GREMLIN Database
ANSR - HTH-type transcriptional regulator AnsR
UniProt: Q07683 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 116 (107)
Sequences: 1355 (1208)
Seq/√Len: 116.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_T31_Y3.3371.00
18_Q22_D2.9261.00
18_Q28_K2.9151.00
51_D63_R2.6721.00
2_N6_L2.6491.00
15_W52_L2.6131.00
10_R35_E2.2431.00
3_L37_G2.2101.00
23_L52_L2.1221.00
27_A30_T2.0691.00
29_S33_G2.0551.00
12_K67_K2.0481.00
26_I31_Y2.0301.00
9_L53_F2.0021.00
57_C61_L1.9341.00
20_T53_F1.7841.00
33_G38_Y1.7831.00
94_S97_E1.7621.00
40_R43_L1.7601.00
100_Q107_T1.6711.00
104_F107_T1.6541.00
33_G39_R1.6311.00
29_S32_A1.6201.00
50_A63_R1.4251.00
58_D63_R1.4231.00
104_F108_K1.4141.00
30_T33_G1.3991.00
93_L98_I1.3851.00
64_E67_K1.3691.00
28_K32_A1.3691.00
27_A33_G1.3681.00
5_R59_E1.3601.00
101_L105_I1.3581.00
20_T49_L1.2971.00
6_L31_Y1.2911.00
43_L46_L1.2620.99
34_Y45_A1.2390.99
19_Y22_D1.2170.99
100_Q104_F1.1880.99
97_E100_Q1.1770.99
42_S45_A1.1660.99
4_D37_G1.1460.99
87_S90_G1.1440.99
34_Y41_P1.1120.99
100_Q108_K1.0990.98
5_R63_R1.0980.98
103_T107_T1.0930.98
17_L28_K1.0860.98
33_G36_S1.0810.98
2_N43_L1.0600.98
32_A36_S1.0460.98
90_G93_L1.0420.98
46_L61_L1.0390.98
101_L108_K1.0260.98
15_W23_L1.0130.97
24_L49_L1.0100.97
17_L31_Y1.0010.97
40_R45_A0.9930.97
34_Y39_R0.9800.97
26_I30_T0.9710.97
55_T59_E0.9710.97
45_A48_M0.9480.96
97_E104_F0.9470.96
102_I106_R0.9310.96
5_R65_K0.9250.95
19_Y23_L0.9240.95
2_N60_L0.9080.95
28_K36_S0.9060.95
75_E78_T0.9050.95
17_L21_A0.8730.94
46_L57_C0.8730.94
6_L53_F0.8700.94
5_R62_G0.8670.94
21_A31_Y0.8260.92
32_A41_P0.8150.91
16_S19_Y0.8040.91
27_A32_A0.8040.91
93_L105_I0.8030.91
5_R8_E0.7920.90
15_W19_Y0.7750.89
85_T88_V0.7600.88
94_S100_Q0.7600.88
28_K38_Y0.7550.88
30_T34_Y0.7550.88
28_K33_G0.7330.86
41_P58_D0.7220.86
85_T90_G0.7200.85
24_L53_F0.7190.85
91_Q98_I0.7130.85
87_S105_I0.7110.85
2_N53_F0.7060.84
82_L91_Q0.7030.84
46_L58_D0.7020.84
50_A57_C0.7020.84
31_Y34_Y0.6950.83
91_Q94_S0.6930.83
21_A29_S0.6910.83
34_Y42_S0.6830.82
88_V100_Q0.6790.82
8_E12_K0.6740.81
66_Q69_T0.6710.81
84_F88_V0.6700.81
32_A42_S0.6690.81
2_N46_L0.6630.80
80_S84_F0.6560.80
95_E99_I0.6510.79
29_S39_R0.6510.79
26_I34_Y0.6510.79
41_P45_A0.6490.79
105_I108_K0.6490.79
83_D89_D0.6440.78
13_K23_L0.6420.78
25_G48_M0.6390.78
28_K31_Y0.6380.78
26_I29_S0.6380.78
76_L97_E0.6370.78
9_L55_T0.6320.77
21_A28_K0.6280.77
92_P107_T0.6180.76
97_E108_K0.6130.75
81_S84_F0.6130.75
39_R42_S0.6090.75
100_Q103_T0.6080.74
34_Y43_L0.6050.74
15_W20_T0.6010.74
2_N41_P0.6000.73
20_T52_L0.5990.73
21_A33_G0.5980.73
77_A106_R0.5940.73
79_W88_V0.5920.72
90_G96_D0.5910.72
39_R43_L0.5900.72
88_V93_L0.5770.71
9_L12_K0.5760.70
48_M51_D0.5760.70
82_L105_I0.5740.70
64_E69_T0.5630.69
94_S98_I0.5620.69
52_L55_T0.5540.67
86_I89_D0.5440.66
20_T23_L0.5370.65
7_T11_K0.5360.65
102_I105_I0.5350.65
7_T10_R0.5340.65
29_S38_Y0.5310.64
85_T93_L0.5290.64
101_L106_R0.5280.64
81_S91_Q0.5270.64
28_K42_S0.5240.63
43_L47_A0.5210.63
103_T108_K0.5200.63
20_T24_L0.5190.62
9_L52_L0.5130.62
32_A39_R0.5120.61
4_D8_E0.5060.61
29_S36_S0.5050.60
7_T28_K0.5040.60
17_L33_G0.5020.60
6_L20_T0.5000.60
99_I103_T0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ndwA 2 0.9914 99.8 0.368 Contact Map
4o8bA 2 0.8362 99.8 0.378 Contact Map
3r1fA 2 0.9914 99.8 0.384 Contact Map
1b0nA 2 0.8793 99.8 0.386 Contact Map
3qwgA 2 0.6897 99.8 0.392 Contact Map
4jcyA 2 0.7586 99.7 0.402 Contact Map
3op9A 4 0.8966 99.7 0.409 Contact Map
3ivpA 2 0.9138 99.7 0.426 Contact Map
2p5tA 2 0.3707 99.7 0.434 Contact Map
2ebyA 2 0.8448 99.6 0.449 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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