GREMLIN Database
YXXF - Uncharacterized transporter YxxF
UniProt: Q07835 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (275)
Sequences: 38645 (28322)
Seq/√Len: 1707.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_S165_A3.2661.00
18_K239_D2.8111.00
103_I162_I2.7611.00
239_D243_F2.6591.00
264_D270_F2.6531.00
45_F203_I2.5071.00
94_K164_W2.4501.00
52_T196_G2.4411.00
91_F167_L2.3221.00
134_S286_G2.3201.00
32_F224_S2.2531.00
239_D242_R2.2371.00
114_L169_A2.2031.00
125_E180_K2.1691.00
118_L177_L2.0911.00
71_S74_D2.0751.00
91_F164_W2.0341.00
105_I260_A2.0151.00
34_E270_F1.9911.00
50_C226_G1.9781.00
19_M240_S1.9561.00
27_G259_V1.9401.00
120_S127_L1.9301.00
216_Q220_I1.9221.00
87_F171_F1.8881.00
49_L199_V1.8661.00
33_S93_F1.8581.00
163_I167_L1.8481.00
116_L135_I1.8471.00
99_T162_I1.8091.00
56_G192_F1.7991.00
110_L114_L1.7751.00
115_V250_S1.7461.00
57_F60_L1.7381.00
119_G125_E1.7341.00
99_T161_G1.7101.00
128_N131_S1.7081.00
226_G231_G1.6861.00
200_I204_P1.6841.00
27_G263_L1.6491.00
98_E160_S1.6381.00
91_F171_F1.6121.00
288_A292_V1.6031.00
52_T199_V1.5951.00
215_S218_N1.5881.00
138_C254_F1.5811.00
245_S248_F1.5771.00
186_S189_T1.5701.00
28_S224_S1.5511.00
204_P207_H1.5291.00
24_V259_V1.5281.00
114_L173_A1.5231.00
74_D184_N1.5121.00
45_F199_V1.5021.00
14_T243_F1.4811.00
273_D276_Q1.4771.00
134_S290_T1.4731.00
58_C62_S1.4421.00
76_L80_A1.4301.00
104_A165_A1.4291.00
118_L122_F1.4261.00
274_L278_L1.4211.00
25_I228_I1.3961.00
77_Q178_L1.3891.00
56_G60_L1.3821.00
114_L170_L1.3721.00
72_K76_L1.3541.00
99_T103_I1.3521.00
159_G162_I1.3521.00
94_K98_E1.3511.00
36_T43_L1.3351.00
101_V264_D1.3251.00
179_G238_F1.3251.00
35_H221_M1.3221.00
119_G123_Y1.3221.00
277_T281_V1.3211.00
138_C286_G1.3111.00
144_L282_M1.3001.00
22_S240_S1.2981.00
38_L218_N1.2951.00
26_F233_V1.2941.00
129_V133_S1.2931.00
80_A178_L1.2791.00
263_L267_F1.2761.00
100_S103_I1.2751.00
94_K97_E1.2721.00
134_S289_L1.2691.00
73_R77_Q1.2671.00
57_F61_A1.2671.00
73_R76_L1.2661.00
54_F231_G1.2651.00
102_T261_I1.2501.00
18_K236_L1.2461.00
281_V285_A1.2411.00
98_E164_W1.2401.00
84_F174_F1.2391.00
79_L197_L1.2371.00
259_V263_L1.2311.00
144_L275_Y1.2301.00
132_V136_I1.2271.00
51_A195_T1.2211.00
43_L225_T1.2181.00
141_G279_G1.2141.00
53_L57_F1.2131.00
31_F263_L1.2111.00
136_I140_L1.2061.00
255_L259_V1.2011.00
106_S280_I1.1981.00
173_A177_L1.1951.00
130_I289_L1.1951.00
211_F214_L1.1941.00
159_G163_I1.1921.00
201_I204_P1.1891.00
82_G197_L1.1871.00
272_P277_T1.1791.00
37_N218_N1.1781.00
217_G220_I1.1751.00
216_Q219_W1.1711.00
45_F49_L1.1511.00
118_L174_F1.1441.00
17_I21_I1.1431.00
72_K75_V1.1401.00
16_V252_I1.1311.00
180_K245_S1.1291.00
220_I224_S1.1251.00
217_G221_M1.1241.00
52_T192_F1.1131.00
86_V201_I1.1121.00
115_V246_T1.1081.00
145_I279_G1.1061.00
83_F201_I1.0961.00
45_F206_I1.0921.00
41_F205_F1.0901.00
160_S164_W1.0891.00
22_S26_F1.0851.00
118_L173_A1.0751.00
32_F221_M1.0731.00
96_F104_A1.0651.00
98_E158_M1.0641.00
123_Y177_L1.0631.00
127_L132_V1.0541.00
22_S236_L1.0521.00
141_G283_I1.0501.00
47_R230_T1.0481.00
86_V202_L1.0461.00
15_A243_F1.0411.00
107_V169_A1.0371.00
120_S126_K1.0331.00
60_L64_Q1.0321.00
101_V268_T1.0311.00
241_L249_I1.0301.00
118_L170_L1.0271.00
77_Q81_C1.0261.00
180_K246_T1.0191.00
98_E161_G1.0191.00
130_I293_R1.0151.00
64_Q186_S1.0141.00
39_P42_E1.0081.00
116_L127_L1.0041.00
33_S96_F1.0021.00
21_I236_L1.0001.00
205_F209_G0.9981.00
84_F171_F0.9981.00
44_V93_F0.9961.00
36_T218_N0.9951.00
115_V176_T0.9951.00
110_L142_T0.9921.00
160_S163_I0.9921.00
15_A240_S0.9901.00
129_V132_V0.9891.00
223_V226_G0.9861.00
130_I292_V0.9831.00
99_T165_A0.9811.00
25_I236_L0.9781.00
28_S263_L0.9761.00
26_F237_F0.9721.00
74_D185_L0.9661.00
220_I223_V0.9631.00
60_L63_G0.9591.00
125_E131_S0.9551.00
121_F124_R0.9541.00
77_Q182_I0.9521.00
37_N215_S0.9481.00
41_F90_V0.9471.00
161_G165_A0.9441.00
36_T221_M0.9421.00
147_G273_D0.9421.00
118_L121_F0.9371.00
274_L277_T0.9361.00
40_S44_V0.9341.00
106_S143_A0.9261.00
143_A147_G0.9231.00
23_M27_G0.9231.00
213_D216_Q0.9191.00
140_L144_L0.9111.00
84_F178_L0.9061.00
219_W223_V0.9041.00
137_I286_G0.9031.00
241_L245_S0.9011.00
92_L96_F0.8971.00
77_Q181_G0.8961.00
48_C198_G0.8941.00
169_A173_A0.8931.00
245_S249_I0.8921.00
31_F267_F0.8911.00
128_N132_V0.8871.00
205_F208_F0.8831.00
115_V173_A0.8821.00
204_P208_F0.8821.00
107_V165_A0.8761.00
42_E206_I0.8761.00
101_V270_F0.8751.00
85_L175_T0.8741.00
76_L79_L0.8611.00
126_K130_I0.8601.00
107_V162_I0.8601.00
54_F57_F0.8481.00
23_M259_V0.8411.00
244_L249_I0.8331.00
49_L203_I0.8331.00
244_L248_F0.8291.00
126_K129_V0.8171.00
59_W63_G0.8171.00
90_V94_K0.8091.00
20_V259_V0.8081.00
133_S137_I0.8061.00
54_F227_I0.8041.00
258_A280_I0.8031.00
174_F178_L0.8021.00
81_C84_F0.8021.00
275_Y278_L0.8011.00
261_I272_P0.8001.00
31_F264_D0.7971.00
265_T272_P0.7971.00
158_M162_I0.7971.00
113_V138_C0.7921.00
142_T146_S0.7821.00
240_S249_I0.7811.00
140_L282_M0.7781.00
196_G200_I0.7771.00
156_Q159_G0.7721.00
62_S186_S0.7711.00
215_S219_W0.7701.00
56_G196_G0.7701.00
207_H210_A0.7701.00
222_V226_G0.7701.00
61_A64_Q0.7661.00
255_L258_A0.7641.00
52_T56_G0.7641.00
86_V90_V0.7631.00
165_A169_A0.7611.00
144_L278_L0.7601.00
75_V197_L0.7581.00
261_I280_I0.7571.00
23_M255_L0.7561.00
44_V202_L0.7521.00
114_L166_V0.7501.00
278_L282_M0.7501.00
286_G290_T0.7501.00
228_I232_I0.7491.00
95_S104_A0.7441.00
181_G184_N0.7431.00
185_L190_T0.7421.00
59_W192_F0.7401.00
280_I284_F0.7401.00
88_N171_F0.7361.00
19_M252_I0.7361.00
196_G199_V0.7361.00
199_V203_I0.7321.00
197_L201_I0.7301.00
192_F196_G0.7291.00
172_Y176_T0.7291.00
58_C188_Y0.7271.00
78_T185_L0.7251.00
107_V166_V0.7241.00
117_L121_F0.7221.00
285_A289_L0.7221.00
78_T190_T0.7201.00
31_F101_V0.7191.00
214_L219_W0.7181.00
85_L234_Y0.7181.00
46_V50_C0.7171.00
87_F91_F0.7111.00
14_T18_K0.7081.00
115_V177_L0.6921.00
127_L131_S0.6921.00
75_V79_L0.6911.00
223_V227_I0.6901.00
141_G286_G0.6881.00
21_I25_I0.6851.00
49_L53_L0.6811.00
110_L113_V0.6781.00
221_M224_S0.6741.00
232_I236_L0.6721.00
54_F226_G0.6711.00
30_G92_L0.6681.00
42_E46_V0.6661.00
16_V248_F0.6661.00
125_E247_K0.6651.00
82_G86_V0.6621.00
109_H112_P0.6601.00
193_L197_L0.6591.00
265_T271_R0.6561.00
120_S124_R0.6561.00
99_T104_A0.6551.00
19_M244_L0.6541.00
137_I289_L0.6541.00
116_L131_S0.6531.00
224_S228_I0.6481.00
197_L200_I0.6481.00
95_S161_G0.6411.00
112_P254_F0.6411.00
25_I233_V0.6401.00
172_Y237_F0.6401.00
189_T193_L0.6401.00
272_P276_Q0.6371.00
88_N175_T0.6351.00
191_T238_F0.6311.00
29_I229_H0.6261.00
251_I290_T0.6231.00
198_G202_L0.6231.00
35_H268_T0.6231.00
200_I203_I0.6211.00
214_L218_N0.6201.00
30_G105_I0.6201.00
55_L231_G0.6191.00
235_L239_D0.6161.00
263_L266_V0.6121.00
92_L168_A0.6111.00
50_C54_F0.6101.00
276_Q280_I0.6101.00
157_L160_S0.6081.00
164_W167_L0.6071.00
271_R275_Y0.6071.00
85_L194_Q0.6071.00
123_Y180_K0.5971.00
215_S220_I0.5951.00
110_L169_A0.5941.00
86_V205_F0.5941.00
264_D268_T0.5921.00
122_F174_F0.5901.00
71_S75_V0.5891.00
25_I229_H0.5881.00
15_A18_K0.5871.00
75_V193_L0.5871.00
262_V266_V0.5851.00
30_G34_E0.5841.00
58_C61_A0.5801.00
109_H142_T0.5791.00
77_Q80_A0.5791.00
25_I232_I0.5781.00
119_G247_K0.5771.00
91_F168_A0.5761.00
261_I265_T0.5741.00
85_L198_G0.5741.00
175_T238_F0.5731.00
116_L120_S0.5731.00
23_M256_D0.5721.00
92_L104_A0.5691.00
193_L196_G0.5691.00
123_Y181_G0.5651.00
53_L56_G0.5631.00
284_F288_A0.5621.00
31_F260_A0.5571.00
41_F202_L0.5551.00
74_D78_T0.5541.00
212_A216_Q0.5541.00
180_K183_H0.5511.00
38_L42_E0.5501.00
117_L135_I0.5491.00
51_A231_G0.5461.00
106_S145_I0.5461.00
79_L83_F0.5441.00
273_D277_T0.5441.00
146_S162_I0.5431.00
93_F97_E0.5431.00
131_S245_S0.5431.00
46_V222_V0.5421.00
70_W74_D0.5421.00
191_T194_Q0.5411.00
170_L174_F0.5411.00
176_T237_F0.5391.00
262_V265_T0.5361.00
212_A215_S0.5341.00
128_N293_R0.5331.00
277_T280_I0.5331.00
179_G241_L0.5311.00
82_G201_I0.5301.00
254_F287_M0.5291.00
218_N221_M0.5271.00
106_S146_S0.5271.00
162_I166_V0.5261.00
144_L276_Q0.5261.00
44_V90_V0.5251.00
68_E71_S0.5191.00
14_T17_I0.5191.00
29_I93_F0.5181.00
85_L89_W0.5181.00
69_K72_K0.5161.00
224_S227_I0.5141.00
109_H169_A0.5141.00
88_N92_L0.5131.00
148_I275_Y0.5111.00
266_V269_G0.5101.00
236_L239_D0.5101.00
187_P191_T0.5091.00
15_A244_L0.5091.00
240_S244_L0.5081.00
176_T250_S0.5071.00
206_I210_A0.5061.00
271_R276_Q0.5031.00
253_V256_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2476 99 0.754 Contact Map
3b5dA 2 0.3248 98.3 0.806 Contact Map
4he8J 1 0.4952 85.2 0.902 Contact Map
4tphA 2 0.8875 81.2 0.907 Contact Map
1pw4A 1 0.8714 73 0.913 Contact Map
4j05A 3 0.9453 72.1 0.914 Contact Map
2cfqA 1 0.5949 67.1 0.917 Contact Map
3wdoA 1 0.8521 58.7 0.921 Contact Map
4pypA 1 0.9068 36.8 0.931 Contact Map
3l1lA 2 0.8553 36.6 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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