GREMLIN Database
NUSG - Transcription termination/antitermination protein NusG
UniProt: Q06795 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 177 (171)
Sequences: 2372 (1216)
Seq/√Len: 93.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_K23_E5.0031.00
34_K72_T4.2421.00
154_V174_I3.9981.00
37_R68_E3.8161.00
103_P107_E3.7211.00
27_E32_Q3.6971.00
44_E55_V3.4811.00
153_K168_E3.3471.00
146_E155_K3.2631.00
36_F68_E3.1391.00
3_K68_E2.7881.00
131_K175_D2.7561.00
44_E57_K2.3001.00
3_K36_F2.1211.00
101_L106_A2.0741.00
18_V85_V2.0561.00
42_E57_K2.0321.00
72_T75_S2.0211.00
128_E176_K2.0111.00
69_I75_S1.9821.00
9_H86_T1.8331.00
14_Y84_G1.7921.00
148_D151_K1.7851.00
43_E58_K1.7711.00
153_K170_E1.7581.00
69_I79_V1.7561.00
156_V169_L1.6871.00
47_D58_K1.6691.00
149_Y171_F1.6481.00
134_D173_Q1.6421.00
129_T141_T1.5641.00
73_D97_K1.5481.00
145_E157_F1.5241.00
66_L109_I1.5201.00
157_F166_P1.5041.00
17_K20_A1.4941.00
61_F66_L1.4921.00
169_L173_Q1.4871.00
157_F164_E1.4821.00
91_S96_S1.4641.00
48_I53_K1.4511.00
142_G156_V1.4340.99
77_Y81_N1.4310.99
3_K70_V1.4130.99
25_R82_T1.3910.99
8_V67_V1.3750.99
22_L85_V1.3530.99
46_T55_V1.3260.99
131_K139_N1.2900.99
125_E128_E1.2900.99
75_S79_V1.2790.99
169_L174_I1.2650.99
126_L147_I1.2360.98
45_E58_K1.1980.98
22_L79_V1.1980.98
130_V156_V1.1570.98
16_N42_E1.1540.98
23_E38_V1.1260.97
60_V66_L1.1220.97
25_R29_M1.1140.97
160_M163_R1.1040.97
61_F109_I1.0980.97
155_K166_P1.0910.97
23_E37_R1.0830.96
11_Y84_G1.0760.96
80_R87_G1.0740.96
37_R110_L1.0710.96
149_Y152_S1.0680.96
49_K54_K1.0650.96
170_E173_Q1.0570.96
156_V162_G1.0440.96
45_E160_M1.0420.96
131_K141_T1.0410.96
31_M75_S1.0390.95
9_H87_G1.0210.95
35_I38_V1.0050.95
22_L26_V1.0000.94
46_T53_K0.9990.94
106_A110_L0.9930.94
76_W80_R0.9780.94
4_N103_P0.9760.94
125_E176_K0.9660.93
104_G108_T0.9600.93
161_F165_T0.9420.92
15_E64_Y0.9360.92
86_T90_G0.9330.92
40_V65_V0.9320.92
34_K70_V0.9310.92
11_Y14_Y0.9250.92
102_L110_L0.9060.91
18_V65_V0.9050.91
91_S97_K0.8860.90
10_T133_I0.8860.90
8_V79_V0.8850.90
7_V101_L0.8850.90
25_R83_P0.8780.90
20_A24_K0.8780.90
120_T152_S0.8750.89
158_V167_V0.8720.89
90_G100_P0.8660.89
159_N164_E0.8620.89
154_V169_L0.8600.89
6_Y15_E0.8590.88
161_F168_E0.8490.88
49_K52_K0.8400.87
10_T14_Y0.8340.87
144_I174_I0.8340.87
26_V35_I0.8340.87
153_K161_F0.8310.87
68_E103_P0.8240.86
9_H14_Y0.8190.86
23_E26_V0.8150.86
38_V78_V0.8130.86
13_G18_V0.8070.85
26_V32_Q0.8010.85
39_V110_L0.7890.84
73_D95_G0.7850.84
125_E130_V0.7830.83
36_F70_V0.7830.83
14_Y17_K0.7800.83
139_N167_V0.7780.83
34_K74_D0.7730.83
104_G107_E0.7670.82
24_K84_G0.7670.82
82_T86_T0.7600.82
109_I114_G0.7580.81
151_K171_F0.7560.81
140_F158_V0.7460.80
119_K130_V0.7450.80
132_V136_P0.7390.80
122_I171_F0.7330.79
155_K168_E0.7300.79
132_V172_T0.7260.79
4_N124_F0.7240.78
3_K37_R0.7240.78
12_S18_V0.7230.78
72_T79_V0.7150.77
89_V104_G0.7100.77
88_F98_P0.7090.77
26_V67_V0.7030.76
18_V22_L0.7000.76
124_F174_I0.6980.76
147_I154_V0.6920.75
98_P137_F0.6870.75
46_T107_E0.6850.74
34_K75_S0.6810.74
83_P91_S0.6810.74
152_S172_T0.6800.74
145_E156_V0.6800.74
24_K28_S0.6790.74
83_P109_I0.6730.73
148_D153_K0.6680.73
131_K140_F0.6580.71
136_P140_F0.6570.71
130_V142_G0.6540.71
124_F144_I0.6500.70
153_K173_Q0.6500.70
136_P173_Q0.6480.70
24_K27_E0.6480.70
29_M74_D0.6410.69
11_Y65_V0.6400.69
87_G96_S0.6380.69
35_I79_V0.6360.69
140_F156_V0.6350.69
129_T143_S0.6350.69
128_E144_I0.6340.69
29_M78_V0.6310.68
20_A23_E0.6310.68
69_I76_W0.6290.68
11_Y86_T0.6280.68
48_I172_T0.6270.68
42_E52_K0.6250.67
133_I175_D0.6240.67
47_D110_L0.6240.67
35_I75_S0.6190.67
20_A54_K0.6180.67
87_G100_P0.6160.66
112_R139_N0.6150.66
29_M83_P0.6090.66
46_T118_R0.6080.65
13_G76_W0.6070.65
156_V166_P0.6060.65
80_R84_G0.6040.65
8_V26_V0.6040.65
25_R38_V0.6010.64
148_D168_E0.5980.64
159_N169_L0.5980.64
7_V84_G0.5960.64
21_N102_L0.5960.64
145_E166_P0.5950.64
8_V24_K0.5950.64
12_S17_K0.5950.64
14_Y21_N0.5940.64
132_V158_V0.5900.63
120_T156_V0.5850.62
156_V174_I0.5850.62
148_D155_K0.5850.62
12_S76_W0.5850.62
17_K84_G0.5800.62
158_V165_T0.5780.61
58_K132_V0.5750.61
17_K21_N0.5730.61
23_E27_E0.5720.61
16_N59_K0.5720.61
9_H65_V0.5700.60
134_D138_A0.5660.60
66_L101_L0.5650.60
108_T113_M0.5620.59
151_K170_E0.5620.59
39_V113_M0.5610.59
51_G147_I0.5590.59
140_F159_N0.5580.59
91_S99_T0.5560.59
107_E111_K0.5550.58
144_I147_I0.5530.58
22_L82_T0.5510.58
102_L160_M0.5470.57
31_M133_I0.5470.57
89_V99_T0.5460.57
154_V176_K0.5450.57
51_G132_V0.5430.57
143_S164_E0.5420.57
21_N25_R0.5410.56
99_T113_M0.5400.56
152_S171_F0.5400.56
50_N54_K0.5390.56
17_K82_T0.5380.56
18_V82_T0.5380.56
155_K160_M0.5370.56
10_T87_G0.5330.55
128_E148_D0.5320.55
45_E109_I0.5320.55
41_P147_I0.5270.55
109_I113_M0.5260.54
67_V108_T0.5250.54
14_Y59_K0.5230.54
21_N35_I0.5220.54
57_K155_K0.5210.54
9_H84_G0.5190.53
136_P155_K0.5180.53
8_V85_V0.5150.53
111_K114_G0.5140.53
89_V149_Y0.5140.53
45_E84_G0.5130.53
168_E171_F0.5110.52
141_T175_D0.5100.52
59_K96_S0.5100.52
25_R78_V0.5100.52
22_L29_M0.5080.52
6_Y64_Y0.5070.52
30_G33_D0.5050.51
133_I141_T0.5030.51
134_D145_E0.5020.51
10_T89_V0.5020.51
49_K58_K0.5010.51
160_M167_V0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jvvA 1 0.3333 100 0.17 Contact Map
1m1hA 1 0.6328 100 0.18 Contact Map
2lq8A 1 0.9435 100 0.222 Contact Map
2xhcA 1 0.9492 100 0.251 Contact Map
2ougA 1 0.791 100 0.258 Contact Map
3p8bB 2 0.8136 100 0.345 Contact Map
1nz8A 1 0.6384 100 0.48 Contact Map
3lpeA 1 0.4746 99.8 0.617 Contact Map
2mi6A 1 0.3503 99.5 0.71 Contact Map
1nz9A 1 0.3277 99.5 0.721 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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