SRFAD - BACSU - GREMLIN Contacts

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SRFAD - Surfactin synthase thioesterase subunit

UniProt:	Q08788	Sequences: MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLAAEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQTEEVAERIFAILNQHPIIQP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	242 (217)
Sequences:	7267 (6191)
Seq/√Len:	420.3

ECOLI - ENTF
BACSU - SRFAD SRFAC PPSE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
66_D	98_K	3.903	1.00
100_E	179_Q	3.610	1.00
108_A	183_H	3.144	1.00
60_D	63_E	2.809	1.00
69_K	95_L	2.791	1.00
19_F	95_L	2.771	1.00
89_G	114_I	2.553	1.00
73_N	102_E	2.545	1.00
73_N	104_I	2.485	1.00
81_V	107_Q	2.379	1.00
182_V	204_A	2.349	1.00
15_Q	41_E	2.261	1.00
18_C	83_F	2.138	1.00
19_F	82_L	2.112	1.00
186_N	211_Q	2.022	1.00
188_L	211_Q	2.019	1.00
128_P	131_Q	1.964	1.00
98_K	102_E	1.908	1.00
215_G	218_F	1.873	1.00
14_T	81_V	1.844	1.00
188_L	213_D	1.831	1.00
186_N	197_A	1.829	1.00
58_I	67_L	1.769	1.00
69_K	98_K	1.676	1.00
185_F	229_R	1.666	1.00
210_H	229_R	1.647	1.00
17_I	72_L	1.646	1.00
69_K	99_L	1.645	1.00
32_L	227_A	1.612	1.00
183_H	210_H	1.603	1.00
82_L	92_T	1.597	1.00
183_H	233_I	1.591	1.00
94_R	170_F	1.590	1.00
98_K	101_R	1.589	1.00
26_S	44_A	1.578	1.00
16_L	83_F	1.572	1.00
87_M	167_L	1.563	1.00
184_V	207_I	1.552	1.00
87_M	91_I	1.546	1.00
77_D	104_I	1.539	1.00
100_E	180_S	1.536	1.00
65_T	98_K	1.524	1.00
82_L	96_A	1.522	1.00
81_V	110_I	1.515	1.00
61_L	65_T	1.502	1.00
80_F	104_I	1.480	1.00
94_R	97_Q	1.466	1.00
65_T	95_L	1.463	1.00
198_E	201_K	1.457	1.00
208_T	233_I	1.446	1.00
17_I	80_F	1.435	1.00
40_C	81_V	1.434	1.00
81_V	108_A	1.430	1.00
179_Q	205_K	1.425	1.00
181_P	206_D	1.423	1.00
62_E	98_K	1.422	1.00
15_Q	43_L	1.422	1.00
83_F	112_S	1.416	1.00
79_P	107_Q	1.415	1.00
48_P	67_L	1.408	1.00
21_F	28_S	1.405	1.00
59_E	165_R	1.399	1.00
26_S	46_E	1.397	1.00
118_H	203_W	1.392	1.00
185_F	212_F	1.387	1.00
85_H	112_S	1.383	1.00
37_Q	231_F	1.367	1.00
20_P	68_Y	1.366	1.00
70_Q	102_E	1.358	1.00
67_L	71_E	1.352	1.00
135_H	138_Q	1.343	1.00
13_K	39_E	1.341	1.00
80_F	106_P	1.336	1.00
189_D	213_D	1.334	1.00
29_F	85_H	1.311	1.00
72_L	95_L	1.307	1.00
94_R	98_K	1.298	1.00
19_F	92_T	1.296	1.00
93_F	170_F	1.282	1.00
57_A	162_S	1.250	1.00
17_I	75_R	1.226	1.00
15_Q	40_C	1.222	1.00
46_E	51_G	1.219	1.00
112_S	218_F	1.218	1.00
97_Q	176_A	1.217	1.00
110_I	183_H	1.216	1.00
101_R	176_A	1.212	1.00
110_I	185_F	1.208	1.00
18_C	42_M	1.206	1.00
71_E	74_L	1.197	1.00
15_Q	78_R	1.193	1.00
35_F	224_E	1.185	1.00
35_F	227_A	1.184	1.00
90_M	114_I	1.143	1.00
16_L	42_M	1.137	1.00
112_S	219_L	1.136	1.00
214_G	218_F	1.126	1.00
25_Y	51_G	1.120	1.00
92_T	109_V	1.118	1.00
199_G	202_K	1.111	1.00
183_H	208_T	1.103	1.00
228_E	232_A	1.096	1.00
90_M	167_L	1.089	1.00
62_E	94_R	1.086	1.00
30_R	34_A	1.083	1.00
185_F	226_V	1.076	1.00
165_R	169_Q	1.072	1.00
222_Q	225_E	1.054	1.00
177_Q	205_K	1.052	1.00
204_A	207_I	1.049	1.00
45_A	68_Y	1.047	1.00
100_E	178_I	1.030	1.00
229_R	232_A	1.029	1.00
110_I	230_I	1.027	1.00
111_I	184_V	1.014	1.00
45_A	72_L	1.006	1.00
61_L	166_A	1.002	1.00
58_I	63_E	0.989	1.00
21_F	29_F	0.986	1.00
184_V	209_F	0.985	1.00
186_N	209_F	0.982	1.00
86_S	113_A	0.980	1.00
86_S	216_H	0.971	1.00
159_S	163_D	0.971	1.00
37_Q	40_C	0.970	1.00
93_F	97_Q	0.967	1.00
81_V	234_L	0.963	1.00
19_F	91_I	0.946	1.00
181_P	208_T	0.945	1.00
58_I	64_L	0.924	1.00
69_K	73_N	0.923	1.00
20_P	47_P	0.917	1.00
83_F	218_F	0.912	1.00
11_S	41_E	0.912	1.00
93_F	172_L	0.910	1.00
46_E	52_T	0.907	1.00
87_M	163_D	0.907	1.00
65_T	94_R	0.906	1.00
14_T	107_Q	0.901	1.00
100_E	105_F	0.897	1.00
99_L	104_I	0.896	1.00
65_T	69_K	0.894	1.00
215_G	221_S	0.892	1.00
97_Q	101_R	0.892	1.00
97_Q	100_E	0.890	1.00
66_D	70_Q	0.889	1.00
13_K	40_C	0.889	1.00
76_P	80_F	0.887	1.00
89_G	111_I	0.875	1.00
48_P	64_L	0.870	1.00
225_E	228_E	0.864	1.00
96_A	109_V	0.863	1.00
149_N	152_V	0.861	1.00
16_L	81_V	0.854	1.00
39_E	231_F	0.852	1.00
96_A	180_S	0.850	1.00
36_L	227_A	0.850	1.00
75_R	80_F	0.849	1.00
21_F	85_H	0.846	1.00
19_F	45_A	0.846	1.00
69_K	102_E	0.845	1.00
64_L	166_A	0.841	1.00
59_E	63_E	0.836	1.00
185_F	210_H	0.830	1.00
181_P	204_A	0.830	1.00
83_F	110_I	0.828	1.00
68_Y	95_L	0.824	1.00
110_I	233_I	0.818	1.00
109_V	182_V	0.816	1.00
150_K	154_S	0.814	1.00
27_A	51_G	0.813	1.00
129_D	161_R	0.797	1.00
49_G	159_S	0.795	1.00
184_V	197_A	0.792	1.00
17_I	43_L	0.792	1.00
75_R	78_R	0.791	1.00
47_P	91_I	0.791	1.00
140_G	143_P	0.786	1.00
20_P	85_H	0.772	1.00
93_F	203_W	0.766	1.00
73_N	80_F	0.762	1.00
9_D	41_E	0.761	1.00
49_G	57_A	0.760	1.00
129_D	154_S	0.758	1.00
111_I	114_I	0.758	1.00
22_A	217_M	0.757	1.00
108_A	181_P	0.755	1.00
82_L	99_L	0.750	1.00
57_A	159_S	0.746	1.00
61_L	170_F	0.743	1.00
25_Y	46_E	0.743	1.00
58_I	166_A	0.742	1.00
212_F	219_L	0.741	1.00
59_E	162_S	0.738	1.00
224_E	228_E	0.735	1.00
197_A	201_K	0.734	1.00
18_C	29_F	0.731	1.00
127_L	131_Q	0.731	1.00
113_A	190_D	0.729	1.00
14_T	40_C	0.728	1.00
210_H	233_I	0.726	1.00
20_P	26_S	0.726	1.00
158_P	162_S	0.725	1.00
61_L	87_M	0.716	1.00
213_D	225_E	0.716	1.00
17_I	44_A	0.716	1.00
28_S	220_L	0.711	1.00
61_L	91_I	0.710	1.00
214_G	219_L	0.710	1.00
172_L	203_W	0.707	1.00
156_F	163_D	0.703	1.00
97_Q	178_I	0.697	1.00
150_K	153_M	0.696	1.00
116_P	203_W	0.694	1.00
16_L	40_C	0.694	1.00
91_I	95_L	0.693	1.00
182_V	207_I	0.690	1.00
136_I	141_G	0.688	1.00
75_R	104_I	0.685	1.00
133_L	153_M	0.683	1.00
47_P	64_L	0.675	1.00
64_L	91_I	0.674	1.00
137_I	144_A	0.670	1.00
162_S	165_R	0.668	1.00
189_D	214_G	0.667	0.99
72_L	82_L	0.665	0.99
21_F	24_G	0.664	0.99
12_E	78_R	0.663	0.99
96_A	178_I	0.662	0.99
28_S	85_H	0.656	0.99
162_S	166_A	0.653	0.99
187_G	219_L	0.652	0.99
189_D	215_G	0.652	0.99
212_F	218_F	0.647	0.99
128_P	132_F	0.646	0.99
108_A	233_I	0.645	0.99
118_H	202_K	0.645	0.99
109_V	180_S	0.641	0.99
19_F	68_Y	0.636	0.99
68_Y	71_E	0.635	0.99
96_A	105_F	0.628	0.99
127_L	135_H	0.627	0.99
31_P	34_A	0.626	0.99
13_K	41_E	0.624	0.99
80_F	99_L	0.624	0.99
70_Q	74_L	0.623	0.99
50_H	163_D	0.621	0.99
195_R	198_E	0.621	0.99
66_D	102_E	0.620	0.99
12_E	39_E	0.619	0.99
22_A	87_M	0.618	0.99
95_L	99_L	0.616	0.99
151_E	155_F	0.616	0.99
225_E	229_R	0.613	0.99
105_F	180_S	0.612	0.99
113_A	218_F	0.610	0.99
63_E	67_L	0.609	0.99
97_Q	172_L	0.609	0.99
226_V	229_R	0.608	0.99
69_K	72_L	0.605	0.99
142_M	146_L	0.605	0.99
15_Q	79_P	0.600	0.99
36_L	42_M	0.600	0.99
111_I	182_V	0.600	0.99
82_L	109_V	0.599	0.99
118_H	199_G	0.595	0.99
133_L	137_I	0.594	0.99
184_V	204_A	0.594	0.99
135_H	139_L	0.594	0.99
157_L	161_R	0.594	0.99
105_F	179_Q	0.592	0.99
85_H	113_A	0.591	0.99
70_Q	73_N	0.590	0.99
193_C	197_A	0.590	0.99
134_D	137_I	0.590	0.99
15_Q	75_R	0.588	0.99
201_K	206_D	0.581	0.99
133_L	150_K	0.581	0.99
136_I	140_G	0.580	0.99
220_L	223_T	0.580	0.99
226_V	233_I	0.577	0.99
96_A	106_P	0.571	0.98
116_P	199_G	0.571	0.98
53_N	67_L	0.569	0.98
61_L	94_R	0.566	0.98
49_G	55_T	0.565	0.98
85_H	217_M	0.564	0.98
158_P	161_R	0.562	0.98
40_C	231_F	0.562	0.98
137_I	143_P	0.561	0.98
90_M	170_F	0.559	0.98
132_F	136_I	0.558	0.98
127_L	132_F	0.558	0.98
226_V	230_I	0.557	0.98
9_D	12_E	0.556	0.98
13_K	78_R	0.556	0.98
113_A	187_G	0.553	0.98
21_F	218_F	0.548	0.98
19_F	65_T	0.547	0.98
198_E	209_F	0.545	0.98
136_I	142_M	0.544	0.98
62_E	65_T	0.543	0.98
160_F	163_D	0.542	0.98
72_L	75_R	0.541	0.98
20_P	45_A	0.539	0.98
229_R	233_I	0.537	0.98
64_L	68_Y	0.532	0.98
47_P	68_Y	0.532	0.98
160_F	164_Y	0.532	0.98
30_R	33_H	0.531	0.98
32_L	230_I	0.525	0.97
194_I	198_E	0.524	0.97
119_I	199_G	0.524	0.97
83_F	230_I	0.518	0.97
97_Q	177_Q	0.517	0.97
47_P	50_H	0.517	0.97
11_S	14_T	0.515	0.97
156_F	159_S	0.515	0.97
112_S	185_F	0.510	0.97
156_F	160_F	0.510	0.97
61_L	90_M	0.509	0.97
78_R	104_I	0.506	0.97
62_E	66_D	0.502	0.97
76_P	104_I	0.501	0.96
164_Y	168_E	0.500	0.96
50_H	53_N	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2k2qB	1	1	100	0.319	Contact Map
2vz8A	2	0	100	0.36	Contact Map
1jmkC	2	0.9132	100	0.41	Contact Map
2cb9A	1	0.8388	100	0.425	Contact Map
1kezA	2	0.9091	100	0.433	Contact Map
3ilsA	1	0.9545	100	0.454	Contact Map
3tejA	1	0.9339	100	0.463	Contact Map
2vsqA	1	0.8636	100	0.487	Contact Map
3qmvA	2	0.9669	100	0.494	Contact Map
2px6A	1	0.9132	99.9	0.499	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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