GREMLIN Database
KAPB - Kinase-associated lipoprotein B
UniProt: Q08429 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 128 (118)
Sequences: 156 (130)
Seq/√Len: 12.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_E34_K6.2491.00
24_T69_Q3.4720.98
99_R121_E3.2610.97
11_K18_V2.7340.93
30_H69_Q2.3310.85
37_A85_P2.2280.82
31_Y74_H2.1100.79
92_R96_A2.0910.78
60_E119_I2.0190.75
62_K123_E1.9310.72
31_Y71_N1.9060.71
112_R115_H1.7780.65
107_S110_A1.7560.64
13_F18_V1.6700.60
60_E116_N1.6690.60
34_K67_G1.6400.59
62_K109_W1.6380.59
69_Q76_M1.6320.58
8_S80_Y1.5940.57
101_K122_K1.5890.56
20_I39_L1.5590.55
24_T31_Y1.5470.54
12_G36_K1.5440.54
119_I123_E1.5360.54
14_Y70_T1.5300.53
53_A106_G1.5240.53
53_A57_F1.5100.52
16_T123_E1.4950.52
62_K98_M1.4770.51
36_K67_G1.4500.49
32_L71_N1.4050.47
26_C74_H1.3870.46
21_G70_T1.3780.46
22_E36_K1.3710.45
9_I80_Y1.3640.45
51_K109_W1.3450.44
93_E111_K1.3420.44
41_H124_Y1.2840.41
29_Q49_H1.2730.41
30_H60_E1.2720.41
32_L51_K1.2410.39
24_T71_N1.2360.39
57_F98_M1.2290.38
25_A65_A1.2270.38
72_I121_E1.1920.37
35_V84_V1.1760.36
24_T76_M1.1640.35
23_I71_N1.1610.35
53_A108_E1.1550.35
43_A96_A1.1510.35
119_I122_K1.1150.33
10_V14_Y1.1060.33
60_E72_I1.1030.33
54_D97_Q1.0890.32
104_E115_H1.0750.31
13_F62_K1.0710.31
40_T118_D1.0500.30
18_V27_R1.0160.29
36_K85_P1.0100.29
12_G70_T1.0020.28
103_N118_D0.9900.28
95_T110_A0.9900.28
14_Y21_G0.9680.27
88_T122_K0.9650.27
53_A105_D0.9630.27
100_A122_K0.9510.26
80_Y93_E0.9490.26
116_N120_L0.9310.26
103_N106_G0.9220.25
16_T76_M0.9130.25
21_G71_N0.9040.25
86_D89_E0.8940.24
28_P69_Q0.8930.24
86_D93_E0.8830.24
33_V97_Q0.8800.24
55_V73_P0.8800.24
20_I84_V0.8780.24
27_R71_N0.8690.23
32_L69_Q0.8560.23
20_I80_Y0.8540.23
86_D107_S0.8430.22
41_H91_L0.8380.22
39_L60_E0.8320.22
86_D101_K0.8280.22
92_R107_S0.8260.22
33_V76_M0.8240.22
52_Q108_E0.8190.22
95_T107_S0.8140.21
12_G62_K0.8070.21
13_F73_P0.8070.21
55_V110_A0.7960.21
33_V110_A0.7860.20
83_E112_R0.7600.20
30_H71_N0.7570.19
24_T30_H0.7460.19
51_K113_S0.7380.19
28_P114_L0.7270.19
12_G43_A0.7230.18
60_E105_D0.7220.18
95_T99_R0.7210.18
95_T119_I0.7160.18
83_E108_E0.7100.18
40_T43_A0.7080.18
34_K69_Q0.7030.18
106_G109_W0.6990.18
62_K120_L0.6950.18
78_K82_G0.6920.18
105_D116_N0.6840.17
65_A71_N0.6810.17
22_E118_D0.6790.17
16_T73_P0.6760.17
111_K118_D0.6650.17
86_D122_K0.6600.17
49_H122_K0.6550.16
98_M116_N0.6520.16
98_M109_W0.6500.16
65_A69_Q0.6480.16
53_A107_S0.6470.16
20_I123_E0.6460.16
34_K98_M0.6450.16
40_T79_P0.6430.16
16_T67_G0.6420.16
89_E111_K0.6390.16
99_R104_E0.6360.16
108_E115_H0.6350.16
108_E112_R0.6330.16
20_I37_A0.6290.16
84_V89_E0.6280.16
40_T96_A0.6260.16
41_H62_K0.6230.16
27_R109_W0.6220.16
54_D110_A0.6210.16
92_R100_A0.6210.16
79_P88_T0.6190.16
13_F76_M0.6130.15
35_V50_P0.6120.15
66_Y81_D0.6120.15
109_W113_S0.6100.15
81_D104_E0.6100.15
110_A123_E0.6090.15
65_A100_A0.6090.15
81_D112_R0.6070.15
108_E111_K0.6050.15
20_I82_G0.6040.15
43_A123_E0.6020.15
72_I107_S0.5970.15
88_T118_D0.5950.15
39_L89_E0.5930.15
33_V66_Y0.5890.15
9_I20_I0.5890.15
24_T55_V0.5780.14
28_P53_A0.5750.14
36_K62_K0.5750.14
32_L99_R0.5750.14
9_I84_V0.5720.14
76_M113_S0.5710.14
89_E117_L0.5700.14
79_P103_N0.5530.14
81_D103_N0.5510.14
21_G41_H0.5500.14
99_R114_L0.5490.14
91_L124_Y0.5460.14
29_Q116_N0.5430.14
18_V55_V0.5390.14
79_P118_D0.5390.14
39_L106_G0.5310.13
49_H106_G0.5220.13
43_A97_Q0.5220.13
20_I115_H0.5150.13
20_I65_A0.5100.13
74_H121_E0.5080.13
31_Y77_V0.5070.13
84_V96_A0.5060.13
34_K108_E0.5030.13
60_E67_G0.5030.13
8_S57_F0.5000.13
36_K43_A0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y71A 2 0.875 100 0.091 Contact Map
3qbyA 3 0.6719 85.9 0.921 Contact Map
4n4gA 1 0.6719 82.7 0.924 Contact Map
4z02A 1 0.75 82.6 0.924 Contact Map
4qw2A 1 0.8438 80 0.927 Contact Map
4ld6A 1 0.7812 79.4 0.927 Contact Map
3h8zA 1 0.4219 78.5 0.928 Contact Map
3pfsA 1 0.7891 78 0.928 Contact Map
1ri0A 1 0.7188 77.6 0.928 Contact Map
3l42A 1 0.8047 73.8 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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