GREMLIN Database
YACL - Uncharacterized PIN and TRAM-domain containing protein YacL
UniProt: Q06754 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 366 (349)
Sequences: 744 (531)
Seq/√Len: 28.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
287_D350_A8.3171.00
339_I359_P7.4971.00
306_V316_G6.0961.00
243_F259_L5.8111.00
184_C193_I3.4981.00
242_D252_K3.2991.00
334_Y337_K3.2001.00
290_N293_K3.1891.00
304_V318_A3.1391.00
181_A227_R2.9701.00
14_G51_F2.9221.00
223_D273_K2.8981.00
225_L277_L2.8751.00
238_I277_L2.8521.00
174_V267_N2.8331.00
306_V359_P2.6611.00
306_V339_I2.5890.99
301_E360_K2.5210.99
88_L125_G2.5020.99
189_L265_V2.3990.99
192_V237_E2.3950.99
303_N340_D2.3760.99
201_E251_S2.3610.99
168_K190_E2.3510.99
188_F283_L2.2750.98
15_G48_A2.2390.98
308_K358_K2.2330.98
341_V357_A2.1610.98
226_N230_K2.1600.98
168_K191_G2.1560.98
167_L192_V2.1540.98
227_R231_E2.1540.98
216_N297_L2.1490.98
195_I228_I2.0880.97
88_L129_F2.0830.97
303_N338_H2.0490.97
203_L221_G2.0360.97
243_F246_I2.0090.97
184_C228_I1.9640.96
117_P121_A1.9310.96
8_A21_L1.9220.96
83_F132_G1.9210.96
351_A354_M1.9050.95
104_L116_I1.8600.95
217_R297_L1.8570.95
251_S278_Q1.8470.95
214_K308_K1.8370.94
306_V328_V1.8290.94
80_D136_K1.8260.94
189_L291_A1.8060.94
129_F132_G1.7990.94
15_G44_A1.7730.93
19_I44_A1.7610.93
77_P80_D1.7610.93
7_Q56_I1.7540.93
47_G126_Y1.7420.93
331_G334_Y1.7230.92
263_V281_A1.6730.91
15_G81_L1.6700.91
214_K223_D1.6520.90
135_K138_E1.6090.89
301_E342_L1.5890.89
107_I124_L1.5760.88
287_D302_M1.5720.88
290_N351_A1.5720.88
219_R351_A1.5600.88
195_I236_V1.5370.87
96_Y121_A1.5300.87
217_R296_V1.5190.86
273_K286_N1.5150.86
156_A159_E1.5060.86
7_Q11_I1.5030.86
175_I295_V1.5000.86
219_R354_M1.5000.86
230_K276_E1.4890.85
170_L195_I1.4710.84
255_K259_L1.4550.84
204_Q287_D1.4310.83
135_K296_V1.4220.82
302_M350_A1.4190.82
330_E333_N1.4180.82
200_L229_Q1.3980.81
184_C232_L1.3930.81
19_I45_A1.3920.81
17_V27_V1.3780.80
290_N300_E1.3530.79
272_N293_K1.3500.79
192_V235_E1.3470.79
52_F55_S1.3310.78
175_I274_V1.3300.78
22_I29_L1.3270.78
288_L312_E1.3190.77
73_L95_A1.3170.77
182_D295_V1.3120.77
208_D250_D1.3000.76
175_I277_L1.2770.75
334_Y339_I1.2540.73
49_I52_F1.2540.73
205_H248_E1.2530.73
217_R351_A1.2380.72
254_V277_L1.2370.72
272_N286_N1.2290.72
212_V216_N1.2160.71
94_I111_I1.2060.70
174_V248_E1.2030.70
302_M343_V1.2020.70
214_K355_I1.1950.70
243_F260_T1.1940.70
47_G117_P1.1910.69
85_S89_V1.1870.69
292_V295_V1.1850.69
138_E353_R1.1820.69
84_G133_F1.1810.69
285_I307_I1.1800.69
242_D255_K1.1590.67
185_Q231_E1.1530.67
174_V295_V1.1520.67
267_N354_M1.1490.67
142_L158_E1.1480.67
236_V276_E1.1330.65
331_G359_P1.1320.65
125_G132_G1.1310.65
77_P86_L1.1270.65
167_L194_V1.1240.65
252_K285_I1.1230.65
175_I287_D1.1200.65
28_L49_I1.1100.64
91_G95_A1.1040.63
88_L126_Y1.0980.63
131_V193_I1.0970.63
211_D293_K1.0960.63
263_V279_K1.0800.62
24_E79_P1.0710.61
252_K256_L1.0700.61
9_F73_L1.0680.61
133_F136_K1.0660.61
113_S201_E1.0580.60
16_V20_F1.0570.60
272_N351_A1.0540.60
37_I52_F1.0510.60
12_I29_L1.0510.60
168_K358_K1.0390.59
217_R321_D1.0360.58
83_F129_F1.0340.58
250_D271_L1.0330.58
244_E357_A1.0320.58
226_N277_L1.0310.58
46_I122_F1.0270.58
242_D245_D1.0260.58
263_V330_E1.0200.57
178_G250_D1.0170.57
242_D246_I1.0160.57
5_I337_K1.0150.57
173_S290_N1.0130.57
172_T250_D1.0110.57
299_G325_M1.0090.56
272_N290_N1.0070.56
174_V285_I1.0060.56
223_D286_N1.0050.56
293_K300_E1.0050.56
273_K308_K1.0020.56
91_G125_G1.0010.56
334_Y359_P1.0010.56
95_A128_G0.9960.55
229_Q278_Q0.9950.55
238_I265_V0.9870.55
104_L115_I0.9860.55
25_L30_N0.9840.54
116_I120_L0.9800.54
175_I225_L0.9750.54
321_D326_I0.9720.54
21_L47_G0.9660.53
210_S318_A0.9630.53
206_I345_S0.9590.53
89_V134_K0.9580.52
204_Q258_K0.9560.52
51_F96_Y0.9540.52
56_I59_T0.9520.52
2_L5_I0.9490.52
275_C287_D0.9460.52
234_I276_E0.9290.50
47_G81_L0.9240.50
254_V275_C0.9230.50
240_E317_V0.9230.50
173_S295_V0.9210.50
252_K267_N0.9210.50
43_S47_G0.9170.49
168_K308_K0.9170.49
90_F123_F0.9130.49
69_I237_E0.9130.49
226_N229_Q0.9100.49
214_K217_R0.9090.49
52_F59_T0.9070.49
311_K346_V0.9060.48
213_L285_I0.9050.48
287_D337_K0.9040.48
257_A264_V0.8970.48
267_N285_I0.8900.47
272_N282_V0.8860.47
184_C360_K0.8860.47
195_I231_E0.8840.47
227_R280_V0.8830.47
20_F44_A0.8830.47
11_I254_V0.8770.46
264_V280_V0.8760.46
172_T249_V0.8720.46
90_F112_F0.8680.46
155_T158_E0.8670.45
229_Q345_S0.8650.45
38_T44_A0.8590.45
201_E205_H0.8590.45
258_K275_C0.8580.45
221_G348_Q0.8580.45
158_E164_D0.8550.45
269_F328_V0.8470.44
276_E296_V0.8460.44
70_E345_S0.8450.44
217_R267_N0.8450.44
32_Q53_L0.8450.44
95_A217_R0.8430.44
224_I291_A0.8430.44
78_V81_L0.8420.44
195_I295_V0.8410.43
17_V193_I0.8400.43
11_I56_I0.8400.43
2_L13_F0.8370.43
243_F255_K0.8310.43
70_E126_Y0.8280.42
21_L24_E0.8270.42
10_F59_T0.8230.42
124_L128_G0.8210.42
90_F260_T0.8140.41
193_I279_K0.8140.41
241_G244_E0.8140.41
186_T307_I0.8130.41
227_R335_I0.8130.41
204_Q350_A0.8120.41
302_M333_N0.8030.41
267_N346_V0.8030.41
239_Y260_T0.8010.40
36_L123_F0.7950.40
44_A227_R0.7890.40
168_K327_V0.7880.39
122_F184_C0.7850.39
186_T198_F0.7830.39
41_Y275_C0.7820.39
9_F119_F0.7810.39
104_L260_T0.7760.39
11_I52_F0.7700.38
53_L98_I0.7690.38
104_L120_L0.7690.38
300_E318_A0.7680.38
13_F17_V0.7660.38
77_P212_V0.7630.38
283_L288_L0.7610.38
288_L311_K0.7610.38
217_R298_P0.7590.37
156_A162_V0.7560.37
197_Q240_E0.7520.37
8_A43_S0.7520.37
200_L341_V0.7510.37
264_V293_K0.7490.37
4_R7_Q0.7460.36
27_V34_I0.7460.36
23_P129_F0.7440.36
201_E216_N0.7440.36
347_L353_R0.7440.36
314_N353_R0.7420.36
188_F286_N0.7420.36
270_N273_K0.7360.36
206_I248_E0.7330.36
169_I245_D0.7320.35
208_D270_N0.7320.35
166_K261_S0.7300.35
96_Y115_I0.7290.35
185_Q230_K0.7290.35
206_I234_I0.7280.35
270_N274_V0.7280.35
223_D272_N0.7260.35
94_I226_N0.7250.35
10_F14_G0.7250.35
4_R201_E0.7240.35
287_D328_V0.7230.35
178_G271_L0.7230.35
51_F55_S0.7220.35
3_K15_G0.7210.35
178_G215_R0.7210.35
243_F252_K0.7200.35
306_V357_A0.7200.35
296_V306_V0.7180.34
172_T271_L0.7180.34
175_I298_P0.7130.34
5_I50_I0.7120.34
69_I122_F0.7110.34
24_E32_Q0.7100.34
195_I285_I0.7090.34
38_T49_I0.7070.34
129_F258_K0.7070.34
8_A159_E0.7050.34
220_R344_T0.7020.33
284_N347_L0.6990.33
47_G204_Q0.6980.33
212_V277_L0.6980.33
183_I229_Q0.6970.33
155_T160_H0.6960.33
217_R277_L0.6960.33
22_I98_I0.6940.33
262_G282_V0.6920.33
21_L31_I0.6900.33
89_V94_I0.6900.33
254_V306_V0.6900.33
185_Q189_L0.6880.32
279_K330_E0.6860.32
249_V267_N0.6860.32
88_L97_L0.6840.32
124_L244_E0.6780.32
219_R344_T0.6780.32
27_V62_V0.6770.32
75_K89_V0.6750.32
25_L85_S0.6750.32
314_N329_E0.6750.32
104_L142_L0.6720.31
224_I231_E0.6710.31
169_I239_Y0.6710.31
169_I301_E0.6700.31
270_N284_N0.6700.31
10_F61_Y0.6680.31
69_I264_V0.6680.31
86_L163_Q0.6670.31
43_S46_I0.6660.31
62_V317_V0.6650.31
206_I277_L0.6600.31
228_I236_V0.6590.30
3_K53_L0.6570.30
172_T270_N0.6570.30
287_D347_L0.6550.30
27_V98_I0.6520.30
92_L312_E0.6520.30
216_N230_K0.6520.30
96_Y124_L0.6510.30
83_F140_I0.6500.30
5_I25_L0.6500.30
197_Q307_I0.6490.30
8_A12_I0.6490.30
241_G259_L0.6480.30
83_F117_P0.6480.30
38_T42_T0.6460.30
168_K345_S0.6460.30
84_G285_I0.6450.30
45_A254_V0.6450.30
78_V292_V0.6440.29
85_S135_K0.6440.29
81_L228_I0.6430.29
176_I348_Q0.6420.29
139_L194_V0.6410.29
47_G121_A0.6380.29
346_V354_M0.6380.29
201_E204_Q0.6380.29
104_L119_F0.6370.29
121_A254_V0.6370.29
82_L146_S0.6360.29
89_V254_V0.6350.29
186_T272_N0.6350.29
296_V302_M0.6340.29
20_F336_G0.6330.29
172_T208_D0.6330.29
21_L39_N0.6320.29
175_I328_V0.6320.29
176_I250_D0.6320.29
168_K273_K0.6310.29
156_A160_H0.6310.29
7_Q55_S0.6300.29
53_L161_E0.6300.29
134_K184_C0.6280.28
65_W112_F0.6270.28
121_A255_K0.6260.28
173_S205_H0.6260.28
112_F122_F0.6240.28
2_L11_I0.6220.28
328_V357_A0.6210.28
175_I205_H0.6200.28
24_E118_V0.6200.28
23_P26_F0.6190.28
304_V326_I0.6190.28
168_K283_L0.6180.28
229_Q309_D0.6170.28
169_I262_G0.6170.28
267_N278_Q0.6150.28
215_R329_E0.6140.28
236_V247_Q0.6140.28
264_V317_V0.6140.28
252_K255_K0.6120.27
39_N43_S0.6070.27
188_F288_L0.6070.27
30_N33_D0.6070.27
17_V20_F0.6070.27
298_P344_T0.6070.27
215_R250_D0.6060.27
25_L105_D0.6050.27
55_S70_E0.6050.27
8_A11_I0.6040.27
186_T329_E0.6020.27
189_L317_V0.6010.27
70_E78_V0.5990.27
178_G208_D0.5970.27
49_I334_Y0.5960.26
262_G281_A0.5950.26
230_K305_Q0.5950.26
331_G339_I0.5950.26
104_L122_F0.5940.26
58_G289_A0.5930.26
52_F90_F0.5900.26
29_L36_L0.5880.26
270_N286_N0.5880.26
208_D271_L0.5860.26
273_K345_S0.5850.26
8_A32_Q0.5840.26
263_V342_L0.5810.26
37_I41_Y0.5810.26
302_M329_E0.5810.26
205_H321_D0.5780.25
3_K63_V0.5770.25
185_Q227_R0.5770.25
219_R300_E0.5750.25
223_D351_A0.5710.25
29_L43_S0.5700.25
78_V138_E0.5680.25
186_T280_V0.5670.25
243_F256_L0.5670.25
155_T159_E0.5670.25
108_P121_A0.5660.25
289_A350_A0.5660.25
239_Y292_V0.5660.25
240_E353_R0.5650.25
260_T314_N0.5640.25
32_Q123_F0.5630.25
76_A133_F0.5620.24
15_G39_N0.5610.24
169_I264_V0.5600.24
241_G251_S0.5590.24
194_V256_L0.5580.24
81_L136_K0.5580.24
108_P113_S0.5570.24
185_Q226_N0.5550.24
194_V240_E0.5540.24
214_K243_F0.5530.24
284_N351_A0.5520.24
80_D285_I0.5510.24
96_Y104_L0.5490.24
7_Q52_F0.5480.24
104_L107_I0.5480.24
162_V334_Y0.5480.24
174_V214_K0.5460.24
51_F313_H0.5450.24
88_L197_Q0.5440.23
86_L136_K0.5440.23
88_L350_A0.5430.23
205_H282_V0.5400.23
339_I355_I0.5400.23
137_D321_D0.5350.23
88_L281_A0.5340.23
207_A337_K0.5340.23
239_Y357_A0.5330.23
169_I226_N0.5320.23
35_P67_K0.5310.23
201_E292_V0.5310.23
207_A321_D0.5310.23
108_P115_I0.5310.23
33_D42_T0.5310.23
224_I227_R0.5300.23
204_Q254_V0.5300.23
68_W72_S0.5290.23
246_I252_K0.5290.23
127_L160_H0.5290.23
106_N113_S0.5270.23
308_K345_S0.5270.23
316_G339_I0.5260.22
205_H246_I0.5260.22
173_S309_D0.5260.22
90_F140_I0.5250.22
42_T158_E0.5240.22
54_I146_S0.5240.22
201_E314_N0.5230.22
246_I259_L0.5230.22
195_I265_V0.5230.22
34_I98_I0.5220.22
132_G358_K0.5210.22
8_A210_S0.5200.22
12_I33_D0.5200.22
17_V69_I0.5200.22
99_V105_D0.5200.22
174_V290_N0.5200.22
220_R298_P0.5200.22
277_L280_V0.5190.22
174_V183_I0.5180.22
216_N314_N0.5180.22
8_A45_A0.5170.22
20_F292_V0.5160.22
10_F107_I0.5150.22
99_V121_A0.5140.22
226_N257_A0.5140.22
26_F43_S0.5140.22
79_P103_P0.5140.22
29_L42_T0.5130.22
184_C337_K0.5120.22
181_A207_A0.5090.22
19_I42_T0.5090.22
99_V339_I0.5090.22
54_I159_E0.5080.22
22_I46_I0.5080.22
52_F58_G0.5080.22
17_V51_F0.5070.21
194_V257_A0.5060.21
89_V207_A0.5060.21
45_A157_D0.5050.21
189_L292_V0.5050.21
81_L108_P0.5050.21
309_D360_K0.5040.21
210_S267_N0.5040.21
49_I155_T0.5030.21
77_P309_D0.5020.21
10_F16_V0.5020.21
188_F249_V0.5000.21
33_D36_L0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ix7A 2 0.3607 100 0.797 Contact Map
3i8oA 2 0.3525 99.9 0.832 Contact Map
2dokA 2 0.3634 99.8 0.85 Contact Map
2lcqA 1 0.3962 99.8 0.856 Contact Map
1o4wA 2 0.3224 98.8 0.915 Contact Map
2hwyA 1 0.2869 98 0.934 Contact Map
4chgA 2 0.3005 97.8 0.935 Contact Map
2h1cA 2 0.3169 97.1 0.943 Contact Map
3zvkA 3 0.3087 96.8 0.946 Contact Map
2fe1A 2 0.3005 96.8 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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