GREMLIN Database
CBL - Cystathionine beta-lyase PatB
UniProt: Q08432 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 387 (344)
Sequences: 43518 (30056)
Seq/√Len: 1620.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_K54_D3.2921.00
111_Q132_H3.1121.00
91_S97_A2.9311.00
70_A282_S2.8841.00
301_E376_Q2.7951.00
346_G384_A2.7581.00
106_T131_R2.7141.00
296_E300_N2.6991.00
76_Q82_K2.6341.00
314_K327_D2.6141.00
179_R183_L2.6141.00
297_K372_L2.4701.00
110_D162_T2.4581.00
153_E191_E2.4531.00
66_K278_E2.4371.00
377_D381_R2.3341.00
111_Q134_L2.1881.00
99_S103_Q2.1741.00
178_S181_D2.1631.00
43_E47_E2.1271.00
303_E307_S2.0911.00
303_E317_K2.0551.00
248_I253_K2.0431.00
305_F379_L2.0141.00
116_P135_H1.9631.00
69_D85_P1.9481.00
243_A277_I1.9161.00
70_A73_G1.8931.00
47_E51_E1.8491.00
183_L187_E1.8171.00
73_G282_S1.8081.00
151_D155_K1.8061.00
301_E305_F1.7921.00
65_Q69_D1.7901.00
197_V229_C1.7831.00
72_C85_P1.7641.00
334_S337_E1.7611.00
377_D380_R1.7541.00
126_V131_R1.7291.00
148_D151_D1.7291.00
153_E184_K1.7201.00
189_C196_V1.7201.00
123_Y127_E1.7001.00
305_F383_K1.6921.00
46_T50_K1.6701.00
307_S315_M1.6601.00
151_D154_T1.6511.00
371_S374_T1.6451.00
340_Q344_K1.6441.00
201_I231_A1.6391.00
193_G225_I1.6331.00
69_D73_G1.6321.00
101_A227_V1.6311.00
305_F308_T1.6291.00
70_A278_E1.6241.00
300_N304_A1.6011.00
301_E372_L1.5951.00
32_M378_G1.5921.00
102_V126_V1.5901.00
346_G381_R1.5901.00
179_R213_T1.5831.00
270_N273_A1.5831.00
304_A308_T1.5831.00
149_F184_K1.5811.00
305_F380_R1.5761.00
111_Q160_S1.5701.00
51_E279_A1.5611.00
150_E184_K1.5571.00
112_V126_V1.5431.00
123_Y135_H1.5411.00
71_V245_A1.5411.00
87_S250_D1.5391.00
101_A197_V1.5251.00
116_P137_P1.5191.00
184_K187_E1.5111.00
337_E341_R1.5101.00
139_L181_D1.4861.00
94_V229_C1.4841.00
303_E315_M1.4801.00
47_E50_K1.4721.00
83_V247_I1.4711.00
246_I257_F1.4371.00
139_L142_D1.4331.00
302_A324_I1.4201.00
111_Q157_S1.4121.00
307_S317_K1.4121.00
232_P277_I1.4061.00
181_D184_K1.4061.00
111_Q161_V1.4051.00
113_V161_V1.4041.00
350_L364_M1.3951.00
289_D293_T1.3901.00
48_A51_E1.3881.00
294_Y297_K1.3881.00
114_V133_I1.3871.00
335_D354_T1.3831.00
48_A279_A1.3731.00
49_L53_L1.3721.00
108_P130_G1.3611.00
305_F376_Q1.3601.00
65_Q85_P1.3591.00
337_E340_Q1.3541.00
46_T54_D1.3511.00
75_M247_I1.3401.00
278_E282_S1.3371.00
302_A379_L1.3331.00
336_A354_T1.3311.00
303_E324_I1.3251.00
86_E250_D1.3251.00
153_E157_S1.3211.00
187_E191_E1.3171.00
294_Y372_L1.3101.00
66_K282_S1.3021.00
137_P151_D1.2981.00
189_C194_V1.2971.00
327_D363_F1.2851.00
27_T347_K1.2821.00
149_F188_L1.2791.00
327_D362_G1.2791.00
183_L218_L1.2731.00
325_W353_G1.2721.00
188_L192_H1.2641.00
230_A245_A1.2641.00
103_Q129_N1.2621.00
153_E192_H1.2611.00
156_L188_L1.2591.00
180_E183_L1.2521.00
153_E188_L1.2511.00
107_E110_D1.2381.00
84_N87_S1.2281.00
51_E55_H1.2171.00
66_K275_T1.2161.00
92_P96_T1.2161.00
188_L194_V1.2121.00
49_L276_A1.2111.00
326_L366_L1.2081.00
370_C374_T1.2041.00
294_Y298_N1.2021.00
285_G289_D1.1941.00
187_E190_L1.1931.00
179_R217_S1.1921.00
380_R384_A1.1881.00
139_L151_D1.1871.00
180_E184_K1.1821.00
208_Y319_D1.1781.00
163_L197_V1.1741.00
113_V136_N1.1701.00
179_R218_L1.1681.00
97_A246_I1.1671.00
289_D292_I1.1661.00
102_V106_T1.1661.00
262_Q266_L1.1631.00
376_Q380_R1.1611.00
279_A282_S1.1601.00
299_M368_A1.1581.00
372_L376_Q1.1561.00
293_T296_E1.1451.00
139_L148_D1.1431.00
68_K72_C1.1421.00
298_N301_E1.1401.00
255_A260_S1.1391.00
299_M303_E1.1371.00
374_T377_D1.1211.00
195_T227_V1.1201.00
227_V248_I1.1161.00
74_W285_G1.1111.00
102_V165_I1.0991.00
214_P217_S1.0981.00
71_V90_F1.0971.00
334_S361_E1.0941.00
44_A283_K1.0891.00
308_T383_K1.0871.00
106_T112_V1.0781.00
279_A283_K1.0651.00
78_R285_G1.0641.00
275_T278_E1.0601.00
301_E304_A1.0571.00
66_K69_D1.0531.00
84_N250_D1.0521.00
190_L223_A1.0491.00
64_D68_K1.0441.00
293_T297_K1.0441.00
250_D254_R1.0421.00
75_M245_A1.0401.00
51_E54_D1.0321.00
248_I252_L1.0301.00
67_T90_F1.0251.00
186_G226_S1.0191.00
227_V246_I1.0181.00
195_T225_I1.0181.00
136_N155_K1.0161.00
28_D347_K1.0111.00
157_S192_H1.0071.00
339_Q350_L1.0031.00
300_N317_K1.0011.00
156_L194_V1.0001.00
329_S362_G0.9981.00
126_V133_I0.9971.00
96_T262_Q0.9971.00
139_L143_G0.9961.00
335_D362_G0.9961.00
304_A307_S0.9921.00
286_P290_E0.9901.00
342_M350_L0.9881.00
44_A47_E0.9811.00
206_M212_H0.9791.00
71_V88_I0.9741.00
290_E294_Y0.9721.00
314_K329_S0.9721.00
150_E154_T0.9701.00
208_Y296_E0.9641.00
104_A261_L0.9621.00
149_F153_E0.9591.00
336_A340_Q0.9581.00
157_S161_V0.9541.00
190_L224_D0.9481.00
72_C88_I0.9421.00
72_C84_N0.9331.00
341_R344_K0.9321.00
341_R346_G0.9321.00
190_L225_I0.9241.00
28_D377_D0.9201.00
89_T253_K0.9201.00
115_Q147_I0.9181.00
313_V328_F0.9181.00
287_W290_E0.9161.00
88_I247_I0.9111.00
46_T53_L0.9081.00
290_E293_T0.9001.00
47_E54_D0.8991.00
43_E46_T0.8951.00
65_Q68_K0.8941.00
97_A229_C0.8921.00
94_V231_A0.8891.00
105_F195_T0.8851.00
149_F185_L0.8841.00
127_E133_I0.8841.00
118_V167_C0.8831.00
299_M318_P0.8801.00
286_P289_D0.8801.00
92_P270_N0.8721.00
336_A352_P0.8691.00
74_W78_R0.8681.00
342_M382_I0.8671.00
298_N371_S0.8671.00
243_A269_L0.8641.00
149_F181_D0.8591.00
224_D249_P0.8591.00
116_P359_G0.8571.00
229_C246_I0.8561.00
302_A305_F0.8551.00
328_F364_M0.8531.00
287_W291_L0.8501.00
179_R211_K0.8421.00
87_S223_A0.8391.00
150_E153_E0.8351.00
161_V194_V0.8331.00
243_A273_A0.8331.00
124_H127_E0.8331.00
196_V215_F0.8331.00
366_L378_G0.8321.00
89_T257_F0.8261.00
44_A279_A0.8251.00
338_L364_M0.8241.00
219_S223_A0.8231.00
26_V347_K0.8201.00
94_V201_I0.8201.00
78_R204_D0.8191.00
311_P383_K0.8161.00
74_W204_D0.8151.00
297_K301_E0.8131.00
73_G76_Q0.8131.00
96_T266_L0.8111.00
115_Q136_N0.8081.00
215_F226_S0.8071.00
215_F218_L0.8051.00
113_V155_K0.8051.00
300_N303_E0.8031.00
57_I275_T0.8011.00
350_L366_L0.7991.00
335_D352_P0.7981.00
305_F311_P0.7981.00
37_M295_I0.7971.00
186_G196_V0.7941.00
213_T217_S0.7891.00
104_A257_F0.7881.00
254_R260_S0.7881.00
95_V121_P0.7881.00
81_W216_A0.7861.00
381_R384_A0.7851.00
195_T252_L0.7841.00
204_D235_T0.7831.00
138_L170_H0.7721.00
147_I181_D0.7711.00
208_Y299_M0.7711.00
87_S249_P0.7701.00
134_L155_K0.7701.00
338_L342_M0.7691.00
99_S129_N0.7691.00
354_T361_E0.7671.00
113_V152_L0.7661.00
48_A52_R0.7611.00
89_T246_I0.7611.00
39_F294_Y0.7611.00
210_H319_D0.7611.00
198_S215_F0.7601.00
308_T311_P0.7571.00
333_L337_E0.7561.00
96_T100_M0.7561.00
68_K85_P0.7551.00
111_Q159_P0.7481.00
297_K300_N0.7471.00
216_A219_S0.7471.00
99_S265_G0.7451.00
288_L292_I0.7431.00
248_I257_F0.7431.00
216_A228_T0.7431.00
156_L161_V0.7401.00
116_P357_G0.7391.00
313_V326_L0.7351.00
304_A376_Q0.7331.00
74_W79_H0.7321.00
72_C83_V0.7291.00
235_T288_L0.7291.00
143_G151_D0.7281.00
271_A275_T0.7271.00
170_H173_S0.7251.00
74_W236_F0.7201.00
335_D339_Q0.7191.00
101_A257_F0.7171.00
227_V252_L0.7161.00
325_W363_F0.7161.00
339_Q352_P0.7141.00
318_P321_S0.7131.00
44_A287_W0.7101.00
155_K159_P0.7031.00
302_A368_A0.6981.00
49_L272_F0.6971.00
100_M257_F0.6961.00
106_T110_D0.6951.00
142_D181_D0.6951.00
136_N151_D0.6931.00
164_F194_V0.6911.00
105_F163_L0.6871.00
335_D361_E0.6851.00
348_V381_R0.6841.00
348_V382_I0.6831.00
213_T218_L0.6811.00
115_Q170_H0.6801.00
333_L341_R0.6751.00
296_E299_M0.6751.00
200_E228_T0.6741.00
292_I296_E0.6721.00
219_S224_D0.6711.00
326_L363_F0.6711.00
177_W181_D0.6691.00
112_V131_R0.6691.00
114_V126_V0.6681.00
232_P245_A0.6661.00
291_L295_I0.6641.00
224_D251_R0.6631.00
28_D374_T0.6621.00
380_R383_K0.6591.00
275_T279_A0.6581.00
156_L192_H0.6561.00
93_G242_Q0.6541.00
299_M317_K0.6521.00
302_A375_L0.6521.00
166_L182_L0.6511.00
32_M375_L0.6511.00
333_L338_L0.6491.00
70_A281_Y0.6471.00
203_S230_A0.6441.00
140_E314_K0.6421.00
111_Q162_T0.6411.00
114_V135_H0.6411.00
50_K53_L0.6401.00
157_S191_E0.6391.00
52_R276_A0.6381.00
306_L326_L0.6381.00
373_A376_Q0.6371.00
301_E379_L0.6351.00
91_S246_I0.6341.00
106_T163_L0.6331.00
298_N372_L0.6331.00
109_G132_H0.6321.00
249_P252_L0.6321.00
95_V119_Y0.6301.00
69_D72_C0.6301.00
99_S125_M0.6281.00
189_C193_G0.6281.00
276_A279_A0.6251.00
122_F126_V0.6231.00
175_R319_D0.6221.00
90_F243_A0.6201.00
38_D298_N0.6191.00
134_L161_V0.6191.00
79_H203_S0.6171.00
308_T376_Q0.6171.00
348_V378_G0.6161.00
62_T65_Q0.6131.00
343_L349_I0.6121.00
122_F164_F0.6111.00
83_V87_S0.6111.00
202_H323_L0.6091.00
207_L296_E0.6091.00
205_L295_I0.6081.00
137_P155_K0.6071.00
49_L52_R0.6061.00
67_T71_V0.6061.00
134_L157_S0.6051.00
66_K70_A0.6031.00
371_S376_Q0.6031.00
29_A349_I0.6001.00
89_T248_I0.5991.00
40_R46_T0.5971.00
30_L377_D0.5971.00
274_V278_E0.5941.00
140_E327_D0.5931.00
177_W182_L0.5931.00
137_P148_D0.5921.00
98_L125_M0.5921.00
169_P320_A0.5901.00
168_N200_E0.5901.00
236_F285_G0.5891.00
315_M324_I0.5881.00
184_K188_L0.5881.00
232_P281_Y0.5881.00
45_I280_A0.5851.00
102_V129_N0.5841.00
152_L188_L0.5831.00
67_T277_I0.5831.00
223_A226_S0.5821.00
377_D384_A0.5821.00
92_P269_L0.5801.00
147_I152_L0.5791.00
262_Q269_L0.5781.00
31_P36_D0.5761.00
102_V131_R0.5761.00
314_K330_A0.5721.00
182_L215_F0.5691.00
311_P379_L0.5681.00
176_S206_M0.5671.00
140_E316_M0.5611.00
135_H358_P0.5611.00
114_V123_Y0.5601.00
327_D330_A0.5601.00
45_I48_A0.5591.00
200_E214_P0.5581.00
134_L159_P0.5581.00
61_T268_G0.5571.00
200_E203_S0.5551.00
41_A46_T0.5541.00
165_I197_V0.5541.00
45_I238_I0.5531.00
33_W349_I0.5521.00
44_A48_A0.5521.00
143_G148_D0.5511.00
251_R254_R0.5501.00
301_E375_L0.5491.00
52_R55_H0.5471.00
213_T216_A0.5451.00
102_V125_M0.5451.00
48_A276_A0.5431.00
46_T49_L0.5421.00
87_S253_K0.5421.00
26_V29_A0.5421.00
55_H279_A0.5411.00
206_M209_G0.5411.00
140_E143_G0.5411.00
186_G218_L0.5401.00
112_V163_L0.5391.00
120_T355_K0.5381.00
334_S354_T0.5371.00
335_D338_L0.5351.00
335_D364_M0.5351.00
75_M228_T0.5351.00
39_F42_P0.5341.00
52_R279_A0.5331.00
291_L294_Y0.5331.00
31_P34_V0.5321.00
316_M327_D0.5311.00
251_R255_A0.5311.00
154_T157_S0.5291.00
168_N176_S0.5281.00
186_G189_C0.5281.00
97_A244_S0.5261.00
189_C225_I0.5251.00
102_V163_L0.5231.00
205_L292_I0.5221.00
339_Q364_M0.5211.00
61_T271_A0.5201.00
353_G363_F0.5191.00
110_D160_S0.5191.00
190_L219_S0.5181.00
74_W203_S0.5161.00
219_S225_I0.5151.00
339_Q343_L0.5141.00
186_G190_L0.5131.00
107_E162_T0.5121.00
30_L381_R0.5121.00
52_R275_T0.5111.00
90_F274_V0.5111.00
67_T278_E0.5101.00
115_Q138_L0.5081.00
214_P228_T0.5061.00
305_F375_L0.5051.00
334_S338_L0.5051.00
101_A229_C0.5041.00
212_H215_F0.5041.00
95_V267_G0.5021.00
215_F219_S0.5021.00
283_K286_P0.5021.00
152_L164_F0.5011.00
41_A45_I0.5001.00
35_A202_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1c7nA 2 0.9948 100 0.282 Contact Map
3b1dA 4 0.9845 100 0.286 Contact Map
4dq6A 2 0.9871 100 0.289 Contact Map
1d2fA 2 0.9302 100 0.289 Contact Map
3t32A 2 0.9251 100 0.29 Contact Map
1gd9A 2 0.9742 100 0.293 Contact Map
1yizA 2 0.9793 100 0.296 Contact Map
3piuA 2 0.9457 100 0.296 Contact Map
2x5dA 3 0.9483 100 0.296 Contact Map
3dzzA 2 0.9793 100 0.298 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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