GREMLIN Database
YNEP - Putative acyl-CoA thioesterase YneP
UniProt: Q45061 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 138 (128)
Sequences: 6483 (4705)
Seq/√Len: 415.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_D63_S3.1791.00
81_E91_G2.5441.00
66_K100_E2.3401.00
5_K75_V2.3251.00
30_M105_A2.2751.00
68_L102_S2.2221.00
65_K104_K2.2081.00
61_N106_T2.2011.00
68_L74_A2.1451.00
5_K77_H2.1201.00
25_N28_V2.0571.00
7_E73_T2.0331.00
27_L60_I1.9761.00
30_M103_I1.9261.00
113_D116_S1.8501.00
7_E75_V1.8211.00
82_D89_V1.8061.00
77_H95_Y1.7891.00
77_H93_H1.7801.00
95_Y101_L1.6601.00
79_W91_G1.6571.00
27_L62_I1.6481.00
54_L114_K1.6331.00
124_K128_D1.6301.00
93_H101_L1.6091.00
30_M94_I1.5521.00
63_S104_K1.5231.00
89_V106_T1.5141.00
62_I103_I1.4851.00
92_Y107_S1.4631.00
72_E96_N1.4571.00
91_G106_T1.4541.00
9_E73_T1.4431.00
76_V94_I1.4191.00
93_H104_K1.4161.00
21_V29_W1.3961.00
86_F119_P1.3821.00
9_E39_K1.3691.00
123_R126_F1.3591.00
9_E36_A1.3431.00
96_N100_E1.3091.00
36_A40_D1.2951.00
84_N87_K1.2911.00
67_P117_F1.2861.00
58_V63_S1.2851.00
96_N102_S1.2821.00
81_E106_T1.2801.00
73_T97_P1.2701.00
127_P131_T1.2701.00
33_G78_T1.2601.00
13_A28_V1.2241.00
47_D50_K1.2201.00
87_K108_S1.2181.00
7_E97_P1.2081.00
60_I107_S1.2071.00
44_L47_D1.1931.00
112_V117_F1.1701.00
11_R14_E1.1611.00
10_V21_V1.1241.00
14_E28_V1.1241.00
31_E34_R1.1171.00
33_G76_V1.1091.00
85_G121_Q1.0891.00
95_Y99_G1.0871.00
89_V108_S1.0841.00
39_K71_G1.0711.00
113_D120_I1.0641.00
56_P112_V1.0471.00
65_K101_L1.0301.00
24_A28_V1.0251.00
53_V111_C1.0231.00
86_F110_I1.0191.00
75_V97_P1.0141.00
59_D108_S1.0131.00
79_W93_H1.0031.00
47_D51_K0.9841.00
8_I76_V0.9641.00
101_L104_K0.9601.00
23_H60_I0.9361.00
81_E89_V0.9331.00
124_K127_P0.9271.00
4_S78_T0.9031.00
74_A102_S0.8961.00
58_V108_S0.8851.00
46_S50_K0.8821.00
51_K125_A0.8681.00
125_A128_D0.8621.00
18_M56_P0.8591.00
22_Y31_E0.8371.00
11_R32_V0.8321.00
39_K44_L0.8311.00
4_S40_D0.8291.00
10_V29_W0.8251.00
91_G104_K0.8201.00
14_E29_W0.8091.00
128_D131_T0.8001.00
52_G115_E0.7911.00
6_K36_A0.7851.00
30_M62_I0.7751.00
36_A39_K0.7731.00
23_H27_L0.7701.00
78_T90_Y0.7641.00
23_H64_Y0.7581.00
34_R57_V0.7561.00
12_Y15_T0.7551.00
86_F121_Q0.7451.00
8_I32_V0.7441.00
37_L78_T0.7441.00
80_I90_Y0.7441.00
34_R92_Y0.7421.00
21_V68_L0.7411.00
6_K32_V0.7381.00
15_T19_G0.7351.00
59_D106_T0.7351.00
23_H34_R0.7331.00
76_V92_Y0.7311.00
60_I105_A0.7301.00
78_T92_Y0.7291.00
75_V99_G0.7241.00
58_V65_K0.7211.00
12_Y17_Q0.7111.00
75_V95_Y0.7081.00
29_W74_A0.7061.00
9_E71_G0.7031.00
8_I29_W0.7031.00
18_M22_Y0.7031.00
83_Y130_H0.7001.00
28_V31_E0.6991.00
11_R28_V0.6861.00
69_H117_F0.6811.00
6_K33_G0.6751.00
92_Y109_H0.6650.99
15_T70_Y0.6600.99
85_G127_P0.6560.99
26_Y68_L0.6560.99
20_I67_P0.6470.99
18_M23_H0.6450.99
32_V36_A0.6430.99
122_F127_P0.6410.99
20_I117_F0.6360.99
46_S49_E0.6340.99
63_S106_T0.6310.99
88_T122_F0.6300.99
20_I56_P0.6300.99
114_K117_F0.6290.99
37_L80_I0.6280.99
83_Y127_P0.6270.99
58_V110_I0.6270.99
18_M54_L0.6210.99
44_L71_G0.6160.99
34_R109_H0.6140.99
125_A129_W0.6100.99
25_N29_W0.6050.99
72_E102_S0.6010.99
94_I103_I0.6010.99
46_S71_G0.6000.99
15_T25_N0.5940.99
30_M92_Y0.5900.99
124_K131_T0.5900.99
13_A22_Y0.5850.99
10_V74_A0.5850.99
13_A32_V0.5780.99
121_Q124_K0.5760.98
12_Y70_Y0.5750.98
127_P130_H0.5690.98
87_K110_I0.5680.98
84_N127_P0.5660.98
37_L41_L0.5640.98
87_K127_P0.5640.98
34_R90_Y0.5620.98
58_V87_K0.5590.98
8_I14_E0.5580.98
22_Y25_N0.5540.98
55_S111_C0.5540.98
14_E25_N0.5530.98
53_V120_I0.5520.98
34_R107_S0.5440.98
57_V107_S0.5340.98
60_I64_Y0.5340.98
83_Y88_T0.5280.97
120_I126_F0.5270.97
111_C122_F0.5270.97
12_Y35_T0.5260.97
62_I105_A0.5210.97
111_C123_R0.5160.97
41_L130_H0.5100.97
55_S90_Y0.5090.97
110_I119_P0.5050.97
82_D108_S0.5030.96
55_S122_F0.5020.96
41_L129_W0.5010.96
90_Y109_H0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2essA 2 0.971 100 0.227 Contact Map
2ownA 3 1 100 0.237 Contact Map
2hljA 2 0.9783 100 0.26 Contact Map
4k00A 4 0.971 100 0.265 Contact Map
3ck1A 4 1 100 0.266 Contact Map
1njkA 4 0.9565 100 0.268 Contact Map
2w3xA 4 1 100 0.281 Contact Map
2hx5A 4 0.9638 100 0.285 Contact Map
3hm0A 4 0.8913 100 0.287 Contact Map
4gakA 2 0.9928 100 0.29 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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