GREMLIN Database
YNEB - Resolvase homolog YneB
UniProt: Q45057 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (211)
Sequences: 118 (94)
Seq/√Len: 6.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_E43_S4.5400.98
203_H207_Q3.6660.92
76_E161_S3.0110.81
114_D123_I2.7000.73
96_G187_A2.6420.71
168_V173_I2.4830.66
179_N185_E2.4660.65
44_E159_G2.4640.65
63_I68_I2.4350.64
2_K37_E2.3840.63
188_A191_R2.3330.61
57_F89_L2.2820.59
112_E203_H2.2610.58
168_V197_V2.1320.54
164_E185_E2.1240.53
165_K180_K2.1170.53
30_I102_T2.0790.52
91_C95_E2.0430.50
98_K107_E2.0200.49
114_D137_R2.0140.49
117_V121_V1.9450.47
188_A193_F1.9160.46
44_E161_S1.8490.43
4_L178_A1.8410.43
112_E207_Q1.8120.42
67_D177_R1.8080.42
158_H174_V1.8080.42
72_L107_E1.7970.41
42_I55_G1.7280.39
148_F195_Y1.6830.37
24_E51_M1.6700.37
100_Y166_I1.6180.35
40_K58_E1.6170.35
14_E166_I1.6160.35
187_A191_R1.6060.35
151_Q173_I1.5930.34
21_K71_I1.5920.34
64_K193_F1.5840.34
134_M137_R1.5660.33
101_T113_A1.5640.33
84_A173_I1.5540.33
70_V170_I1.5400.33
4_L170_I1.5230.32
73_V196_D1.5160.32
174_V206_F1.5100.32
123_I131_I1.5100.32
89_L131_I1.4870.31
92_I203_H1.4680.30
30_I113_A1.4680.30
83_N115_S1.4620.30
89_L122_S1.4590.30
104_H122_S1.4510.30
63_I71_I1.4450.30
57_F69_D1.4270.29
37_E191_R1.4100.29
25_E142_R1.4090.28
91_C193_F1.3960.28
51_M123_I1.3910.28
40_K144_V1.3830.28
42_I85_K1.3780.28
88_L95_E1.3500.27
45_K101_T1.3450.27
76_E179_N1.3260.26
103_A179_N1.3070.26
15_Q131_I1.2790.25
113_A119_E1.2750.25
51_M164_E1.2610.24
65_N148_F1.2480.24
5_I44_E1.2440.24
173_I193_F1.2410.24
113_A121_V1.2280.23
33_E38_V1.2270.23
30_I73_V1.2260.23
55_G208_E1.2260.23
89_L211_E1.2230.23
63_I84_A1.2220.23
54_D109_E1.2160.23
144_V168_V1.2160.23
121_V193_F1.2140.23
43_S51_M1.2040.23
35_G157_Q1.1880.22
54_D174_V1.1800.22
84_A95_E1.1510.21
52_D191_R1.1470.21
165_K168_V1.1450.21
84_A193_F1.1430.21
116_M138_R1.1410.21
67_D71_I1.1360.21
107_E117_V1.1350.21
164_E206_F1.1340.21
55_G142_R1.1300.21
71_I99_V1.1230.21
15_Q115_S1.1170.21
49_Y54_D1.0900.20
141_K145_K1.0890.20
115_S156_N1.0850.20
50_E145_K1.0790.20
95_E179_N1.0690.19
28_T196_D1.0630.19
57_F131_I1.0560.19
85_K134_M1.0530.19
21_K141_K1.0520.19
52_D99_V1.0500.19
25_E141_K1.0490.19
7_A15_Q1.0450.19
50_E142_R1.0360.19
157_Q170_I1.0330.19
5_I41_V1.0170.18
149_K209_Y1.0150.18
107_E209_Y1.0030.18
18_T65_N1.0020.18
12_N134_M0.9990.18
103_A141_K0.9980.18
32_A96_G0.9950.18
76_E113_A0.9910.18
28_T210_I0.9910.18
21_K100_Y0.9880.18
76_E103_A0.9800.17
44_E160_N0.9790.17
79_L156_N0.9770.17
155_K212_N0.9720.17
60_L70_V0.9480.17
99_V123_I0.9460.17
180_K207_Q0.9380.17
33_E160_N0.9380.17
86_I179_N0.9330.17
24_E97_V0.9290.16
29_A166_I0.9290.16
12_N37_E0.9290.16
111_S117_V0.9230.16
52_D83_N0.9170.16
4_L62_E0.9160.16
54_D97_V0.9160.16
36_M72_L0.9150.16
142_R158_H0.9140.16
85_K107_E0.9010.16
40_K165_K0.9010.16
64_K84_A0.9000.16
158_H161_S0.8980.16
18_T68_I0.8950.16
88_L117_V0.8920.16
76_E85_K0.8890.16
51_M101_T0.8870.16
59_L174_V0.8850.16
7_A89_L0.8730.15
99_V134_M0.8680.15
166_I191_R0.8660.15
68_I95_E0.8630.15
146_N168_V0.8430.15
62_E73_V0.8390.15
73_V109_E0.8370.15
134_M188_A0.8350.15
111_S121_V0.8350.15
17_E193_F0.8280.14
18_T185_E0.8280.14
46_A121_V0.8240.14
98_K165_K0.8240.14
59_L68_I0.8120.14
76_E142_R0.8100.14
104_H193_F0.8080.14
107_E121_V0.8070.14
56_V88_L0.8060.14
12_N180_K0.7990.14
142_R193_F0.7980.14
37_E71_I0.7920.14
45_K171_S0.7910.14
2_K71_I0.7870.14
57_F88_L0.7850.14
84_A122_S0.7790.14
40_K52_D0.7780.14
98_K197_V0.7700.13
107_E111_S0.7700.13
86_I137_R0.7690.13
57_F121_V0.7680.13
51_M93_Y0.7660.13
3_A70_V0.7650.13
3_A46_A0.7650.13
113_A122_S0.7640.13
12_N165_K0.7620.13
34_N56_V0.7620.13
113_A117_V0.7610.13
76_E114_D0.7580.13
77_T114_D0.7550.13
167_E184_A0.7520.13
63_I73_V0.7500.13
104_H115_S0.7460.13
12_N52_D0.7440.13
20_L45_K0.7420.13
40_K71_I0.7390.13
184_A199_K0.7380.13
37_E145_K0.7350.13
92_I95_E0.7310.13
5_I79_L0.7290.13
41_V178_A0.7280.13
73_V83_N0.7220.13
165_K211_E0.7210.13
96_G211_E0.7210.13
95_E193_F0.7170.13
72_L111_S0.7160.13
164_E195_Y0.7100.12
112_E118_L0.7090.12
161_S180_K0.7090.12
79_L134_M0.6990.12
65_N211_E0.6980.12
88_L137_R0.6950.12
174_V209_Y0.6910.12
24_E28_T0.6860.12
69_D131_I0.6850.12
94_R138_R0.6850.12
94_R116_M0.6850.12
84_A168_V0.6810.12
122_S179_N0.6790.12
85_K121_V0.6770.12
103_A193_F0.6770.12
17_E179_N0.6750.12
30_I86_I0.6710.12
52_D196_D0.6710.12
51_M185_E0.6710.12
146_N199_K0.6660.12
21_K38_V0.6620.12
5_I170_I0.6620.12
2_K158_H0.6610.12
55_G83_N0.6610.12
42_I188_A0.6610.12
73_V146_N0.6580.12
51_M142_R0.6560.12
74_Q197_V0.6520.12
39_V69_D0.6510.12
84_A91_C0.6500.12
34_N166_I0.6480.12
41_V58_E0.6470.11
107_E134_M0.6460.11
61_D110_L0.6460.11
12_N149_K0.6460.11
28_T35_G0.6450.11
18_T187_A0.6430.11
41_V160_N0.6330.11
32_A69_D0.6300.11
69_D178_A0.6280.11
109_E152_K0.6280.11
46_A137_R0.6270.11
167_E174_V0.6230.11
116_M127_Y0.6200.11
127_Y138_R0.6200.11
56_V166_I0.6180.11
68_I73_V0.6170.11
14_E83_N0.6170.11
65_N85_K0.6160.11
73_V76_E0.6160.11
5_I70_V0.6150.11
15_Q67_D0.6140.11
4_L28_T0.6120.11
51_M131_I0.6070.11
85_K113_A0.6070.11
97_V121_V0.6040.11
96_G191_R0.6000.11
112_E148_F0.6000.11
105_R164_E0.6000.11
12_N191_R0.5910.11
14_E188_A0.5890.11
119_E123_I0.5840.11
103_A170_I0.5830.11
174_V197_V0.5790.11
38_V141_K0.5770.10
59_L67_D0.5760.10
97_V137_R0.5760.10
42_I56_V0.5730.10
164_E197_V0.5710.10
151_Q177_R0.5690.10
12_N28_T0.5680.10
32_A156_N0.5640.10
14_E196_D0.5640.10
46_A111_S0.5590.10
51_M134_M0.5590.10
17_E196_D0.5560.10
155_K159_G0.5560.10
165_K208_E0.5540.10
14_E96_G0.5520.10
92_I184_A0.5510.10
34_N164_E0.5500.10
28_T66_A0.5500.10
24_E67_D0.5400.10
92_I166_I0.5380.10
6_Y16_Q0.5330.10
11_T16_Q0.5330.10
10_S16_Q0.5330.10
9_V16_Q0.5330.10
8_R11_T0.5330.10
6_Y11_T0.5330.10
6_Y10_S0.5330.10
6_Y9_V0.5330.10
8_R16_Q0.5330.10
50_E211_E0.5320.10
59_L117_V0.5290.10
29_A167_E0.5280.10
43_S118_L0.5280.10
112_E116_M0.5270.10
112_E138_R0.5270.10
28_T65_N0.5270.10
36_M171_S0.5270.10
28_T41_V0.5260.10
146_N184_A0.5240.10
85_K180_K0.5200.10
83_N152_K0.5180.10
38_V149_K0.5160.10
59_L72_L0.5140.10
15_Q98_K0.5090.10
61_D99_V0.5080.10
101_T190_L0.5080.10
30_I137_R0.5040.10
166_I187_A0.5030.09
115_S193_F0.5030.09
114_D132_H0.5030.09
12_N39_V0.5030.09
85_K122_S0.5010.09
18_T156_N0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gdtA 2 0.8341 100 0.767 Contact Map
4bqqA 2 0.9493 99.9 0.781 Contact Map
3g13A 2 0.6912 99.9 0.787 Contact Map
3guvA 2 0.6498 99.9 0.792 Contact Map
2r0qC 3 0.8295 99.9 0.792 Contact Map
3uj3X 2 0.5622 99.9 0.8 Contact Map
3ilxA 2 0.6175 99.9 0.805 Contact Map
3lhkA 2 0.6406 99.8 0.814 Contact Map
3bvpA 4 0.6037 99.8 0.816 Contact Map
2gm5A 4 0.5668 99.8 0.829 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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