GREMLIN Database
SYC - Cysteine--tRNA ligase
UniProt: Q06752 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 466 (421)
Sequences: 20262 (11242)
Seq/√Len: 547.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_L60_Y5.5441.00
127_D131_K3.9381.00
58_K355_E3.8611.00
353_A370_V3.8371.00
85_D88_T3.3871.00
145_K148_A3.2691.00
36_Y96_A3.1771.00
283_Q306_E3.1311.00
128_Q131_K3.1141.00
50_T294_L3.0531.00
429_E433_N2.9311.00
265_E271_L2.9311.00
23_K61_D2.9161.00
78_A81_E2.9151.00
132_K244_A2.8821.00
56_E107_R2.8761.00
134_Y148_A2.7421.00
82_L92_R2.7251.00
102_G108_K2.6961.00
145_K176_E2.6301.00
96_A99_E2.6071.00
400_D404_S2.5541.00
352_K356_E2.5201.00
128_Q132_K2.4951.00
397_E401_R2.4091.00
87_P91_E2.3921.00
356_E361_D2.3711.00
58_K359_D2.3381.00
363_N366_N2.3291.00
124_E128_Q2.3181.00
95_K99_E2.2491.00
52_R56_E2.2191.00
84_E92_R2.1891.00
54_Y58_K2.1841.00
176_E179_L2.1421.00
55_L58_K2.1421.00
370_V373_D2.1421.00
125_F245_L2.1221.00
195_D200_K2.0881.00
98_F102_G2.0451.00
222_D251_A1.9731.00
84_E88_T1.9621.00
357_E366_N1.9381.00
346_K377_H1.9261.00
103_A282_K1.9241.00
401_R408_F1.9151.00
279_D282_K1.8861.00
405_V408_F1.8821.00
400_D405_V1.8731.00
48_Y225_A1.8661.00
425_E429_E1.8611.00
52_R62_V1.8471.00
121_A215_K1.8341.00
99_E103_A1.8041.00
91_E95_K1.7901.00
349_E353_A1.7671.00
404_S407_G1.7301.00
278_H282_K1.7251.00
357_E370_V1.7161.00
84_E89_I1.7001.00
392_I395_F1.6951.00
350_H374_L1.6801.00
422_D426_K1.6741.00
129_L244_A1.6661.00
390_H394_A1.6561.00
401_R405_V1.6511.00
401_R404_S1.6491.00
54_Y355_E1.6021.00
428_N432_R1.5971.00
51_V362_F1.5791.00
393_T397_E1.5751.00
346_K349_E1.5741.00
421_E425_E1.5711.00
113_P116_M1.5491.00
95_K98_F1.5201.00
159_S162_E1.5111.00
280_I289_L1.5081.00
391_V394_A1.4911.00
189_E192_I1.4891.00
345_E349_E1.4791.00
306_E310_E1.4701.00
397_E400_D1.4671.00
400_D403_V1.4651.00
45_A101_V1.4611.00
252_K362_F1.4471.00
262_I305_S1.4411.00
191_E194_W1.4371.00
276_L279_D1.4341.00
20_E23_K1.4201.00
355_E359_D1.4191.00
20_E25_K1.4061.00
76_I80_N1.4041.00
400_D407_G1.4031.00
112_H115_V1.4031.00
26_M52_R1.3961.00
422_D425_E1.3911.00
288_L313_K1.3901.00
88_T92_R1.3861.00
184_W187_A1.3851.00
103_A281_I1.3811.00
188_K191_E1.3651.00
410_L413_Q1.3591.00
211_A214_K1.3551.00
205_W208_E1.3551.00
78_A82_L1.3501.00
27_Y30_G1.3361.00
353_A356_E1.3341.00
416_L419_E1.3311.00
358_M367_A1.3261.00
219_D248_K1.3161.00
386_H389_D1.3141.00
214_K217_L1.3071.00
213_V217_L1.2911.00
46_I293_M1.2831.00
191_E195_D1.2821.00
68_F94_I1.2811.00
396_I399_F1.2791.00
351_R355_E1.2761.00
318_R375_A1.2731.00
89_I93_F1.2681.00
77_K81_E1.2661.00
190_G194_W1.2551.00
348_E351_R1.2501.00
68_F98_F1.2471.00
213_V216_Y1.2461.00
208_E211_A1.2461.00
103_A278_H1.2441.00
151_G154_K1.2431.00
394_A405_V1.2411.00
189_E194_W1.2391.00
380_Y384_K1.2371.00
183_L186_A1.2331.00
390_H393_T1.2331.00
393_T396_I1.2201.00
211_A215_K1.2181.00
429_E432_R1.2181.00
307_E310_E1.2171.00
404_S408_F1.2151.00
210_S214_K1.2141.00
147_R177_D1.2121.00
338_E341_D1.2051.00
176_E180_D1.2031.00
346_K350_H1.2011.00
209_C212_M1.1981.00
18_P21_E1.1981.00
340_D381_Y1.1981.00
193_S196_S1.1971.00
190_G193_S1.1951.00
192_I195_D1.1951.00
128_Q245_L1.1941.00
279_D283_Q1.1911.00
186_A189_E1.1801.00
235_H253_Y1.1801.00
99_E102_G1.1771.00
403_V407_G1.1731.00
99_E278_H1.1701.00
402_I405_V1.1691.00
45_A106_C1.1681.00
44_P257_N1.1661.00
391_V395_F1.1601.00
70_D114_R1.1581.00
27_Y34_Y1.1541.00
127_D130_V1.1501.00
54_Y358_M1.1481.00
398_M402_I1.1391.00
180_D184_W1.1341.00
189_E193_S1.1341.00
184_W188_K1.1231.00
92_R96_A1.1201.00
354_F367_A1.1171.00
346_K376_K1.1141.00
418_Q422_D1.1121.00
341_D345_E1.1041.00
347_V351_R1.1031.00
209_C216_Y1.1031.00
262_I307_E1.1021.00
42_A104_L1.0991.00
36_Y278_H1.0971.00
162_E165_S1.0951.00
283_Q310_E1.0891.00
54_Y359_D1.0891.00
52_R107_R1.0841.00
207_I210_S1.0831.00
109_A112_H1.0771.00
22_G60_Y1.0771.00
287_Q320_K1.0761.00
191_E196_S1.0741.00
124_E127_D1.0651.00
337_T340_D1.0621.00
322_A375_A1.0611.00
180_D183_L1.0601.00
351_R401_R1.0601.00
208_E213_V1.0571.00
219_D222_D1.0551.00
399_F402_I1.0521.00
210_S213_V1.0491.00
209_C213_V1.0491.00
350_H370_V1.0481.00
392_I396_I1.0481.00
108_K111_L1.0471.00
30_G34_Y1.0471.00
397_E405_V1.0431.00
108_K112_H1.0391.00
180_D188_K1.0391.00
206_H209_C1.0371.00
354_F358_M1.0361.00
307_E311_N1.0351.00
347_V374_L1.0341.00
394_A398_M1.0301.00
181_F184_W1.0271.00
191_E197_P1.0241.00
118_N216_Y1.0191.00
313_K317_S1.0151.00
212_M216_Y1.0141.00
190_G196_S1.0141.00
29_C34_Y1.0121.00
134_Y244_A1.0081.00
118_N121_A1.0081.00
190_G195_D1.0081.00
292_F308_L1.0061.00
37_I41_N1.0061.00
31_P34_Y1.0051.00
100_D278_H1.0021.00
94_I98_F0.9991.00
98_F110_D0.9981.00
35_N41_N0.9971.00
194_W197_P0.9951.00
51_V55_L0.9871.00
322_A378_A0.9821.00
261_N303_N0.9821.00
394_A397_E0.9821.00
267_M273_N0.9821.00
91_E114_R0.9811.00
98_F112_H0.9761.00
24_V60_Y0.9761.00
423_L426_K0.9721.00
417_D421_E0.9711.00
413_Q416_L0.9641.00
202_R205_W0.9631.00
168_R171_V0.9591.00
391_V408_F0.9551.00
394_A407_G0.9551.00
50_T358_M0.9541.00
425_E428_N0.9541.00
366_N369_S0.9531.00
347_V401_R0.9431.00
398_M401_R0.9431.00
395_F398_M0.9421.00
357_E367_A0.9391.00
211_A216_Y0.9351.00
212_M215_K0.9341.00
353_A357_E0.9331.00
430_A433_N0.9311.00
354_F371_L0.9311.00
82_L89_I0.9301.00
108_K113_P0.9281.00
264_N303_N0.9271.00
75_L86_V0.9261.00
88_T91_E0.9201.00
98_F108_K0.9191.00
419_E435_D0.9141.00
315_A372_F0.9141.00
231_T255_L0.9071.00
120_D123_I0.9051.00
57_Y404_S0.9031.00
129_L241_Q0.9011.00
129_L132_K0.9001.00
176_E181_F0.8991.00
400_D408_F0.8861.00
369_S373_D0.8851.00
182_A185_K0.8841.00
348_E352_K0.8831.00
121_A124_E0.8791.00
180_D186_A0.8781.00
35_N78_A0.8781.00
426_K430_A0.8771.00
344_L348_E0.8671.00
418_Q421_E0.8671.00
390_H395_F0.8641.00
179_L183_L0.8631.00
216_Y242_S0.8621.00
209_C215_K0.8611.00
153_G156_S0.8581.00
192_I196_S0.8531.00
165_S168_R0.8521.00
161_D168_R0.8511.00
395_F408_F0.8501.00
354_F370_V0.8411.00
51_V223_I0.8391.00
202_R206_H0.8371.00
349_E352_K0.8351.00
178_A181_F0.8331.00
344_L394_A0.8321.00
120_D124_E0.8321.00
378_A395_F0.8251.00
144_F149_F0.8241.00
193_S200_K0.8241.00
186_A190_G0.8221.00
415_L418_Q0.8221.00
393_T405_V0.8221.00
193_S198_W0.8201.00
185_K188_K0.8191.00
44_P256_H0.8191.00
267_M274_F0.8171.00
55_L359_D0.8171.00
48_Y64_Y0.8171.00
399_F408_F0.8121.00
193_S197_P0.8121.00
285_D288_L0.8081.00
175_K178_A0.8081.00
93_F96_A0.8051.00
342_Q346_K0.8041.00
262_I274_F0.7991.00
123_I127_D0.7981.00
248_K251_A0.7971.00
167_A170_R0.7971.00
28_V225_A0.7941.00
353_A366_N0.7911.00
249_T252_K0.7901.00
428_N431_R0.7901.00
411_G414_E0.7871.00
183_L187_A0.7871.00
92_R95_K0.7821.00
192_I197_P0.7821.00
194_W199_G0.7801.00
132_K246_T0.7771.00
213_V221_I0.7751.00
412_E415_L0.7751.00
402_I407_G0.7751.00
219_D242_S0.7741.00
310_E314_S0.7741.00
183_L188_K0.7731.00
169_I172_G0.7731.00
403_V408_F0.7711.00
183_L190_G0.7711.00
109_A115_V0.7691.00
397_E408_F0.7691.00
193_S199_G0.7691.00
36_Y93_F0.7681.00
208_E212_M0.7661.00
43_R302_I0.7651.00
177_D180_D0.7651.00
377_H380_Y0.7641.00
396_I407_G0.7641.00
336_L344_L0.7631.00
49_D53_N0.7631.00
281_I286_P0.7631.00
393_T408_F0.7611.00
353_A373_D0.7571.00
396_I403_V0.7561.00
46_I106_C0.7561.00
158_Q163_L0.7551.00
396_I400_D0.7551.00
415_L419_E0.7531.00
189_E196_S0.7531.00
118_N201_G0.7531.00
218_G222_D0.7521.00
419_E423_L0.7511.00
139_E173_E0.7511.00
403_V406_L0.7481.00
115_V122_I0.7471.00
25_K34_Y0.7441.00
427_R431_R0.7421.00
391_V397_E0.7421.00
342_Q345_E0.7411.00
152_Y155_L0.7411.00
37_I100_D0.7411.00
52_R64_Y0.7401.00
357_E361_D0.7391.00
271_L274_F0.7351.00
350_H354_F0.7341.00
291_F312_T0.7341.00
336_L341_D0.7321.00
202_R210_S0.7321.00
75_L90_S0.7291.00
345_E348_E0.7281.00
424_I428_N0.7271.00
51_V364_T0.7251.00
257_N260_I0.7231.00
175_K182_A0.7231.00
430_A434_R0.7221.00
223_I362_F0.7191.00
204_G207_I0.7181.00
223_I254_W0.7171.00
180_D185_K0.7161.00
53_N107_R0.7121.00
25_K63_Q0.7111.00
167_A171_V0.7091.00
391_V396_I0.7081.00
134_Y186_A0.7081.00
36_Y100_D0.7081.00
130_V135_A0.7071.00
166_G169_I0.7061.00
291_F368_I0.7051.00
109_A117_E0.7021.00
319_L375_A0.7001.00
397_E403_V0.7001.00
342_Q377_H0.6951.00
28_V34_Y0.6941.00
176_E183_L0.6941.00
414_E417_D0.6931.00
46_I294_L0.6931.00
82_L85_D0.6911.00
397_E404_S0.6901.00
358_M406_L0.6891.00
325_N383_Q0.6881.00
111_L117_E0.6881.00
181_F185_K0.6881.00
310_E313_K0.6871.00
228_Q259_Y0.6861.00
46_I50_T0.6861.00
412_E416_L0.6851.00
24_V29_C0.6851.00
28_V48_Y0.6841.00
399_F404_S0.6841.00
20_E61_D0.6831.00
397_E407_G0.6831.00
209_C214_K0.6811.00
226_G235_H0.6811.00
61_D218_G0.6801.00
350_H353_A0.6781.00
308_L311_N0.6781.00
41_N45_A0.6771.00
380_Y383_Q0.6771.00
423_L427_R0.6761.00
78_A89_I0.6751.00
175_K181_F0.6721.00
113_P117_E0.6711.00
352_K355_E0.6691.00
392_I399_F0.6681.00
39_I274_F0.6671.00
72_D76_I0.6661.00
105_G286_P0.6661.00
25_K29_C0.6661.00
383_Q386_H0.6651.00
343_W377_H0.6641.00
357_E363_N0.6631.00
264_N272_G0.6621.00
177_D181_F0.6611.00
110_D113_P0.6601.00
190_G197_P0.6591.00
291_F315_A0.6591.00
141_D175_K0.6571.00
177_D183_L0.6571.00
50_T364_T0.6531.00
223_I252_K0.6531.00
211_A217_L0.6521.00
220_Q252_K0.6511.00
24_V27_Y0.6501.00
201_G206_H0.6491.00
42_A277_V0.6481.00
391_V400_D0.6481.00
411_G415_L0.6471.00
263_D303_N0.6471.00
143_Y157_Q0.6461.00
101_V106_C0.6431.00
94_I114_R0.6431.00
100_D276_L0.6421.00
393_T407_G0.6421.00
267_M275_V0.6411.00
29_C32_T0.6401.00
214_K246_T0.6401.00
258_G261_N0.6401.00
182_A186_A0.6391.00
224_H238_E0.6371.00
432_R436_F0.6371.00
391_V407_G0.6361.00
391_V404_S0.6361.00
95_K102_G0.6361.00
431_R436_F0.6321.00
210_S216_Y0.6321.00
420_I423_L0.6321.00
195_D198_W0.6301.00
195_D199_G0.6291.00
47_V294_L0.6291.00
391_V398_M0.6271.00
179_L182_A0.6241.00
51_V255_L0.6231.00
24_V34_Y0.6221.00
82_L93_F0.6211.00
208_E216_Y0.6191.00
181_F188_K0.6181.00
243_E249_T0.6181.00
308_L312_T0.6171.00
292_F312_T0.6161.00
182_A187_A0.6161.00
181_F186_A0.6151.00
410_L415_L0.6141.00
339_D342_Q0.6131.00
437_A440_D0.6111.00
321_T325_N0.6101.00
396_I405_V0.6091.00
192_I198_W0.6091.00
296_V302_I0.6041.00
25_K222_D0.6021.00
25_K221_I0.6021.00
26_M29_C0.6021.00
183_L189_E0.6021.00
393_T400_D0.6011.00
394_A401_R0.5981.00
265_E272_G0.5961.00
228_Q231_T0.5941.00
426_K429_E0.5941.00
192_I199_G0.5941.00
47_V225_A0.5891.00
324_S327_Q0.5861.00
420_I426_K0.5861.00
206_H211_A0.5861.00
205_W210_S0.5851.00
26_M34_Y0.5851.00
279_D306_E0.5841.00
395_F400_D0.5841.00
175_K180_D0.5841.00
19_L252_K0.5841.00
417_D424_I0.5831.00
36_Y276_L0.5820.99
417_D428_N0.5810.99
23_K63_Q0.5800.99
424_I427_R0.5800.99
142_V151_G0.5790.99
178_A188_K0.5780.99
63_Q111_L0.5770.99
189_E199_G0.5770.99
27_Y32_T0.5760.99
262_I303_N0.5740.99
417_D420_I0.5730.99
345_E414_E0.5730.99
209_C217_L0.5730.99
343_W374_L0.5720.99
413_Q417_D0.5690.99
94_I112_H0.5690.99
207_I211_A0.5690.99
398_M403_V0.5680.99
396_I404_S0.5680.99
39_I267_M0.5670.99
147_R167_A0.5660.99
199_G206_H0.5660.99
228_Q301_P0.5660.99
349_E417_D0.5650.99
399_F403_V0.5640.99
79_A86_V0.5630.99
204_G209_C0.5630.99
214_K219_D0.5610.99
206_H210_S0.5610.99
268_S271_L0.5610.99
203_P206_H0.5600.99
175_K179_L0.5600.99
410_L414_E0.5600.99
182_A188_K0.5570.99
132_K247_G0.5560.99
275_V304_Y0.5560.99
304_Y309_L0.5560.99
119_M123_I0.5560.99
206_H212_M0.5550.99
33_V45_A0.5540.99
189_E197_P0.5530.99
111_L216_Y0.5530.99
347_V398_M0.5520.99
191_E198_W0.5520.99
294_L368_I0.5510.99
44_P48_Y0.5510.99
205_W214_K0.5500.99
187_A190_G0.5490.99
311_N315_A0.5490.99
165_S171_V0.5480.99
158_Q161_D0.5480.99
284_H310_E0.5480.99
430_A435_D0.5460.99
325_N382_L0.5460.99
204_G208_E0.5460.99
390_H405_V0.5450.99
416_L420_I0.5450.99
199_G202_R0.5440.99
164_R167_A0.5440.99
366_N370_V0.5430.99
71_V119_M0.5420.99
274_F277_V0.5420.99
185_K189_E0.5410.99
111_L115_V0.5400.99
204_G210_S0.5400.99
56_E110_D0.5380.99
210_S215_K0.5380.99
191_E199_G0.5370.99
327_Q331_N0.5370.99
419_E422_D0.5370.99
161_D164_R0.5360.99
421_E424_I0.5350.99
166_G171_V0.5330.99
30_G33_V0.5330.99
199_G205_W0.5330.99
66_S112_H0.5320.99
341_D410_L0.5310.99
254_W298_Y0.5300.99
436_F440_D0.5290.99
339_D385_D0.5290.99
329_R333_S0.5280.99
434_R437_A0.5250.99
201_G207_I0.5250.99
129_L135_A0.5250.99
189_E195_D0.5240.99
390_H408_F0.5240.99
179_L186_A0.5240.99
200_K206_H0.5240.99
398_M404_S0.5240.99
141_D173_E0.5230.99
77_K80_N0.5230.99
390_H396_I0.5230.99
218_G221_I0.5220.99
187_A191_E0.5210.99
325_N329_R0.5210.99
205_W209_C0.5200.99
390_H397_E0.5160.99
212_M217_L0.5150.99
159_S164_R0.5140.99
391_V403_V0.5140.99
202_R207_I0.5100.99
110_D116_M0.5080.99
24_V30_G0.5070.99
24_V223_I0.5070.99
201_G204_G0.5070.99
120_D207_I0.5060.99
414_E418_Q0.5060.99
208_E214_K0.5050.99
399_F407_G0.5050.99
367_A370_V0.5050.99
206_H216_Y0.5040.99
232_F236_E0.5030.99
356_E359_D0.5020.99
178_A183_L0.5020.99
56_E62_V0.5020.99
186_A191_E0.5010.98
196_S199_G0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tqoA 1 0.8155 100 0.227 Contact Map
1li5A 1 0.8155 100 0.234 Contact Map
3sp1A 1 0.9056 100 0.261 Contact Map
1gaxA 1 0.9871 100 0.295 Contact Map
1rqgA 2 0.9464 100 0.313 Contact Map
3kflA 1 0.912 100 0.319 Contact Map
3ziuA 1 0.9614 100 0.326 Contact Map
1ffyA 1 0.9807 100 0.337 Contact Map
1ileA 1 0.9785 100 0.345 Contact Map
4py2A 1 0.8948 100 0.348 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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