432_G435_S1.0190.99
117_R120_A1.0170.99
227_V295_F1.0150.99
66_S89_F1.0150.99
228_I239_G1.0090.98
145_Y202_L1.0050.98
329_V351_I0.9980.98
379_N384_V0.9970.98
287_T356_H0.9960.98
47_L91_I0.9960.98
382_N385_E0.9820.98
258_Y321_N0.9780.98
478_E482_S0.9770.98
395_I401_T0.9760.98
102_H162_I0.9730.98
288_S293_G0.9700.98
393_G399_K0.9690.98
318_A329_V0.9670.98
406_P422_A0.9610.98
66_S87_R0.9580.98
268_I284_G0.9550.98
366_A372_V0.9470.98
393_G402_A0.9460.98
355_V363_Q0.9450.98
414_S421_I0.9410.98
354_L362_I0.9390.98
425_N429_G0.9370.98
411_H422_A0.9300.97
392_N396_L0.9270.97
314_N332_A0.9260.97
238_V241_A0.9260.97
365_V368_N0.9250.97
484_A490_V0.9160.97
408_N411_H0.9150.97
290_S294_P0.9110.97
147_A153_I0.9070.97
101_D104_A0.9070.97
478_E481_V0.9060.97
386_A390_A0.9010.97
404_G408_N0.9010.97
38_N97_V0.9000.97
55_T321_N0.9000.97
145_Y234_M0.8970.97
366_A370_A0.8950.97
326_W356_H0.8930.97
389_F399_K0.8890.97
394_R398_E0.8890.97
436_F439_N0.8880.97
368_N373_T0.8840.96
239_G244_I0.8840.96
158_A165_W0.8790.96
287_T298_R0.8770.96
382_N389_F0.8740.96
497_T501_N0.8660.96
445_G449_E0.8660.96
147_A190_P0.8660.96
366_A373_T0.8650.96
412_V421_I0.8640.96
385_E389_F0.8630.96
239_G242_S0.8590.96
491_F505_F0.8580.96
406_P410_Q0.8540.96
352_N364_E0.8530.96
393_G396_L0.8510.96
134_K138_G0.8480.96
414_S422_A0.8460.95
282_E305_P0.8440.95
412_V417_N0.8430.95
492_F505_F0.8400.95
390_A393_G0.8370.95
63_Y105_I0.8350.95
115_G119_I0.8350.95
193_F197_D0.8340.95
393_G398_E0.8320.95
303_K306_G0.8300.95
405_G411_H0.8300.95
134_K194_V0.8260.95
53_A318_A0.8240.95
253_S264_Y0.8240.95
389_F392_N0.8240.95
408_N414_S0.8220.95
290_S293_G0.8210.95
385_E506_D0.8190.95
119_I122_W0.8180.95
400_S403_P0.8180.95
258_Y326_W0.8180.95
445_G450_V0.8180.95
156_L168_P0.8170.95
394_R402_A0.8170.95
301_F362_I0.8170.95
103_G107_V0.8140.94
63_Y144_L0.8070.94
195_D198_G0.8070.94
148_N151_G0.8070.94
395_I400_S0.8030.94
146_F156_L0.8030.94
409_N507_Y0.8000.94
415_I419_D0.7990.94
108_A167_D0.7970.94
367_A374_Q0.7930.94
63_Y129_P0.7930.94
389_F394_R0.7930.94
396_L400_S0.7920.94
65_S129_P0.7920.94
422_A438_A0.7920.94
116_G119_I0.7910.94
443_T447_K0.7890.93
319_V326_W0.7840.93
393_G401_T0.7840.93
54_L131_I0.7840.93
201_Y229_K0.7830.93
105_I156_L0.7760.93
91_I101_D0.7730.93
463_L466_P0.7730.93
369_Y373_T0.7710.93
225_A266_Y0.7690.93
96_M329_V0.7660.92
437_K441_A0.7640.92
404_G407_V0.7640.92
474_W478_E0.7630.92
429_G434_R0.7600.92
375_I379_N0.7600.92
406_P414_S0.7600.92
49_A347_R0.7580.92
63_Y90_V0.7540.92
366_A371_G0.7530.92
155_V230_L0.7530.92
428_F432_G0.7510.92
322_F327_Y0.7490.92
412_V418_G0.7490.92
387_E397_T0.7470.91
157_T166_T0.7470.91
159_D164_P0.7430.91
95_D99_W0.7430.91
256_H318_A0.7420.91
311_G350_H0.7410.91
380_P383_R0.7390.91
326_W354_L0.7380.91
313_G343_G0.7350.91
421_I427_D0.7340.91
64_M91_I0.7340.91
130_S254_G0.7310.91
137_N143_F0.7280.90
296_T361_S0.7270.90
281_G315_N0.7270.90
42_L53_A0.7270.90
199_T238_V0.7260.90
409_N422_A0.7250.90
52_V316_H0.7240.90
394_R488_H0.7220.90
410_Q503_F0.7220.90
88_V129_P0.7190.90
50_D128_A0.7180.90
227_V255_L0.7170.90
134_K200_G0.7150.90
225_A253_S0.7140.90
433_A436_F0.7130.89
153_I202_L0.7130.89
435_S440_V0.7100.89
443_T450_V0.7090.89
427_D433_A0.7090.89
191_A203_Y0.7070.89
327_Y351_I0.7060.89
59_R102_H0.6990.89
321_N325_E0.6980.88
137_N141_K0.6980.88
167_D172_P0.6950.88
55_T59_R0.6950.88
57_N92_S0.6940.88
267_C281_G0.6940.88
258_Y261_T0.6930.88
422_A428_F0.6920.88
383_R506_D0.6910.88
448_I455_A0.6910.88
407_V422_A0.6910.88
447_K452_L0.6900.88
376_S380_P0.6890.88
134_K143_F0.6880.88
378_L388_T0.6870.88
133_V137_N0.6860.88
133_V142_F0.6850.88
432_G440_V0.6850.88
376_S379_N0.6840.87
188_F253_S0.6810.87
382_N386_A0.6810.87
397_T401_T0.6810.87
407_V410_Q0.6780.87
416_Q419_D0.6780.87
475_R478_E0.6730.87
314_N330_Y0.6730.87
247_P297_Y0.6710.86
420_W492_F0.6710.86
130_S318_A0.6680.86
410_Q422_A0.6670.86
379_N383_R0.6660.86
404_G414_S0.6660.86
469_G472_Q0.6650.86
255_L291_P0.6650.86
132_A192_V0.6640.86
435_S438_A0.6620.86
360_G363_Q0.6600.86
430_A434_R0.6600.86
415_I418_G0.6590.85
291_P294_P0.6590.85
391_W403_P0.6590.85
91_I252_D0.6580.85
409_N414_S0.6560.85
406_P409_N0.6550.85
261_T288_S0.6550.85
265_S354_L0.6520.85
267_C317_H0.6520.85
412_V422_A0.6510.85
100_T376_S0.6510.85
407_V509_Q0.6490.85
55_T320_F0.6460.84
422_A425_N0.6450.84
261_T296_T0.6450.84
288_S292_M0.6450.84
495_T503_F0.6440.84
319_V328_V0.6430.84
153_I190_P0.6430.84
203_Y253_S0.6430.84
195_D291_P0.6420.84
392_N395_I0.6400.84
196_D260_G0.6390.84
451_R464_N0.6380.84
380_P387_E0.6370.83
89_F101_D0.6370.83
55_T322_F0.6360.83
254_G318_A0.6360.83
130_S203_Y0.6360.83
442_S446_G0.6350.83
328_V352_N0.6340.83
442_S445_G0.6320.83
443_T449_E0.6320.83
195_D262_Y0.6320.83
204_A241_A0.6310.83
390_A394_R0.6310.83
406_P421_I0.6300.83
156_L165_W0.6300.83
202_L252_D0.6300.83
118_G121_K0.6300.83
463_L478_E0.6290.83
436_F441_A0.6290.83
300_H303_K0.6280.83
436_F440_V0.6280.83
107_V164_P0.6280.83
365_V373_T0.6250.82
283_I286_M0.6250.82
374_Q377_N0.6240.82
449_E455_A0.6230.82
90_V162_I0.6200.82
394_R399_K0.6190.82
153_I187_L0.6190.82
199_T232_P0.6190.82
52_V254_G0.6190.82
120_A123_A0.6180.82
185_V237_V0.6150.81
245_D248_F0.6140.81
457_G462_T0.6130.81
117_R122_W0.6130.81
200_G232_P0.6110.81
261_T361_S0.6100.81
326_W362_I0.6090.81
317_H329_V0.6090.81
404_G410_Q0.6090.81
53_A320_F0.6080.81
405_G457_G0.6070.80
298_R357_N0.6060.80
491_F508_W0.6040.80
425_N430_A0.6040.80
202_L228_I0.6040.80
50_D347_R0.6030.80
383_R509_Q0.6010.80
474_W482_S0.5990.80
461_G480_A0.5990.80
426_A490_V0.5980.79
158_A161_P0.5980.79
225_A264_Y0.5970.79
435_S439_N0.5970.79
298_R361_S0.5960.79
419_D422_A0.5960.79
415_I421_I0.5950.79
298_R363_Q0.5950.79
395_I403_P0.5940.79
93_S99_W0.5940.79
330_Y350_H0.5930.79
407_V419_D0.5920.79
138_G141_K0.5910.79
405_G408_N0.5910.79
407_V423_V0.5880.78
145_Y155_V0.5870.78
377_N381_Y0.5870.78
397_T400_S0.5870.78
449_E495_T0.5850.78
430_A435_S0.5830.78
157_T168_P0.5820.78
334_T348_S0.5820.78
382_N388_T0.5800.77
394_R400_S0.5790.77
145_Y192_V0.5780.77
443_T451_R0.5780.77
237_V240_S0.5780.77
420_W435_S0.5780.77
368_N374_Q0.5770.77
65_S127_W0.5770.77
469_G473_T0.5770.77
445_G448_I0.5760.77
367_A372_V0.5750.77
191_A254_G0.5750.77
387_E392_N0.5740.77
410_Q438_A0.5730.77
192_V202_L0.5730.77
147_A186_W0.5730.77
65_S281_G0.5720.76
146_F154_G0.5720.76
88_V105_I0.5710.76
367_A373_T0.5670.76
384_V390_A0.5670.76
92_S101_D0.5670.76
61_Y142_F0.5670.76
193_F291_P0.5660.76
43_I62_I0.5650.76
391_W401_T0.5650.76
444_L447_K0.5640.75
365_V369_Y0.5630.75
424_G427_D0.5610.75
404_G421_I0.5610.75
264_Y286_M0.5600.75
193_F199_T0.5600.75
301_F305_P0.5600.75
269_N315_N0.5590.75
371_G374_Q0.5580.75
462_T480_A0.5580.75
428_F434_R0.5570.75
392_N397_T0.5560.74
398_E402_A0.5560.74
404_G422_A0.5560.74
443_T448_I0.5550.74
398_E403_P0.5550.74
438_A441_A0.5550.74
63_Y88_V0.5550.74
389_F395_I0.5550.74
42_L62_I0.5530.74
407_V411_H0.5530.74
375_I380_P0.5500.74
393_G400_S0.5500.74
442_S447_K0.5490.73
100_T162_I0.5490.73
159_D162_I0.5470.73
409_N421_I0.5470.73
331_H348_S0.5450.73
99_W262_Y0.5450.73
304_N314_N0.5450.73
160_S163_G0.5440.73
469_G474_W0.5420.73
420_W425_N0.5410.72
226_R243_T0.5410.72
387_E395_I0.5400.72
380_P390_A0.5400.72
119_I123_A0.5390.72
226_R241_A0.5390.72
430_A433_A0.5390.72
205_G226_R0.5380.72
479_T482_S0.5370.72
427_D487_V0.5350.72
409_N413_T0.5350.72
456_D461_G0.5340.71
420_W423_V0.5330.71
147_A155_V0.5330.71
396_L401_T0.5320.71
50_D65_S0.5310.71
120_A124_G0.5300.71
86_N346_Y0.5290.71
90_V105_I0.5280.71
126_S147_A0.5260.70
450_V454_S0.5230.70
66_S86_N0.5230.70
389_F396_L0.5210.70
137_N232_P0.5200.69
378_L384_V0.5190.69
265_S318_A0.5190.69
449_E468_T0.5190.69
382_N392_N0.5170.69
202_L237_V0.5170.69
407_V412_V0.5160.69
367_A371_G0.5160.69
488_H491_F0.5150.69
384_V388_T0.5140.69
354_L364_E0.5130.68
432_G436_F0.5130.68
225_A268_I0.5130.68
447_K466_P0.5130.68
502_L506_D0.5130.68
444_L450_V0.5120.68
57_N94_A0.5120.68
356_H361_S0.5120.68
279_P333_Q0.5110.68
411_H416_Q0.5110.68
62_I349_P0.5100.68
404_G411_H0.5100.68
387_E396_L0.5080.68
394_R403_P0.5070.68
68_D86_N0.5070.68
200_G230_L0.5060.67
456_D460_V0.5040.67
253_S269_N0.5030.67
49_A349_P0.5020.67
256_H356_H0.5020.67
331_H334_T0.5000.66
399_K403_P0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c7fA 1 0.9493 100 0.289 Contact Map
3c2uA 3 0.8285 100 0.4 Contact Map
1yrzA 1 0.8226 100 0.402 Contact Map
2exhA 3 0.8265 100 0.411 Contact Map
1yifA 3 0.8265 100 0.412 Contact Map
3zxkA 1 0.7895 100 0.432 Contact Map
2x8sA 1 0.7427 100 0.449 Contact Map
4kc7A 1 0.7427 100 0.49 Contact Map
4kcaA 2 0.8538 100 0.491 Contact Map
4novA 1 0.5595 100 0.498 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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