GREMLIN Database
DHA - Alanine dehydrogenase
UniProt: Q08352 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 378 (352)
Sequences: 4810 (2587)
Seq/√Len: 137.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_D63_Q4.2851.00
32_R56_E3.3671.00
86_K110_G3.3581.00
100_P104_Q3.2921.00
170_T230_A3.2381.00
168_K191_D3.1561.00
104_Q108_D3.0021.00
143_G232_L2.9601.00
48_E52_S2.9121.00
249_T252_M2.9101.00
177_V265_V2.8391.00
48_E51_E2.8271.00
7_K36_E2.8191.00
45_F310_I2.7481.00
29_N325_N2.7471.00
2_I32_R2.7111.00
352_E356_R2.6591.00
250_E290_H2.6291.00
322_Q335_N2.6191.00
34_L58_I2.4801.00
282_H285_P2.4571.00
23_V55_A2.4391.00
275_T294_H2.4081.00
22_G313_T2.3891.00
326_K334_D2.3761.00
224_A255_Q2.3621.00
37_T57_I2.3481.00
243_K246_T2.3461.00
71_M320_A2.3361.00
330_K334_D2.3321.00
72_K80_E2.3141.00
29_N321_L2.3111.00
250_E274_E2.3081.00
168_K229_E2.2381.00
58_I64_V2.1441.00
94_L113_A2.1441.00
38_G47_N2.1361.00
262_I273_V2.1061.00
93_Y127_L2.0661.00
62_K83_Y2.0541.00
154_K257_K2.0171.00
113_A344_T2.0131.00
191_D214_K1.9471.00
332_L342_L1.9331.00
228_A255_Q1.9231.00
253_V262_I1.8911.00
250_E254_K1.8531.00
69_M89_V1.8051.00
26_L320_A1.7721.00
112_T345_A1.7561.00
107_K349_V1.7521.00
24_S28_S1.7301.00
68_E85_R1.7281.00
37_T47_N1.7081.00
2_I34_L1.7021.00
51_E56_E1.6971.00
288_E291_G1.6821.00
250_E289_K1.6551.00
184_M188_L1.6091.00
4_G67_A1.5791.00
183_K207_D1.5641.00
251_E254_K1.5541.00
199_A315_V1.5401.00
46_E49_A1.5351.00
179_T205_L1.5351.00
5_V18_L1.5261.00
120_S124_T1.5221.00
133_E203_R1.5161.00
61_P65_W1.5021.00
81_Y105_A1.4591.00
140_A234_I1.4581.00
78_P105_A1.4561.00
248_V273_V1.4561.00
204_Q207_D1.4531.00
288_E293_V1.4491.00
11_N283_D1.4471.00
85_R88_L1.4471.00
18_L23_V1.4441.00
101_E104_Q1.4401.00
224_A252_M1.4401.00
34_L67_A1.4301.00
38_G41_L1.4221.00
221_V225_D1.4171.00
63_Q66_D1.4171.00
146_F286_T1.4101.00
227_V233_L1.4051.00
254_K289_K1.3901.00
204_Q208_I1.3891.00
107_K344_T1.3801.00
64_V70_V1.3761.00
322_Q326_K1.3721.00
17_A71_M1.3691.00
69_M320_A1.3631.00
14_N302_G1.3551.00
18_L22_G1.3511.00
120_S337_A1.3431.00
4_G64_V1.3381.00
254_K290_H1.3281.00
252_M255_Q1.3251.00
154_K260_S1.3171.00
146_F295_Y1.3161.00
233_L273_V1.3141.00
349_V355_A1.3041.00
99_E102_L1.3031.00
86_K109_K1.2891.00
105_A108_D1.2841.00
225_D229_E1.2671.00
219_N222_N1.2651.00
2_I67_A1.2641.00
182_A194_I1.2611.00
70_V88_L1.2551.00
227_V252_M1.2501.00
61_P64_V1.2481.00
217_I221_V1.2401.00
166_R214_K1.2371.00
78_P101_E1.2261.00
158_L167_G1.2251.00
145_Q151_K1.2211.00
116_Y312_L1.2161.00
83_Y88_L1.2141.00
119_V338_L1.2111.00
250_E275_T1.2071.00
224_A228_A1.2021.00
119_V341_G1.1951.00
114_I342_L1.1861.00
87_G111_V1.1821.00
282_H289_K1.1811.00
177_V236_A1.1791.00
171_I182_A1.1730.99
201_R204_Q1.1710.99
227_V230_A1.1660.99
227_V248_V1.1600.99
281_T298_A1.1590.99
224_A251_E1.1580.99
82_V109_K1.1530.99
71_M316_T1.1510.99
9_I77_L1.1510.99
112_T328_A1.1480.99
174_G201_R1.1410.99
351_Y354_V1.1340.99
105_A109_K1.1270.99
84_F111_V1.1240.99
169_V185_A1.1220.99
2_I66_D1.1160.99
281_T284_Q1.1120.99
114_I319_Y1.1100.99
36_E61_P1.1030.99
16_V39_A1.1000.99
336_T340_A1.0740.99
145_Q148_E1.0730.99
49_A52_S1.0720.99
10_K74_K1.0700.99
90_L106_L1.0700.99
337_A340_A1.0680.99
161_V311_A1.0630.99
16_V50_Y1.0630.99
172_I223_I1.0630.99
330_K333_A1.0620.99
326_K330_K1.0590.99
287_Y296_A1.0590.99
14_N42_G1.0500.99
34_L66_D1.0470.99
12_N283_D1.0440.99
51_E57_I1.0420.99
174_G205_L1.0400.99
260_S292_V1.0300.99
27_I53_A1.0250.99
168_K226_A1.0160.99
34_L56_E1.0110.98
134_V150_P1.0040.98
280_T284_Q0.9940.98
258_P291_G0.9930.98
106_L344_T0.9910.98
179_T201_R0.9900.98
281_T285_P0.9900.98
230_A233_L0.9840.98
65_W83_Y0.9840.98
253_V290_H0.9740.98
20_P45_F0.9720.98
216_L226_A0.9700.98
64_V67_A0.9690.98
323_I338_L0.9690.98
6_P65_W0.9590.98
23_V53_A0.9570.98
31_H324_A0.9510.98
196_D202_L0.9480.98
222_N225_D0.9440.98
182_A209_F0.9430.98
262_I292_V0.9430.98
233_L248_V0.9370.97
246_T274_E0.9370.97
172_I247_L0.9330.97
216_L220_P0.9320.97
60_D64_V0.9300.97
336_T339_R0.9280.97
6_P70_V0.9230.97
82_V105_A0.9220.97
238_L269_Q0.9160.97
227_V255_Q0.9150.97
141_Q148_E0.9110.97
86_K346_N0.9100.97
106_L113_A0.9060.97
104_Q107_K0.9060.97
37_T51_E0.9030.97
111_V344_T0.8990.97
186_V213_I0.8980.97
183_K208_I0.8970.97
9_I36_E0.8950.97
35_V55_A0.8950.97
343_N351_Y0.8930.97
87_G346_N0.8900.97
140_A184_M0.8890.97
151_K232_L0.8860.96
306_R310_I0.8860.96
58_I63_Q0.8850.96
134_V308_S0.8830.96
94_L106_L0.8820.96
6_P72_K0.8820.96
146_F293_V0.8800.96
19_T313_T0.8790.96
95_H98_A0.8790.96
121_E336_T0.8790.96
140_A185_A0.8770.96
27_I33_V0.8760.96
170_T195_I0.8760.96
205_L212_Q0.8740.96
3_I31_H0.8730.96
233_L260_S0.8720.96
206_D211_H0.8710.96
127_L312_L0.8700.96
169_V190_A0.8700.96
345_A350_T0.8700.96
34_L64_V0.8660.96
216_L219_N0.8630.96
121_E340_A0.8620.96
91_F320_A0.8540.96
186_V210_G0.8530.96
19_T45_F0.8520.96
267_I281_T0.8510.96
62_K82_V0.8500.96
331_A338_L0.8440.95
122_G200_D0.8440.95
119_V337_A0.8410.95
249_T274_E0.8370.95
206_D212_Q0.8330.95
25_Q321_L0.8320.95
110_G347_G0.8320.95
319_Y337_A0.8260.95
200_D204_Q0.8260.95
193_T230_A0.8250.95
74_K301_P0.8240.95
265_V300_M0.8200.95
297_V303_A0.8200.95
225_D228_A0.8190.95
58_I66_D0.8170.94
148_E151_K0.8160.94
182_A192_V0.8150.94
90_L94_L0.8090.94
253_V273_V0.8070.94
41_L46_E0.8010.94
186_V212_Q0.8000.94
216_L222_N0.7970.94
65_W88_L0.7950.94
142_I145_Q0.7940.94
116_Y316_T0.7920.93
84_F88_L0.7910.93
233_L256_M0.7890.93
193_T226_A0.7880.93
25_Q317_V0.7880.93
179_T207_D0.7870.93
179_T209_F0.7850.93
89_V114_I0.7840.93
24_S224_A0.7830.93
280_T283_D0.7820.93
216_L223_I0.7810.93
79_E83_Y0.7800.93
195_I223_I0.7750.93
343_N349_V0.7750.93
253_V275_T0.7730.93
78_P81_Y0.7720.93
77_L80_E0.7710.93
141_Q159_A0.7690.92
88_L111_V0.7670.92
333_A345_A0.7670.92
22_G317_V0.7660.92
195_I226_A0.7650.92
56_E66_D0.7640.92
28_S220_P0.7640.92
89_V112_T0.7630.92
288_E292_V0.7600.92
267_I296_A0.7580.92
238_L244_A0.7510.92
8_E13_E0.7500.92
43_S305_P0.7490.91
170_T223_I0.7480.91
66_D85_R0.7470.91
251_E274_E0.7430.91
254_K275_T0.7420.91
120_S123_R0.7420.91
129_T176_V0.7420.91
302_G305_P0.7390.91
16_V309_T0.7370.91
74_K95_H0.7370.91
262_I294_H0.7370.91
244_A269_Q0.7370.91
333_A342_L0.7350.91
283_D298_A0.7330.91
231_D257_K0.7310.90
74_K268_D0.7300.90
26_L321_L0.7240.90
96_L106_L0.7230.90
142_I300_M0.7220.90
179_T183_K0.7220.90
109_K344_T0.7150.89
322_Q338_L0.7150.89
281_T288_E0.7150.89
147_L232_L0.7130.89
114_I341_G0.7110.89
110_G348_H0.7100.89
120_S340_A0.7060.89
253_V292_V0.7060.89
327_G331_A0.7040.89
223_I227_V0.7030.89
209_F212_Q0.6970.88
45_F306_R0.6960.88
250_E253_V0.6950.88
280_T285_P0.6930.88
235_C273_V0.6920.88
235_C272_I0.6920.88
199_A217_I0.6910.88
74_K302_G0.6860.87
122_G337_A0.6860.87
140_A263_V0.6850.87
329_V333_A0.6850.87
210_G213_I0.6850.87
267_I273_V0.6840.87
170_T226_A0.6830.87
89_V323_I0.6820.87
25_Q29_N0.6810.87
89_V328_A0.6800.87
174_G182_A0.6790.87
183_K209_F0.6790.87
227_V253_V0.6780.87
21_G310_I0.6780.87
171_I186_V0.6770.87
170_T233_L0.6770.87
285_P289_K0.6740.87
73_V312_L0.6710.86
21_G221_V0.6700.86
127_L319_Y0.6680.86
286_T293_V0.6670.86
267_I298_A0.6670.86
168_K193_T0.6670.86
272_I296_A0.6650.86
142_I146_F0.6640.86
289_K294_H0.6640.86
328_A345_A0.6640.86
200_D203_R0.6610.85
220_P224_A0.6610.85
275_T292_V0.6600.85
61_P80_E0.6580.85
2_I56_E0.6580.85
82_V108_D0.6570.85
199_A203_R0.6570.85
201_R205_L0.6560.85
226_A230_A0.6530.85
25_Q28_S0.6520.85
257_K260_S0.6500.84
45_F50_Y0.6480.84
218_S221_V0.6470.84
282_H287_Y0.6460.84
44_G306_R0.6440.84
149_K305_P0.6430.84
5_V16_V0.6410.84
72_K76_P0.6390.83
124_T318_P0.6360.83
18_L26_L0.6360.83
58_I70_V0.6350.83
27_I32_R0.6320.83
322_Q334_D0.6310.83
69_M91_F0.6300.83
72_K77_L0.6290.83
6_P80_E0.6290.83
172_I195_I0.6290.83
282_H290_H0.6280.82
46_E51_E0.6260.82
42_G45_F0.6250.82
332_L338_L0.6250.82
37_T58_I0.6250.82
317_V321_L0.6240.82
39_A43_S0.6230.82
209_F213_I0.6220.82
344_T349_V0.6210.82
23_V27_I0.6210.82
9_I79_E0.6200.82
129_T203_R0.6200.82
133_E311_A0.6200.82
141_Q158_L0.6190.82
7_K38_G0.6190.82
112_T342_L0.6180.81
18_L71_M0.6160.81
179_T204_Q0.6150.81
118_T351_Y0.6130.81
138_M145_Q0.6120.81
76_P90_L0.6110.81
265_V268_D0.6080.80
189_G212_Q0.6080.80
256_M260_S0.6070.80
198_N201_R0.6050.80
174_G209_F0.6050.80
118_T343_N0.6020.80
6_P9_I0.6020.80
10_K75_E0.6010.80
179_T198_N0.6000.79
121_E337_A0.5990.79
222_N226_A0.5980.79
103_A351_Y0.5970.79
195_I216_L0.5970.79
5_V71_M0.5950.79
202_L206_D0.5930.79
345_A348_H0.5900.78
206_D214_K0.5870.78
338_L342_L0.5870.78
203_R206_D0.5860.78
275_T289_K0.5840.78
19_T22_G0.5810.77
180_N184_M0.5810.77
90_L111_V0.5810.77
82_V86_K0.5810.77
268_D302_G0.5810.77
49_A306_R0.5810.77
81_Y102_L0.5800.77
124_T322_Q0.5800.77
128_L132_S0.5800.77
22_G26_L0.5790.77
283_D289_K0.5760.77
158_L232_L0.5750.77
214_K226_A0.5750.77
179_T208_I0.5750.77
202_L214_K0.5740.76
68_E87_G0.5740.76
251_E255_Q0.5730.76
17_A313_T0.5720.76
46_E258_P0.5700.76
129_T199_A0.5700.76
18_L313_T0.5700.76
103_A107_K0.5700.76
112_T346_N0.5690.76
250_E294_H0.5680.76
248_V252_M0.5680.76
226_A229_E0.5680.76
141_Q188_L0.5680.76
262_I296_A0.5680.76
240_P266_A0.5680.76
167_G234_I0.5660.75
17_A43_S0.5660.75
65_W72_K0.5630.75
144_A151_K0.5620.75
5_V35_V0.5590.75
89_V331_A0.5580.74
148_E304_V0.5580.74
236_A272_I0.5560.74
37_T60_D0.5560.74
95_H269_Q0.5550.74
281_T286_T0.5520.74
82_V85_R0.5520.74
223_I247_L0.5510.74
284_Q298_A0.5490.73
114_I328_A0.5490.73
285_P295_Y0.5490.73
81_Y111_V0.5490.73
32_R66_D0.5470.73
180_N183_K0.5460.73
77_L81_Y0.5460.73
134_V157_L0.5450.73
138_M148_E0.5440.73
339_R350_T0.5430.72
41_L48_E0.5430.72
100_P103_A0.5430.72
1_M32_R0.5420.72
299_N302_G0.5420.72
193_T216_L0.5410.72
174_G196_D0.5390.72
268_D298_A0.5380.72
38_G42_G0.5380.72
184_M189_G0.5380.72
79_E82_V0.5370.72
246_T249_T0.5350.71
98_A103_A0.5330.71
45_F305_P0.5320.71
47_N51_E0.5310.71
165_S310_I0.5290.71
286_T297_V0.5290.71
134_V161_V0.5270.70
281_T289_K0.5270.70
285_P293_V0.5250.70
213_I226_A0.5250.70
24_S220_P0.5250.70
280_T286_T0.5250.70
138_M142_I0.5240.70
328_A346_N0.5240.70
199_A202_L0.5230.70
138_M303_A0.5230.70
284_Q288_E0.5220.70
65_W80_E0.5220.70
194_I213_I0.5210.69
167_G188_L0.5200.69
318_P322_Q0.5190.69
95_H117_E0.5190.69
170_T213_I0.5180.69
281_T287_Y0.5180.69
137_R184_M0.5170.69
149_K306_R0.5170.69
160_G163_G0.5120.68
268_D284_Q0.5110.68
25_Q220_P0.5100.68
224_A249_T0.5100.68
186_V209_F0.5090.68
263_V295_Y0.5080.67
145_Q150_P0.5060.67
141_Q145_Q0.5060.67
72_K92_T0.5030.67
202_L212_Q0.5020.67
206_D215_T0.5020.67
166_R212_Q0.5010.66
326_K331_A0.5010.66
3_I71_M0.5010.66
285_P297_V0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qrjA 1 0.8519 100 0.266 Contact Map
1x13A 2 0.9286 100 0.41 Contact Map
3p2yA 2 0.8836 100 0.483 Contact Map
4dioA 2 0.9021 100 0.535 Contact Map
2eezA 5 0.9021 100 0.562 Contact Map
1l7dA 2 0.918 100 0.565 Contact Map
1pjcA 5 0.9497 100 0.59 Contact Map
4lmpA 5 0.9735 100 0.598 Contact Map
4izhA 2 0.9259 100 0.603 Contact Map
3ce6A 4 0.8968 100 0.723 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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