GREMLIN Database
NRGA - Ammonium transporter NrgA
UniProt: Q07429 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 404 (388)
Sequences: 5444 (2904)
Seq/√Len: 147.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_V363_F4.6681.00
18_L202_L4.5231.00
371_K374_S4.0421.00
319_W323_A3.5951.00
266_A286_G3.3641.00
239_G284_I3.3431.00
175_L370_I3.2611.00
274_V282_I3.2261.00
57_F134_S3.1891.00
293_G315_I2.8961.00
382_T385_E2.8501.00
149_W357_A2.7991.00
322_I352_I2.7281.00
200_G257_V2.6511.00
326_L341_F2.6351.00
96_L223_M2.6291.00
48_A237_I2.5941.00
318_T355_I2.5611.00
349_W353_V2.5181.00
371_K375_L2.4811.00
208_F230_N2.4221.00
245_W251_P2.4021.00
155_A354_A2.3081.00
289_V319_W2.2951.00
212_V226_F2.2681.00
367_F371_K2.2671.00
78_L98_M2.2411.00
290_C316_G2.2301.00
143_W149_W2.2211.00
13_A99_M2.1991.00
285_I319_W2.1671.00
237_I260_A2.0831.00
156_L272_G2.0241.00
224_Y228_N2.0241.00
235_A280_I2.0141.00
267_I274_V1.9821.00
140_V358_T1.9551.00
51_S102_M1.9521.00
178_V367_F1.9441.00
5_D91_T1.9241.00
140_V167_S1.9121.00
56_L77_G1.9061.00
381_A390_L1.9021.00
127_L377_L1.8901.00
136_V365_V1.8901.00
50_V133_A1.8891.00
12_C213_G1.8761.00
162_N321_G1.8721.00
237_I256_A1.8721.00
352_I356_A1.8701.00
116_F120_M1.8651.00
53_V130_V1.7881.00
43_S113_S1.7741.00
61_L70_I1.7701.00
266_A282_I1.7321.00
109_T129_S1.7191.00
121_R378_P1.7111.00
323_A326_L1.6941.00
197_F253_M1.6871.00
30_M254_L1.6771.00
63_F97_F1.6671.00
346_S350_K1.6631.00
62_A141_A1.6471.00
55_V231_T1.6371.00
361_F365_V1.6351.00
45_S126_L1.6261.00
52_I280_I1.6171.00
171_A362_V1.6161.00
124_A373_V1.6001.00
153_L353_V1.5811.00
51_S230_N1.5791.00
243_V288_A1.5781.00
53_V138_T1.5631.00
8_F11_F1.5421.00
345_A349_W1.5311.00
98_M227_I1.5291.00
59_Y94_H1.5101.00
143_W357_A1.4991.00
75_W94_H1.4921.00
196_T257_V1.4891.00
169_G314_G1.4821.00
153_L350_K1.4811.00
339_G342_Y1.4811.00
171_A366_T1.4721.00
166_I170_V1.4701.00
322_I348_I1.4691.00
170_V363_F1.4671.00
231_T280_I1.4621.00
297_L301_F1.4461.00
349_W352_I1.4431.00
385_E393_T1.4101.00
4_G7_V1.4071.00
373_V377_L1.4071.00
41_M256_A1.4011.00
293_G311_G1.3951.00
51_S234_A1.3931.00
353_V357_A1.3891.00
127_L373_V1.3851.00
350_K353_V1.3541.00
111_I309_A1.3541.00
17_W205_F1.3521.00
156_L273_F1.3511.00
193_L254_L1.3481.00
17_W47_I1.3441.00
144_V163_V1.3401.00
53_V134_S1.3231.00
319_W326_L1.3231.00
373_V376_F1.3181.00
296_S300_K1.3171.00
374_S378_P1.3081.00
116_F175_L1.2941.00
383_E387_S1.2941.00
53_V57_F1.2911.00
288_A292_W1.2891.00
170_V359_Y1.2861.00
5_D219_D1.2841.00
49_I126_L1.2821.00
131_L369_I1.2791.00
6_T93_P1.2781.00
6_T96_L1.2751.00
120_M379_L1.2711.00
191_H400_Y1.2661.00
150_I354_A1.2621.00
162_N358_T1.2511.00
243_V292_W1.2411.00
178_V371_K1.2411.00
46_S125_F1.2411.00
215_A222_A1.2381.00
55_V280_I1.2331.00
49_I130_V1.2331.00
388_L393_T1.2281.00
52_I235_A1.2231.00
52_I238_A1.2201.00
38_S42_H1.2181.00
215_A219_D1.2151.00
9_M92_I1.2001.00
176_A303_Y1.1931.00
261_I312_L1.1911.00
8_F12_C1.1901.00
115_A172_G1.1861.00
353_V356_A1.1851.00
204_W260_A1.1831.00
348_I352_I1.1781.00
47_I106_V1.1731.00
224_Y276_P1.1651.00
325_G348_I1.1561.00
340_L343_G1.1511.00
170_V174_V1.1481.00
192_N195_Y1.1411.00
99_M226_F1.1391.00
28_G36_V1.1320.99
167_S362_V1.1310.99
146_G151_G1.1300.99
322_I355_I1.1250.99
166_I359_Y1.1240.99
53_V133_A1.1240.99
166_I355_I1.1230.99
277_F281_I1.1220.99
275_T329_T1.1220.99
9_M96_L1.1200.99
121_R124_A1.1110.99
13_A96_L1.1060.99
63_F101_Q1.1020.99
35_N390_L1.1020.99
321_G355_I1.1010.99
14_L205_F1.1000.99
318_T359_Y1.0960.99
385_E394_M1.0960.99
126_L130_V1.0850.99
314_G359_Y1.0740.99
144_V358_T1.0710.99
134_S138_T1.0650.99
38_S395_H1.0650.99
17_W103_T1.0640.99
165_H168_S1.0630.99
282_I323_A1.0620.99
20_T106_V1.0580.99
133_A138_T1.0540.99
77_G277_F1.0530.99
166_I318_T1.0500.99
360_V364_I1.0500.99
7_V11_F1.0500.99
42_H113_S1.0490.99
293_G297_L1.0410.99
30_M196_T1.0390.99
383_E386_E1.0330.99
341_F344_D1.0300.99
303_Y311_G1.0290.99
177_I303_Y1.0260.99
359_Y363_F1.0250.99
368_V372_I1.0220.99
32_K118_E1.0180.99
285_I289_V1.0180.99
231_T276_P1.0170.99
235_A284_I1.0150.99
275_T278_A1.0130.99
162_N166_I1.0110.99
173_L303_Y1.0100.99
230_N233_A1.0090.99
284_I288_A1.0070.99
384_E388_L0.9980.99
245_W249_K0.9940.99
21_P198_L0.9930.99
154_G350_K0.9910.99
97_F216_L0.9850.99
120_M179_L0.9820.99
233_A236_G0.9810.98
330_T342_Y0.9810.98
346_S349_W0.9810.98
124_A377_L0.9770.98
298_K311_G0.9730.98
236_G259_G0.9730.98
140_V361_F0.9660.98
155_A321_G0.9620.98
365_V369_I0.9620.98
9_M216_L0.9620.98
281_I285_I0.9610.98
373_V378_P0.9570.98
95_S224_Y0.9560.98
239_G287_G0.9550.98
215_A221_V0.9550.98
310_F314_G0.9500.98
36_V191_H0.9480.98
262_A316_G0.9440.98
39_T117_A0.9440.98
369_I373_V0.9430.98
380_R386_E0.9370.98
372_I375_L0.9350.98
178_V374_S0.9340.98
326_L348_I0.9330.98
364_I368_V0.9320.98
370_I379_L0.9250.98
204_W230_N0.9210.98
239_G288_A0.9200.98
238_A242_L0.9190.98
64_A72_G0.9180.98
325_G351_Q0.9160.98
174_V178_V0.9120.98
14_L226_F0.9120.98
174_V367_F0.9110.98
102_M230_N0.9060.97
45_S241_I0.9050.97
294_V311_G0.9030.97
36_V399_A0.9010.97
258_S312_L0.9010.97
347_L350_K0.9000.97
363_F367_F0.8990.97
15_L209_G0.8970.97
161_G269_P0.8940.97
149_W353_V0.8920.97
207_W268_T0.8910.97
339_G343_G0.8900.97
52_I56_L0.8890.97
113_S125_F0.8870.97
18_L205_F0.8830.97
197_F257_V0.8800.97
285_I323_A0.8790.97
367_F374_S0.8780.97
95_S227_I0.8780.97
95_S223_M0.8710.97
235_A239_G0.8710.97
46_S129_S0.8710.97
4_G218_L0.8680.97
211_N268_T0.8650.97
140_V362_V0.8650.97
135_L365_V0.8590.97
262_A312_L0.8580.96
228_N271_A0.8570.96
32_K188_S0.8560.96
225_A271_A0.8550.96
25_L198_L0.8530.96
373_V379_L0.8520.96
170_V314_G0.8510.96
65_P74_E0.8460.96
87_D90_D0.8460.96
39_T43_S0.8430.96
323_A327_F0.8410.96
282_I327_F0.8410.96
369_I372_I0.8380.96
147_G152_Q0.8360.96
278_A281_I0.8360.96
274_V327_F0.8360.96
318_T322_I0.8360.96
177_I363_F0.8360.96
232_A267_I0.8350.96
75_W81_V0.8340.96
35_N118_E0.8290.96
241_I251_P0.8290.96
195_Y198_L0.8270.96
140_V143_W0.8260.96
352_I355_I0.8210.96
92_I216_L0.8180.95
270_A274_V0.8180.95
273_F328_A0.8180.95
101_Q214_S0.8170.95
236_G239_G0.8150.95
243_V287_G0.8150.95
7_V218_L0.8150.95
356_A360_V0.8120.95
149_W153_L0.8090.95
193_L253_M0.8080.95
239_G243_V0.7970.95
36_V40_A0.7960.95
252_T397_E0.7940.95
131_L135_L0.7940.95
61_L138_T0.7930.95
20_T43_S0.7910.95
147_G151_G0.7860.94
167_S171_A0.7860.94
374_S377_L0.7820.94
31_V307_L0.7790.94
25_L194_I0.7770.94
385_E388_L0.7770.94
348_I355_I0.7760.94
9_M13_A0.7680.94
119_R304_D0.7680.94
258_S287_G0.7660.94
93_P96_L0.7640.93
162_N265_V0.7620.93
266_A323_A0.7610.93
242_L246_I0.7570.93
130_V134_S0.7570.93
174_V177_I0.7560.93
345_A352_I0.7550.93
51_S260_A0.7550.93
270_A282_I0.7520.93
57_F138_T0.7520.93
368_V371_K0.7490.93
41_M122_F0.7490.93
243_V291_F0.7480.93
123_G127_L0.7460.93
296_S299_K0.7450.93
6_T92_I0.7430.92
267_I282_I0.7430.92
37_L253_M0.7380.92
46_S113_S0.7350.92
25_L195_Y0.7340.92
170_V318_T0.7320.92
266_A319_W0.7320.92
114_G305_D0.7320.92
17_W106_V0.7280.92
54_W141_A0.7220.91
294_V308_D0.7200.91
162_N355_I0.7180.91
366_T370_I0.7180.91
142_H146_G0.7120.91
40_A197_F0.7120.91
107_L110_A0.7120.91
340_L344_D0.7100.91
289_V315_I0.7080.91
278_A342_Y0.7060.90
381_A386_E0.7050.90
112_I171_A0.7040.90
184_D188_S0.7040.90
55_V98_M0.7030.90
65_P68_S0.7030.90
293_G296_S0.6970.90
170_V310_F0.6950.90
60_T73_L0.6930.90
75_W78_L0.6920.90
7_V12_C0.6920.90
120_M370_I0.6920.90
49_I238_A0.6880.89
292_W297_L0.6870.89
59_Y63_F0.6870.89
128_F171_A0.6840.89
314_G318_T0.6830.89
120_M175_L0.6830.89
38_S113_S0.6790.89
92_I96_L0.6780.89
360_V367_F0.6780.89
132_W171_A0.6780.89
10_F14_L0.6760.88
136_V369_I0.6760.88
136_V366_T0.6760.88
73_L76_A0.6750.88
88_Y91_T0.6740.88
128_F366_T0.6730.88
45_S122_F0.6730.88
23_L201_A0.6720.88
116_F370_I0.6710.88
123_G245_W0.6700.88
250_K396_G0.6690.88
51_S106_V0.6690.88
39_T42_H0.6680.88
7_V14_L0.6670.88
60_T64_A0.6670.88
266_A316_G0.6630.87
247_I291_F0.6630.87
173_L177_I0.6630.87
196_T254_L0.6620.87
104_F210_F0.6610.87
253_M257_V0.6600.87
244_E255_G0.6600.87
241_I256_A0.6580.87
218_L222_A0.6580.87
287_G290_C0.6550.87
227_I276_P0.6540.87
37_L397_E0.6530.87
122_F395_H0.6520.87
113_S116_F0.6520.87
158_F225_A0.6480.86
156_L328_A0.6470.86
128_F132_W0.6460.86
13_A103_T0.6450.86
179_L379_L0.6450.86
59_Y75_W0.6450.86
332_V339_G0.6410.86
54_W62_A0.6400.86
51_S231_T0.6400.86
181_K302_G0.6390.85
286_G319_W0.6390.85
356_A359_Y0.6380.85
73_L77_G0.6380.85
172_G176_A0.6380.85
364_I367_F0.6360.85
155_A162_N0.6360.85
144_V151_G0.6340.85
255_G290_C0.6340.85
59_Y97_F0.6310.85
281_I327_F0.6300.85
61_L139_P0.6300.85
23_L107_L0.6290.85
298_K301_F0.6280.85
128_F370_I0.6280.85
61_L73_L0.6270.84
166_I314_G0.6260.84
247_I296_S0.6240.84
145_W163_V0.6220.84
175_L366_T0.6220.84
344_D348_I0.6210.84
207_W264_L0.6200.84
392_L398_K0.6190.84
311_G315_I0.6190.84
170_V362_V0.6180.84
48_A238_A0.6160.83
21_P202_L0.6150.83
232_A286_G0.6130.83
268_T272_G0.6130.83
182_R304_D0.6120.83
165_H313_H0.6110.83
66_G142_H0.6110.83
215_A225_A0.6100.83
211_N229_T0.6090.83
19_M211_N0.6090.83
99_M102_M0.6060.82
329_T342_Y0.6050.82
311_G314_G0.6040.82
388_L392_L0.6040.82
47_I230_N0.6020.82
118_E188_S0.6010.82
167_S358_T0.6000.82
144_V155_A0.6000.82
42_H117_A0.5990.82
340_L345_A0.5990.82
116_F129_S0.5980.82
136_V362_V0.5980.82
262_A290_C0.5970.81
98_M102_M0.5940.81
278_A329_T0.5940.81
211_N214_S0.5940.81
347_L351_Q0.5940.81
222_A225_A0.5920.81
105_A133_A0.5920.81
10_F223_M0.5920.81
361_F364_I0.5890.81
150_I155_A0.5890.81
47_I102_M0.5880.80
143_W361_F0.5880.80
122_F251_P0.5880.80
165_H321_G0.5870.80
8_F215_A0.5850.80
210_F229_T0.5830.80
287_G319_W0.5830.80
247_I292_W0.5830.80
10_F226_F0.5810.80
180_G380_R0.5790.79
74_E78_L0.5780.79
127_L369_I0.5760.79
103_T164_V0.5760.79
19_M203_I0.5760.79
35_N381_A0.5760.79
67_N70_I0.5740.79
178_V363_F0.5720.79
112_I116_F0.5710.78
236_G266_A0.5710.78
103_T226_F0.5690.78
116_F125_F0.5670.78
42_H125_F0.5660.78
344_D347_L0.5660.78
298_K308_D0.5660.78
13_A226_F0.5650.78
349_W356_A0.5640.78
74_E77_G0.5630.78
274_V279_S0.5620.77
210_F268_T0.5610.77
46_S110_A0.5600.77
324_T348_I0.5600.77
224_Y332_V0.5590.77
384_E387_S0.5580.77
242_L245_W0.5580.77
243_V289_V0.5560.77
88_Y94_H0.5540.76
62_A138_T0.5530.76
221_V224_Y0.5520.76
92_I97_F0.5490.76
24_A40_A0.5490.76
109_T133_A0.5480.76
44_F260_A0.5470.76
38_S116_F0.5470.76
75_W80_G0.5460.75
189_S398_K0.5460.75
109_T116_F0.5460.75
329_T332_V0.5450.75
47_I51_S0.5450.75
321_G324_T0.5430.75
221_V225_A0.5380.74
285_I327_F0.5370.74
174_V359_Y0.5360.74
46_S109_T0.5360.74
18_L21_P0.5360.74
284_I287_G0.5360.74
23_L42_H0.5350.74
121_R385_E0.5350.74
68_S152_Q0.5350.74
298_K315_I0.5340.74
32_K35_N0.5340.74
90_D217_T0.5330.74
286_G289_V0.5320.74
73_L81_V0.5320.74
350_K354_A0.5310.73
362_V366_T0.5310.73
298_K310_F0.5310.73
112_I132_W0.5310.73
130_V238_A0.5300.73
42_H116_F0.5300.73
386_E389_G0.5280.73
298_K303_Y0.5270.73
366_T369_I0.5270.73
34_K188_S0.5260.73
128_F373_V0.5240.72
319_W327_F0.5230.72
40_A194_I0.5220.72
248_N291_F0.5210.72
178_V370_I0.5200.72
258_S298_K0.5200.72
296_S301_F0.5190.72
77_G80_G0.5180.72
355_I359_Y0.5180.72
130_V133_A0.5170.71
64_A75_W0.5170.71
358_T362_V0.5170.71
170_V355_I0.5160.71
381_A385_E0.5160.71
43_S107_L0.5160.71
200_G260_A0.5150.71
156_L347_L0.5140.71
360_V363_F0.5140.71
165_H233_A0.5140.71
153_L357_A0.5120.71
55_V277_F0.5100.70
252_T255_G0.5100.70
230_N234_A0.5100.70
79_K83_F0.5100.70
121_R376_F0.5100.70
324_T347_L0.5080.70
126_L245_W0.5080.70
43_S46_S0.5060.70
159_A214_S0.5060.70
60_T72_G0.5050.70
182_R380_R0.5040.69
230_N260_A0.5040.69
20_T110_A0.5040.69
174_V364_I0.5020.69
48_A234_A0.5020.69
64_A142_H0.5020.69
130_V138_T0.5020.69
289_V316_G0.5010.69
275_T342_Y0.5010.69
280_I284_I0.5010.69
275_T279_S0.5000.69
169_G317_G0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b2hA 3 0.9604 100 0.028 Contact Map
1u7gA 3 0.9332 100 0.113 Contact Map
3hd6A 3 0.9332 100 0.271 Contact Map
3b9wA 3 0.8663 100 0.292 Contact Map
4j05A 3 0.7995 40.9 0.968 Contact Map
4xnjA 1 0.505 39.5 0.968 Contact Map
4uvmA 1 0.5025 19.9 0.973 Contact Map
1pw4A 1 0.5173 19.7 0.973 Contact Map
4tphA 2 0.5074 16.8 0.974 Contact Map
1qleD 1 0.052 15.1 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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