GREMLIN Database
YNET - Uncharacterized protein YneT
UniProt: Q45065 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 135 (126)
Sequences: 1866 (1270)
Seq/√Len: 113.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_S67_E3.4911.00
89_E113_M2.8881.00
38_A131_H2.4561.00
45_E59_V2.3691.00
18_R45_E2.3511.00
112_Q116_E2.2381.00
40_Q59_V2.2361.00
16_S74_I2.1601.00
62_V69_D2.1271.00
63_S67_E2.1181.00
68_I72_I2.1141.00
85_P107_N2.0721.00
66_K90_E2.0561.00
103_Q129_V2.0561.00
88_A99_F2.0101.00
26_D53_I1.8121.00
66_K93_E1.8111.00
24_L36_S1.8011.00
37_K41_D1.7811.00
11_E15_R1.7771.00
45_E70_G1.7661.00
12_I98_V1.6951.00
111_Y123_M1.6851.00
10_K14_Q1.6331.00
84_L101_A1.6191.00
47_I70_G1.5571.00
18_R70_G1.5511.00
71_P97_P1.5481.00
65_L94_T1.4371.00
88_A110_A1.4101.00
27_R30_R1.3911.00
106_V124_D1.3741.00
53_I56_A1.3741.00
49_V68_I1.3721.00
55_E60_K1.3181.00
56_A61_A1.3030.99
42_A131_H1.3000.99
85_P113_M1.2950.99
83_Q86_G1.2790.99
125_L130_A1.2770.99
74_I127_I1.2260.99
72_I94_T1.2240.99
16_S98_V1.2220.99
92_L117_K1.2180.99
111_Y121_V1.2050.99
86_G89_E1.1880.99
77_V101_A1.1850.99
92_L113_M1.1640.99
108_E123_M1.1630.99
34_M128_K1.1600.99
113_M117_K1.1570.99
40_Q57_L1.1570.99
98_V120_T1.1360.99
112_Q115_K1.1150.98
18_R47_I1.1120.98
111_Y115_K1.1120.98
74_I98_V1.1080.98
6_K130_A1.1040.98
80_R83_Q1.0900.98
77_V99_F1.0850.98
92_L119_R1.0850.98
114_L119_R1.0820.98
16_S73_D1.0780.98
21_V46_I1.0700.98
31_T34_M1.0670.98
88_A114_L1.0520.98
103_Q130_A1.0380.97
19_I127_I1.0190.97
33_H37_K1.0090.97
19_I74_I0.9960.97
108_E112_Q0.9880.97
21_V36_S0.9870.97
31_T35_V0.9860.97
99_F114_L0.9810.96
106_V123_M0.9740.96
25_S32_S0.9710.96
11_E120_T0.9650.96
79_R83_Q0.9640.96
64_S90_E0.9640.96
22_V75_V0.9520.96
40_Q46_I0.9390.95
84_L105_L0.9320.95
8_E120_T0.9320.95
38_A128_K0.9310.95
30_R80_R0.9170.95
76_N127_I0.9140.95
85_P89_E0.9110.95
96_A119_R0.9050.94
92_L96_A0.8690.93
27_R52_T0.8660.93
78_F102_Q0.8640.93
85_P109_E0.8550.93
40_Q45_E0.8520.92
34_M37_K0.8460.92
24_L56_A0.8450.92
54_D63_S0.8300.91
101_A121_V0.8270.91
53_I61_A0.8210.91
107_N110_A0.8130.91
55_E61_A0.8120.91
107_N113_M0.8060.90
50_N53_I0.8040.90
22_V91_F0.8000.90
95_D119_R0.7980.90
11_E14_Q0.7820.89
91_F119_R0.7730.88
19_I44_Y0.7620.88
15_R97_P0.7610.88
54_D60_K0.7600.87
39_M127_I0.7520.87
26_D52_T0.7490.87
35_V78_F0.7480.87
47_I68_I0.7270.85
33_H57_L0.7180.84
12_I122_I0.7120.84
62_V68_I0.7100.84
89_E93_E0.7060.83
91_F99_F0.6930.82
29_D34_M0.6920.82
25_S87_V0.6910.82
39_M46_I0.6850.81
32_S36_S0.6790.81
84_L107_N0.6750.80
38_A42_A0.6730.80
48_P61_A0.6620.79
55_E58_G0.6610.79
103_Q128_K0.6510.78
86_G90_E0.6500.78
28_P33_H0.6500.78
6_K10_K0.6440.77
88_A92_L0.6430.77
81_S107_N0.6420.77
24_L46_I0.6410.77
36_S39_M0.6350.76
7_A10_K0.6350.76
36_S46_I0.6330.76
92_L95_D0.6260.75
9_I125_L0.6240.75
26_D33_H0.6230.75
108_E111_Y0.6210.75
35_V102_Q0.6200.75
77_V84_L0.6180.74
46_I59_V0.6180.74
26_D56_A0.6180.74
34_M38_A0.6150.74
48_P60_K0.6140.74
8_E11_E0.6120.74
97_P120_T0.6100.73
28_P37_K0.6080.73
91_F95_D0.6070.73
68_I94_T0.6070.73
30_R105_L0.6040.73
101_A114_L0.5910.71
22_V87_V0.5910.71
36_S57_L0.5820.70
77_V87_V0.5820.70
9_I122_I0.5700.68
103_Q106_V0.5690.68
50_N61_A0.5690.68
26_D32_S0.5670.68
21_V24_L0.5670.68
76_N102_Q0.5640.68
88_A113_M0.5620.67
116_E119_R0.5570.67
59_V62_V0.5550.66
73_D97_P0.5540.66
24_L35_V0.5500.66
127_I131_H0.5420.64
8_E12_I0.5420.64
86_G107_N0.5410.64
81_S105_L0.5400.64
8_E15_R0.5300.63
16_S127_I0.5290.63
25_S50_N0.5280.62
6_K125_L0.5280.62
91_F96_A0.5260.62
13_L44_Y0.5260.62
24_L40_Q0.5250.62
28_P35_V0.5240.62
89_E92_L0.5220.62
24_L61_A0.5120.60
115_K120_T0.5120.60
7_A11_E0.5110.60
50_N80_R0.5080.60
88_A107_N0.5060.59
60_K67_E0.5060.59
34_M41_D0.5040.59
26_D50_N0.5030.59
32_S78_F0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ff4A 1 0.8889 100 0.467 Contact Map
2csuA 2 0.9333 99.9 0.523 Contact Map
2duwA 1 0.9778 99.9 0.575 Contact Map
1iukA 1 0.9778 99.8 0.58 Contact Map
1y81A 1 0.8593 99.8 0.6 Contact Map
2d59A 1 1 99.8 0.606 Contact Map
3pffA 2 0.9037 99.7 0.639 Contact Map
2fp4A 1 0.963 99.6 0.667 Contact Map
2yv1A 1 0.9037 99.5 0.688 Contact Map
3mwdB 1 0.9037 99.5 0.689 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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