GREMLIN Database
PLSY - Glycerol-3-phosphate acyltransferase
UniProt: Q45064 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (187)
Sequences: 3196 (2353)
Seq/√Len: 172.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_S59_G4.0631.00
19_G39_L3.4011.00
7_I86_F3.3431.00
142_M172_I3.0071.00
84_G111_V2.8261.00
65_T114_F2.7231.00
130_F143_L2.6331.00
180_K184_N2.4451.00
45_F53_G2.3191.00
17_P97_A2.3121.00
64_G107_T2.3091.00
131_L140_S2.3021.00
11_Y95_I2.2361.00
89_L93_F2.1811.00
173_Y176_R2.1301.00
136_F182_I2.1281.00
126_V151_Y2.1211.00
15_S96_F1.9621.00
92_V104_A1.8931.00
13_I67_A1.8791.00
34_H47_T1.8281.00
88_V108_S1.7681.00
6_L83_A1.7581.00
105_V171_V1.7571.00
22_V52_A1.7351.00
29_I34_H1.7191.00
57_I61_I1.6891.00
17_P39_L1.6791.00
131_L190_V1.6441.00
30_D33_E1.6401.00
94_P97_A1.5921.00
41_A106_A1.5591.00
152_S164_V1.5561.00
62_L65_T1.5561.00
20_L97_A1.5441.00
180_K183_I1.5341.00
92_V174_R1.4681.00
134_T140_S1.4621.00
21_I25_L1.4581.00
177_A181_R1.4581.00
146_I172_I1.4531.00
149_V165_T1.4311.00
176_R180_K1.4161.00
41_A57_I1.4141.00
126_V147_Y1.3871.00
88_V92_V1.3831.00
88_V167_L1.3801.00
65_T69_A1.3791.00
149_V168_T1.3671.00
7_I82_L1.3591.00
67_A83_A1.3401.00
137_V141_S1.3261.00
10_A83_A1.3101.00
109_G120_F1.3001.00
22_V59_G1.2951.00
20_L39_L1.2921.00
121_I125_A1.2821.00
10_A86_F1.2811.00
92_V171_V1.2721.00
153_F161_L1.2691.00
39_L97_A1.2571.00
161_L165_T1.2561.00
130_F134_T1.2401.00
44_A48_L1.2371.00
122_T151_Y1.2341.00
23_G44_A1.2311.00
42_T137_V1.2221.00
6_L10_A1.2141.00
127_F137_V1.2031.00
71_P79_H1.2021.00
26_A52_A1.1891.00
130_F140_S1.1811.00
145_G171_V1.1741.00
142_M179_I1.1701.00
23_G29_I1.1671.00
23_G48_L1.1671.00
108_S171_V1.1381.00
130_F139_L1.1351.00
11_Y94_P1.1331.00
177_A180_K1.1241.00
29_I48_L1.1221.00
108_S167_L1.1181.00
15_S95_I1.1091.00
135_K189_K1.0951.00
106_A110_G1.0941.00
148_T164_V1.0911.00
138_S182_I1.0861.00
139_L143_L1.0861.00
12_L15_S1.0741.00
68_T114_F1.0731.00
128_F132_Y1.0651.00
44_A56_V1.0641.00
136_F189_K1.0631.00
116_A119_L1.0520.99
71_P83_A1.0420.99
20_L23_G1.0400.99
45_F190_V1.0380.99
116_A152_S1.0350.99
134_T139_L1.0210.99
136_F139_L1.0040.99
50_V54_S1.0010.99
22_V55_V1.0010.99
127_F140_S0.9990.99
20_L32_R0.9990.99
109_G144_T0.9950.99
105_V141_S0.9910.99
92_V170_F0.9890.99
132_Y135_K0.9870.99
16_I21_I0.9770.99
31_I44_A0.9700.99
39_L94_P0.9630.99
29_I33_E0.9630.99
150_I154_F0.9620.99
36_S46_R0.9610.99
64_G110_G0.9610.99
119_L152_S0.9570.99
23_G31_I0.9560.99
64_G111_V0.9450.99
7_I79_H0.9340.99
85_V166_L0.9260.99
28_G48_L0.9200.99
123_M148_T0.9160.99
42_T46_R0.9020.98
68_T72_F0.8950.98
49_G52_A0.8940.98
55_V59_G0.8930.98
180_K186_T0.8910.98
19_G56_V0.8880.98
147_Y151_Y0.8830.98
19_G38_N0.8820.98
48_L56_V0.8800.98
76_V79_H0.8780.98
42_T138_S0.8680.98
168_T172_I0.8640.98
179_I183_I0.8450.98
169_I173_Y0.8270.97
149_V161_L0.8190.97
56_V59_G0.8110.97
72_F80_P0.8070.97
68_T80_P0.8070.97
162_I166_L0.8060.97
58_A62_L0.8040.97
69_A73_L0.8030.97
181_R187_E0.8010.97
22_V27_K0.7850.96
37_G47_T0.7830.96
62_L66_L0.7790.96
130_F147_Y0.7760.96
31_I39_L0.7660.96
67_A87_A0.7650.96
149_V164_V0.7640.96
149_V153_F0.7620.96
136_F188_P0.7590.96
17_P20_L0.7560.95
28_G49_G0.7560.95
119_L151_Y0.7550.95
24_K30_D0.7540.95
48_L52_A0.7520.95
88_V104_A0.7480.95
108_S144_T0.7470.95
33_E37_G0.7430.95
140_S144_T0.7350.95
45_F54_S0.7340.95
22_V26_A0.7290.94
161_L164_V0.7280.94
81_L163_V0.7270.94
118_L121_I0.7260.94
113_L120_F0.7220.94
68_T71_P0.7210.94
159_Y162_I0.7170.94
69_A72_F0.7160.94
136_F140_S0.7160.94
158_T162_I0.7110.94
163_V167_L0.7010.93
32_R94_P0.6980.93
141_S175_H0.6960.93
84_G87_A0.6910.93
135_K190_V0.6900.93
181_R186_T0.6900.93
46_R138_S0.6900.93
88_V111_V0.6880.93
173_Y177_A0.6830.92
42_T178_N0.6780.92
39_L104_A0.6770.92
15_S87_A0.6770.92
20_L31_I0.6750.92
61_I113_L0.6720.92
6_L74_M0.6710.92
178_N187_E0.6670.91
127_F144_T0.6660.91
87_A107_T0.6630.91
162_I169_I0.6570.91
129_I133_L0.6540.91
80_P115_Y0.6520.90
44_A53_G0.6500.90
27_K52_A0.6480.90
36_S42_T0.6460.90
175_H178_N0.6460.90
57_I106_A0.6450.90
165_T169_I0.6440.90
86_F89_L0.6430.90
41_A56_V0.6400.90
4_A8_I0.6370.89
85_V167_L0.6370.89
142_M146_I0.6360.89
67_A71_P0.6360.89
13_I66_L0.6350.89
69_A114_F0.6350.89
82_L86_F0.6340.89
71_P80_P0.6330.89
45_F50_V0.6280.89
51_K55_V0.6270.89
42_T141_S0.6270.89
23_G47_T0.6230.88
79_H83_A0.6220.88
108_S145_G0.6220.88
94_P100_K0.6180.88
17_P94_P0.6180.88
112_L164_V0.6160.88
23_G34_H0.6120.87
76_V80_P0.6110.87
93_F174_R0.6040.87
138_S181_R0.6030.87
9_L13_I0.6020.87
38_N43_N0.5990.86
181_R188_P0.5970.86
93_F170_F0.5950.86
38_N103_K0.5910.86
103_K175_H0.5900.86
138_S141_S0.5890.85
131_L137_V0.5870.85
17_P96_F0.5840.85
70_L74_M0.5840.85
92_V108_S0.5830.85
57_I109_G0.5760.84
59_G171_V0.5750.84
112_L167_L0.5740.84
10_A13_I0.5720.84
151_Y155_V0.5710.84
23_G27_K0.5690.83
127_F131_L0.5680.83
46_R178_N0.5670.83
31_I47_T0.5660.83
44_A52_A0.5640.83
146_I169_I0.5570.82
150_I158_T0.5570.82
152_S161_L0.5560.82
12_L96_F0.5540.82
64_G68_T0.5480.81
145_G168_T0.5480.81
43_N103_K0.5450.81
23_G26_A0.5450.81
105_V138_S0.5400.80
13_I64_G0.5390.80
46_R141_S0.5350.80
54_S58_A0.5340.79
94_P108_S0.5320.79
139_L182_I0.5310.79
138_S187_E0.5240.78
19_G31_I0.5230.78
89_L170_F0.5170.77
36_S178_N0.5140.77
131_L135_K0.5140.77
77_D80_P0.5120.77
36_S138_S0.5120.77
153_F165_T0.5120.77
157_D160_L0.5120.77
80_P83_A0.5110.76
54_S57_I0.5100.76
93_F173_Y0.5080.76
32_R97_A0.5070.76
6_L71_P0.5070.76
62_L67_A0.5060.76
138_S178_N0.5060.76
39_L48_L0.5060.76
61_I65_T0.5060.76
20_L24_K0.5020.75
160_L164_V0.5010.75
79_H82_L0.5010.75
72_F114_F0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k3fA 3 0.9482 1.9 0.968 Contact Map
2e5zA 1 0.2902 1.9 0.968 Contact Map
4ldsA 2 0.8394 1.8 0.968 Contact Map
2bzwB 1 0.1399 1.7 0.969 Contact Map
2m0qA 1 0.3575 1.5 0.97 Contact Map
4dveA 3 0.4352 1.4 0.97 Contact Map
2gsvA 3 0.1399 1.4 0.97 Contact Map
4yypB 1 0.0881 1.4 0.97 Contact Map
3wdoA 1 0.7772 1.3 0.971 Contact Map
2voyD 1 0.1192 1.3 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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