GREMLIN Database
XYNC - Glucuronoxylanase XynC
UniProt: Q45070 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (344)
Sequences: 2027 (1509)
Seq/√Len: 81.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_P179_T5.6281.00
332_Y352_G4.2671.00
43_E351_K3.5251.00
149_L166_I3.5091.00
94_W159_N3.3931.00
155_F158_N3.2071.00
46_V333_V3.1221.00
157_K162_N2.9701.00
248_K292_D2.9251.00
72_G107_H2.9001.00
66_Q69_T2.7471.00
81_S330_P2.5861.00
47_I288_M2.5491.00
143_A147_Q2.4881.00
191_R220_D2.4751.00
150_N195_G2.4631.00
43_E333_V2.4501.00
124_E138_K2.4181.00
48_R255_D2.3931.00
42_A336_D2.3741.00
154_T195_G2.3341.00
188_R192_E2.3341.00
87_V113_A2.3181.00
257_W295_A2.3151.00
191_R222_Q2.3001.00
302_R306_G2.3001.00
302_R305_Y2.2851.00
308_M311_D2.2471.00
72_G76_N2.2061.00
98_V161_V2.1661.00
352_G355_K2.1631.00
111_V161_V2.0611.00
112_F297_V2.0521.00
87_V149_L2.0311.00
203_A227_M2.0101.00
245_P291_G2.0021.00
332_Y355_K1.9921.00
200_R228_D1.9891.00
73_N79_G1.9711.00
358_I372_F1.9491.00
103_S106_K1.9271.00
360_A370_Q1.9161.00
67_R103_S1.8991.00
113_A163_L1.8871.00
234_L261_V1.8671.00
54_N83_L1.8591.00
151_D155_F1.8571.00
332_Y353_D1.8561.00
115_P169_Q1.8511.00
307_P314_I1.8471.00
102_K159_N1.8371.00
68_E103_S1.8301.00
138_K141_K1.8231.00
335_I356_V1.8081.00
114_S167_S1.8061.00
37_T373_V1.7961.00
193_N225_A1.7821.00
40_V335_I1.7771.00
308_M313_T1.7381.00
345_V360_A1.7281.00
44_K334_R1.7171.00
82_I295_A1.7071.00
136_R185_E1.6741.00
282_Q363_K1.6511.00
349_A358_I1.6401.00
329_R332_Y1.6021.00
154_T197_I1.5831.00
50_F288_M1.5801.00
281_S361_I1.5571.00
147_Q150_N1.5360.99
223_A226_N1.5330.99
231_G259_T1.5310.99
63_T66_Q1.5300.99
288_M328_V1.5290.99
187_L220_D1.5180.99
202_I231_G1.5070.99
68_E72_G1.5030.99
113_A152_F1.4770.99
284_I288_M1.4740.99
39_N42_A1.4630.99
154_T196_S1.4610.99
71_F107_H1.4560.99
166_I201_V1.4310.99
44_K335_I1.4230.99
73_N76_N1.4210.99
105_V161_V1.4020.99
78_L322_A1.3910.99
48_R110_I1.3860.99
85_I101_A1.3810.99
322_A326_K1.3760.99
276_E280_V1.3670.99
286_N289_V1.3660.99
274_W278_L1.3550.99
64_A68_E1.3510.99
232_T256_L1.3410.99
71_F104_A1.3360.99
87_V152_F1.3260.98
151_D154_T1.3170.98
181_W186_I1.3150.98
115_P149_L1.3140.98
203_A217_I1.3140.98
255_D294_Q1.3100.98
173_D204_P1.2970.98
329_R352_G1.2950.98
372_F379_A1.2890.98
153_V163_L1.2880.98
145_Y149_L1.2860.98
147_Q195_G1.2840.98
307_P311_D1.2760.98
337_A347_V1.2730.98
277_A280_V1.2650.98
285_H324_F1.2620.98
228_D254_K1.2530.98
153_V197_I1.2520.98
110_I164_Y1.2510.98
117_N123_V1.2500.98
184_Q216_P1.2450.98
124_E135_K1.2380.98
74_G77_Q1.2360.98
335_I351_K1.2240.97
85_I152_F1.2150.97
245_P292_D1.2110.97
150_N197_I1.2090.97
103_S107_H1.1990.97
183_P216_P1.1980.97
273_R277_A1.1800.97
79_G329_R1.1750.97
301_I305_Y1.1630.96
86_H90_N1.1590.96
277_A316_K1.1580.96
50_F325_S1.1550.96
285_H361_I1.1520.96
78_L326_K1.1510.96
303_R306_G1.1490.96
120_S132_T1.1430.96
188_R191_R1.1420.96
62_L70_A1.1380.96
307_P312_G1.1330.96
332_Y357_V1.1290.96
274_W277_A1.1270.96
258_M261_V1.1160.96
219_N251_G1.1110.95
289_V348_S1.1110.95
309_K312_G1.1010.95
307_P313_T1.0990.95
124_E136_R1.0980.95
221_P225_A1.0940.95
42_A335_I1.0940.95
26_G29_E1.0780.95
87_V166_I1.0750.95
346_Y363_K1.0740.94
55_H58_W1.0720.94
190_M226_N1.0710.94
94_W98_V1.0700.94
281_S320_N1.0660.94
93_N156_M1.0640.94
307_P310_E1.0580.94
211_K214_S1.0560.94
215_D250_K1.0500.94
39_N336_D1.0500.94
137_L140_N1.0450.94
47_I50_F1.0320.93
47_I328_V1.0270.93
54_N101_A1.0250.93
152_F156_M1.0240.93
319_Y322_A1.0190.93
190_M227_M1.0190.93
93_N99_E1.0170.93
333_V336_D1.0130.93
280_V283_H1.0120.93
287_A296_Y1.0070.92
298_W321_M1.0060.92
282_Q346_Y1.0050.92
40_V374_L1.0040.92
167_S205_E1.0010.92
48_R294_Q1.0000.92
38_V335_I0.9970.92
67_R99_E0.9880.92
98_V159_N0.9880.92
172_P235_Y0.9870.92
74_G79_G0.9860.92
46_V331_G0.9840.91
88_D148_H0.9830.91
110_I330_P0.9820.91
281_S324_F0.9810.91
111_V163_L0.9800.91
146_A150_N0.9760.91
92_N95_Y0.9730.91
232_T293_F0.9710.91
44_K336_D0.9710.91
175_A180_W0.9710.91
222_Q225_A0.9630.91
248_K252_A0.9620.91
71_F103_S0.9570.90
40_V356_V0.9560.90
89_E177_E0.9550.90
273_R280_V0.9520.90
228_D255_D0.9510.90
273_R279_D0.9490.90
263_Y317_R0.9470.90
209_Y236_G0.9440.90
190_M201_V0.9360.89
54_N104_A0.9270.89
89_E117_N0.9260.89
245_P248_K0.9230.89
215_D219_N0.9170.88
86_H177_E0.9170.88
125_T130_G0.9160.88
52_G80_F0.8960.87
47_I289_V0.8940.87
115_P118_P0.8920.87
187_L223_A0.8920.87
73_N326_K0.8910.87
80_F298_W0.8890.87
56_P86_H0.8860.87
123_V176_H0.8860.87
78_L327_F0.8850.86
48_R257_W0.8840.86
143_A194_A0.8810.86
150_N154_T0.8760.86
137_L142_Y0.8750.86
50_F315_S0.8730.86
105_V162_N0.8670.85
309_K314_I0.8630.85
139_Y188_R0.8630.85
116_W123_V0.8600.85
273_R276_E0.8600.85
328_V359_V0.8590.85
168_V190_M0.8540.84
184_Q187_L0.8480.84
244_Y247_F0.8470.84
220_D223_A0.8450.84
373_V376_N0.8400.83
112_F202_I0.8390.83
274_W280_V0.8360.83
40_V375_Q0.8330.83
272_D276_E0.8330.83
45_Q334_R0.8330.83
141_K144_A0.8310.83
77_Q322_A0.8290.83
35_D371_N0.8270.83
88_D177_E0.8260.82
67_R71_F0.8230.82
224_L254_K0.8210.82
234_L296_Y0.8200.82
165_A229_I0.8180.82
285_H348_S0.8160.82
218_L230_L0.8140.82
146_A189_F0.8120.81
217_I227_M0.8100.81
55_H59_A0.8080.81
263_Y266_S0.8070.81
130_G133_S0.8020.81
371_N378_S0.8020.81
173_D210_L0.8010.80
208_Q237_T0.7980.80
101_A111_V0.7920.80
280_V298_W0.7870.79
147_Q151_D0.7860.79
262_Y317_R0.7860.79
185_E188_R0.7810.79
26_G30_V0.7800.79
173_D206_S0.7780.78
309_K313_T0.7770.78
90_N177_E0.7750.78
86_H116_W0.7720.78
133_S137_L0.7660.77
217_I223_A0.7610.77
220_D326_K0.7610.77
119_P148_H0.7600.77
33_A368_V0.7570.77
142_Y192_E0.7550.76
144_A147_Q0.7480.76
83_L101_A0.7480.76
264_P279_D0.7460.76
46_V294_Q0.7460.76
143_A192_E0.7460.76
70_A314_I0.7450.75
113_A153_V0.7440.75
247_F251_G0.7430.75
331_G349_A0.7400.75
96_K152_F0.7300.74
63_T312_G0.7290.74
105_V164_Y0.7280.74
205_E233_H0.7270.74
215_D218_L0.7260.74
117_N120_S0.7240.73
142_Y185_E0.7200.73
327_F357_V0.7190.73
156_M263_Y0.7170.73
351_K356_V0.7160.73
171_E233_H0.7160.73
27_A30_V0.7130.72
308_M312_G0.7120.72
28_T31_L0.7070.72
80_F321_M0.7060.71
200_R255_D0.7040.71
337_A349_A0.7040.71
94_W155_F0.7030.71
88_D121_D0.7030.71
134_A137_L0.7020.71
284_I296_Y0.7020.71
25_P30_V0.7010.71
212_N215_D0.7000.71
324_F359_V0.6990.71
221_P366_T0.6970.71
39_N338_T0.6960.70
285_H289_V0.6930.70
135_K185_E0.6910.70
256_L293_F0.6890.70
105_V111_V0.6860.69
191_R223_A0.6830.69
153_V166_I0.6820.69
344_N364_S0.6790.69
25_P28_T0.6790.69
112_F231_G0.6780.68
89_E176_H0.6780.68
98_V102_K0.6740.68
369_N373_V0.6730.68
53_M262_Y0.6700.67
36_V347_V0.6690.67
116_W169_Q0.6660.67
68_E106_K0.6660.67
125_T180_W0.6650.67
372_F375_Q0.6640.67
32_A35_D0.6640.67
55_H205_E0.6630.67
83_L111_V0.6630.67
79_G326_K0.6620.67
36_V337_A0.6620.67
167_S181_W0.6610.66
54_N100_T0.6610.66
217_I220_D0.6600.66
234_L262_Y0.6600.66
209_Y293_F0.6590.66
174_Y207_F0.6550.66
80_F325_S0.6530.65
52_G301_I0.6510.65
220_D226_N0.6480.65
98_V101_A0.6480.65
272_D277_A0.6480.65
328_V357_V0.6460.65
157_K199_A0.6450.65
178_W183_P0.6450.65
246_L250_K0.6440.64
332_Y354_N0.6430.64
324_F328_V0.6430.64
288_M324_F0.6420.64
66_Q312_G0.6390.64
303_R310_E0.6380.64
139_Y142_Y0.6350.63
104_A108_G0.6340.63
49_G82_I0.6320.63
102_K106_K0.6310.63
334_R350_Y0.6300.63
204_P209_Y0.6300.63
187_L191_R0.6290.63
349_A356_V0.6280.62
115_P168_V0.6270.62
54_N58_W0.6260.62
113_A161_V0.6230.62
62_L67_R0.6220.62
234_L287_A0.6210.62
276_E283_H0.6210.62
333_V351_K0.6210.62
153_V168_V0.6210.62
262_Y298_W0.6190.61
194_A333_V0.6180.61
338_T380_S0.6170.61
138_K188_R0.6160.61
43_E184_Q0.6140.61
164_Y199_A0.6120.61
310_E313_T0.6120.61
203_A218_L0.6120.61
120_S125_T0.6110.60
353_D357_V0.6090.60
131_D137_L0.6090.60
105_V109_A0.6080.60
182_T185_E0.6060.60
201_V224_L0.6050.60
364_S368_V0.6040.60
263_Y279_D0.6040.60
133_S178_W0.6040.60
288_M293_F0.6000.59
68_E107_H0.5980.59
25_P29_E0.5980.59
131_D134_A0.5960.58
98_V156_M0.5950.58
53_M57_A0.5930.58
176_H208_Q0.5920.58
104_A107_H0.5910.58
281_S288_M0.5910.58
374_L377_G0.5900.58
122_M141_K0.5880.57
86_H97_E0.5880.57
165_A257_W0.5870.57
156_M230_L0.5870.57
258_M294_Q0.5860.57
67_R70_A0.5860.57
39_N43_E0.5860.57
77_Q353_D0.5850.57
167_S231_G0.5840.57
38_V160_G0.5830.57
184_Q365_N0.5770.56
82_I112_F0.5770.56
174_Y178_W0.5770.56
311_D314_I0.5750.56
174_Y213_L0.5750.56
55_H300_Y0.5750.56
284_I314_I0.5740.56
115_P300_Y0.5740.56
190_M203_A0.5740.56
116_W176_H0.5720.55
36_V372_F0.5710.55
88_D168_V0.5710.55
260_E299_W0.5710.55
156_M163_L0.5710.55
52_G323_H0.5690.55
82_I297_V0.5680.55
181_W189_F0.5680.55
33_A371_N0.5680.55
167_S233_H0.5670.55
193_N197_I0.5660.55
292_D334_R0.5650.55
82_I257_W0.5650.55
169_Q186_I0.5640.54
135_K138_K0.5620.54
328_V350_Y0.5620.54
372_F378_S0.5610.54
137_L145_Y0.5610.54
193_N226_N0.5610.54
61_D302_R0.5600.54
102_K105_V0.5600.54
57_A261_V0.5590.54
280_V284_I0.5590.54
230_L256_L0.5560.53
25_P31_L0.5550.53
216_P219_N0.5540.53
198_N226_N0.5540.53
29_E33_A0.5540.53
102_K225_A0.5540.53
204_P207_F0.5520.53
66_Q311_D0.5510.53
373_V378_S0.5500.53
104_A109_A0.5490.52
277_A320_N0.5480.52
344_N368_V0.5480.52
279_D287_A0.5470.52
220_D225_A0.5470.52
162_N198_N0.5460.52
158_N198_N0.5450.52
202_I229_I0.5450.52
78_L81_S0.5440.52
84_R235_Y0.5440.52
173_D207_F0.5430.52
86_H176_H0.5420.52
196_S228_D0.5410.51
276_E279_D0.5410.51
30_V184_Q0.5400.51
112_F167_S0.5390.51
157_K198_N0.5380.51
64_A67_R0.5380.51
271_A277_A0.5370.51
44_K292_D0.5360.51
83_L104_A0.5360.51
53_M90_N0.5350.51
74_G81_S0.5340.50
101_A161_V0.5340.50
300_Y323_H0.5320.50
41_S46_V0.5310.50
367_G379_A0.5300.50
120_S176_H0.5270.50
279_D283_H0.5270.50
234_L298_W0.5250.49
47_I348_S0.5250.49
135_K178_W0.5250.49
206_S258_M0.5240.49
28_T41_S0.5230.49
45_Q235_Y0.5230.49
134_A138_K0.5230.49
89_E189_F0.5220.49
75_Q198_N0.5210.49
277_A281_S0.5200.49
186_I213_L0.5200.49
164_Y200_R0.5180.48
46_V369_N0.5180.48
328_V337_A0.5170.48
191_R226_N0.5170.48
220_D224_L0.5170.48
279_D282_Q0.5170.48
261_V296_Y0.5150.48
137_L179_T0.5150.48
284_I324_F0.5150.48
121_D148_H0.5150.48
167_S235_Y0.5140.48
42_A221_P0.5140.48
241_Q246_L0.5140.48
53_M77_Q0.5140.48
33_A338_T0.5130.48
221_P307_P0.5120.48
81_S325_S0.5120.48
90_N176_H0.5100.47
111_V159_N0.5100.47
68_E95_Y0.5090.47
36_V222_Q0.5080.47
275_P280_V0.5080.47
92_N96_K0.5060.47
156_M159_N0.5060.47
29_E95_Y0.5060.47
190_M217_I0.5040.47
56_P152_F0.5030.46
176_H262_Y0.5020.46
258_M287_A0.5010.46
284_I287_A0.5000.46
154_T157_K0.5000.46
124_E140_N0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qawA 3 0.9218 100 0.221 Contact Map
4uqdA 1 0.9194 100 0.239 Contact Map
2nt0A 4 0.9289 100 0.262 Contact Map
4fmvA 1 0.8934 100 0.272 Contact Map
2y24A 1 0.8957 100 0.281 Contact Map
3clwA 1 0.8981 100 0.303 Contact Map
4ccdA 1 0.8555 100 0.317 Contact Map
2wnwA 2 0.9028 100 0.363 Contact Map
4m29A 1 0.846 100 0.692 Contact Map
1uhvA 3 0.891 100 0.704 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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