GREMLIN Database
RSMH - Ribosomal RNA small subunit methyltransferase H
UniProt: Q07876 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (303)
Sequences: 4108 (2701)
Seq/√Len: 155.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
215_D218_R4.3601.00
151_F205_V4.2611.00
27_C99_F3.2261.00
35_S48_L2.9461.00
37_Y40_Q2.8881.00
15_G306_I2.7871.00
47_R73_I2.7291.00
279_K308_E2.6501.00
95_D232_K2.6501.00
174_S181_Q2.6481.00
99_F223_A2.6131.00
77_S81_Y2.5631.00
149_R153_K2.3851.00
51_F77_S2.3271.00
138_V142_W2.3021.00
138_V212_A2.2841.00
142_W212_A2.2341.00
31_G106_P2.2251.00
176_I185_L2.2111.00
25_V94_V2.2041.00
236_R308_E2.1631.00
83_K226_Q2.1601.00
55_D129_Q2.1481.00
80_R219_V2.1381.00
278_L307_A2.1321.00
170_A181_Q2.0931.00
120_D180_G2.0361.00
78_N219_V2.0291.00
144_Y165_R2.0291.00
9_L37_Y2.0181.00
53_Q219_V2.0091.00
51_F85_Y1.9921.00
58_L74_L1.9671.00
77_S85_Y1.9621.00
146_D149_R1.9121.00
93_E232_K1.9041.00
166_K189_A1.8921.00
11_E289_S1.8791.00
36_T64_V1.8761.00
103_V108_L1.8381.00
143_R146_D1.8221.00
87_N230_V1.8011.00
53_Q78_N1.7681.00
83_K229_E1.7601.00
228_I278_L1.6991.00
148_V161_K1.6981.00
5_K295_E1.6871.00
291_E295_E1.6791.00
152_F160_S1.6571.00
144_Y148_V1.6321.00
19_K95_D1.5961.00
137_E141_E1.5931.00
49_I91_V1.5621.00
80_R222_E1.5341.00
105_S298_R1.5301.00
117_Y203_K1.5221.00
55_D76_K1.5181.00
94_V97_I1.5171.00
144_Y161_K1.5171.00
42_L46_G1.5041.00
156_E245_L1.4921.00
128_D131_A1.4561.00
105_S109_D1.4471.00
86_L91_V1.4431.00
138_V209_I1.4401.00
76_K130_S1.4381.00
15_G238_S1.4361.00
147_L151_F1.4321.00
166_K169_E1.4271.00
37_Y41_Q1.4201.00
101_L220_F1.4141.00
221_E249_I1.3861.00
63_E66_S1.3821.00
186_I205_V1.3811.00
136_K177_Q1.3751.00
134_S137_E1.3721.00
170_A173_K1.3711.00
185_L189_A1.3671.00
238_S304_L1.3641.00
254_F307_A1.3621.00
8_L286_I1.3611.00
25_V86_L1.3501.00
144_Y168_E1.3451.00
109_D298_R1.3301.00
168_E171_R1.3301.00
82_L230_V1.3301.00
10_R14_D1.3281.00
285_P303_K1.3271.00
152_F161_K1.3231.00
220_F250_C1.3231.00
234_G308_E1.3121.00
228_I257_K1.3091.00
169_E172_M1.3091.00
227_A237_V1.2961.00
133_L141_E1.2761.00
263_L272_E1.2491.00
142_W147_L1.2461.00
153_K221_E1.2391.00
238_S306_I1.2371.00
231_L237_V1.2291.00
148_V152_F1.2271.00
261_P270_I1.2271.00
55_D59_Q1.2251.00
75_I89_Q1.2231.00
258_S280_L1.2171.00
36_T67_D1.2071.00
257_K277_E1.2071.00
184_D187_K1.2021.00
13_V37_Y1.1981.00
76_K128_D1.1911.00
14_D41_Q1.1901.00
261_P272_E1.1871.00
290_Q294_E1.1871.00
50_A72_L1.1711.00
120_D178_T1.1691.00
218_R221_E1.1681.00
75_I85_Y1.1671.00
36_T40_Q1.1661.00
254_F280_L1.1631.00
149_R152_F1.1601.00
263_L270_I1.1571.00
56_T110_T1.1511.00
85_Y88_E1.1491.00
21_D45_K1.1481.00
22_G96_G1.1451.00
12_T238_S1.1351.00
281_I306_I1.1331.00
287_T303_K1.1331.00
133_L142_W1.1201.00
73_I89_Q1.1171.00
81_Y84_E1.1141.00
177_Q181_Q1.1101.00
24_Y96_G1.1090.99
12_T98_L1.1060.99
288_A302_A1.1030.99
23_T49_I1.0980.99
156_E248_R1.0850.99
253_T257_K1.0840.99
56_T106_P1.0810.99
170_A188_D1.0780.99
111_P119_H1.0750.99
170_A176_I1.0670.99
39_L72_L1.0590.99
217_L249_I1.0570.99
165_R169_E1.0470.99
136_K175_P1.0460.99
162_Q189_A1.0440.99
29_L50_A1.0430.99
24_Y38_L1.0410.99
174_S177_Q1.0360.99
122_P136_K1.0340.99
6_T12_T1.0340.99
59_Q62_K1.0310.99
187_K200_H1.0310.99
85_Y89_Q1.0290.99
192_A195_R1.0270.99
139_V176_I1.0220.99
154_Y211_I1.0160.99
140_N171_R1.0160.99
159_F190_I1.0110.99
8_L240_I1.0050.99
180_G184_D1.0020.99
183_V186_I0.9990.99
97_I227_A0.9990.99
21_D43_S0.9970.99
184_D188_D0.9960.99
257_K278_L0.9920.99
170_A185_L0.9920.99
23_T91_V0.9910.99
59_Q63_E0.9910.99
6_T13_V0.9910.99
38_L46_G0.9850.99
55_D130_S0.9740.99
229_E277_E0.9740.99
148_V164_A0.9730.99
195_R198_G0.9690.99
49_I89_Q0.9640.99
31_G60_H0.9630.99
49_I75_I0.9610.99
65_L68_Y0.9550.98
287_T293_L0.9520.98
35_S50_A0.9510.98
183_V202_A0.9500.98
215_D219_V0.9460.98
36_T68_Y0.9450.98
18_I42_L0.9340.98
237_V254_F0.9290.98
199_G203_K0.9250.98
163_I205_V0.9230.98
135_A209_I0.9200.98
159_F191_P0.9140.98
101_L239_V0.9130.98
34_H240_I0.9110.98
60_H106_P0.9090.98
23_T94_V0.9080.98
58_L76_K0.9060.98
144_Y164_A0.9040.98
21_D42_L0.8970.98
24_Y46_G0.8960.98
34_H98_L0.8910.98
25_V51_F0.8900.98
138_V150_I0.8890.98
48_L72_L0.8870.98
262_E274_F0.8800.97
29_L65_L0.8790.97
225_E253_T0.8640.97
148_V160_S0.8640.97
80_R215_D0.8590.97
162_Q191_P0.8570.97
39_L71_Q0.8570.97
293_L299_A0.8560.97
5_K299_A0.8550.97
162_Q166_K0.8520.97
97_I230_V0.8510.97
278_L309_K0.8480.97
132_T137_E0.8460.97
82_L227_A0.8450.97
18_I38_L0.8440.97
106_P110_T0.8410.97
223_A227_A0.8400.97
159_F162_Q0.8390.97
282_T285_P0.8390.97
247_D305_R0.8370.97
176_I181_Q0.8320.96
265_P268_P0.8260.96
133_L138_V0.8260.96
252_T255_K0.8210.96
218_R222_E0.8210.96
166_K188_D0.8200.96
282_T286_I0.8170.96
166_K170_A0.8120.96
192_A196_R0.8100.96
40_Q67_D0.8090.96
35_S38_L0.8080.96
140_N176_I0.8080.96
190_I195_R0.8080.96
157_E163_I0.8060.96
56_T59_Q0.8060.96
142_W146_D0.8050.96
217_L245_L0.8050.96
215_D222_E0.8040.96
297_N300_R0.8020.96
83_K230_V0.8020.96
10_R37_Y0.7990.95
35_S72_L0.7970.95
138_V213_V0.7930.95
53_Q80_R0.7860.95
237_V307_A0.7830.95
228_I253_T0.7800.95
29_L64_V0.7790.95
289_S293_L0.7760.95
82_L97_I0.7760.95
4_H7_V0.7750.95
211_I243_H0.7750.95
16_L96_G0.7740.95
82_L226_Q0.7740.95
222_E226_Q0.7730.95
62_K74_L0.7670.94
29_L32_A0.7670.94
264_P269_V0.7660.94
264_P268_P0.7620.94
224_L253_T0.7610.94
224_L239_V0.7580.94
157_E204_R0.7570.94
263_L271_P0.7520.94
99_F239_V0.7520.94
9_L12_T0.7500.94
12_T240_I0.7490.94
3_Q31_G0.7480.94
38_L48_L0.7460.94
40_Q68_Y0.7440.93
200_H203_K0.7380.93
32_A36_T0.7350.93
228_I307_A0.7330.93
86_L230_V0.7320.93
61_A65_L0.7320.93
56_T129_Q0.7320.93
43_S46_G0.7300.93
138_V147_L0.7270.93
50_A74_L0.7260.93
121_A179_T0.7250.93
288_A293_L0.7240.92
6_T242_F0.7210.92
12_T38_L0.7200.92
180_G183_V0.7180.92
12_T304_L0.7170.92
61_A74_L0.7160.92
170_A174_S0.7150.92
183_V206_F0.7140.92
255_K259_S0.7120.92
261_P273_E0.7070.92
203_K300_R0.7070.92
257_K307_A0.7030.91
133_L137_E0.7020.91
159_F166_K0.7020.91
157_E205_V0.6970.91
151_F163_I0.6940.91
16_L38_L0.6920.91
151_F157_E0.6920.91
122_P134_S0.6900.91
99_F220_F0.6900.91
270_I274_F0.6880.90
29_L61_A0.6860.90
19_K22_G0.6800.90
111_P121_A0.6790.90
8_L12_T0.6770.90
258_S278_L0.6750.90
269_V272_E0.6680.89
18_I46_G0.6680.89
190_I198_G0.6660.89
280_L283_R0.6650.89
60_H63_E0.6640.89
18_I24_Y0.6640.89
11_E286_I0.6630.89
162_Q165_R0.6610.89
150_I212_A0.6600.89
10_R291_E0.6580.88
24_Y42_L0.6580.88
103_V127_M0.6560.88
27_C223_A0.6560.88
55_D128_D0.6550.88
20_P46_G0.6530.88
258_S307_A0.6510.88
270_I273_E0.6500.88
10_R41_Q0.6490.88
29_L74_L0.6470.88
167_I182_L0.6440.87
97_I231_L0.6440.87
58_L72_L0.6360.87
166_K185_L0.6360.87
108_L118_H0.6330.86
25_V82_L0.6320.86
134_S213_V0.6310.86
199_G300_R0.6310.86
144_Y172_M0.6300.86
53_Q127_M0.6290.86
252_T256_E0.6280.86
258_S276_P0.6260.86
209_I213_V0.6250.86
19_K24_Y0.6250.86
15_G304_L0.6210.85
211_I245_L0.6180.85
112_E178_T0.6150.85
51_F75_I0.6150.85
262_E271_P0.6130.85
281_I308_E0.6120.85
147_L212_A0.6070.84
117_Y199_G0.6060.84
233_P309_K0.6050.84
212_A215_D0.6030.84
6_T37_Y0.6020.84
261_P271_P0.6020.84
286_I306_I0.5980.83
145_E161_K0.5980.83
262_E270_I0.5940.83
118_H300_R0.5930.83
240_I302_A0.5890.82
39_L70_G0.5890.82
229_E257_K0.5870.82
170_A184_D0.5860.82
221_E252_T0.5850.82
267_L271_P0.5840.82
139_V209_I0.5840.82
91_V94_V0.5830.82
223_A226_Q0.5820.82
38_L98_L0.5800.81
136_K209_I0.5790.81
98_L240_I0.5780.81
15_G18_I0.5780.81
135_A213_V0.5770.81
263_L273_E0.5760.81
164_A168_E0.5760.81
271_P276_P0.5760.81
81_Y85_Y0.5750.81
291_E294_E0.5720.80
31_G56_T0.5700.80
256_E259_S0.5700.80
29_L36_T0.5690.80
147_L205_V0.5690.80
241_T303_K0.5690.80
3_Q106_P0.5690.80
27_C97_I0.5680.80
169_E173_K0.5670.80
149_R161_K0.5660.80
251_K305_R0.5650.80
255_K258_S0.5640.79
277_E307_A0.5620.79
283_R303_K0.5610.79
15_G281_I0.5610.79
27_C94_V0.5590.79
42_L71_Q0.5590.79
29_L58_L0.5580.79
145_E149_R0.5580.79
187_K195_R0.5570.79
18_I21_D0.5560.79
22_G308_E0.5560.79
149_R160_S0.5550.78
227_A239_V0.5520.78
27_C82_L0.5510.78
243_H301_S0.5500.78
32_A98_L0.5500.78
262_E272_E0.5480.78
225_E256_E0.5480.78
62_K66_S0.5470.77
16_L236_R0.5460.77
161_K165_R0.5440.77
139_V167_I0.5430.77
49_I86_L0.5420.77
139_V179_T0.5410.77
181_Q185_L0.5410.77
23_T47_R0.5400.76
36_T65_L0.5390.76
14_D238_S0.5390.76
60_H64_V0.5390.76
220_F224_L0.5380.76
61_A64_V0.5380.76
272_E275_E0.5340.76
139_V142_W0.5320.75
183_V200_H0.5310.75
225_E257_K0.5300.75
97_I223_A0.5300.75
122_P179_T0.5290.75
86_L94_V0.5260.75
35_S98_L0.5250.74
129_Q134_S0.5240.74
171_R175_P0.5240.74
202_A205_V0.5240.74
53_Q128_D0.5180.74
10_R289_S0.5170.73
190_I205_V0.5170.73
99_F227_A0.5160.73
155_G245_L0.5150.73
57_A127_M0.5150.73
10_R295_E0.5150.73
224_L250_C0.5140.73
3_Q110_T0.5140.73
42_L45_K0.5130.73
285_P288_A0.5130.73
15_G286_I0.5110.73
181_Q184_D0.5110.73
159_F163_I0.5100.72
223_A228_I0.5100.72
17_N308_E0.5100.72
61_A68_Y0.5090.72
247_D251_K0.5070.72
151_F209_I0.5060.72
255_K280_L0.5050.72
49_I94_V0.5040.71
240_I288_A0.5040.71
84_E88_E0.5030.71
228_I309_K0.5030.71
146_D212_A0.5020.71
153_K160_S0.5000.71
18_I95_D0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tkaA 2 0.9035 100 0.209 Contact Map
1wg8A 1 0.9003 100 0.243 Contact Map
1m6yA 1 0.926 100 0.287 Contact Map
3eeyA 3 0.5949 99.1 0.9 Contact Map
1sqgA 1 0.6367 99 0.903 Contact Map
4ponA 2 0.5402 98.9 0.906 Contact Map
2yxlA 1 0.6495 98.9 0.908 Contact Map
1o54A 4 0.5659 98.8 0.909 Contact Map
1jsxA 1 0.4952 98.8 0.909 Contact Map
2avdA 2 0.5305 98.8 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0205 seconds.