GREMLIN Database
YNEQ - Uncharacterized protein YneQ
UniProt: Q45062 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 99 (97)
Sequences: 184 (150)
Seq/√Len: 15.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_V44_G5.2191.00
22_I43_A3.6120.99
16_A21_E3.5920.99
28_Y39_T3.5250.99
90_L93_H3.1500.99
17_V72_P2.9090.98
80_T83_Y2.7690.97
55_G64_W2.6180.95
61_K64_W2.4870.94
9_E96_R2.0110.84
48_I52_V1.9440.82
55_G58_Y1.9350.81
12_R16_A1.9090.80
82_K86_E1.7710.75
47_D50_K1.6890.71
17_V46_A1.4700.60
28_Y89_N1.4580.59
28_Y66_H1.4290.58
6_K79_E1.4070.57
37_A64_W1.3870.56
77_L94_L1.3820.55
84_I88_E1.3500.53
55_G79_E1.3380.53
8_E11_N1.3260.52
6_K9_E1.3190.52
68_K77_L1.2770.49
11_N19_R1.1960.45
30_L40_V1.1720.43
17_V69_S1.1610.43
31_D40_V1.1610.43
20_G47_D1.1530.42
25_L30_L1.1510.42
37_A77_L1.1240.41
77_L80_T1.1220.41
31_D77_L1.1000.39
56_A86_E1.0960.39
58_Y87_Q1.0860.39
9_E97_F1.0760.38
21_E69_S1.0660.38
5_V77_L1.0640.38
12_R21_E1.0070.35
8_E12_R0.9890.34
44_G71_F0.9760.33
31_D34_F0.9650.32
30_L81_Q0.9480.32
17_V71_F0.9450.31
55_G61_K0.9300.31
61_K67_K0.9290.31
56_A92_D0.9200.30
88_E91_T0.9130.30
5_V89_N0.9080.30
10_L47_D0.9070.30
91_T94_L0.8920.29
37_A70_E0.8860.29
70_E95_I0.8820.28
18_K72_P0.8740.28
37_A55_G0.8720.28
13_W44_G0.8470.27
67_K93_H0.8400.27
6_K90_L0.8350.26
48_I67_K0.8340.26
19_R38_K0.8320.26
58_Y64_W0.8220.26
13_W71_F0.8170.26
90_L95_I0.8130.25
12_R15_Q0.7930.25
15_Q38_K0.7840.24
13_W45_C0.7830.24
86_E94_L0.7700.24
28_Y67_K0.7700.24
89_N94_L0.7680.24
92_D97_F0.7640.23
6_K82_K0.7610.23
10_L50_K0.7610.23
11_N37_A0.7580.23
12_R92_D0.7550.23
6_K36_E0.7530.23
82_K90_L0.7520.23
23_A65_I0.7490.23
7_R11_N0.7470.23
66_H85_L0.7410.22
8_E95_I0.7390.22
55_G66_H0.7300.22
16_A19_R0.7300.22
81_Q93_H0.7250.22
15_Q19_R0.7230.22
19_R25_L0.7200.22
82_K91_T0.7160.21
56_A74_F0.7110.21
56_A62_K0.7080.21
52_V67_K0.6960.21
19_R47_D0.6950.21
93_H97_F0.6890.20
18_K70_E0.6850.20
24_F55_G0.6630.20
15_Q66_H0.6610.19
50_K79_E0.6610.19
53_Q56_A0.6530.19
13_W24_F0.6500.19
80_T97_F0.6430.19
39_T59_G0.6280.18
11_N82_K0.6230.18
62_K72_P0.6220.18
62_K70_E0.6200.18
22_I93_H0.6200.18
60_L64_W0.6170.18
49_D91_T0.6140.18
38_K96_R0.6110.18
52_V56_A0.6110.18
57_A66_H0.6090.18
16_A50_K0.6090.18
10_L81_Q0.6060.18
63_E96_R0.6020.17
6_K49_D0.6020.17
53_Q59_G0.5950.17
49_D53_Q0.5950.17
52_V71_F0.5880.17
37_A61_K0.5830.17
5_V82_K0.5830.17
62_K82_K0.5810.17
25_L92_D0.5790.17
46_A81_Q0.5790.17
28_Y38_K0.5730.17
25_L93_H0.5730.17
94_L97_F0.5730.17
10_L72_P0.5640.16
30_L48_I0.5640.16
43_A50_K0.5600.16
72_P97_F0.5600.16
22_I63_E0.5560.16
67_K82_K0.5540.16
49_D86_E0.5490.16
9_E84_I0.5490.16
58_Y80_T0.5450.16
15_Q86_E0.5360.15
11_N71_F0.5340.15
56_A89_N0.5290.15
18_K97_F0.5200.15
90_L97_F0.5180.15
49_D71_F0.5160.15
32_D48_I0.5160.15
15_Q82_K0.5140.15
5_V52_V0.5120.15
13_W17_V0.5080.15
18_K79_E0.5010.14
71_F95_I0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jrtA 1 0.3434 22.7 0.945 Contact Map
2qjzA 1 0.8182 19.7 0.947 Contact Map
3ayvA 2 0.8485 13 0.95 Contact Map
1wyoA 1 0.8384 9.4 0.954 Contact Map
1qzpA 1 0.2525 8.9 0.954 Contact Map
1yu8X 1 0.2525 8.7 0.954 Contact Map
2k6mS 1 0.2525 8.4 0.955 Contact Map
3ddeA 3 0.8889 8.4 0.955 Contact Map
1rw1A 1 0.6465 8.1 0.955 Contact Map
4xrpC 1 0.5859 7.7 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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