GREMLIN Database
KINB - Sporulation kinase B
UniProt: Q08430 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 428 (366)
Sequences: 34373 (30310)
Seq/√Len: 1584.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
362_T417_T3.5581.00
283_F319_G3.5301.00
363_D367_G3.4941.00
356_T421_K3.1881.00
396_F400_E3.1711.00
234_V255_V3.1221.00
407_S419_T3.0581.00
360_N417_T2.9411.00
319_G402_H2.8231.00
339_V364_N2.6591.00
308_E347_H2.6341.00
349_S360_N2.5921.00
373_M410_S2.5711.00
358_M421_K2.5441.00
231_R260_D2.5071.00
238_F256_L2.5021.00
308_E345_M2.4871.00
310_E349_S2.4561.00
369_T372_Q2.4501.00
360_N419_T2.4441.00
282_V318_Y2.4371.00
327_A399_I2.3461.00
351_K358_M2.3401.00
408_F418_V2.3261.00
399_I404_G2.3181.00
411_S414_K2.2761.00
347_H362_T2.2651.00
373_M408_F2.2631.00
238_F253_K2.2511.00
282_V316_L2.2201.00
358_M419_T2.2131.00
345_M364_N2.2091.00
349_S362_T2.1281.00
395_T406_I2.1231.00
351_K360_N2.0951.00
409_N417_T2.0801.00
231_R259_L2.0741.00
377_G406_I2.0701.00
339_V344_G1.9891.00
405_T421_K1.9881.00
409_N419_T1.9841.00
327_A398_I1.9801.00
291_E325_K1.9801.00
410_S416_T1.9751.00
245_N248_S1.9571.00
344_G364_N1.9561.00
375_K378_E1.9541.00
310_E347_H1.9351.00
284_D287_A1.8951.00
306_T345_M1.8921.00
281_E321_A1.8671.00
368_M376_L1.8641.00
399_I420_I1.8511.00
296_M329_I1.8481.00
370_D373_M1.8471.00
280_K318_Y1.8281.00
319_G324_L1.8101.00
333_K337_E1.7991.00
368_M372_Q1.7911.00
353_N358_M1.7441.00
182_V185_L1.7411.00
231_R263_Q1.7271.00
372_Q375_K1.7191.00
372_Q381_Y1.7151.00
327_A395_T1.6761.00
300_A336_I1.6711.00
398_I402_H1.6691.00
166_G171_E1.6461.00
189_I192_S1.6291.00
263_Q267_T1.6291.00
407_S421_K1.6281.00
230_V259_L1.6061.00
234_V256_L1.5951.00
214_E218_S1.5871.00
375_K381_Y1.5821.00
193_I196_N1.5791.00
368_M416_T1.5491.00
200_R204_I1.5271.00
235_Q256_L1.5131.00
112_F116_I1.5111.00
222_E326_Q1.4951.00
199_L202_Q1.4811.00
230_V255_V1.4701.00
369_T412_F1.4681.00
320_D323_K1.4671.00
196_N199_L1.4631.00
238_F249_A1.4621.00
328_V359_I1.4601.00
347_H364_N1.4591.00
400_E405_T1.4581.00
359_I420_I1.4541.00
278_Y320_D1.4541.00
372_Q383_L1.4531.00
233_F251_Y1.4251.00
339_V346_I1.4241.00
200_R203_L1.4231.00
330_N395_T1.3981.00
185_L192_S1.3911.00
186_S189_I1.3781.00
323_K326_Q1.3731.00
237_L252_K1.3701.00
338_A382_S1.3581.00
240_D248_S1.3421.00
256_L260_D1.3411.00
286_S290_K1.3391.00
185_L193_I1.3311.00
185_L189_I1.3231.00
146_L150_S1.3211.00
291_E321_A1.3121.00
363_D415_G1.3051.00
189_I193_I1.2981.00
295_L325_K1.2951.00
297_V301_N1.2871.00
377_G408_F1.2861.00
237_L248_S1.2711.00
52_C56_P1.2691.00
181_S185_L1.2631.00
182_V186_S1.2501.00
185_L190_I1.2471.00
323_K398_I1.2391.00
410_S413_Q1.2381.00
208_K214_E1.2271.00
284_D316_L1.2241.00
378_E381_Y1.2221.00
376_L408_F1.2171.00
179_R185_L1.2131.00
311_T350_A1.2111.00
324_L402_H1.2091.00
212_V216_A1.2071.00
234_V259_L1.2061.00
286_S350_A1.2021.00
218_S379_P1.1941.00
229_V233_F1.1921.00
280_K402_H1.1841.00
264_G322_T1.1811.00
293_S309_A1.1741.00
234_V238_F1.1721.00
196_N200_R1.1711.00
198_A202_Q1.1691.00
199_L203_L1.1541.00
231_R256_L1.1531.00
188_Y192_S1.1511.00
410_S414_K1.1501.00
404_G422_L1.1471.00
197_I200_R1.1251.00
171_E174_V1.1231.00
397_S400_E1.1221.00
233_F254_L1.1171.00
377_G418_V1.1121.00
323_K401_H1.1101.00
356_T405_T1.1081.00
290_K309_A1.1031.00
56_P60_M1.1011.00
156_A160_L1.0971.00
268_N323_K1.0961.00
178_F183_L1.0951.00
234_V252_K1.0951.00
373_M377_G1.0931.00
204_I207_E1.0901.00
229_V258_E1.0861.00
224_R267_T1.0801.00
399_I406_I1.0781.00
321_A325_K1.0771.00
214_E379_P1.0671.00
190_I193_I1.0651.00
253_K257_S1.0651.00
207_E212_V1.0631.00
178_F185_L1.0511.00
197_I201_S1.0471.00
243_L248_S1.0431.00
363_D416_T1.0401.00
382_S387_G1.0401.00
288_L292_T1.0321.00
192_S196_N1.0241.00
245_N249_A1.0211.00
232_G236_L1.0091.00
328_V332_M1.0061.00
272_M393_T1.0061.00
408_F416_T1.0031.00
185_L188_Y1.0011.00
289_I350_A1.0011.00
286_S311_T0.9901.00
67_L70_I0.9891.00
215_L219_V0.9891.00
312_E315_L0.9861.00
186_S193_I0.9861.00
377_G396_F0.9821.00
335_S346_I0.9801.00
299_Y302_Y0.9761.00
229_V232_G0.9721.00
231_R235_Q0.9651.00
164_K168_F0.9631.00
254_L258_E0.9601.00
283_F288_L0.9601.00
223_V262_A0.9521.00
292_T329_I0.9511.00
404_G420_I0.9511.00
278_Y323_K0.9471.00
178_F182_V0.9361.00
193_I197_I0.9351.00
397_S401_H0.9311.00
288_L319_G0.9301.00
194_A197_I0.9291.00
153_I156_A0.9291.00
249_A253_K0.9241.00
305_V339_V0.9241.00
182_V187_I0.9201.00
164_K167_I0.9191.00
186_S192_S0.9191.00
367_G416_T0.9181.00
111_P116_I0.9151.00
390_L394_V0.9141.00
190_I194_A0.9091.00
204_I208_K0.9071.00
292_T325_K0.9051.00
271_D326_Q0.9051.00
399_I422_L0.9031.00
312_E351_K0.9011.00
338_A366_V0.9011.00
112_F117_P0.8991.00
331_L420_I0.8961.00
267_T271_D0.8951.00
71_P75_C0.8931.00
258_E261_R0.8911.00
327_A420_I0.8871.00
202_Q205_H0.8831.00
201_S205_H0.8801.00
180_S183_L0.8771.00
179_R182_V0.8721.00
395_T399_I0.8671.00
292_T296_M0.8651.00
328_V361_I0.8641.00
161_N165_S0.8641.00
66_G70_I0.8621.00
299_Y333_K0.8621.00
203_L207_E0.8611.00
195_E198_A0.8591.00
322_T325_K0.8581.00
362_T411_S0.8571.00
353_N356_T0.8471.00
379_P397_S0.8461.00
166_G174_V0.8441.00
201_S204_I0.8421.00
332_M348_I0.8401.00
331_L395_T0.8401.00
250_D254_L0.8391.00
255_V259_L0.8311.00
270_L273_A0.8291.00
158_N161_N0.8291.00
368_M374_Q0.8281.00
283_F321_A0.8281.00
331_L418_V0.8281.00
259_L263_Q0.8221.00
78_Y81_T0.8201.00
178_F181_S0.8201.00
68_Q71_P0.8191.00
113_L116_I0.8191.00
202_Q206_S0.8181.00
368_M408_F0.8151.00
315_L350_A0.8141.00
150_S154_L0.8081.00
246_K249_A0.8071.00
58_H62_Y0.8001.00
280_K403_H0.7971.00
329_I333_K0.7971.00
279_E320_D0.7961.00
326_Q398_I0.7941.00
295_L329_I0.7931.00
53_I57_I0.7891.00
194_A198_A0.7881.00
242_T245_N0.7881.00
192_S195_E0.7861.00
131_K134_L0.7851.00
71_P74_I0.7801.00
257_S291_E0.7791.00
70_I74_I0.7761.00
293_S297_V0.7741.00
353_N421_K0.7721.00
151_S155_S0.7711.00
184_L187_I0.7701.00
225_N229_V0.7671.00
188_Y191_E0.7651.00
337_E387_G0.7631.00
195_E199_L0.7621.00
368_M373_M0.7621.00
370_D410_S0.7601.00
290_K294_S0.7591.00
289_I348_I0.7571.00
248_S251_Y0.7551.00
293_S307_V0.7541.00
268_N326_Q0.7541.00
331_L406_I0.7531.00
224_R263_Q0.7521.00
236_L240_D0.7521.00
326_Q329_I0.7481.00
233_F258_E0.7481.00
164_K170_Y0.7461.00
186_S190_I0.7461.00
116_I119_L0.7451.00
227_L266_I0.7441.00
304_S342_G0.7431.00
216_A219_V0.7391.00
304_S341_H0.7371.00
335_S361_I0.7361.00
205_H208_K0.7361.00
300_A307_V0.7351.00
74_I77_F0.7351.00
70_I73_I0.7341.00
325_K329_I0.7331.00
292_T332_M0.7331.00
306_T309_A0.7311.00
112_F115_I0.7301.00
323_K327_A0.7291.00
238_F252_K0.7281.00
363_D366_V0.7271.00
332_M346_I0.7261.00
287_A291_E0.7231.00
305_V309_A0.7201.00
223_V266_I0.7191.00
285_L359_I0.7191.00
376_L418_V0.7181.00
112_F119_L0.7181.00
129_K132_K0.7181.00
178_F186_S0.7171.00
160_L164_K0.7161.00
57_I61_D0.7161.00
182_V192_S0.7151.00
54_I58_H0.7121.00
211_I214_E0.7121.00
63_I67_L0.7111.00
330_N333_K0.7091.00
278_Y401_H0.7071.00
323_K402_H0.7061.00
156_A159_I0.7051.00
261_R325_K0.7001.00
305_V336_I0.6991.00
296_M333_K0.6981.00
198_A201_S0.6971.00
289_I328_V0.6961.00
171_E175_S0.6961.00
213_S276_Q0.6961.00
369_T383_L0.6951.00
182_V189_I0.6941.00
368_M410_S0.6941.00
103_A106_V0.6941.00
182_V193_I0.6941.00
285_L357_I0.6921.00
147_F151_S0.6911.00
300_A346_I0.6911.00
111_P114_I0.6901.00
222_E226_P0.6901.00
163_Q174_V0.6891.00
268_N322_T0.6891.00
407_S420_I0.6871.00
111_P115_I0.6871.00
182_V190_I0.6831.00
64_Q68_Q0.6821.00
280_K319_G0.6821.00
131_K135_L0.6821.00
214_E397_S0.6801.00
382_S386_N0.6791.00
156_A164_K0.6791.00
216_A220_A0.6781.00
356_T423_P0.6771.00
187_I191_E0.6771.00
215_L222_E0.6761.00
187_I190_I0.6741.00
191_E195_E0.6731.00
150_S153_I0.6731.00
63_I66_G0.6711.00
370_D411_S0.6711.00
348_I361_I0.6691.00
143_E147_F0.6671.00
296_M332_M0.6631.00
254_L257_S0.6601.00
360_N409_N0.6601.00
260_D263_Q0.6601.00
222_E265_I0.6591.00
148_F152_W0.6591.00
222_E330_N0.6591.00
129_K133_L0.6561.00
219_V269_Y0.6561.00
101_P104_M0.6541.00
312_E350_A0.6531.00
72_V75_C0.6531.00
373_M418_V0.6511.00
74_I78_Y0.6501.00
253_K256_L0.6501.00
248_S252_K0.6501.00
327_A402_H0.6491.00
184_L188_Y0.6481.00
294_S298_S0.6481.00
75_C79_I0.6471.00
208_K213_S0.6461.00
59_E62_Y0.6461.00
372_Q385_T0.6451.00
301_N304_S0.6451.00
152_W155_S0.6451.00
271_D323_K0.6441.00
250_D253_K0.6401.00
298_S301_N0.6391.00
179_R183_L0.6371.00
276_Q379_P0.6351.00
66_G69_M0.6341.00
120_F123_K0.6321.00
278_Y402_H0.6321.00
337_E384_K0.6301.00
286_S313_P0.6291.00
222_E394_V0.6291.00
132_K135_L0.6291.00
110_L115_I0.6291.00
221_H225_N0.6281.00
53_I56_P0.6271.00
404_G423_P0.6261.00
56_P59_E0.6251.00
284_D314_D0.6251.00
296_M336_I0.6251.00
112_F118_I0.6241.00
165_S169_V0.6231.00
55_F59_E0.6191.00
288_L324_L0.6191.00
161_N164_K0.6181.00
51_L59_E0.6141.00
303_K336_I0.6131.00
205_H211_I0.6121.00
264_G268_N0.6121.00
183_L187_I0.6111.00
176_G179_R0.6101.00
228_T232_G0.6101.00
114_I119_L0.6101.00
170_Y173_A0.6101.00
229_V254_L0.6091.00
58_H61_D0.6091.00
376_L381_Y0.6071.00
373_M409_N0.6061.00
331_L399_I0.6061.00
396_F405_T0.6051.00
119_L123_K0.6041.00
180_S186_S0.6041.00
67_L71_P0.6031.00
251_Y254_L0.6021.00
358_M407_S0.5991.00
352_R357_I0.5981.00
167_I170_Y0.5981.00
178_F192_S0.5961.00
218_S222_E0.5961.00
285_L317_I0.5951.00
293_S348_I0.5941.00
156_A161_N0.5901.00
111_P117_P0.5891.00
235_Q239_N0.5891.00
300_A303_K0.5891.00
75_C78_Y0.5871.00
291_E295_L0.5871.00
262_A266_I0.5861.00
287_A321_A0.5861.00
113_L117_P0.5851.00
172_A175_S0.5851.00
247_S251_Y0.5851.00
350_A359_I0.5841.00
406_I418_V0.5811.00
104_M107_F0.5811.00
144_I148_F0.5801.00
399_I405_T0.5801.00
292_T295_L0.5801.00
176_G183_L0.5791.00
258_E295_L0.5791.00
394_V398_I0.5781.00
179_R186_S0.5781.00
123_K126_F0.5781.00
289_I292_T0.5771.00
71_P78_Y0.5771.00
283_F318_Y0.5741.00
230_V234_V0.5731.00
220_A226_P0.5701.00
271_D274_K0.5691.00
368_M418_V0.5671.00
181_S192_S0.5671.00
305_V346_I0.5621.00
203_L206_S0.5591.00
288_L291_E0.5581.00
298_S302_Y0.5571.00
339_V342_G0.5541.00
168_F172_A0.5531.00
350_A357_I0.5531.00
132_K136_S0.5531.00
75_C82_A0.5531.00
289_I309_A0.5531.00
166_G169_V0.5501.00
110_L114_I0.5501.00
288_L321_A0.5491.00
193_I200_R0.5491.00
243_L247_S0.5491.00
105_F108_T0.5481.00
324_L328_V0.5461.00
376_L393_T0.5451.00
288_L325_K0.5441.00
314_D352_R0.5441.00
170_Y174_V0.5441.00
233_F255_V0.5431.00
340_P366_V0.5431.00
57_I60_M0.5431.00
232_G259_L0.5431.00
251_Y255_V0.5421.00
220_A270_L0.5411.00
237_L255_V0.5401.00
237_L251_Y0.5401.00
284_D315_L0.5391.00
65_Y69_M0.5371.00
272_M397_S0.5351.00
102_S105_F0.5321.00
199_L204_I0.5301.00
340_P344_G0.5271.00
294_S297_V0.5271.00
290_K311_T0.5261.00
393_T397_S0.5251.00
242_T248_S0.5251.00
206_S212_V0.5251.00
395_T398_I0.5231.00
311_T315_L0.5231.00
256_L259_L0.5231.00
110_L117_P0.5231.00
207_E213_S0.5221.00
142_V146_L0.5221.00
182_V188_Y0.5211.00
223_V226_P0.5211.00
69_M72_V0.5201.00
300_A304_S0.5191.00
120_F124_W0.5181.00
103_A109_L0.5181.00
300_A305_V0.5171.00
346_I361_I0.5151.00
290_K293_S0.5131.00
167_I174_V0.5131.00
68_Q72_V0.5121.00
286_S314_D0.5111.00
240_D245_N0.5101.00
270_L274_K0.5091.00
252_K256_L0.5091.00
73_I76_L0.5081.00
73_I77_F0.5071.00
151_S158_N0.5061.00
370_D374_Q0.5051.00
352_R356_T0.5051.00
303_K341_H0.5031.00
260_D264_G0.5031.00
269_Y273_A0.5011.00
275_Q397_S0.5001.00
183_L189_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.6355 100 0.359 Contact Map
4bixA 2 0.5257 100 0.394 Contact Map
4q20A 2 0.528 100 0.415 Contact Map
4gczA 2 0.8271 100 0.419 Contact Map
3d36A 2 0.514 100 0.42 Contact Map
4ctiA 2 0.5327 100 0.424 Contact Map
3a0rA 2 0.771 100 0.428 Contact Map
3jz3A 2 0.3668 100 0.429 Contact Map
4e01A 3 0.6776 100 0.435 Contact Map
2q8gA 2 0.6986 100 0.436 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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