GREMLIN Database
YNEA - Cell division suppressor protein YneA
UniProt: Q45056 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 105 (81)
Sequences: 222 (209)
Seq/√Len: 23.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_I46_D5.9581.00
40_I55_V4.5481.00
32_Q81_I2.3200.97
44_Q52_A2.1990.96
48_L87_L2.0300.94
73_K90_P1.8450.91
58_T67_I1.7670.89
55_V89_I1.7000.87
40_I54_Q1.6400.85
48_L73_K1.6250.84
14_F27_Y1.6070.83
48_L67_I1.5380.80
37_Y48_L1.4750.78
42_V87_L1.4550.77
70_V87_L1.4530.76
47_T50_S1.4290.75
29_S89_I1.4200.75
67_I71_A1.4090.74
39_K86_E1.3880.73
48_L71_A1.3730.72
17_I98_A1.3340.70
58_T68_E1.3180.69
45_G83_P1.2610.66
19_S56_A1.2560.65
30_S56_A1.2480.65
13_L98_A1.2270.63
49_W52_A1.2090.62
15_T21_V1.2090.62
49_W68_E1.1870.61
76_L85_D1.1780.60
18_L23_L1.1470.58
22_I99_Y1.1090.55
15_T89_I1.1000.55
81_I86_E1.0890.54
12_G47_T1.0870.54
21_V36_Q1.0830.54
41_E45_G1.0820.54
52_A57_D1.0810.53
17_I24_M1.0740.53
47_T53_D1.0590.52
32_Q96_Q1.0410.51
22_I34_L1.0240.50
94_K98_A1.0160.49
29_S36_Q1.0030.48
34_L51_I0.9880.47
56_A92_K0.9860.47
37_Y40_I0.9740.46
70_V76_L0.9580.45
37_Y46_D0.9410.44
57_D67_I0.9000.41
73_K88_V0.8900.40
52_A72_D0.8860.40
46_D72_D0.8850.40
39_K88_V0.8820.40
75_Q80_D0.8790.40
78_T93_K0.8640.39
34_L38_V0.8610.38
26_S35_N0.8420.37
77_Q87_L0.8310.36
57_D68_E0.8150.35
43_Q46_D0.8110.35
41_E86_E0.7970.34
41_E84_G0.7940.34
22_I25_L0.7930.34
40_I50_S0.7880.34
58_T78_T0.7880.34
33_E42_V0.7830.33
36_Q73_K0.7770.33
11_V83_P0.7740.33
42_V48_L0.7730.33
20_A36_Q0.7730.33
46_D77_Q0.7690.32
27_Y30_S0.7620.32
57_D92_K0.7620.32
25_L29_S0.7610.32
39_K89_I0.7510.31
48_L76_L0.7370.31
38_V58_T0.7290.30
72_D93_K0.7270.30
33_E52_A0.7200.30
38_V91_L0.6990.28
43_Q83_P0.6950.28
25_L28_T0.6890.28
37_Y90_P0.6780.27
45_G53_D0.6640.26
16_V92_K0.6630.26
13_L23_L0.6630.26
17_I21_V0.6560.26
49_W87_L0.6540.26
14_F98_A0.6420.25
52_A87_L0.6410.25
35_N52_A0.6410.25
57_D71_A0.6340.25
17_I95_H0.6340.25
72_D75_Q0.6190.24
67_I81_I0.6190.24
70_V94_K0.6050.23
44_Q51_I0.6010.23
58_T96_Q0.5950.23
57_D70_V0.5870.22
26_S54_Q0.5800.22
14_F44_Q0.5650.21
31_G40_I0.5560.21
22_I95_H0.5500.21
52_A71_A0.5500.21
81_I84_G0.5460.20
32_Q50_S0.5450.20
39_K70_V0.5440.20
48_L88_V0.5410.20
57_D73_K0.5400.20
33_E69_W0.5380.20
93_K99_Y0.5350.20
27_Y79_S0.5330.20
15_T28_T0.5320.20
33_E78_T0.5290.20
38_V54_Q0.5250.20
27_Y47_T0.5250.20
50_S84_G0.5160.19
38_V76_L0.5100.19
14_F20_A0.5070.19
36_Q89_I0.5000.18
73_K89_I0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4b8vA 2 0.6286 99.4 0.492 Contact Map
2mkxA 1 0.4857 99.3 0.518 Contact Map
2djpA 1 0.7143 99.2 0.528 Contact Map
4xcmA 2 0.5143 99.2 0.537 Contact Map
2mpwA 1 0.8 99.1 0.547 Contact Map
1e0gA 1 0.4571 99.1 0.551 Contact Map
4pxvA 1 0.4476 99.1 0.559 Contact Map
4uz3A 1 0.6952 99.1 0.561 Contact Map
4a1kA 2 0.5905 99 0.567 Contact Map
2l9yA 1 0.8952 99 0.567 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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