GREMLIN Database
ALST - Amino-acid carrier protein AlsT
UniProt: Q45068 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 465 (432)
Sequences: 3767 (2329)
Seq/√Len: 112.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_V310_A4.6911.00
117_L428_V4.0941.00
220_A308_S3.5371.00
134_I417_V3.3481.00
110_V425_A3.3131.00
228_I231_F3.2031.00
120_V136_K3.0681.00
138_L420_L2.9581.00
307_T311_F2.9391.00
236_A240_K2.9231.00
109_F429_Y2.9161.00
222_F226_T2.7591.00
40_F102_A2.7051.00
235_I239_V2.6801.00
230_A233_G2.6701.00
205_S354_S2.5841.00
34_R426_Y2.5761.00
27_L419_A2.5091.00
204_V208_I2.4821.00
363_G380_Y2.4151.00
10_N14_D2.3981.00
237_T241_N2.3971.00
146_V150_L2.3291.00
187_A385_I2.3011.00
6_N401_D2.2711.00
214_G218_L2.2391.00
11_I15_F2.1951.00
118_Y424_V2.1871.00
27_L415_L2.1431.00
174_A345_A2.1351.00
29_L103_V2.0831.00
200_R203_A2.0711.00
151_I366_N2.0671.00
135_Q369_F2.0591.00
244_G247_Q2.0581.00
134_I144_G2.0561.00
233_G236_A2.0511.00
191_A385_I2.0351.00
13_S405_L1.9961.00
286_H431_D1.9751.00
34_R423_N1.9521.00
135_Q141_R1.9461.00
9_I405_L1.9321.00
78_N301_D1.9321.00
234_V314_L1.9101.00
44_I48_R1.8921.00
45_E48_R1.8901.00
30_F422_S1.8831.00
184_I188_V1.8771.00
9_I401_D1.8741.00
252_G255_G1.8731.00
378_N381_R1.8651.00
94_V238_I1.8581.00
397_Q401_D1.8351.00
225_I228_I1.7951.00
286_H435_Q1.7941.00
145_I370_I1.7891.00
189_L349_F1.7781.00
187_A389_V1.7561.00
299_F303_F1.7541.00
412_L416_I1.7231.00
122_D125_D1.7221.00
364_E381_R1.6981.00
180_I389_V1.6951.00
285_S289_K1.6791.00
208_I350_L1.6691.00
288_A428_V1.6661.00
258_V262_Q1.6601.00
236_A239_V1.6561.00
8_L12_P1.6551.00
86_I94_V1.6421.00
150_L409_I1.6401.00
257_I261_A1.6381.00
45_E432_Y1.6371.00
32_T39_Q1.6321.00
234_V311_F1.6131.00
80_T324_G1.6131.00
64_Q202_V1.5941.00
259_I262_Q1.5841.00
249_V252_G1.5791.00
36_G430_K1.5731.00
41_R433_A1.5601.00
333_N341_P1.5301.00
17_W408_G1.5291.00
88_T259_I1.5231.00
194_I360_Y1.5061.00
178_N181_V1.5001.00
218_L222_F1.4941.00
423_N427_K1.4851.00
191_A195_F1.4831.00
428_V431_D1.4821.00
231_F234_V1.4691.00
226_T229_T1.4691.00
7_S10_N1.4661.00
24_L265_L1.4661.00
367_I371_K1.4581.00
115_A280_A1.4481.00
135_Q145_I1.4401.00
226_T335_H1.4381.00
147_F410_M1.4321.00
220_A312_I1.4231.00
431_D435_Q1.4201.00
224_V315_L1.4151.00
224_V231_F1.4141.00
45_E49_I1.4131.00
64_Q206_Q1.4111.00
67_F205_S1.4091.00
74_V305_I1.4081.00
279_A294_Q1.3881.00
224_V311_F1.3861.00
117_L424_V1.3841.00
181_V185_V1.3831.00
32_T37_F1.3821.00
105_M299_F1.3811.00
241_N245_F1.3771.00
183_A392_S1.3701.00
23_I419_A1.3631.00
34_R422_S1.3621.00
378_N382_I1.3581.00
35_F38_I1.3581.00
12_P405_L1.3511.00
167_I186_L1.3451.00
145_I149_I1.3411.00
382_I386_A1.3381.00
19_Y22_Y1.3381.00
168_A182_V1.3321.00
434_K438_Q1.3301.00
98_W307_T1.3301.00
234_V315_L1.3221.00
177_V182_V1.3131.00
62_S284_V1.3101.00
426_Y430_K1.3090.99
237_T314_L1.3050.99
76_T348_M1.3050.99
250_G254_G1.2870.99
36_G433_A1.2820.99
232_P236_A1.2770.99
402_M406_F1.2760.99
9_I398_I1.2760.99
30_F34_R1.2730.99
203_A206_Q1.2670.99
162_V403_A1.2670.99
134_I143_L1.2630.99
225_I229_T1.2570.99
147_F276_P1.2400.99
180_I184_I1.2390.99
141_R144_G1.2130.99
281_T361_Y1.2120.99
224_V228_I1.2070.99
63_M67_F1.2060.99
102_A303_F1.2060.99
79_L325_I1.2010.99
61_S64_Q1.1990.99
272_M411_A1.1980.99
424_V427_K1.1940.99
6_N10_N1.1930.99
389_V393_L1.1900.99
39_Q106_A1.1870.99
43_F47_F1.1860.99
229_T232_P1.1860.99
121_R126_F1.1840.99
204_V357_V1.1820.99
152_T155_F1.1820.99
66_F300_F1.1770.99
183_A389_V1.1730.99
221_L225_I1.1680.99
139_G142_W1.1670.99
178_N182_V1.1590.99
108_S112_S1.1550.99
189_L353_F1.1530.99
12_P15_F1.1520.99
37_F40_F1.1520.99
203_A207_L1.1510.99
356_V388_V1.1480.99
316_Y335_H1.1460.99
42_Y433_A1.1430.99
164_T392_S1.1410.99
278_A362_Y1.1370.99
137_G421_L1.1350.99
122_D127_R1.1300.99
237_T240_K1.1290.98
138_L142_W1.1120.98
316_Y331_A1.1110.98
240_K246_E1.1110.98
30_F426_Y1.1060.98
222_F336_I1.1060.98
22_Y26_G1.1050.98
371_K376_W1.1050.98
23_I412_L1.1040.98
142_W146_V1.1000.98
7_S11_I1.0970.98
31_F110_V1.0960.98
241_N244_G1.0950.98
318_V330_A1.0940.98
217_I221_L1.0900.98
231_F235_I1.0880.98
367_I376_W1.0880.98
227_N315_L1.0860.98
330_A333_N1.0840.98
330_A334_H1.0840.98
112_S294_Q1.0810.98
133_Y417_V1.0800.98
11_I14_D1.0800.98
172_D179_K1.0800.98
313_I328_T1.0740.98
43_F299_F1.0730.98
113_T288_A1.0730.98
42_Y292_F1.0730.98
188_V192_F1.0560.98
80_T166_T1.0520.98
190_T353_F1.0500.98
8_L11_I1.0470.98
227_N230_A1.0460.98
342_T346_V1.0460.98
109_F113_T1.0460.98
113_T291_G1.0430.97
309_T328_T1.0420.97
109_F288_A1.0400.97
100_V261_A1.0350.97
72_S358_G1.0300.97
25_I100_V1.0290.97
68_I198_L1.0280.97
217_I308_S1.0270.97
326_Q330_A1.0260.97
87_A327_V1.0170.97
247_Q250_G1.0090.97
343_F347_A1.0080.97
169_G326_Q1.0070.97
296_L300_F1.0040.97
159_F359_N1.0040.97
50_V293_I1.0030.97
313_I327_V1.0020.97
196_G200_R0.9950.97
228_I232_P0.9950.97
430_K434_K0.9930.97
181_V184_I0.9930.97
83_A328_T0.9900.97
251_G255_G0.9870.96
223_V335_H0.9860.96
62_S293_I0.9850.96
42_Y45_E0.9840.96
249_V253_I0.9800.96
152_T367_I0.9730.96
105_M303_F0.9710.96
386_A390_Y0.9710.96
208_I354_S0.9690.96
233_G237_T0.9690.96
310_A314_L0.9630.96
411_A415_L0.9600.96
64_Q203_A0.9560.96
211_V215_I0.9540.96
390_Y394_S0.9530.96
336_I339_W0.9470.96
83_A313_I0.9470.96
166_T348_M0.9450.95
429_Y433_A0.9420.95
46_M296_L0.9350.95
127_R365_T0.9340.95
35_F426_Y0.9330.95
45_E436_R0.9320.95
98_W235_I0.9310.95
248_V251_G0.9300.95
269_E274_S0.9270.95
155_F274_S0.9270.95
86_I314_L0.9260.95
47_F296_L0.9240.95
230_A315_L0.9240.95
223_V332_L0.9180.95
20_L408_G0.9180.95
165_N400_W0.9150.95
130_P276_P0.9090.94
120_V135_Q0.9080.94
151_I410_M0.9060.94
248_V252_G0.9050.94
86_I310_A0.9050.94
25_I265_L0.9050.94
46_M295_T0.8990.94
82_V306_C0.8990.94
377_L381_R0.8980.94
267_S301_D0.8940.94
199_K203_A0.8940.94
270_A298_V0.8910.94
305_I308_S0.8900.94
175_F342_T0.8890.94
190_T356_V0.8880.94
141_R145_I0.8840.94
315_L335_H0.8810.93
169_G172_D0.8750.93
224_V234_V0.8740.93
70_A74_V0.8730.93
105_M295_T0.8690.93
333_N337_G0.8690.93
86_I313_I0.8670.93
134_I142_W0.8660.93
246_E252_G0.8660.93
112_S297_G0.8640.93
59_G283_H0.8640.93
159_F272_M0.8630.93
419_A422_S0.8630.93
424_V428_V0.8620.93
80_T83_A0.8610.93
222_F225_I0.8530.92
173_G326_Q0.8520.92
323_D326_Q0.8520.92
21_F25_I0.8520.92
285_S432_Y0.8500.92
31_F418_I0.8440.92
91_P237_T0.8430.92
193_I204_V0.8420.92
88_T253_I0.8410.92
73_R108_S0.8400.92
143_L417_V0.8390.92
420_L423_N0.8380.92
126_F283_H0.8370.92
153_V406_F0.8360.92
60_V202_V0.8360.92
95_F243_L0.8350.92
338_G341_P0.8340.91
215_I347_A0.8320.91
23_I27_L0.8320.91
79_L344_I0.8280.91
340_A344_I0.8270.91
171_L349_F0.8260.91
110_V426_Y0.8250.91
299_F304_I0.8240.91
422_S426_Y0.8220.91
10_N401_D0.8220.91
49_I293_I0.8220.91
383_A386_A0.8150.91
401_D405_L0.8140.90
223_V312_I0.8130.90
84_L259_I0.8130.90
237_T319_T0.8110.90
95_F99_V0.8100.90
143_L146_V0.8060.90
120_V127_R0.8060.90
235_I311_F0.8050.90
209_V212_M0.8040.90
116_Q119_K0.8040.90
34_R37_F0.7980.90
365_T368_E0.7970.90
303_F307_T0.7960.89
190_T388_V0.7930.89
201_V361_Y0.7930.89
219_I347_A0.7920.89
110_V113_T0.7920.89
308_S312_I0.7910.89
161_A394_S0.7910.89
284_V289_K0.7880.89
170_A329_Q0.7870.89
235_I307_T0.7850.89
276_P280_A0.7850.89
155_F380_Y0.7850.89
150_L413_I0.7820.89
130_P133_Y0.7820.89
164_T356_V0.7820.89
74_V213_A0.7810.89
180_I393_L0.7800.88
267_S302_T0.7740.88
159_F407_M0.7710.88
166_T325_I0.7700.88
229_T233_G0.7690.88
28_G104_G0.7680.88
46_M292_F0.7660.88
20_L411_A0.7660.88
66_F293_I0.7620.87
387_M390_Y0.7600.87
171_L182_V0.7590.87
207_L211_V0.7590.87
128_G280_A0.7570.87
28_G103_V0.7570.87
26_G419_A0.7570.87
32_T40_F0.7560.87
78_N267_S0.7560.87
172_D182_V0.7550.87
289_K432_Y0.7540.87
294_Q297_G0.7530.87
183_A393_L0.7520.87
142_W145_I0.7520.87
231_F311_F0.7520.87
86_I319_T0.7500.86
198_L361_Y0.7440.86
425_A429_Y0.7420.86
38_I429_Y0.7420.86
108_S275_A0.7420.86
219_I336_I0.7400.86
376_W379_I0.7390.86
342_T345_A0.7350.85
73_R294_Q0.7350.85
238_I310_A0.7340.85
170_A325_I0.7340.85
6_N398_I0.7330.85
423_N430_K0.7320.85
160_N403_A0.7310.85
241_N246_E0.7310.85
245_F248_V0.7280.85
38_I42_Y0.7200.84
162_V400_W0.7150.84
35_F429_Y0.7140.84
198_L201_V0.7140.84
195_F378_N0.7140.84
339_W342_T0.7120.84
84_L87_A0.7100.83
219_I343_F0.7080.83
67_F206_Q0.7050.83
209_V213_A0.7040.83
213_A305_I0.7040.83
293_I297_G0.7030.83
256_I259_I0.7000.82
169_G173_G0.6970.82
6_N397_Q0.6950.82
359_N407_M0.6930.82
226_T230_A0.6910.82
430_K433_A0.6910.82
212_M267_S0.6890.81
317_S320_P0.6880.81
279_A297_G0.6880.81
50_V296_L0.6860.81
16_I412_L0.6860.81
79_L351_F0.6860.81
104_G107_S0.6840.81
21_F265_L0.6830.81
159_F403_A0.6830.81
15_F19_Y0.6800.81
72_S359_N0.6790.81
155_F359_N0.6780.80
227_N335_H0.6780.80
48_R51_G0.6760.80
57_N121_R0.6730.80
286_H432_Y0.6730.80
35_F110_V0.6720.80
394_S399_V0.6720.80
379_I382_I0.6680.79
316_Y321_K0.6670.79
49_I432_Y0.6660.79
112_S279_A0.6650.79
71_A298_V0.6650.79
241_N256_I0.6650.79
68_I358_G0.6640.79
122_D365_T0.6630.79
374_K378_N0.6610.79
49_I289_K0.6600.79
217_I220_A0.6590.79
240_K244_G0.6590.79
329_Q333_N0.6570.78
325_I348_M0.6550.78
76_T352_A0.6540.78
74_V300_F0.6540.78
160_N384_V0.6530.78
267_S303_F0.6520.78
274_S359_N0.6510.78
36_G44_I0.6500.78
31_F422_S0.6460.77
420_L424_V0.6420.77
333_N338_G0.6420.77
59_G126_F0.6410.77
344_I347_A0.6410.77
110_V429_Y0.6400.77
187_A191_A0.6390.76
423_N426_Y0.6390.76
167_I352_A0.6390.76
131_A366_N0.6380.76
151_I155_F0.6380.76
159_F411_A0.6360.76
38_I106_A0.6340.76
172_D176_H0.6340.76
240_K245_F0.6310.75
245_F249_V0.6300.75
76_T166_T0.6290.75
300_F304_I0.6290.75
179_K182_V0.6280.75
216_Y220_A0.6280.75
230_A234_V0.6280.75
94_V98_W0.6270.75
8_L15_F0.6270.75
244_G252_G0.6270.75
311_F315_L0.6260.75
161_A164_T0.6260.75
239_V314_L0.6250.75
145_I148_A0.6230.75
123_G373_S0.6230.75
272_M407_M0.6210.74
109_F425_A0.6200.74
37_F102_A0.6190.74
72_S272_M0.6190.74
66_F297_G0.6190.74
115_A276_P0.6190.74
87_A322_G0.6180.74
16_I408_G0.6170.74
160_N359_N0.6160.74
80_T323_D0.6150.74
60_V281_T0.6150.74
280_A381_R0.6140.74
27_L31_F0.6130.73
345_A349_F0.6120.73
127_R368_E0.6100.73
113_T425_A0.6090.73
31_F425_A0.6060.73
215_I346_V0.6060.73
423_N428_V0.6050.72
157_L383_A0.6030.72
20_L412_L0.6010.72
155_F159_F0.6000.72
221_L224_V0.6000.72
416_I420_L0.6000.72
288_A425_A0.5980.72
101_A302_T0.5980.72
238_I314_L0.5970.71
183_A187_A0.5960.71
189_L192_F0.5920.71
215_I219_I0.5920.71
160_N380_Y0.5900.71
113_T428_V0.5890.70
223_V316_Y0.5890.70
117_L427_K0.5890.70
171_L175_F0.5880.70
145_I369_F0.5860.70
390_Y393_L0.5860.70
182_V186_L0.5840.70
98_W239_V0.5840.70
87_A323_D0.5830.70
146_V149_I0.5830.70
130_P277_N0.5820.70
175_F182_V0.5820.70
36_G423_N0.5810.69
161_A399_V0.5800.69
99_V239_V0.5800.69
60_V68_I0.5790.69
169_G179_K0.5790.69
328_T331_A0.5790.69
133_Y414_N0.5780.69
318_V327_V0.5770.69
16_I411_A0.5770.69
84_L396_F0.5750.69
122_D373_S0.5730.68
228_I233_G0.5720.68
62_S282_A0.5710.68
9_I13_S0.5700.68
417_V420_L0.5680.68
50_V300_F0.5670.68
176_H179_K0.5670.68
279_A290_Q0.5660.67
113_T429_Y0.5660.67
255_G258_V0.5660.67
386_A389_V0.5650.67
40_F44_I0.5650.67
108_S119_K0.5650.67
190_T194_I0.5640.67
100_V265_L0.5630.67
23_I416_I0.5630.67
46_M50_V0.5620.67
73_R279_A0.5610.67
182_V185_V0.5610.67
318_V321_K0.5610.67
368_E373_S0.5600.67
153_V158_I0.5600.67
95_F239_V0.5600.67
217_I304_I0.5600.67
380_Y384_V0.5600.67
312_I332_L0.5580.66
356_V384_V0.5570.66
97_M302_T0.5570.66
198_L202_V0.5570.66
58_K283_H0.5560.66
246_E249_V0.5550.66
431_D434_K0.5550.66
84_L400_W0.5540.66
48_R52_E0.5540.66
131_A277_N0.5530.66
58_K284_V0.5520.65
275_A362_Y0.5520.65
78_N93_A0.5510.65
232_P235_I0.5510.65
230_A237_T0.5510.65
154_S407_M0.5510.65
194_I381_R0.5500.65
101_A104_G0.5490.65
137_G140_A0.5480.65
268_N302_T0.5470.65
115_A275_A0.5450.65
185_V188_V0.5450.65
162_V399_V0.5440.64
166_T324_G0.5410.64
76_T167_I0.5410.64
38_I292_F0.5400.64
367_I379_I0.5400.64
162_V166_T0.5390.64
110_V418_I0.5380.64
107_S275_A0.5360.63
161_A165_N0.5360.63
94_V307_T0.5360.63
134_I140_A0.5360.63
435_Q438_Q0.5340.63
84_L324_G0.5330.63
107_S268_N0.5320.63
93_A254_G0.5320.63
40_F43_F0.5310.63
16_I405_L0.5300.62
110_V422_S0.5300.62
348_M355_S0.5290.62
205_S278_A0.5270.62
292_F433_A0.5260.62
16_I19_Y0.5260.62
125_D199_K0.5250.62
42_Y437_K0.5250.62
193_I353_F0.5240.61
148_A370_I0.5230.61
434_K437_K0.5220.61
134_I413_I0.5220.61
355_S359_N0.5220.61
174_A341_P0.5200.61
348_M352_A0.5190.61
157_L384_V0.5190.61
433_A437_K0.5190.61
88_T258_V0.5180.61
258_V405_L0.5180.61
361_Y380_Y0.5180.61
73_R112_S0.5180.61
266_F403_A0.5170.60
169_G324_G0.5170.60
38_I43_F0.5140.60
219_I349_F0.5140.60
82_V267_S0.5140.60
92_G242_A0.5130.60
138_L417_V0.5120.60
108_S297_G0.5120.60
244_G248_V0.5110.60
66_F70_A0.5100.59
140_A420_L0.5090.59
171_L345_A0.5090.59
38_I109_F0.5080.59
290_Q298_V0.5080.59
49_I294_Q0.5080.59
275_A331_A0.5070.59
316_Y319_T0.5070.59
80_T348_M0.5070.59
432_Y436_R0.5070.59
213_A356_V0.5060.59
392_S395_G0.5060.59
86_I257_I0.5050.59
223_V334_H0.5040.59
241_N252_G0.5040.59
167_I349_F0.5040.59
168_A392_S0.5040.59
62_S290_Q0.5030.58
84_L166_T0.5020.58
318_V334_H0.5020.58
395_G398_I0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.7914 99.9 0.857 Contact Map
3giaA 1 0.8172 99.8 0.87 Contact Map
4djkA 2 0.7591 99.7 0.891 Contact Map
4wgvA 2 0.7656 98.3 0.94 Contact Map
2xq2A 2 0.8366 98.2 0.94 Contact Map
3dh4A 3 0.7978 97.9 0.946 Contact Map
4us3A 1 0.8215 97.5 0.95 Contact Map
2jlnA 1 0.8086 96.8 0.955 Contact Map
2a65A 2 0.8172 96.3 0.957 Contact Map
4xp4A 1 0.8151 94.6 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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