GREMLIN Database
COTZ - Spore coat protein Z
UniProt: Q08312 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (138)
Sequences: 136 (100)
Seq/√Len: 8.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_R86_S9.1531.00
48_F134_I3.7230.97
52_T55_S3.3670.94
47_P137_L2.9760.89
81_E91_S2.7490.84
13_V134_I2.7110.84
46_V139_P2.5540.80
27_C31_C2.3180.72
91_S121_N2.2590.70
17_E21_N2.2510.70
83_V88_A2.2410.70
13_V48_F2.1270.65
80_V88_A2.1230.65
84_H88_A1.7990.52
13_V55_S1.7890.52
80_V83_V1.7570.50
60_A78_F1.7520.50
47_P62_G1.7400.49
47_P117_L1.6990.48
62_G92_L1.6690.46
36_L82_R1.6200.44
21_N25_E1.6180.44
57_P61_F1.6050.44
117_L137_L1.6040.44
92_L139_P1.6020.44
46_V92_L1.5880.43
46_V91_S1.5130.40
59_V76_V1.5110.40
78_F90_L1.4910.39
91_S139_P1.4750.38
54_K57_P1.4460.37
81_E121_N1.4260.36
9_V133_A1.4240.36
75_T92_L1.3950.35
34_K139_P1.3840.35
44_D80_V1.3550.34
91_S122_Y1.3520.34
19_L91_S1.3480.33
74_N134_I1.3300.33
46_V62_G1.3260.33
31_C136_C1.3100.32
23_V30_G1.2970.32
15_N19_L1.2760.31
49_A57_P1.2600.30
95_A138_N1.2590.30
13_V52_T1.2470.30
30_G92_L1.2020.28
12_A91_S1.1930.28
62_G139_P1.1570.27
58_L123_C1.1530.27
49_A137_L1.1460.26
90_L126_V1.1420.26
117_L126_V1.0910.25
25_E40_H1.0740.24
16_I20_Q1.0410.23
36_L117_L1.0260.23
51_F124_I1.0240.23
49_A59_V1.0240.23
15_N75_T1.0240.23
46_V81_E1.0230.23
78_F126_V1.0180.22
71_P129_D1.0000.22
14_E18_D0.9990.22
5_T56_T0.9970.22
48_F72_C0.9900.22
16_I124_I0.9740.21
55_S91_S0.9700.21
36_L81_E0.9600.21
47_P92_L0.9500.20
11_E71_P0.9490.20
88_A131_F0.9460.20
31_C87_C0.9450.20
23_V46_V0.9440.20
7_S94_I0.9400.20
51_F120_T0.9140.19
47_P84_H0.9100.19
8_C16_I0.9100.19
35_L78_F0.8860.19
16_I58_L0.8830.19
10_R13_V0.8710.18
40_H43_G0.8670.18
55_S81_E0.8670.18
12_A125_E0.8590.18
79_R119_K0.8590.18
121_N135_N0.8530.18
48_F55_S0.8500.18
12_A133_A0.8410.18
52_T122_Y0.8390.18
26_D82_R0.8370.17
30_G70_G0.8330.17
75_T81_E0.8270.17
96_F100_K0.8150.17
19_L60_A0.8150.17
22_A134_I0.8140.17
75_T113_E0.8100.17
97_D100_K0.8090.17
37_S124_I0.8000.17
77_F107_D0.8000.17
7_S14_E0.7970.17
91_S135_N0.7920.16
47_P93_L0.7920.16
77_F134_I0.7910.16
13_V86_S0.7820.16
72_C114_V0.7620.16
9_V135_N0.7540.16
17_E38_V0.7530.16
110_T114_V0.7440.15
125_E141_L0.7430.15
53_S71_P0.7350.15
77_F141_L0.7310.15
18_D41_S0.7290.15
62_G137_L0.7220.15
44_D107_D0.7190.15
9_V117_L0.7170.15
105_F108_K0.7140.15
20_Q45_T0.7140.15
60_A92_L0.7110.15
76_V95_A0.7110.15
92_L137_L0.7040.14
42_L49_A0.6940.14
102_I114_V0.6920.14
8_C136_C0.6910.14
34_K89_T0.6900.14
11_E53_S0.6890.14
12_A89_T0.6890.14
34_K56_T0.6770.14
73_F99_H0.6770.14
11_E21_N0.6750.14
87_C136_C0.6750.14
19_L92_L0.6720.14
87_C132_C0.6670.14
77_F94_I0.6660.14
62_G91_S0.6650.14
17_E83_V0.6570.14
51_F137_L0.6560.13
52_T106_T0.6520.13
52_T91_S0.6510.13
55_S135_N0.6500.13
11_E119_K0.6500.13
95_A114_V0.6490.13
44_D89_T0.6490.13
56_T61_F0.6430.13
26_D36_L0.6390.13
10_R80_V0.6390.13
12_A103_L0.6330.13
9_V49_A0.6320.13
19_L139_P0.6320.13
95_A135_N0.6310.13
91_S138_N0.6290.13
44_D77_F0.6290.13
51_F59_V0.6280.13
57_P142_I0.6220.13
18_D116_R0.6190.13
19_L121_N0.6180.13
94_I104_D0.6180.13
4_K119_K0.6170.13
87_C127_D0.6170.13
44_D76_V0.6160.13
34_K44_D0.6150.13
28_P120_T0.6070.13
4_K101_H0.6040.12
84_H137_L0.5960.12
19_L138_N0.5960.12
26_D113_E0.5930.12
12_A140_R0.5920.12
23_V92_L0.5900.12
8_C87_C0.5900.12
36_L137_L0.5810.12
4_K99_H0.5790.12
73_F77_F0.5770.12
12_A109_D0.5740.12
101_H104_D0.5690.12
27_C30_G0.5690.12
5_T90_L0.5620.12
50_I131_F0.5580.12
38_V42_L0.5570.12
44_D88_A0.5570.12
13_V16_I0.5560.12
14_E98_E0.5550.12
87_C130_C0.5510.12
19_L47_P0.5510.12
62_G121_N0.5490.12
25_E129_D0.5480.11
15_N44_D0.5450.11
18_D80_V0.5390.11
82_R137_L0.5390.11
23_V72_C0.5380.11
117_L141_L0.5360.11
22_A63_N0.5320.11
8_C123_C0.5310.11
7_S89_T0.5300.11
14_E106_T0.5290.11
45_T58_L0.5270.11
54_K89_T0.5250.11
30_G135_N0.5240.11
81_E135_N0.5220.11
56_T96_F0.5170.11
45_T79_R0.5160.11
84_H142_I0.5160.11
49_A117_L0.5150.11
58_L131_F0.5130.11
53_S58_L0.5130.11
8_C20_Q0.5090.11
53_S74_N0.5090.11
32_H36_L0.5020.11
18_D85_G0.5010.11
38_V72_C0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d23B 4 0.3378 4 0.963 Contact Map
1fu9A 1 0.2365 3.2 0.965 Contact Map
1rjuV 1 0.2432 3 0.965 Contact Map
3c5xC 1 0.473 2.4 0.967 Contact Map
1psyA 1 0.3716 2.3 0.967 Contact Map
2l9zA 1 0.2635 2.1 0.968 Contact Map
4b03D 5 0.5608 2 0.968 Contact Map
3ob4A 2 0.3446 1.8 0.969 Contact Map
2lzoA 1 0.1216 1.6 0.97 Contact Map
2v2fA 1 0.1014 1.6 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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