GREMLIN Database
SRFAD - Surfactin synthase thioesterase subunit
UniProt: Q08788 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 242 (217)
Sequences: 7267 (6191)
Seq/√Len: 420.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_D98_K3.9031.00
100_E179_Q3.6101.00
108_A183_H3.1441.00
60_D63_E2.8091.00
69_K95_L2.7911.00
19_F95_L2.7711.00
89_G114_I2.5531.00
73_N102_E2.5451.00
73_N104_I2.4851.00
81_V107_Q2.3791.00
182_V204_A2.3491.00
15_Q41_E2.2611.00
18_C83_F2.1381.00
19_F82_L2.1121.00
186_N211_Q2.0221.00
188_L211_Q2.0191.00
128_P131_Q1.9641.00
98_K102_E1.9081.00
215_G218_F1.8731.00
14_T81_V1.8441.00
188_L213_D1.8311.00
186_N197_A1.8291.00
58_I67_L1.7691.00
69_K98_K1.6761.00
185_F229_R1.6661.00
210_H229_R1.6471.00
17_I72_L1.6461.00
69_K99_L1.6451.00
32_L227_A1.6121.00
183_H210_H1.6031.00
82_L92_T1.5971.00
183_H233_I1.5911.00
94_R170_F1.5901.00
98_K101_R1.5891.00
26_S44_A1.5781.00
16_L83_F1.5721.00
87_M167_L1.5631.00
184_V207_I1.5521.00
87_M91_I1.5461.00
77_D104_I1.5391.00
100_E180_S1.5361.00
65_T98_K1.5241.00
82_L96_A1.5221.00
81_V110_I1.5151.00
61_L65_T1.5021.00
80_F104_I1.4801.00
94_R97_Q1.4661.00
65_T95_L1.4631.00
198_E201_K1.4571.00
208_T233_I1.4461.00
17_I80_F1.4351.00
40_C81_V1.4341.00
81_V108_A1.4301.00
179_Q205_K1.4251.00
181_P206_D1.4231.00
62_E98_K1.4221.00
15_Q43_L1.4221.00
83_F112_S1.4161.00
79_P107_Q1.4151.00
48_P67_L1.4081.00
21_F28_S1.4051.00
59_E165_R1.3991.00
26_S46_E1.3971.00
118_H203_W1.3921.00
185_F212_F1.3871.00
85_H112_S1.3831.00
37_Q231_F1.3671.00
20_P68_Y1.3661.00
70_Q102_E1.3581.00
67_L71_E1.3521.00
135_H138_Q1.3431.00
13_K39_E1.3411.00
80_F106_P1.3361.00
189_D213_D1.3341.00
29_F85_H1.3111.00
72_L95_L1.3071.00
94_R98_K1.2981.00
19_F92_T1.2961.00
93_F170_F1.2821.00
57_A162_S1.2501.00
17_I75_R1.2261.00
15_Q40_C1.2221.00
46_E51_G1.2191.00
112_S218_F1.2181.00
97_Q176_A1.2171.00
110_I183_H1.2161.00
101_R176_A1.2121.00
110_I185_F1.2081.00
18_C42_M1.2061.00
71_E74_L1.1971.00
15_Q78_R1.1931.00
35_F224_E1.1851.00
35_F227_A1.1841.00
90_M114_I1.1431.00
16_L42_M1.1371.00
112_S219_L1.1361.00
214_G218_F1.1261.00
25_Y51_G1.1201.00
92_T109_V1.1181.00
199_G202_K1.1111.00
183_H208_T1.1031.00
228_E232_A1.0961.00
90_M167_L1.0891.00
62_E94_R1.0861.00
30_R34_A1.0831.00
185_F226_V1.0761.00
165_R169_Q1.0721.00
222_Q225_E1.0541.00
177_Q205_K1.0521.00
204_A207_I1.0491.00
45_A68_Y1.0471.00
100_E178_I1.0301.00
229_R232_A1.0291.00
110_I230_I1.0271.00
111_I184_V1.0141.00
45_A72_L1.0061.00
61_L166_A1.0021.00
58_I63_E0.9891.00
21_F29_F0.9861.00
184_V209_F0.9851.00
186_N209_F0.9821.00
86_S113_A0.9801.00
86_S216_H0.9711.00
159_S163_D0.9711.00
37_Q40_C0.9701.00
93_F97_Q0.9671.00
81_V234_L0.9631.00
19_F91_I0.9461.00
181_P208_T0.9451.00
58_I64_L0.9241.00
69_K73_N0.9231.00
20_P47_P0.9171.00
83_F218_F0.9121.00
11_S41_E0.9121.00
93_F172_L0.9101.00
46_E52_T0.9071.00
87_M163_D0.9071.00
65_T94_R0.9061.00
14_T107_Q0.9011.00
100_E105_F0.8971.00
99_L104_I0.8961.00
65_T69_K0.8941.00
215_G221_S0.8921.00
97_Q101_R0.8921.00
97_Q100_E0.8901.00
66_D70_Q0.8891.00
13_K40_C0.8891.00
76_P80_F0.8871.00
89_G111_I0.8751.00
48_P64_L0.8701.00
225_E228_E0.8641.00
96_A109_V0.8631.00
149_N152_V0.8611.00
16_L81_V0.8541.00
39_E231_F0.8521.00
96_A180_S0.8501.00
36_L227_A0.8501.00
75_R80_F0.8491.00
21_F85_H0.8461.00
19_F45_A0.8461.00
69_K102_E0.8451.00
64_L166_A0.8411.00
59_E63_E0.8361.00
185_F210_H0.8301.00
181_P204_A0.8301.00
83_F110_I0.8281.00
68_Y95_L0.8241.00
110_I233_I0.8181.00
109_V182_V0.8161.00
150_K154_S0.8141.00
27_A51_G0.8131.00
129_D161_R0.7971.00
49_G159_S0.7951.00
184_V197_A0.7921.00
17_I43_L0.7921.00
75_R78_R0.7911.00
47_P91_I0.7911.00
140_G143_P0.7861.00
20_P85_H0.7721.00
93_F203_W0.7661.00
73_N80_F0.7621.00
9_D41_E0.7611.00
49_G57_A0.7601.00
129_D154_S0.7581.00
111_I114_I0.7581.00
22_A217_M0.7571.00
108_A181_P0.7551.00
82_L99_L0.7501.00
57_A159_S0.7461.00
61_L170_F0.7431.00
25_Y46_E0.7431.00
58_I166_A0.7421.00
212_F219_L0.7411.00
59_E162_S0.7381.00
224_E228_E0.7351.00
197_A201_K0.7341.00
18_C29_F0.7311.00
127_L131_Q0.7311.00
113_A190_D0.7291.00
14_T40_C0.7281.00
210_H233_I0.7261.00
20_P26_S0.7261.00
158_P162_S0.7251.00
61_L87_M0.7161.00
213_D225_E0.7161.00
17_I44_A0.7161.00
28_S220_L0.7111.00
61_L91_I0.7101.00
214_G219_L0.7101.00
172_L203_W0.7071.00
156_F163_D0.7031.00
97_Q178_I0.6971.00
150_K153_M0.6961.00
116_P203_W0.6941.00
16_L40_C0.6941.00
91_I95_L0.6931.00
182_V207_I0.6901.00
136_I141_G0.6881.00
75_R104_I0.6851.00
133_L153_M0.6831.00
47_P64_L0.6751.00
64_L91_I0.6741.00
137_I144_A0.6701.00
162_S165_R0.6681.00
189_D214_G0.6670.99
72_L82_L0.6650.99
21_F24_G0.6640.99
12_E78_R0.6630.99
96_A178_I0.6620.99
28_S85_H0.6560.99
162_S166_A0.6530.99
187_G219_L0.6520.99
189_D215_G0.6520.99
212_F218_F0.6470.99
128_P132_F0.6460.99
108_A233_I0.6450.99
118_H202_K0.6450.99
109_V180_S0.6410.99
19_F68_Y0.6360.99
68_Y71_E0.6350.99
96_A105_F0.6280.99
127_L135_H0.6270.99
31_P34_A0.6260.99
13_K41_E0.6240.99
80_F99_L0.6240.99
70_Q74_L0.6230.99
50_H163_D0.6210.99
195_R198_E0.6210.99
66_D102_E0.6200.99
12_E39_E0.6190.99
22_A87_M0.6180.99
95_L99_L0.6160.99
151_E155_F0.6160.99
225_E229_R0.6130.99
105_F180_S0.6120.99
113_A218_F0.6100.99
63_E67_L0.6090.99
97_Q172_L0.6090.99
226_V229_R0.6080.99
69_K72_L0.6050.99
142_M146_L0.6050.99
15_Q79_P0.6000.99
36_L42_M0.6000.99
111_I182_V0.6000.99
82_L109_V0.5990.99
118_H199_G0.5950.99
133_L137_I0.5940.99
184_V204_A0.5940.99
135_H139_L0.5940.99
157_L161_R0.5940.99
105_F179_Q0.5920.99
85_H113_A0.5910.99
70_Q73_N0.5900.99
193_C197_A0.5900.99
134_D137_I0.5900.99
15_Q75_R0.5880.99
201_K206_D0.5810.99
133_L150_K0.5810.99
136_I140_G0.5800.99
220_L223_T0.5800.99
226_V233_I0.5770.99
96_A106_P0.5710.98
116_P199_G0.5710.98
53_N67_L0.5690.98
61_L94_R0.5660.98
49_G55_T0.5650.98
85_H217_M0.5640.98
158_P161_R0.5620.98
40_C231_F0.5620.98
137_I143_P0.5610.98
90_M170_F0.5590.98
132_F136_I0.5580.98
127_L132_F0.5580.98
226_V230_I0.5570.98
9_D12_E0.5560.98
13_K78_R0.5560.98
113_A187_G0.5530.98
21_F218_F0.5480.98
19_F65_T0.5470.98
198_E209_F0.5450.98
136_I142_M0.5440.98
62_E65_T0.5430.98
160_F163_D0.5420.98
72_L75_R0.5410.98
20_P45_A0.5390.98
229_R233_I0.5370.98
64_L68_Y0.5320.98
47_P68_Y0.5320.98
160_F164_Y0.5320.98
30_R33_H0.5310.98
32_L230_I0.5250.97
194_I198_E0.5240.97
119_I199_G0.5240.97
83_F230_I0.5180.97
97_Q177_Q0.5170.97
47_P50_H0.5170.97
11_S14_T0.5150.97
156_F159_S0.5150.97
112_S185_F0.5100.97
156_F160_F0.5100.97
61_L90_M0.5090.97
78_R104_I0.5060.97
62_E66_D0.5020.97
76_P104_I0.5010.96
164_Y168_E0.5000.96
50_H53_N0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k2qB 1 1 100 0.319 Contact Map
2vz8A 2 0 100 0.36 Contact Map
1jmkC 2 0.9132 100 0.41 Contact Map
2cb9A 1 0.8388 100 0.425 Contact Map
1kezA 2 0.9091 100 0.433 Contact Map
3ilsA 1 0.9545 100 0.454 Contact Map
3tejA 1 0.9339 100 0.463 Contact Map
2vsqA 1 0.8636 100 0.487 Contact Map
3qmvA 2 0.9669 100 0.494 Contact Map
2px6A 1 0.9132 99.9 0.499 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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