GREMLIN Database
CYSE - Serine acetyltransferase
UniProt: Q06750 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (175)
Sequences: 2540 (1286)
Seq/√Len: 97.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_K141_E4.8341.00
121_I127_I4.2071.00
124_D142_G3.6091.00
123_D141_E3.1691.00
78_R98_N3.0891.00
161_V166_G3.0221.00
122_K138_T2.9531.00
142_G158_F2.7631.00
137_I154_D2.7351.00
8_E77_R2.6391.00
44_A48_R2.4581.00
96_G123_D2.3351.00
11_D23_Y2.3081.00
77_R97_N2.3071.00
116_K120_T2.2901.00
141_E157_D2.1641.00
99_V121_I2.1491.00
155_V161_V2.1181.00
67_I84_G2.1071.00
74_T94_E2.0371.00
14_F23_Y2.0361.00
8_E78_R2.0171.00
96_G122_K1.9941.00
28_L52_F1.9741.00
97_N123_D1.9741.00
51_Y54_A1.9111.00
81_I87_V1.8831.00
38_A61_S1.8741.00
98_N124_D1.8421.00
76_G97_N1.8341.00
156_P168_V1.8171.00
138_T154_D1.8091.00
33_L37_W1.8071.00
121_I139_V1.7961.00
143_S155_V1.7151.00
143_S159_S1.6681.00
60_V64_F1.6041.00
132_K148_G1.6011.00
52_F56_L1.5901.00
12_T16_Q1.5771.00
75_I95_I1.5251.00
159_S168_V1.5191.00
101_V127_I1.5131.00
16_Q100_T1.4821.00
79_F123_D1.4701.00
94_E136_S1.4141.00
29_T52_F1.3740.99
36_I79_F1.3690.99
143_S157_D1.3600.99
66_G85_M1.3560.99
39_H61_S1.2860.99
98_N123_D1.2480.99
146_G162_V1.2460.99
43_H47_K1.2450.99
124_D141_E1.2380.99
139_V145_I1.2360.99
161_V168_V1.2330.99
130_G148_G1.2290.99
45_L53_L1.2250.99
20_A26_V1.1950.98
144_K160_T1.1920.98
68_E85_M1.1850.98
9_D40_R1.1810.98
133_V137_I1.1770.98
43_H74_T1.1600.98
79_F95_I1.1440.98
62_R85_M1.1400.98
75_I79_F1.1390.98
139_V143_S1.1160.97
122_K157_D1.0930.97
10_I27_I1.0800.97
10_I33_L1.0770.97
29_T56_L1.0720.97
99_V123_D1.0530.96
10_I23_Y1.0420.96
58_S68_E1.0370.96
50_F54_A1.0350.96
75_I89_I1.0250.96
140_G157_D1.0220.96
94_E120_T1.0160.95
156_P159_S1.0060.95
174_K177_R0.9930.95
133_V145_I0.9760.94
128_A152_L0.9740.94
158_F172_N0.9710.94
173_G176_V0.9700.94
103_Q106_T0.9660.94
46_Y51_Y0.9650.94
60_V63_F0.9640.94
79_F101_V0.9600.94
14_F26_V0.9510.94
159_S171_Q0.9490.94
42_A57_I0.9470.93
20_A30_Y0.9450.93
160_T169_V0.9320.93
113_E136_S0.9280.93
13_V33_L0.9250.93
120_T136_S0.9240.93
86_G104_G0.9120.92
72_G91_E0.9010.92
21_R25_E0.8790.91
172_N175_K0.8760.90
13_V80_F0.8750.90
80_F100_T0.8680.90
24_F28_L0.8580.90
149_S165_P0.8560.89
11_D15_D0.8390.88
26_V30_Y0.8350.88
21_R51_Y0.8300.88
59_Q68_E0.8230.88
150_V164_I0.8130.87
139_V154_D0.8050.86
50_F53_L0.8050.86
59_Q63_F0.8020.86
103_Q112_K0.8010.86
45_L50_F0.7970.86
96_G138_T0.7940.86
101_V121_I0.7910.85
37_W41_I0.7880.85
19_A30_Y0.7840.85
94_E116_K0.7760.84
171_Q174_K0.7720.84
99_V141_E0.7650.83
77_R98_N0.7610.83
104_G130_G0.7500.82
29_T59_Q0.7440.82
38_A60_V0.7400.81
122_K143_S0.7350.81
127_I131_A0.7340.81
59_Q85_M0.7340.81
149_S166_G0.7320.81
162_V166_G0.7320.81
22_S26_V0.7310.81
147_A163_G0.7310.81
12_T78_R0.7310.81
5_M77_R0.7290.80
172_N176_V0.7190.79
119_P135_G0.7180.79
96_G141_E0.7160.79
9_D37_W0.7140.79
170_V175_K0.7140.79
7_K11_D0.7120.79
44_A47_K0.7080.78
6_L37_W0.7030.78
38_A42_A0.6980.77
20_A34_H0.6950.77
141_E158_F0.6910.77
89_I95_I0.6890.76
151_V166_G0.6870.76
29_T126_L0.6850.76
35_A67_I0.6840.76
31_S62_R0.6800.76
82_D117_R0.6760.75
7_K23_Y0.6750.75
76_G98_N0.6650.74
145_I161_V0.6640.74
93_C121_I0.6640.74
156_P161_V0.6560.73
110_T160_T0.6540.73
47_K74_T0.6520.72
3_F6_L0.6510.72
56_L60_V0.6500.72
39_H58_S0.6490.72
22_S25_E0.6480.72
161_V169_V0.6460.72
12_T98_N0.6440.72
149_S161_V0.6440.72
10_I26_V0.6400.71
92_T118_H0.6380.71
81_I101_V0.6350.70
39_H75_I0.6330.70
110_T144_K0.6320.70
69_I75_I0.6310.70
71_P117_R0.6290.70
104_G132_K0.6270.70
112_K148_G0.6230.69
151_V163_G0.6210.69
124_D158_F0.6150.68
44_A49_K0.6140.68
111_G115_G0.6100.67
111_G152_L0.6090.67
47_K177_R0.6080.67
127_I145_I0.6080.67
42_A61_S0.6050.67
112_K136_S0.6030.67
148_G164_I0.6010.66
46_Y70_H0.5970.66
12_T100_T0.5950.66
71_P118_H0.5950.66
158_F171_Q0.5950.66
150_V163_G0.5890.65
163_G166_G0.5880.65
3_F7_K0.5880.65
112_K115_G0.5880.65
25_E55_R0.5870.64
95_I127_I0.5860.64
53_L57_I0.5850.64
46_Y72_G0.5830.64
171_Q176_V0.5830.64
88_V118_H0.5800.64
18_P82_D0.5770.63
132_K164_I0.5770.63
32_G35_A0.5760.63
8_E15_D0.5700.62
132_K150_V0.5690.62
143_S168_V0.5680.62
160_T167_R0.5680.62
143_S158_F0.5670.62
38_A57_I0.5660.62
36_I75_I0.5650.62
68_E84_G0.5610.61
107_L118_H0.5590.61
5_M33_L0.5590.61
83_H88_V0.5570.60
45_L54_A0.5550.60
71_P82_D0.5530.60
71_P92_T0.5510.60
27_I37_W0.5510.60
100_T126_L0.5500.60
90_G118_H0.5490.59
170_V173_G0.5470.59
172_N177_R0.5440.59
95_I121_I0.5420.58
62_R68_E0.5410.58
83_H119_P0.5400.58
82_D118_H0.5370.58
78_R111_G0.5360.58
70_H117_R0.5350.57
45_L57_I0.5330.57
63_F85_M0.5330.57
11_D26_V0.5320.57
110_T113_E0.5300.57
38_A64_F0.5280.56
103_Q129_T0.5270.56
70_H90_G0.5260.56
158_F174_K0.5250.56
82_D90_G0.5250.56
81_I84_G0.5240.56
25_E29_T0.5240.56
149_S163_G0.5230.56
4_R77_R0.5220.56
14_F79_F0.5220.56
41_I48_R0.5190.55
55_R58_S0.5170.55
159_S170_V0.5150.55
144_K152_L0.5140.54
103_Q136_S0.5130.54
92_T117_R0.5130.54
31_S59_Q0.5110.54
8_E98_N0.5080.54
19_A109_G0.5080.54
71_P90_G0.5080.54
153_H169_V0.5080.54
17_D82_D0.5030.53
4_R152_L0.5030.53
142_G172_N0.5030.53
49_K53_L0.5020.53
83_H135_G0.5020.53
145_I166_G0.5010.53
15_D27_I0.5010.53
151_V155_V0.5000.52
82_D92_T0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n6aA 3 0.7788 100 0.372 Contact Map
3q1xA 3 0.7465 100 0.404 Contact Map
1ssqA 6 0.8571 100 0.405 Contact Map
4h7oA 6 0.8618 100 0.405 Contact Map
4hzdA 5 0.8065 100 0.428 Contact Map
3f1xA 6 0.7465 100 0.43 Contact Map
4hurA 3 0.7926 100 0.561 Contact Map
1mr7A 3 0.7742 100 0.566 Contact Map
3fttA 3 0.7834 100 0.572 Contact Map
1krrA 3 0.8249 100 0.573 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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