PARC - BACSU - GREMLIN Contacts

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PARC - DNA topoisomerase 4 subunit A

UniProt:	Q45066	Sequences: MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLIEMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPAMFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPTGGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMDEFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVAIHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVIATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIEELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVTVTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVHQLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHYKAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAGVKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELKKNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTAVWRLHTEQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	806 (733)
Sequences:	5085 (2524)
Seq/√Len:	93.2

ECOLI - GYRA PARC
BACSU - PARC GYRA
HALSA - Q9HR29

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
73_I	84_V	5.766	1.00
372_K	453_E	5.529	1.00
187_G	478_A	4.667	1.00
198_Q	467_T	4.460	1.00
191_D	474_K	4.287	1.00
195_K	202_C	4.122	1.00
660_T	686_I	3.974	1.00
62_F	103_E	3.573	1.00
195_K	210_V	3.468	1.00
454_S	461_K	3.365	1.00
140_N	369_Q	3.346	1.00
454_S	458_N	3.228	1.00
192_A	211_I	3.141	1.00
390_E	411_K	3.106	1.00
245_A	319_Y	3.089	1.00
451_E	461_K	3.069	1.00
111_I	299_L	2.998	1.00
196_R	349_L	2.960	1.00
196_R	202_C	2.940	1.00
612_K	643_E	2.905	1.00
145_V	156_V	2.869	1.00
369_Q	373_D	2.830	1.00
451_E	454_S	2.805	1.00
661_H	693_F	2.766	1.00
393_A	397_S	2.754	1.00
203_S	206_E	2.683	1.00
661_H	692_D	2.678	1.00
194_I	471_K	2.675	1.00
58_F	131_S	2.673	1.00
187_G	480_T	2.620	1.00
205_D	233_E	2.614	1.00
383_K	414_F	2.598	1.00
68_T	124_A	2.596	1.00
143_E	362_N	2.593	1.00
67_K	75_N	2.552	1.00
162_F	167_V	2.509	1.00
207_L	345_L	2.503	1.00
655_Q	667_W	2.487	1.00
361_T	365_V	2.469	1.00
204_V	344_S	2.455	1.00
639_K	681_A	2.448	1.00
190_I	470_L	2.448	1.00
511_K	538_R	2.441	1.00
472_A	476_K	2.404	1.00
420_E	424_S	2.404	1.00
197_I	463_L	2.385	1.00
187_G	191_D	2.363	1.00
187_G	474_K	2.341	1.00
132_E	477_Y	2.334	1.00
246_E	260_T	2.324	1.00
207_L	346_P	2.295	1.00
195_K	199_M	2.274	1.00
689_K	731_R	2.254	1.00
373_D	417_P	2.251	1.00
255_E	311_A	2.241	1.00
99_N	479_D	2.239	1.00
181_I	332_M	2.234	1.00
652_G	670_E	2.221	1.00
202_C	206_E	2.216	1.00
684_K	687_N	2.210	1.00
666_L	730_K	2.206	1.00
556_N	643_E	2.196	1.00
244_K	484_V	2.195	1.00
139_K	367_E	2.166	1.00
336_H	343_M	2.160	1.00
461_K	464_K	2.156	1.00
103_E	125_R	2.146	1.00
357_K	463_L	2.138	1.00
453_E	457_S	2.131	1.00
448_K	452_L	2.130	1.00
610_F	697_G	2.129	1.00
288_S	306_K	2.127	1.00
666_L	726_T	2.122	1.00
245_A	257_I	2.122	1.00
610_F	658_M	2.116	1.00
676_V	680_A	2.112	1.00
199_M	206_E	2.110	1.00
259_I	303_I	2.102	1.00
444_E	448_K	2.100	1.00
378_V	438_L	2.085	1.00
651_N	654_S	2.081	1.00
128_P	476_K	2.060	1.00
167_V	189_V	2.048	1.00
612_K	642_D	2.040	1.00
146_P	153_K	2.031	1.00
723_F	735_M	2.030	1.00
505_V	565_V	2.027	1.00
374_R	441_E	2.022	1.00
370_K	373_D	2.018	1.00
65_A	88_M	2.010	1.00
205_D	229_R	2.008	1.00
650_T	670_E	2.006	1.00
189_V	211_I	2.002	1.00
612_K	693_F	1.969	1.00
658_M	685_G	1.952	1.00
229_R	233_E	1.950	1.00
361_T	456_L	1.949	1.00
440_E	444_E	1.947	1.00
245_A	315_L	1.946	1.00
364_S	452_L	1.935	1.00
464_K	468_N	1.934	1.00
405_K	420_E	1.932	1.00
360_V	466_I	1.926	1.00
146_P	150_D	1.924	1.00
47_I	87_A	1.912	1.00
394_T	407_N	1.902	1.00
357_K	459_D	1.870	1.00
344_S	347_S	1.860	1.00
436_T	440_E	1.859	1.00
710_T	736_L	1.856	1.00
686_I	694_V	1.853	1.00
240_I	325_Q	1.843	1.00
545_M	549_D	1.843	1.00
502_S	546_N	1.838	1.00
204_V	233_E	1.837	1.00
194_I	467_T	1.836	1.00
36_A	351_A	1.833	1.00
243_G	259_I	1.830	1.00
726_T	730_K	1.826	1.00
346_P	350_D	1.820	1.00
270_N	273_K	1.813	1.00
557_K	589_D	1.813	1.00
616_V	685_G	1.812	1.00
262_I	301_V	1.805	1.00
250_I	256_Q	1.801	1.00
351_A	354_G	1.796	1.00
443_E	447_K	1.795	1.00
400_D	403_D	1.789	1.00
341_M	347_S	1.783	1.00
202_C	210_V	1.781	1.00
375_H	442_A	1.780	1.00
455_I	465_V	1.772	1.00
196_R	350_D	1.770	1.00
82_S	86_E	1.767	1.00
462_L	465_V	1.752	1.00
458_N	461_K	1.751	1.00
249_T	255_E	1.751	1.00
196_R	353_I	1.743	1.00
83_S	87_A	1.741	1.00
555_T	592_I	1.735	1.00
365_V	369_Q	1.706	1.00
383_K	387_I	1.693	1.00
63_R	67_K	1.693	1.00
181_I	348_I	1.690	1.00
204_V	346_P	1.684	1.00
67_K	71_N	1.675	1.00
193_V	353_I	1.666	1.00
350_D	354_G	1.649	1.00
439_K	443_E	1.644	1.00
213_G	228_I	1.642	1.00
162_F	473_L	1.631	1.00
143_E	156_V	1.621	1.00
672_E	727_S	1.618	1.00
206_E	209_E	1.613	1.00
608_L	616_V	1.611	1.00
367_E	452_L	1.611	1.00
336_H	351_A	1.608	1.00
608_L	656_I	1.605	1.00
88_M	124_A	1.602	1.00
402_R	406_N	1.598	1.00
397_S	407_N	1.583	1.00
615_M	684_K	1.579	1.00
401_K	428_Y	1.570	1.00
132_E	135_R	1.557	1.00
434_D	437_A	1.539	1.00
406_N	410_A	1.536	1.00
451_E	455_I	1.532	1.00
658_M	694_V	1.530	1.00
36_A	348_I	1.522	1.00
337_N	354_G	1.516	1.00
391_V	408_L	1.509	1.00
50_A	71_N	1.501	1.00
448_K	451_E	1.500	1.00
450_E	454_S	1.493	1.00
67_K	152_S	1.483	1.00
724_E	733_V	1.480	1.00
655_Q	669_G	1.474	1.00
332_M	348_I	1.472	1.00
240_I	327_T	1.461	1.00
171_T	180_D	1.453	1.00
363_R	469_S	1.450	1.00
89_V	116_P	1.448	1.00
199_M	202_C	1.446	1.00
225_V	487_E	1.445	1.00
503_E	547_T	1.441	1.00
244_K	261_E	1.419	0.99
606_Y	675_V	1.418	0.99
726_T	733_V	1.414	0.99
230_K	233_E	1.409	0.99
226_D	230_K	1.397	0.99
293_E	302_V	1.396	0.99
361_T	462_L	1.383	0.99
91_M	97_V	1.382	0.99
65_A	124_A	1.380	0.99
67_K	74_G	1.378	0.99
546_N	549_D	1.378	0.99
512_D	534_K	1.373	0.99
442_A	446_G	1.373	0.99
323_D	326_I	1.371	0.99
134_L	158_L	1.369	0.99
382_M	442_A	1.362	0.99
610_F	694_V	1.357	0.99
399_S	403_D	1.349	0.99
459_D	463_L	1.349	0.99
272_V	301_V	1.348	0.99
193_V	349_L	1.345	0.99
247_I	257_I	1.341	0.99
708_L	735_M	1.337	0.99
405_K	416_E	1.336	0.99
275_M	290_V	1.331	0.99
718_M	723_F	1.327	0.99
607_L	647_V	1.326	0.99
479_D	482_R	1.325	0.99
50_A	73_I	1.309	0.99
295_D	298_G	1.308	0.99
556_N	591_T	1.304	0.99
67_K	119_M	1.303	0.99
511_K	540_L	1.302	0.99
450_E	453_E	1.300	0.99
287_I	303_I	1.298	0.99
379_E	446_G	1.297	0.99
556_N	590_E	1.296	0.99
75_N	152_S	1.293	0.99
274_K	277_E	1.291	0.99
357_K	462_L	1.285	0.99
608_L	673_V	1.281	0.99
557_K	587_D	1.276	0.99
454_S	457_S	1.276	0.99
254_R	288_S	1.273	0.99
423_V	428_Y	1.273	0.99
447_K	451_E	1.271	0.99
275_M	303_I	1.265	0.99
471_K	474_K	1.257	0.99
379_E	442_A	1.255	0.99
71_N	75_N	1.254	0.99
409_I	419_A	1.252	0.99
232_Y	330_F	1.250	0.99
394_T	411_K	1.248	0.99
180_D	329_N	1.247	0.99
468_N	472_A	1.242	0.99
271_L	301_V	1.240	0.98
98_R	479_D	1.240	0.98
387_I	414_F	1.238	0.98
309_A	314_I	1.237	0.98
232_Y	345_L	1.236	0.98
140_N	365_V	1.233	0.98
347_S	350_D	1.232	0.98
238_K	327_T	1.232	0.98
660_T	692_D	1.228	0.98
467_T	471_K	1.224	0.98
293_E	300_R	1.219	0.98
248_E	300_R	1.216	0.98
554_F	647_V	1.208	0.98
204_V	207_L	1.205	0.98
734_V	737_R	1.203	0.98
61_N	125_R	1.199	0.98
471_K	475_K	1.196	0.98
468_N	471_K	1.191	0.98
272_V	290_V	1.191	0.98
204_V	208_M	1.188	0.98
291_R	304_E	1.186	0.98
736_L	742_N	1.180	0.98
655_Q	725_K	1.178	0.98
618_K	675_V	1.172	0.98
190_I	474_K	1.168	0.98
382_M	439_K	1.168	0.98
403_D	407_N	1.164	0.98
637_N	680_A	1.164	0.98
196_R	346_P	1.161	0.98
444_E	447_K	1.161	0.98
390_E	393_A	1.161	0.98
256_Q	304_E	1.160	0.98
409_I	416_E	1.155	0.98
609_F	644_L	1.153	0.98
333_V	342_L	1.150	0.98
29_Q	335_I	1.150	0.98
195_K	206_E	1.147	0.97
49_Y	52_H	1.146	0.97
455_I	461_K	1.146	0.97
377_I	421_A	1.142	0.97
11_P	14_E	1.141	0.97
228_I	239_I	1.133	0.97
243_G	324_L	1.133	0.97
354_G	357_K	1.132	0.97
352_Y	356_Q	1.127	0.97
360_V	469_S	1.125	0.97
20_F	30_D	1.125	0.97
447_K	450_E	1.118	0.97
738_E	742_N	1.118	0.97
368_L	449_I	1.116	0.97
606_Y	618_K	1.115	0.97
552_L	560_Y	1.114	0.97
221_I	244_K	1.113	0.97
73_I	148_F	1.113	0.97
376_H	415_T	1.111	0.97
247_I	315_L	1.110	0.97
241_I	326_I	1.105	0.97
562_Y	627_Q	1.104	0.97
13_E	17_G	1.094	0.97
365_V	372_K	1.093	0.97
241_I	483_S	1.092	0.97
213_G	485_I	1.091	0.97
245_A	259_I	1.089	0.97
63_R	151_T	1.087	0.97
54_D	71_N	1.085	0.96
221_I	241_I	1.081	0.96
603_P	622_T	1.076	0.96
654_S	701_Q	1.071	0.96
705_S	717_R	1.070	0.96
381_L	438_L	1.070	0.96
657_F	665_G	1.069	0.96
718_M	722_E	1.068	0.96
18_D	22_R	1.067	0.96
615_M	681_A	1.066	0.96
48_L	134_L	1.061	0.96
375_H	449_I	1.057	0.96
334_A	348_I	1.055	0.96
502_S	547_T	1.055	0.96
138_D	367_E	1.054	0.96
528_G	573_W	1.053	0.96
220_G	243_G	1.053	0.96
559_S	587_D	1.051	0.96
360_V	462_L	1.051	0.96
400_D	406_N	1.051	0.96
620_E	675_V	1.049	0.96
58_F	128_P	1.047	0.96
305_L	309_A	1.047	0.96
610_F	685_G	1.046	0.96
231_A	330_F	1.044	0.96
435_I	439_K	1.040	0.96
239_I	330_F	1.039	0.95
382_M	438_L	1.039	0.95
687_N	731_R	1.038	0.95
571_I	575_D	1.037	0.95
378_V	445_L	1.037	0.95
133_L	160_A	1.037	0.95
545_M	565_V	1.034	0.95
608_L	650_T	1.030	0.95
404_A	431_T	1.027	0.95
572_R	575_D	1.024	0.95
662_L	692_D	1.022	0.95
388_L	396_R	1.022	0.95
336_H	341_M	1.021	0.95
460_K	468_N	1.020	0.95
497_E	564_P	1.020	0.95
102_I	124_A	1.016	0.95
225_V	228_I	1.016	0.95
248_E	258_V	1.012	0.95
613_N	641_E	1.012	0.95
472_A	475_K	1.007	0.95
50_A	84_V	1.007	0.95
161_M	356_Q	1.006	0.95
162_F	190_I	1.005	0.95
701_Q	704_D	1.003	0.95
183_P	217_P	1.003	0.95
648_H	697_G	0.996	0.94
73_I	82_S	0.991	0.94
191_D	194_I	0.988	0.94
72_V	84_V	0.987	0.94
620_E	623_H	0.986	0.94
57_T	60_K	0.984	0.94
190_I	193_V	0.984	0.94
182_P	332_M	0.983	0.94
140_N	362_N	0.982	0.94
374_R	378_V	0.981	0.94
364_S	455_I	0.979	0.94
129_I	164_N	0.977	0.94
407_N	410_A	0.974	0.94
227_G	230_K	0.974	0.94
36_A	343_M	0.973	0.94
219_G	244_K	0.972	0.94
44_Q	96_K	0.971	0.94
387_I	390_E	0.971	0.94
259_I	324_L	0.970	0.94
398_S	407_N	0.968	0.93
194_I	474_K	0.967	0.93
547_T	565_V	0.966	0.93
738_E	741_K	0.963	0.93
613_N	642_D	0.961	0.93
208_M	233_E	0.960	0.93
167_V	186_L	0.956	0.93
533_M	539_M	0.956	0.93
305_L	314_I	0.952	0.93
646_D	697_G	0.952	0.93
199_M	203_S	0.949	0.93
274_K	323_D	0.948	0.93
366_Y	370_K	0.948	0.93
615_M	639_K	0.948	0.93
191_D	471_K	0.948	0.93
221_I	486_E	0.945	0.93
624_Y	635_A	0.942	0.92
619_T	624_Y	0.941	0.92
619_T	623_H	0.939	0.92
609_F	635_A	0.938	0.92
56_N	68_T	0.937	0.92
739_L	743_P	0.937	0.92
687_N	729_A	0.937	0.92
451_E	468_N	0.936	0.92
225_V	229_R	0.935	0.92
443_E	446_G	0.934	0.92
416_E	420_E	0.933	0.92
637_N	679_R	0.931	0.92
375_H	446_G	0.927	0.92
101_L	133_L	0.926	0.92
740_K	743_P	0.926	0.92
451_E	458_N	0.926	0.92
54_D	67_K	0.923	0.92
657_F	706_I	0.919	0.92
461_K	465_V	0.914	0.91
554_F	560_Y	0.909	0.91
349_L	353_I	0.906	0.91
367_E	448_K	0.904	0.91
54_D	68_T	0.903	0.91
708_L	723_F	0.902	0.91
202_C	353_I	0.901	0.91
460_K	464_K	0.900	0.91
509_V	595_A	0.897	0.91
736_L	741_K	0.897	0.91
266_V	271_L	0.897	0.91
369_Q	372_K	0.896	0.91
193_V	470_L	0.896	0.91
421_A	425_L	0.894	0.90
385_L	435_I	0.893	0.90
165_L	334_A	0.892	0.90
99_N	129_I	0.892	0.90
211_I	345_L	0.889	0.90
660_T	694_V	0.886	0.90
664_Y	731_R	0.882	0.90
609_F	647_V	0.881	0.90
451_E	465_V	0.881	0.90
676_V	681_A	0.880	0.90
63_R	75_N	0.880	0.90
394_T	419_A	0.880	0.90
464_K	475_K	0.879	0.90
195_K	209_E	0.878	0.90
199_M	210_V	0.876	0.89
71_N	148_F	0.872	0.89
59_D	131_S	0.872	0.89
295_D	299_L	0.871	0.89
379_E	415_T	0.870	0.89
224_G	227_G	0.869	0.89
507_V	565_V	0.864	0.89
112_D	268_K	0.860	0.89
553_L	595_A	0.859	0.89
591_T	643_E	0.855	0.88
129_I	162_F	0.854	0.88
636_L	644_L	0.853	0.88
383_K	413_E	0.852	0.88
425_L	429_R	0.851	0.88
505_V	547_T	0.849	0.88
135_R	356_Q	0.848	0.88
226_D	229_R	0.846	0.88
557_K	590_E	0.846	0.88
50_A	76_Y	0.844	0.88
197_I	467_T	0.840	0.87
457_S	461_K	0.838	0.87
242_R	325_Q	0.838	0.87
455_I	462_L	0.835	0.87
440_E	443_E	0.835	0.87
198_Q	471_K	0.834	0.87
25_K	29_Q	0.834	0.87
50_A	54_D	0.833	0.87
473_L	477_Y	0.827	0.87
658_M	686_I	0.826	0.87
258_V	302_V	0.826	0.87
688_L	692_D	0.823	0.86
272_V	276_D	0.819	0.86
395_I	427_L	0.818	0.86
99_N	478_A	0.817	0.86
605_A	649_V	0.816	0.86
186_L	473_L	0.816	0.86
391_V	412_Y	0.816	0.86
610_F	616_V	0.813	0.86
368_L	453_E	0.812	0.86
604_S	622_T	0.810	0.85
15_V	19_R	0.806	0.85
37_R	157_V	0.805	0.85
668_F	673_V	0.805	0.85
437_A	440_E	0.805	0.85
257_I	315_L	0.804	0.85
126_L	130_A	0.804	0.85
101_L	164_N	0.803	0.85
161_M	473_L	0.803	0.85
245_A	311_A	0.802	0.85
509_V	543_F	0.800	0.85
140_N	373_D	0.799	0.85
211_I	344_S	0.798	0.85
391_V	414_F	0.794	0.84
187_G	475_K	0.794	0.84
549_D	599_K	0.793	0.84
204_V	210_V	0.792	0.84
196_R	200_P	0.792	0.84
290_V	303_I	0.792	0.84
624_Y	676_V	0.790	0.84
394_T	412_Y	0.790	0.84
148_F	151_T	0.790	0.84
57_T	131_S	0.790	0.84
446_G	450_E	0.789	0.84
194_I	198_Q	0.789	0.84
608_L	685_G	0.788	0.84
30_D	170_S	0.788	0.84
586_I	592_I	0.786	0.84
390_E	412_Y	0.786	0.84
611_T	636_L	0.785	0.84
315_L	319_Y	0.784	0.84
644_L	647_V	0.783	0.83
364_S	456_L	0.783	0.83
49_Y	53_T	0.782	0.83
343_M	351_A	0.782	0.83
167_V	190_I	0.782	0.83
628_R	631_K	0.782	0.83
399_S	432_N	0.782	0.83
401_K	420_E	0.781	0.83
191_D	478_A	0.779	0.83
580_F	592_I	0.778	0.83
191_D	210_V	0.777	0.83
54_D	148_F	0.775	0.83
193_V	352_Y	0.774	0.83
233_E	346_P	0.774	0.83
212_K	225_V	0.774	0.83
608_L	697_G	0.773	0.83
507_V	568_L	0.773	0.83
504_D	546_N	0.773	0.83
385_L	438_L	0.773	0.83
68_T	73_I	0.772	0.83
331_N	342_L	0.771	0.83
99_N	480_T	0.769	0.82
54_D	75_N	0.769	0.82
607_L	621_L	0.769	0.82
664_Y	689_K	0.766	0.82
69_V	119_M	0.766	0.82
659_A	735_M	0.765	0.82
189_V	192_A	0.765	0.82
545_M	597_P	0.764	0.82
621_L	649_V	0.764	0.82
393_A	396_R	0.763	0.82
210_V	346_P	0.763	0.82
386_S	435_I	0.763	0.82
375_H	379_E	0.763	0.82
161_M	472_A	0.762	0.82
61_N	151_T	0.762	0.82
135_R	161_M	0.761	0.82
384_A	388_L	0.760	0.82
628_R	633_L	0.759	0.82
191_D	212_K	0.758	0.81
63_R	152_S	0.758	0.81
364_S	465_V	0.756	0.81
502_S	548_T	0.756	0.81
62_F	105_H	0.756	0.81
249_T	252_G	0.755	0.81
727_S	730_K	0.755	0.81
238_K	329_N	0.754	0.81
136_D	141_T	0.753	0.81
221_I	484_V	0.753	0.81
710_T	713_G	0.752	0.81
165_L	348_I	0.752	0.81
661_H	695_V	0.752	0.81
606_Y	652_G	0.752	0.81
277_E	281_D	0.752	0.81
387_I	394_T	0.752	0.81
273_K	277_E	0.751	0.81
190_I	473_L	0.749	0.81
555_T	590_E	0.748	0.81
610_F	646_D	0.748	0.81
550_V	562_Y	0.747	0.81
362_N	365_V	0.747	0.81
33_L	334_A	0.745	0.80
191_D	475_K	0.745	0.80
129_I	186_L	0.745	0.80
69_V	81_D	0.745	0.80
268_K	292_D	0.744	0.80
105_H	578_Q	0.743	0.80
426_Q	429_R	0.742	0.80
224_G	228_I	0.741	0.80
556_N	593_V	0.741	0.80
192_A	207_L	0.740	0.80
113_G	267_N	0.740	0.80
358_E	365_V	0.738	0.80
186_L	190_I	0.738	0.80
454_S	459_D	0.737	0.80
147_N	151_T	0.736	0.80
394_T	428_Y	0.735	0.79
618_K	670_E	0.733	0.79
198_Q	460_K	0.733	0.79
228_I	231_A	0.732	0.79
193_V	466_I	0.732	0.79
458_N	464_K	0.732	0.79
706_I	720_L	0.730	0.79
208_M	346_P	0.730	0.79
364_S	448_K	0.730	0.79
703_S	721_S	0.729	0.79
255_E	305_L	0.728	0.79
73_I	87_A	0.727	0.79
555_T	561_I	0.727	0.79
68_T	74_G	0.726	0.79
509_V	541_H	0.726	0.79
381_L	433_T	0.725	0.79
100_V	127_S	0.724	0.78
648_H	699_I	0.724	0.78
136_D	139_K	0.724	0.78
507_V	543_F	0.724	0.78
600_E	603_P	0.724	0.78
341_M	351_A	0.723	0.78
127_S	130_A	0.723	0.78
514_Y	579_H	0.723	0.78
237_G	243_G	0.722	0.78
664_Y	726_T	0.721	0.78
669_G	725_K	0.721	0.78
672_E	726_T	0.719	0.78
203_S	346_P	0.719	0.78
71_N	74_G	0.719	0.78
380_G	414_F	0.719	0.78
343_M	347_S	0.719	0.78
284_V	317_F	0.719	0.78
505_V	517_R	0.718	0.78
97_V	100_V	0.717	0.78
53_T	76_Y	0.716	0.78
510_T	537_D	0.716	0.78
243_G	319_Y	0.715	0.78
129_I	132_E	0.714	0.77
388_L	391_V	0.714	0.77
454_S	464_K	0.713	0.77
598_I	621_L	0.713	0.77
368_L	372_K	0.711	0.77
380_G	415_T	0.710	0.77
611_T	642_D	0.710	0.77
739_L	742_N	0.709	0.77
506_Y	520_Q	0.707	0.77
283_K	321_N	0.707	0.77
691_D	719_S	0.707	0.77
474_K	478_A	0.706	0.77
55_G	60_K	0.706	0.77
185_H	478_A	0.705	0.77
543_F	595_A	0.705	0.77
270_N	274_K	0.705	0.77
376_H	417_P	0.705	0.77
700_L	720_L	0.702	0.76
147_N	152_S	0.702	0.76
27_I	175_A	0.701	0.76
60_K	125_R	0.699	0.76
719_S	722_E	0.698	0.76
119_M	152_S	0.697	0.76
561_I	632_A	0.696	0.76
454_S	462_L	0.696	0.76
613_N	693_F	0.695	0.76
98_R	482_R	0.695	0.76
371_A	448_K	0.693	0.75
59_D	125_R	0.693	0.75
514_Y	582_N	0.693	0.75
239_I	327_T	0.692	0.75
26_Y	30_D	0.692	0.75
65_A	73_I	0.691	0.75
724_E	727_S	0.691	0.75
54_D	63_R	0.689	0.75
390_E	394_T	0.689	0.75
56_N	73_I	0.689	0.75
111_I	262_I	0.688	0.75
423_V	429_R	0.688	0.75
469_S	472_A	0.688	0.75
389_D	396_R	0.687	0.75
254_R	306_K	0.687	0.75
392_I	395_I	0.687	0.75
21_G	148_F	0.686	0.75
553_L	584_I	0.686	0.75
384_A	391_V	0.686	0.75
74_G	152_S	0.684	0.74
517_R	570_D	0.684	0.74
402_R	405_K	0.684	0.74
451_E	464_K	0.684	0.74
553_L	580_F	0.683	0.74
381_L	384_A	0.682	0.74
137_I	144_F	0.682	0.74
465_V	468_N	0.681	0.74
220_G	244_K	0.679	0.74
157_V	355_H	0.678	0.74
86_E	90_R	0.678	0.74
543_F	551_L	0.677	0.74
350_D	353_I	0.677	0.74
191_D	480_T	0.677	0.74
605_A	651_N	0.677	0.74
208_M	211_I	0.676	0.74
381_L	425_L	0.676	0.74
518_T	522_S	0.675	0.73
659_A	696_S	0.675	0.73
243_G	301_V	0.671	0.73
204_V	345_L	0.671	0.73
68_T	72_V	0.670	0.73
35_D	157_V	0.670	0.73
436_T	439_K	0.669	0.73
164_N	167_V	0.669	0.73
313_G	498_V	0.668	0.73
665_G	726_T	0.668	0.73
519_S	522_S	0.667	0.73
62_F	125_R	0.666	0.72
637_N	681_A	0.665	0.72
243_G	262_I	0.665	0.72
515_L	580_F	0.664	0.72
238_K	241_I	0.662	0.72
598_I	601_F	0.662	0.72
330_F	348_I	0.662	0.72
503_E	519_S	0.661	0.72
67_K	151_T	0.661	0.72
549_D	597_P	0.660	0.72
534_K	576_M	0.660	0.72
337_N	341_M	0.659	0.72
241_I	328_Y	0.659	0.72
653_E	669_G	0.659	0.72
508_T	518_T	0.659	0.72
432_N	435_I	0.657	0.71
208_M	229_R	0.656	0.71
404_A	423_V	0.656	0.71
56_N	63_R	0.656	0.71
372_K	449_I	0.653	0.71
195_K	207_L	0.652	0.71
604_S	620_E	0.652	0.71
247_I	311_A	0.651	0.71
378_V	442_A	0.651	0.71
209_E	225_V	0.651	0.71
360_V	363_R	0.651	0.71
381_L	421_A	0.650	0.71
126_L	148_F	0.648	0.70
248_E	259_I	0.647	0.70
222_I	239_I	0.647	0.70
33_L	170_S	0.644	0.70
73_I	81_D	0.643	0.70
734_V	738_E	0.643	0.70
276_D	290_V	0.643	0.70
216_F	328_Y	0.643	0.70
222_I	228_I	0.643	0.70
329_N	333_V	0.642	0.70
268_K	294_T	0.642	0.70
30_D	335_I	0.642	0.70
219_G	262_I	0.641	0.70
22_R	29_Q	0.640	0.69
730_K	733_V	0.640	0.69
393_A	411_K	0.639	0.69
65_A	119_M	0.639	0.69
237_G	245_A	0.638	0.69
198_Q	475_K	0.637	0.69
593_V	609_F	0.636	0.69
720_L	723_F	0.636	0.69
245_A	260_T	0.636	0.69
132_E	476_K	0.635	0.69
205_D	208_M	0.634	0.69
56_N	125_R	0.632	0.68
251_R	256_Q	0.631	0.68
399_S	436_T	0.631	0.68
268_K	299_L	0.631	0.68
506_Y	544_E	0.630	0.68
667_W	725_K	0.629	0.68
30_D	86_E	0.629	0.68
248_E	256_Q	0.629	0.68
657_F	667_W	0.628	0.68
52_H	137_I	0.628	0.68
276_D	289_E	0.627	0.68
371_A	449_I	0.627	0.68
426_Q	431_T	0.627	0.68
719_S	723_F	0.627	0.68
296_R	517_R	0.626	0.68
337_N	343_M	0.625	0.68
267_N	271_L	0.623	0.67
562_Y	625_K	0.622	0.67
82_S	88_M	0.622	0.67
259_I	301_V	0.621	0.67
488_K	492_I	0.621	0.67
145_V	154_E	0.621	0.67
92_S	104_M	0.621	0.67
148_F	238_K	0.621	0.67
269_A	272_V	0.620	0.67
551_L	565_V	0.619	0.67
387_I	391_V	0.619	0.67
624_Y	680_A	0.618	0.67
201_S	206_E	0.617	0.67
387_I	411_K	0.617	0.67
502_S	599_K	0.617	0.67
73_I	119_M	0.617	0.67
60_K	63_R	0.616	0.67
355_H	359_V	0.615	0.66
660_T	664_Y	0.615	0.66
67_K	148_F	0.615	0.66
65_A	152_S	0.614	0.66
160_A	352_Y	0.614	0.66
353_I	467_T	0.612	0.66
500_V	566_H	0.612	0.66
624_Y	679_R	0.612	0.66
707_V	715_V	0.610	0.66
203_S	233_E	0.610	0.66
712_R	743_P	0.609	0.66
539_M	542_Q	0.609	0.66
502_S	549_D	0.609	0.66
216_F	239_I	0.608	0.66
392_I	396_R	0.608	0.66
367_E	451_E	0.607	0.65
401_K	405_K	0.607	0.65
91_M	96_K	0.606	0.65
351_A	355_H	0.605	0.65
52_H	134_L	0.605	0.65
378_V	441_E	0.603	0.65
258_V	300_R	0.603	0.65
645_I	694_V	0.603	0.65
656_I	670_E	0.603	0.65
710_T	742_N	0.602	0.65
43_V	86_E	0.602	0.65
187_G	479_D	0.602	0.65
202_C	350_D	0.602	0.65
86_E	116_P	0.601	0.65
474_K	480_T	0.601	0.65
63_R	71_N	0.601	0.65
665_G	733_V	0.600	0.64
385_L	431_T	0.600	0.64
92_S	102_I	0.600	0.64
119_M	149_D	0.600	0.64
627_Q	631_K	0.600	0.64
161_M	469_S	0.599	0.64
250_I	253_G	0.599	0.64
192_A	202_C	0.599	0.64
705_S	719_S	0.598	0.64
162_F	193_V	0.598	0.64
594_K	647_V	0.598	0.64
223_Q	486_E	0.598	0.64
659_A	665_G	0.598	0.64
541_H	595_A	0.598	0.64
495_N	567_Q	0.597	0.64
220_G	241_I	0.597	0.64
405_K	419_A	0.596	0.64
247_I	305_L	0.596	0.64
563_C	584_I	0.596	0.64
543_F	597_P	0.595	0.64
275_M	322_T	0.595	0.64
269_A	276_D	0.595	0.64
130_A	133_L	0.594	0.64
43_V	87_A	0.594	0.64
288_S	309_A	0.593	0.64
656_I	699_I	0.592	0.63
596_I	607_L	0.591	0.63
258_V	301_V	0.591	0.63
424_S	428_Y	0.591	0.63
634_V	679_R	0.590	0.63
251_R	254_R	0.590	0.63
248_E	293_E	0.588	0.63
420_E	428_Y	0.588	0.63
136_D	360_V	0.587	0.63
51_M	102_I	0.587	0.63
99_N	167_V	0.586	0.63
291_R	300_R	0.586	0.63
59_D	105_H	0.586	0.63
728_R	732_G	0.586	0.63
634_V	637_N	0.585	0.63
659_A	706_I	0.585	0.63
50_A	63_R	0.585	0.63
50_A	72_V	0.585	0.63
227_G	231_A	0.584	0.62
196_R	206_E	0.584	0.62
651_N	670_E	0.584	0.62
405_K	423_V	0.584	0.62
385_L	434_D	0.584	0.62
670_E	673_V	0.583	0.62
602_D	605_A	0.582	0.62
204_V	347_S	0.581	0.62
47_I	97_V	0.581	0.62
410_A	413_E	0.580	0.62
371_A	452_L	0.580	0.62
403_D	406_N	0.580	0.62
382_M	435_I	0.579	0.62
353_I	463_L	0.578	0.62
550_V	601_F	0.578	0.62
407_N	419_A	0.577	0.61
386_S	396_R	0.577	0.61
456_L	462_L	0.576	0.61
423_V	438_L	0.576	0.61
238_K	331_N	0.574	0.61
56_N	61_N	0.574	0.61
560_Y	627_Q	0.574	0.61
133_L	162_F	0.574	0.61
317_F	321_N	0.574	0.61
460_K	463_L	0.573	0.61
61_N	67_K	0.572	0.61
554_F	635_A	0.572	0.61
193_V	462_L	0.571	0.61
443_E	450_E	0.571	0.61
451_E	457_S	0.571	0.61
228_I	232_Y	0.570	0.61
113_G	116_P	0.570	0.61
361_T	459_D	0.570	0.61
17_G	21_G	0.570	0.61
271_L	324_L	0.569	0.60
53_T	71_N	0.569	0.60
91_M	182_P	0.569	0.60
408_L	413_E	0.568	0.60
36_A	334_A	0.567	0.60
405_K	409_I	0.567	0.60
279_R	289_E	0.567	0.60
242_R	319_Y	0.566	0.60
26_Y	29_Q	0.566	0.60
357_K	361_T	0.566	0.60
562_Y	626_A	0.566	0.60
377_I	417_P	0.566	0.60
243_G	326_I	0.566	0.60
711_Q	743_P	0.565	0.60
386_S	432_N	0.565	0.60
171_T	328_Y	0.565	0.60
180_D	328_Y	0.565	0.60
614_G	686_I	0.564	0.60
75_N	151_T	0.564	0.60
441_E	445_L	0.563	0.60
119_M	148_F	0.563	0.60
501_A	548_T	0.563	0.60
729_A	732_G	0.563	0.60
653_E	671_D	0.562	0.59
54_D	73_I	0.561	0.59
725_K	730_K	0.561	0.59
464_K	467_T	0.561	0.59
243_G	271_L	0.561	0.59
334_A	344_S	0.561	0.59
610_F	648_H	0.560	0.59
494_I	499_M	0.558	0.59
201_S	346_P	0.558	0.59
52_H	126_L	0.557	0.59
606_Y	620_E	0.557	0.59
654_S	670_E	0.557	0.59
181_I	349_L	0.557	0.59
395_I	431_T	0.557	0.59
54_D	119_M	0.557	0.59
660_T	688_L	0.556	0.59
610_F	645_I	0.555	0.59
616_V	658_M	0.555	0.59
192_A	195_K	0.555	0.59
700_L	704_D	0.555	0.59
206_E	210_V	0.554	0.58
44_Q	84_V	0.554	0.58
230_K	234_T	0.554	0.58
714_A	742_N	0.553	0.58
12_L	22_R	0.553	0.58
648_H	698_E	0.552	0.58
254_R	304_E	0.551	0.58
171_T	265_E	0.551	0.58
553_L	592_I	0.550	0.58
375_H	445_L	0.550	0.58
40_L	48_L	0.550	0.58
136_D	363_R	0.550	0.58
391_V	427_L	0.549	0.58
285_E	306_K	0.548	0.58
401_K	424_S	0.547	0.57
714_A	718_M	0.547	0.57
236_K	331_N	0.547	0.57
659_A	736_L	0.546	0.57
198_Q	464_K	0.546	0.57
400_D	404_A	0.546	0.57
707_V	713_G	0.545	0.57
49_Y	137_I	0.545	0.57
193_V	196_R	0.545	0.57
715_V	723_F	0.545	0.57
247_I	255_E	0.544	0.57
454_S	460_K	0.544	0.57
394_T	397_S	0.544	0.57
201_S	468_N	0.544	0.57
419_A	690_E	0.543	0.57
313_G	500_V	0.542	0.57
667_W	700_L	0.542	0.57
44_Q	86_E	0.542	0.57
265_E	423_V	0.542	0.57
609_F	636_L	0.541	0.57
165_L	181_I	0.541	0.57
206_E	471_K	0.541	0.57
167_V	187_G	0.541	0.57
662_L	691_D	0.540	0.56
553_L	563_C	0.539	0.56
197_I	353_I	0.539	0.56
425_L	432_N	0.539	0.56
275_M	318_L	0.539	0.56
12_L	16_I	0.539	0.56
194_I	475_K	0.539	0.56
231_A	345_L	0.539	0.56
579_H	736_L	0.538	0.56
512_D	536_T	0.538	0.56
431_T	436_T	0.538	0.56
222_I	330_F	0.537	0.56
233_E	344_S	0.537	0.56
105_H	296_R	0.536	0.56
613_N	691_D	0.536	0.56
114_D	268_K	0.536	0.56
208_M	212_K	0.536	0.56
271_L	275_M	0.535	0.56
723_F	726_T	0.535	0.56
54_D	57_T	0.534	0.56
262_I	269_A	0.533	0.56
63_R	119_M	0.533	0.56
662_L	689_K	0.533	0.56
316_N	498_V	0.533	0.56
714_A	717_R	0.532	0.55
447_K	468_N	0.532	0.55
601_F	605_A	0.532	0.55
134_L	137_I	0.531	0.55
82_S	116_P	0.531	0.55
428_Y	431_T	0.530	0.55
447_K	461_K	0.530	0.55
205_D	209_E	0.530	0.55
557_K	643_E	0.530	0.55
508_T	523_F	0.529	0.55
223_Q	488_K	0.529	0.55
400_D	428_Y	0.529	0.55
276_D	280_I	0.529	0.55
44_Q	83_S	0.528	0.55
554_F	644_L	0.528	0.55
110_S	114_D	0.528	0.55
523_F	544_E	0.527	0.55
138_D	141_T	0.527	0.55
76_Y	338_R	0.527	0.55
140_N	153_K	0.527	0.55
383_K	412_Y	0.527	0.55
272_V	292_D	0.527	0.55
327_T	330_F	0.527	0.55
20_F	105_H	0.527	0.55
514_Y	577_G	0.526	0.55
160_A	356_Q	0.525	0.54
412_Y	415_T	0.525	0.54
26_Y	335_I	0.525	0.54
56_N	88_M	0.524	0.54
386_S	412_Y	0.524	0.54
26_Y	108_N	0.524	0.54
516_K	577_G	0.523	0.54
665_G	735_M	0.523	0.54
297_T	300_R	0.523	0.54
393_A	407_N	0.522	0.54
21_G	83_S	0.522	0.54
282_K	285_E	0.522	0.54
296_R	299_L	0.522	0.54
253_G	307_K	0.521	0.54
654_S	699_I	0.521	0.54
167_V	473_L	0.521	0.54
133_L	158_L	0.519	0.54
96_K	273_K	0.519	0.54
213_G	660_T	0.518	0.53
190_I	462_L	0.518	0.53
162_F	356_Q	0.518	0.53
129_I	477_Y	0.518	0.53
236_K	329_N	0.518	0.53
399_S	431_T	0.518	0.53
50_A	56_N	0.517	0.53
366_Y	369_Q	0.517	0.53
506_Y	523_F	0.517	0.53
194_I	470_L	0.517	0.53
20_F	331_N	0.517	0.53
537_D	577_G	0.517	0.53
709_F	713_G	0.516	0.53
124_A	127_S	0.516	0.53
192_A	349_L	0.515	0.53
334_A	343_M	0.515	0.53
218_T	264_F	0.515	0.53
734_V	741_K	0.515	0.53
324_L	729_A	0.514	0.53
646_D	658_M	0.513	0.53
177_Y	333_V	0.513	0.53
20_F	356_Q	0.512	0.53
712_R	742_N	0.512	0.53
132_E	138_D	0.511	0.52
68_T	84_V	0.511	0.52
250_I	304_E	0.510	0.52
389_D	395_I	0.510	0.52
105_H	131_S	0.509	0.52
257_I	314_I	0.509	0.52
188_E	208_M	0.509	0.52
394_T	426_Q	0.508	0.52
84_V	284_V	0.508	0.52
357_K	466_I	0.508	0.52
56_N	124_A	0.508	0.52
388_L	445_L	0.508	0.52
27_I	32_A	0.507	0.52
382_M	443_E	0.507	0.52
293_E	304_E	0.507	0.52
22_R	25_K	0.507	0.52
421_A	432_N	0.507	0.52
50_A	119_M	0.506	0.52
305_L	311_A	0.506	0.52
132_E	473_L	0.506	0.52
112_D	294_T	0.505	0.52
698_E	706_I	0.505	0.52
144_F	641_E	0.505	0.52
501_A	547_T	0.505	0.52
266_V	323_D	0.505	0.52
655_Q	702_Q	0.503	0.51
611_T	644_L	0.503	0.51
600_E	618_K	0.503	0.51
15_V	26_Y	0.503	0.51
606_Y	670_E	0.503	0.51
356_Q	469_S	0.503	0.51
54_D	152_S	0.503	0.51
517_R	547_T	0.503	0.51
249_T	253_G	0.502	0.51
406_N	409_I	0.502	0.51
401_K	429_R	0.502	0.51
96_K	265_E	0.502	0.51
360_V	463_L	0.501	0.51
708_L	718_M	0.501	0.51
237_G	242_R	0.501	0.51
435_I	438_L	0.501	0.51
412_Y	447_K	0.501	0.51
432_N	436_T	0.501	0.51
189_V	689_K	0.501	0.51
568_L	583_L	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1zvuA	2	0.83	100	0.187	Contact Map
2inrA	2	0.5484	100	0.319	Contact Map
4i3hA	2	0.6017	100	0.319	Contact Map
2novA	2	0.562	100	0.321	Contact Map
2xcsB	2	0.5968	100	0.323	Contact Map
2xkjE	2	0.5943	100	0.331	Contact Map
3ilwA	2	0.5695	100	0.336	Contact Map
4ckkA	2	0.5608	100	0.348	Contact Map
4gfhA	2	0.562	100	0.449	Contact Map
3l4jA	1	0.5608	100	0.468	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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