GREMLIN Database
TLP - Small, acid-soluble spore protein Tlp
UniProt: Q45060 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 83 (69)
Sequences: 162 (130)
Seq/√Len: 15.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_D22_K4.0001.00
40_S48_D3.2000.99
23_L26_M2.7350.97
25_D29_N2.5260.95
39_A44_A2.3990.93
27_V70_I2.1750.89
57_A60_E2.0910.87
38_E60_E2.0710.86
28_Q34_I2.0430.85
40_S44_A2.0160.85
22_K26_M1.9610.83
34_I37_A1.7360.74
31_I67_R1.6930.72
23_L52_I1.6580.71
46_G71_Q1.5960.68
58_R74_S1.4480.60
29_N77_R1.2980.52
49_K53_K1.2850.51
47_E51_R1.2460.49
50_Q53_K1.2300.48
48_D51_R1.2220.47
38_E57_A1.2210.47
40_S43_F1.2180.47
40_S62_S1.1980.46
37_A52_I1.1690.44
62_S65_A1.1560.43
54_E58_R1.1550.43
37_A65_A1.1360.42
20_V74_S1.1220.42
12_N72_D1.1080.41
49_K54_E1.0870.40
60_E78_Q1.0460.37
10_Q36_E1.0060.35
66_F72_D0.9920.35
20_V24_Q0.9850.34
25_D34_I0.9580.33
29_N34_I0.9560.33
28_Q32_E0.9470.32
44_A48_D0.9260.31
12_N68_N0.9220.31
40_S72_D0.8630.28
50_Q68_N0.8550.28
35_E40_S0.8550.28
28_Q63_I0.8460.27
31_I66_F0.8370.27
67_R71_Q0.8320.27
67_R74_S0.8260.26
37_A60_E0.8120.26
31_I63_I0.8080.26
35_E42_E0.7990.25
61_Q64_E0.7970.25
52_I75_A0.7820.25
22_K63_I0.7760.24
34_I64_E0.7720.24
11_P43_F0.7650.24
45_S54_E0.7610.24
21_E77_R0.7220.22
25_D54_E0.7210.22
46_G50_Q0.7210.22
65_A68_N0.7160.22
71_Q75_A0.7130.22
37_A53_K0.7080.22
26_M66_F0.7030.21
11_P44_A0.6890.21
43_F48_D0.6880.21
11_P47_E0.6870.21
25_D77_R0.6670.20
57_A61_Q0.6660.20
25_D51_R0.6650.20
32_E51_R0.6620.20
57_A71_Q0.6380.19
57_A76_A0.6360.19
46_G62_S0.6310.19
49_K72_D0.6300.19
36_E65_A0.6270.19
40_S52_I0.6260.19
25_D78_Q0.6140.18
41_M49_K0.6130.18
45_S74_S0.6120.18
43_F65_A0.6070.18
12_N43_F0.6010.18
15_D76_A0.5960.18
64_E74_S0.5890.17
41_M44_A0.5890.17
20_V76_A0.5870.17
35_E62_S0.5830.17
27_V35_E0.5810.17
26_M63_I0.5780.17
23_L66_F0.5760.17
71_Q74_S0.5730.17
17_S42_E0.5640.16
45_S78_Q0.5590.16
23_L27_V0.5390.16
32_E54_E0.5190.15
40_S46_G0.5190.15
34_I60_E0.5140.15
28_Q49_K0.5130.15
22_K46_G0.5110.15
41_M51_R0.5100.15
35_E67_R0.5090.15
45_S50_Q0.5070.15
27_V31_I0.5010.15
53_K78_Q0.5010.15
17_S26_M0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2azeA 1 0.4578 8.8 0.927 Contact Map
4cfgA 2 0.8193 3.7 0.939 Contact Map
3tyyA 2 0.6265 3.4 0.94 Contact Map
4pxuA 3 0.3855 2.9 0.942 Contact Map
3m4iA 2 0.4337 2.2 0.946 Contact Map
4yv4A 3 0.4699 2.1 0.946 Contact Map
3b5nB 1 0.4578 2.1 0.946 Contact Map
2npsB 1 0.494 2.1 0.946 Contact Map
4tn3A 2 1 1.9 0.947 Contact Map
3c01A 1 0 1.8 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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