GREMLIN Database
ISPD - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
UniProt: Q06755 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 232 (220)
Sequences: 4395 (3474)
Seq/√Len: 234.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_D38_R3.6201.00
140_R148_E2.7211.00
52_V90_G2.6631.00
118_L163_A2.6081.00
31_P34_I2.5651.00
82_E85_H2.5431.00
131_A200_V2.4301.00
102_V169_L2.4231.00
32_V210_L2.4001.00
111_K204_S2.3821.00
55_E78_A2.2521.00
88_Y92_K2.1811.00
114_Q130_L2.0581.00
43_H116_D2.0531.00
141_V200_V2.0361.00
113_E117_E2.0151.00
168_L190_V2.0041.00
166_L170_M1.9971.00
140_R154_S1.9521.00
101_L163_A1.9411.00
45_Q116_D1.8871.00
125_T199_R1.8051.00
151_E154_S1.7991.00
4_D48_K1.7871.00
48_K75_E1.7761.00
138_I157_A1.7561.00
7_I40_F1.7381.00
175_E179_K1.7361.00
16_M25_I1.7331.00
190_V196_G1.7331.00
81_D85_H1.7191.00
99_I122_A1.6881.00
126_G165_R1.6831.00
129_I187_A1.6331.00
171_K175_E1.6281.00
134_V155_L1.6211.00
92_K174_A1.6201.00
8_P52_V1.5701.00
5_V40_F1.5281.00
139_K191_E1.4921.00
58_R78_A1.4881.00
52_V86_S1.4771.00
21_N57_E1.4691.00
168_L196_G1.4511.00
4_D94_V1.4501.00
40_F115_I1.4301.00
7_I37_L1.4291.00
41_D72_T1.3971.00
33_I61_F1.3921.00
38_R42_S1.3841.00
41_D71_Q1.3771.00
129_I158_V1.3771.00
122_A126_G1.3621.00
101_L119_I1.3601.00
138_I155_L1.3531.00
139_K149_T1.3501.00
26_E29_G1.3501.00
149_T191_E1.3361.00
111_K114_Q1.3151.00
179_K192_Q1.3091.00
140_R150_I1.3011.00
137_T149_T1.3001.00
82_E182_L1.3001.00
118_L201_V1.2941.00
134_V157_A1.2891.00
135_K205_Y1.2761.00
193_M196_G1.2721.00
16_M216_L1.2721.00
129_I146_V1.2701.00
109_F219_A1.2671.00
157_A205_Y1.2641.00
141_V156_W1.2631.00
159_Q203_G1.2591.00
58_R62_Q1.2431.00
118_L130_L1.2411.00
131_A156_W1.2351.00
48_K95_K1.2331.00
30_D35_H1.2331.00
34_I38_R1.2321.00
42_S112_H1.2281.00
30_D34_I1.2171.00
18_A25_I1.2161.00
117_E202_E1.1961.00
190_V193_M1.1951.00
145_Q197_S1.1931.00
122_A128_A1.1851.00
114_Q204_S1.1851.00
217_T221_A1.1841.00
173_H189_L1.1841.00
10_A79_G1.1831.00
134_V138_I1.1791.00
121_E201_V1.1651.00
43_H46_C1.1571.00
167_S171_K1.1531.00
137_T184_T1.1461.00
28_K220_E1.1431.00
41_D73_S1.1421.00
181_F192_Q1.1351.00
88_Y177_E1.1281.00
53_I76_L1.1271.00
53_I61_F1.1211.00
110_I115_I1.1171.00
132_V203_G1.1041.00
183_G189_L1.1021.00
91_L100_V1.1021.00
94_V166_L1.0981.00
122_A163_A1.0961.00
28_K224_E1.0951.00
89_K92_K1.0831.00
173_H186_D1.0831.00
171_K196_G1.0811.00
6_V90_G1.0731.00
208_I218_S1.0691.00
170_M174_A1.0661.00
39_V110_I1.0601.00
84_Q173_H1.0571.00
8_P87_V1.0531.00
142_Q147_S1.0481.00
172_A193_M1.0371.00
132_V159_Q1.0291.00
75_E93_A1.0271.00
43_H112_H1.0261.00
92_K170_M1.0171.00
3_Y119_I1.0161.00
77_V93_A1.0091.00
95_K170_M1.0051.00
165_R168_L0.9991.00
14_K82_E0.9831.00
132_V205_Y0.9811.00
58_R76_L0.9781.00
109_F223_M0.9751.00
53_I58_R0.9751.00
100_V166_L0.9731.00
24_F57_E0.9701.00
45_Q120_A0.9691.00
27_L219_A0.9641.00
85_H177_E0.9641.00
130_L156_W0.9621.00
41_D49_I0.9611.00
164_F190_V0.9541.00
220_E224_E0.9531.00
136_D157_A0.9431.00
84_Q183_G0.9381.00
130_L203_G0.9311.00
26_E31_P0.9311.00
126_G168_L0.9241.00
176_A183_G0.9201.00
210_L219_A0.9181.00
126_G196_G0.9131.00
98_K165_R0.9031.00
133_P202_E0.9011.00
24_F61_F0.9011.00
206_T222_I0.9001.00
5_V46_C0.8980.99
12_Q54_N0.8970.99
217_T220_E0.8950.99
99_I163_A0.8950.99
36_T39_V0.8940.99
183_G188_S0.8940.99
110_I114_Q0.8920.99
50_I94_V0.8900.99
99_I123_E0.8830.99
59_E62_Q0.8820.99
183_G192_Q0.8810.99
116_D120_A0.8800.99
121_E199_R0.8760.99
48_K74_I0.8700.99
97_E167_S0.8530.99
25_I216_L0.8480.99
3_Y46_C0.8430.99
109_F208_I0.8390.99
135_K212_T0.8390.99
60_H63_Q0.8350.99
20_R60_H0.8310.99
41_D74_I0.8300.99
145_Q199_R0.8300.99
139_K146_V0.8220.99
85_H89_K0.8150.99
174_A178_R0.8100.99
138_I150_I0.8060.99
98_K166_L0.8050.99
176_A189_L0.8050.99
80_G85_H0.8050.99
208_I222_I0.8050.99
9_A33_I0.8020.99
37_L65_L0.8000.99
121_E128_A0.7980.99
173_H177_E0.7970.99
50_I77_V0.7940.99
171_K174_A0.7920.99
146_V158_V0.7820.99
54_N57_E0.7780.99
34_I68_Y0.7740.98
114_Q117_E0.7740.98
218_S221_A0.7700.98
39_V112_H0.7680.98
169_L186_D0.7670.98
31_P35_H0.7660.98
77_V89_K0.7650.98
175_E178_R0.7600.98
205_Y214_D0.7600.98
34_I64_L0.7580.98
133_P156_W0.7580.98
95_K166_L0.7570.98
121_E125_T0.7560.98
43_H119_I0.7530.98
112_H116_D0.7460.98
45_Q123_E0.7460.98
8_P36_T0.7450.98
176_A181_F0.7430.98
88_Y170_M0.7420.98
13_G21_N0.7420.98
24_F60_H0.7420.98
26_E220_E0.7410.98
176_A180_G0.7400.98
99_I119_I0.7370.98
63_Q67_D0.7360.98
184_T188_S0.7330.98
99_I165_R0.7290.98
62_Q66_S0.7260.98
140_R155_L0.7160.98
13_G23_L0.7060.97
125_T145_Q0.7030.97
21_N54_N0.7020.97
122_A165_R0.6970.97
88_Y174_A0.6950.97
50_I75_E0.6950.97
172_A190_V0.6940.97
218_S222_I0.6940.97
208_I219_A0.6900.97
140_R147_S0.6890.97
37_L51_L0.6850.97
156_W200_V0.6830.97
43_H115_I0.6800.97
127_A190_V0.6790.97
85_H182_L0.6720.96
139_K158_V0.6720.96
44_R116_D0.6710.96
4_D50_I0.6660.96
120_A123_E0.6630.96
41_D70_F0.6620.96
109_F222_I0.6590.96
3_Y99_I0.6570.96
6_V50_I0.6520.96
134_V150_I0.6510.96
127_A164_F0.6470.95
50_I93_A0.6460.95
150_I155_L0.6430.95
114_Q159_Q0.6390.95
31_P64_L0.6340.95
87_V102_V0.6330.95
137_T152_R0.6320.95
169_L173_H0.6280.95
160_T185_D0.6280.95
162_Q185_D0.6270.95
90_G93_A0.6240.95
127_A196_G0.6230.94
61_F65_L0.6230.94
62_Q76_L0.6220.94
10_A54_N0.6210.94
16_M213_P0.6150.94
24_F53_I0.6130.94
35_H223_M0.6120.94
4_D166_L0.6100.94
21_N24_F0.6100.94
84_Q176_A0.6080.94
141_V146_V0.6080.94
46_C72_T0.6080.94
10_A53_I0.6070.94
214_D218_S0.6060.94
142_Q154_S0.6060.94
121_E124_Q0.6030.93
128_A163_A0.6020.93
4_D98_K0.6000.93
127_A165_R0.5990.93
142_Q145_Q0.5980.93
135_K157_A0.5970.93
37_L70_F0.5950.93
168_L171_K0.5950.93
128_A201_V0.5930.93
7_I105_G0.5890.93
51_L76_L0.5880.93
111_K206_T0.5860.93
6_V91_L0.5840.92
120_A124_Q0.5810.92
150_I154_S0.5800.92
36_T106_A0.5800.92
185_D189_L0.5770.92
87_V173_H0.5700.91
129_I139_K0.5660.91
46_C119_I0.5660.91
46_C101_L0.5620.91
34_I67_D0.5610.91
84_Q189_L0.5590.91
63_Q66_S0.5580.91
87_V186_D0.5580.91
12_Q56_Q0.5550.90
8_P106_A0.5550.90
101_L118_L0.5520.90
86_S90_G0.5520.90
130_L201_V0.5510.90
77_V90_G0.5490.90
131_A158_V0.5470.90
184_T189_L0.5420.89
104_D160_T0.5380.89
169_L190_V0.5350.89
45_Q119_I0.5320.88
135_K214_D0.5310.88
101_L115_I0.5270.88
101_L122_A0.5260.88
70_F73_S0.5250.88
119_I163_A0.5230.88
141_V147_S0.5220.87
94_V97_E0.5210.87
37_L49_I0.5200.87
114_Q207_N0.5180.87
7_I36_T0.5180.87
126_G197_S0.5180.87
110_I130_L0.5170.87
99_I126_G0.5150.87
8_P105_G0.5130.87
206_T217_T0.5120.86
94_V100_V0.5110.86
93_A96_Q0.5080.86
185_D188_S0.5060.86
117_E120_A0.5050.86
3_Y47_D0.5030.86
23_L106_A0.5010.85
111_K207_N0.5010.85
186_D191_E0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cvhA 2 0.9612 100 0.431 Contact Map
1w55A 4 0.9095 100 0.467 Contact Map
4mybA 2 0.9009 100 0.472 Contact Map
1i52A 2 0.9526 100 0.473 Contact Map
4zdqA 2 0.9569 100 0.475 Contact Map
2yc3A 2 0.9267 100 0.481 Contact Map
1vgwA 2 0.8879 100 0.484 Contact Map
3q80A 2 0.9397 100 0.488 Contact Map
2xwlA 2 0.9483 100 0.498 Contact Map
2vshA 2 0.9138 100 0.504 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0081 seconds.