GREMLIN Database
YCXC - Uncharacterized transporter YcxC
UniProt: Q08794 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 312 (276)
Sequences: 39371 (28641)
Seq/√Len: 1724.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_G159_I3.1921.00
12_A244_Y2.9671.00
98_E156_S2.8181.00
244_Y248_R2.8041.00
269_G275_E2.6821.00
89_F158_L2.5161.00
48_F191_A2.4681.00
41_A198_N2.4611.00
26_F229_Y2.4131.00
86_F161_L2.3271.00
244_Y247_S2.3251.00
65_R68_D2.2961.00
129_F291_G2.2451.00
100_G265_T2.1771.00
109_F163_A2.1601.00
46_I231_G2.1541.00
86_F158_L2.1361.00
221_P225_L2.1291.00
120_E174_R2.1161.00
113_F171_T2.0721.00
13_A245_T2.0631.00
27_V88_A1.9561.00
28_K275_E1.9561.00
21_G264_V1.9271.00
45_T194_F1.9021.00
123_T126_Q1.8681.00
115_A122_P1.8241.00
52_T187_Y1.8151.00
111_M130_T1.8011.00
181_K184_E1.7791.00
105_A109_F1.7651.00
114_A120_E1.7561.00
93_Y154_K1.7441.00
195_V199_A1.7431.00
110_T255_S1.7131.00
220_E223_F1.7001.00
250_E253_K1.6971.00
94_S155_G1.6851.00
21_G268_A1.6831.00
94_S156_S1.6691.00
68_D179_R1.6551.00
293_V297_I1.6521.00
157_L161_L1.6371.00
133_S259_H1.6161.00
33_T223_F1.6031.00
199_A202_L1.5991.00
278_A281_H1.5861.00
22_L229_Y1.5851.00
89_F93_Y1.5731.00
86_F165_S1.5511.00
34_A223_F1.5491.00
109_F167_A1.5451.00
18_F264_V1.5441.00
231_G236_L1.5311.00
129_F295_S1.5151.00
41_A194_F1.4861.00
48_F194_F1.4821.00
53_V56_L1.4801.00
99_A159_I1.4691.00
77_L80_P1.4671.00
89_F92_V1.4411.00
173_A243_N1.4301.00
153_L156_S1.4071.00
109_F164_L1.4061.00
30_A39_I1.4021.00
52_T56_L1.4021.00
129_F294_G1.3741.00
222_G226_A1.3681.00
47_A190_S1.3671.00
29_I226_A1.3601.00
113_F117_V1.3531.00
66_V69_V1.3391.00
114_A118_L1.3211.00
67_K71_D1.3181.00
66_V70_I1.3151.00
39_I230_L1.3081.00
53_V57_F1.3021.00
67_K70_I1.3021.00
12_A241_L1.2971.00
20_I238_T1.2971.00
71_D172_A1.2911.00
70_I74_P1.2831.00
133_S291_G1.2751.00
196_V199_A1.2741.00
268_A272_I1.2741.00
16_Y245_T1.2731.00
124_W128_G1.2711.00
279_W283_A1.2561.00
222_G225_L1.2491.00
28_K32_Q1.2421.00
25_L268_A1.2391.00
10_Y257_F1.2371.00
93_Y158_L1.2361.00
49_A53_V1.2341.00
96_S269_G1.2281.00
97_S266_M1.2281.00
139_F287_C1.2231.00
221_P224_V1.2231.00
95_S98_E1.2221.00
154_K158_L1.2121.00
136_G284_G1.2111.00
153_L157_L1.2001.00
264_V268_A1.1971.00
282_L286_V1.1951.00
50_A236_L1.1931.00
37_F200_I1.1811.00
35_E38_D1.1791.00
286_V290_I1.1761.00
125_T294_G1.1721.00
260_V264_V1.1711.00
139_F280_Y1.1701.00
127_K131_V1.1681.00
225_L229_Y1.1681.00
136_G288_I1.1561.00
60_V181_K1.1561.00
94_S98_E1.1541.00
41_A201_A1.1531.00
54_P58_G1.1501.00
101_I285_A1.1441.00
16_Y241_L1.1421.00
167_A171_T1.1411.00
76_A80_P1.1341.00
91_L99_A1.1311.00
174_R178_Q1.1301.00
277_L282_L1.1181.00
94_S159_I1.1111.00
68_D71_D1.1101.00
93_Y155_G1.1091.00
115_A121_R1.1091.00
131_V135_A1.1091.00
26_F226_A1.1071.00
93_Y152_S1.1041.00
246_L254_M1.1021.00
110_T251_A1.0961.00
140_I284_G1.0961.00
124_W127_K1.0921.00
175_K178_Q1.0881.00
87_Q91_L1.0861.00
15_L241_L1.0841.00
154_K157_L1.0801.00
200_I204_R1.0791.00
174_R250_E1.0771.00
19_I241_L1.0751.00
22_L268_A1.0691.00
113_F168_M1.0601.00
125_T298_N1.0601.00
118_L171_T1.0581.00
9_A248_R1.0541.00
132_L291_G1.0511.00
110_T170_N1.0501.00
74_P172_A1.0481.00
174_R251_A1.0481.00
43_R235_S1.0451.00
41_A45_T1.0441.00
16_Y20_I1.0441.00
48_F187_Y1.0261.00
33_T220_E1.0241.00
11_I15_L1.0191.00
9_A245_T1.0161.00
19_I233_L1.0111.00
199_A203_V0.9991.00
45_T198_N0.9971.00
44_F193_G0.9941.00
113_F167_A0.9911.00
79_Y169_Y0.9891.00
37_F85_S0.9881.00
73_L192_I0.9861.00
96_S273_L0.9821.00
77_L196_V0.9811.00
40_L88_A0.9791.00
138_M142_V0.9751.00
102_I156_S0.9741.00
142_V278_A0.9641.00
110_T167_A0.9621.00
27_V91_L0.9611.00
56_L60_V0.9611.00
111_M122_P0.9601.00
30_A226_A0.9581.00
279_W282_L0.9581.00
20_I242_S0.9571.00
120_E126_Q0.9501.00
71_D176_M0.9501.00
105_A137_V0.9481.00
225_L228_V0.9451.00
102_I163_A0.9411.00
123_T127_K0.9401.00
155_G159_I0.9371.00
163_A167_A0.9261.00
68_D180_F0.9241.00
125_T297_I0.9241.00
113_F116_Y0.9241.00
30_A223_F0.9241.00
228_V231_G0.9201.00
36_P40_L0.9181.00
38_D201_A0.9161.00
122_P127_K0.9101.00
85_S89_F0.8951.00
17_S21_G0.8931.00
71_D75_L0.8861.00
75_L79_Y0.8851.00
152_S156_S0.8831.00
250_E254_M0.8791.00
59_W62_L0.8781.00
219_R224_V0.8761.00
25_L272_I0.8751.00
249_I254_M0.8751.00
70_I73_L0.8681.00
249_I253_K0.8601.00
220_E224_V0.8591.00
113_F164_L0.8561.00
224_V228_V0.8551.00
200_I203_V0.8551.00
202_L205_H0.8541.00
42_H46_I0.8511.00
102_I159_I0.8461.00
76_A192_I0.8411.00
101_I138_M0.8411.00
116_Y119_K0.8381.00
69_V192_I0.8311.00
203_V206_G0.8271.00
17_S264_V0.8261.00
52_T191_A0.8251.00
246_L250_E0.8241.00
69_V73_L0.8191.00
50_A232_V0.8191.00
219_R223_F0.8001.00
10_Y253_K0.7981.00
71_D175_K0.7951.00
159_I163_A0.7941.00
78_L168_M0.7941.00
121_R125_T0.7921.00
266_M277_L0.7921.00
78_L165_S0.7891.00
245_T254_M0.7821.00
150_S153_L0.7791.00
270_F277_L0.7741.00
191_A195_V0.7731.00
96_S275_E0.7701.00
227_I231_G0.7661.00
168_M172_A0.7661.00
266_M285_A0.7651.00
27_V31_L0.7651.00
48_F52_T0.7631.00
263_I285_A0.7611.00
135_A287_C0.7611.00
270_F276_S0.7541.00
121_R124_W0.7531.00
137_V141_F0.7531.00
73_L77_L0.7501.00
139_F283_A0.7501.00
40_L197_F0.7491.00
285_A289_M0.7441.00
280_Y283_A0.7421.00
38_D42_H0.7411.00
180_F185_L0.7401.00
25_L269_G0.7371.00
58_G61_K0.7361.00
83_F165_S0.7361.00
50_A53_V0.7341.00
112_V116_Y0.7341.00
74_P77_L0.7311.00
220_E225_L0.7271.00
188_I192_I0.7271.00
71_D74_P0.7261.00
13_A257_F0.7251.00
142_V145_G0.7211.00
65_R69_V0.7181.00
187_Y191_A0.7171.00
194_F198_N0.7131.00
25_L96_S0.7101.00
115_A119_K0.7101.00
51_A236_L0.7061.00
17_S260_V0.7061.00
136_G291_G0.7061.00
55_I187_Y0.7021.00
111_M126_Q0.7011.00
56_L59_W0.7001.00
240_F244_Y0.6961.00
228_V232_V0.6951.00
56_L61_K0.6941.00
260_V263_I0.6941.00
186_T189_M0.6891.00
201_A205_H0.6881.00
54_P183_T0.6881.00
14_I264_V0.6851.00
135_A139_F0.6851.00
256_A295_S0.6841.00
223_F226_A0.6831.00
105_A108_I0.6831.00
73_L76_A0.6811.00
237_V241_L0.6811.00
122_P126_Q0.6801.00
57_F60_V0.6771.00
283_A287_C0.6771.00
108_I133_S0.6771.00
110_T171_T0.6751.00
166_S170_N0.6721.00
192_I196_V0.6721.00
24_F87_Q0.6711.00
29_I273_L0.6691.00
83_F169_Y0.6691.00
45_T49_A0.6681.00
269_G273_L0.6651.00
277_L281_H0.6621.00
128_G132_L0.6601.00
94_S99_A0.6591.00
72_I180_F0.6571.00
290_I294_G0.6571.00
192_I195_V0.6561.00
34_A39_I0.6551.00
266_M270_F0.6531.00
111_M115_A0.6521.00
15_L19_I0.6511.00
78_L172_A0.6501.00
226_A229_Y0.6501.00
118_L175_K0.6431.00
72_I76_A0.6391.00
102_I160_L0.6391.00
90_G155_G0.6371.00
202_L206_G0.6311.00
229_Y233_L0.6311.00
291_G295_S0.6301.00
184_E188_I0.6261.00
276_S280_Y0.6251.00
13_A249_I0.6241.00
126_Q250_E0.6241.00
166_S242_S0.6191.00
88_A92_V0.6191.00
120_E252_F0.6181.00
195_V198_N0.6161.00
24_F100_G0.6131.00
81_A165_S0.6121.00
281_H285_A0.6111.00
50_A231_G0.6101.00
151_A154_K0.6081.00
104_A137_V0.6061.00
188_I191_A0.6061.00
47_A236_L0.6051.00
63_S66_V0.6021.00
87_Q162_S0.6001.00
29_I33_T0.5961.00
57_F61_K0.5951.00
69_V188_I0.5951.00
49_A52_T0.5941.00
158_L161_L0.5941.00
87_Q99_A0.5931.00
267_I271_V0.5911.00
9_A249_I0.5891.00
37_F204_R0.5891.00
186_T243_N0.5881.00
101_I140_I0.5861.00
233_L237_V0.5861.00
292_V295_S0.5861.00
19_I238_T0.5811.00
34_A38_D0.5801.00
117_V168_M0.5791.00
169_Y243_N0.5761.00
156_S160_L0.5731.00
268_A271_V0.5701.00
193_G197_F0.5701.00
141_F156_S0.5691.00
191_A194_F0.5681.00
105_A163_A0.5681.00
80_P193_G0.5681.00
72_I185_L0.5681.00
69_V72_I0.5671.00
42_H227_I0.5671.00
46_I50_A0.5671.00
104_A107_P0.5661.00
136_G287_C0.5651.00
132_L294_G0.5651.00
259_H292_V0.5641.00
76_A79_Y0.5571.00
175_K179_R0.5531.00
215_F219_R0.5511.00
150_S154_K0.5511.00
55_I184_E0.5481.00
196_V200_I0.5481.00
170_N242_S0.5471.00
90_G99_A0.5461.00
100_G104_A0.5451.00
258_N261_S0.5441.00
169_Y173_A0.5431.00
24_F28_K0.5421.00
35_E204_R0.5421.00
278_A282_L0.5391.00
75_L80_P0.5381.00
143_M280_Y0.5351.00
10_Y14_I0.5321.00
73_L196_V0.5271.00
229_Y232_V0.5251.00
31_L92_V0.5241.00
38_D205_H0.5231.00
107_P259_H0.5221.00
31_L91_L0.5211.00
114_A252_F0.5211.00
17_S261_S0.5191.00
294_G298_N0.5181.00
83_F87_Q0.5171.00
46_I49_A0.5141.00
118_L174_R0.5131.00
14_I17_S0.5131.00
180_F184_E0.5121.00
33_T222_G0.5111.00
68_D72_I0.5101.00
13_A242_S0.5101.00
40_L85_S0.5081.00
164_L168_M0.5071.00
23_S27_V0.5061.00
109_F160_L0.5051.00
123_T298_N0.5041.00
276_S281_H0.5041.00
134_V259_H0.5031.00
19_I237_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2468 98.7 0.765 Contact Map
3b5dA 2 0.3237 98.3 0.793 Contact Map
1pw4A 1 0.9487 53.9 0.919 Contact Map
3wdoA 1 0.9295 53.6 0.919 Contact Map
4pypA 1 0.9135 47.5 0.922 Contact Map
4he8J 1 0.5032 45.9 0.923 Contact Map
2cfqA 1 0.5897 40.7 0.925 Contact Map
4j05A 3 0.9263 38.3 0.926 Contact Map
4xnjA 1 0.7276 20.8 0.935 Contact Map
4zw9A 1 0.9551 19.5 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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