CWLC - BACSU - GREMLIN Contacts

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CWLC - Sporulation-specific N-acetylmuramoyl-L-alanine amidase

UniProt:	Q06320	Sequences: MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYEGVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTTYQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFIQSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLKDGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	255 (220)
Sequences:	978 (794)
Seq/√Len:	53.6

ECOLI - AMIB AMIC AMIA
BACSU - CWLC YRVJ CWLD YQII LYTC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
107_I	138_L	4.445	1.00
31_I	142_N	3.324	1.00
6_I	32_A	3.221	1.00
76_L	171_L	2.927	1.00
34_A	161_Q	2.903	1.00
186_Y	191_G	2.881	1.00
36_R	50_L	2.802	1.00
30_Q	160_I	2.782	1.00
32_A	78_I	2.734	1.00
28_T	80_V	2.676	1.00
23_Q	26_T	2.569	1.00
81_N	89_E	2.533	1.00
75_F	129_V	2.440	1.00
3_K	47_S	2.423	1.00
8_P	32_A	2.290	1.00
89_E	123_K	2.253	1.00
188_V	191_G	2.241	1.00
36_R	40_T	2.227	1.00
64_T	128_H	2.204	1.00
82_S	146_D	2.162	1.00
110_E	173_Q	2.129	1.00
17_A	145_I	2.100	1.00
5_F	51_S	2.060	1.00
140_T	167_H	2.029	1.00
19_G	151_A	2.021	1.00
65_N	69_N	1.985	1.00
59_S	62_D	1.928	1.00
193_F	199_A	1.910	1.00
108_H	119_D	1.867	0.99
22_L	151_A	1.836	0.99
189_Q	192_A	1.819	0.99
25_K	55_D	1.800	0.99
27_L	80_V	1.759	0.99
49_L	66_A	1.759	0.99
88_F	111_V	1.745	0.99
67_A	135_M	1.731	0.99
128_H	132_E	1.726	0.99
62_D	65_N	1.663	0.99
39_L	171_L	1.660	0.99
90_S	108_H	1.650	0.99
35_L	168_A	1.626	0.98
49_L	70_W	1.615	0.98
37_T	40_T	1.600	0.98
128_H	131_R	1.576	0.98
158_S	162_S	1.573	0.98
165_R	169_N	1.557	0.98
12_G	25_K	1.550	0.98
22_L	155_K	1.540	0.98
198_N	210_G	1.527	0.98
110_E	169_N	1.503	0.97
29_L	52_R	1.486	0.97
38_I	165_R	1.451	0.97
103_Y	138_L	1.441	0.96
120_R	123_K	1.438	0.96
20_N	151_A	1.436	0.96
30_Q	34_A	1.433	0.96
11_G	25_K	1.423	0.96
11_G	55_D	1.422	0.96
218_K	223_K	1.418	0.96
38_I	168_A	1.415	0.96
186_Y	192_A	1.380	0.95
7_D	63_R	1.378	0.95
74_F	103_Y	1.378	0.95
142_N	167_H	1.355	0.95
5_F	66_A	1.354	0.95
193_F	196_K	1.335	0.95
185_L	190_I	1.333	0.95
186_Y	189_Q	1.325	0.94
34_A	157_S	1.303	0.94
197_A	214_I	1.296	0.94
104_Q	122_K	1.292	0.94
187_K	191_G	1.281	0.93
62_D	69_N	1.273	0.93
96_V	126_N	1.268	0.93
111_V	140_T	1.241	0.92
193_F	202_L	1.233	0.92
129_V	139_L	1.225	0.92
14_D	25_K	1.220	0.91
89_E	120_R	1.211	0.91
199_A	206_A	1.198	0.91
4_I	46_V	1.188	0.90
12_G	55_D	1.187	0.90
4_I	39_L	1.181	0.90
127_F	139_L	1.178	0.90
91_Y	127_F	1.173	0.90
208_A	212_D	1.170	0.90
101_T	124_T	1.149	0.89
93_Y	137_A	1.124	0.88
52_R	55_D	1.117	0.87
83_G	146_D	1.104	0.87
115_V	143_G	1.091	0.86
86_T	118_A	1.077	0.85
12_G	52_R	1.075	0.85
85_G	146_D	1.074	0.85
7_D	129_V	1.066	0.85
106_T	174_A	1.066	0.85
84_G	146_D	1.066	0.85
29_L	55_D	1.060	0.84
143_G	150_D	1.059	0.84
11_G	14_D	1.056	0.84
117_F	143_G	1.056	0.84
207_E	213_S	1.049	0.84
14_D	57_Y	1.048	0.84
215_V	219_D	1.048	0.84
25_K	29_L	1.047	0.84
18_T	23_Q	1.044	0.83
4_I	74_F	1.036	0.83
209_K	212_D	1.035	0.83
181_S	184_G	1.034	0.83
146_D	150_D	1.032	0.83
218_K	222_Y	1.020	0.82
91_Y	125_A	1.015	0.82
68_N	135_M	1.012	0.82
215_V	218_K	1.011	0.81
40_T	48_L	1.011	0.81
40_T	53_T	0.998	0.81
196_K	200_D	0.996	0.80
206_A	211_F	0.982	0.80
194_K	197_A	0.973	0.79
5_F	72_A	0.967	0.78
106_T	170_G	0.966	0.78
109_S	173_Q	0.965	0.78
25_K	52_R	0.964	0.78
91_Y	123_K	0.963	0.78
61_N	65_N	0.962	0.78
153_K	162_S	0.956	0.78
153_K	159_F	0.942	0.77
156_T	159_F	0.928	0.76
51_S	66_A	0.913	0.74
105_S	109_S	0.910	0.74
35_L	167_H	0.902	0.73
3_K	71_G	0.901	0.73
151_A	155_K	0.895	0.73
106_T	173_Q	0.892	0.73
110_E	113_Q	0.890	0.72
195_V	204_S	0.888	0.72
200_D	204_S	0.880	0.72
186_Y	190_I	0.878	0.71
205_N	209_K	0.878	0.71
34_A	38_I	0.877	0.71
9_G	141_E	0.877	0.71
61_N	128_H	0.874	0.71
81_N	121_G	0.869	0.71
14_D	52_R	0.866	0.70
97_G	131_R	0.860	0.70
96_V	125_A	0.857	0.70
152_N	156_T	0.852	0.69
60_L	128_H	0.851	0.69
216_L	222_Y	0.848	0.69
43_Y	46_V	0.837	0.68
14_D	29_L	0.836	0.68
188_V	192_A	0.834	0.67
186_Y	199_A	0.829	0.67
35_L	78_I	0.825	0.67
193_F	211_F	0.821	0.66
189_Q	202_L	0.817	0.66
175_F	179_K	0.814	0.66
196_K	213_S	0.810	0.65
197_A	204_S	0.803	0.65
202_L	205_N	0.803	0.65
79_H	141_E	0.802	0.64
35_L	164_A	0.798	0.64
62_D	66_A	0.795	0.64
39_L	168_A	0.791	0.63
35_L	76_L	0.777	0.62
10_H	141_E	0.774	0.62
71_G	99_P	0.772	0.61
12_G	29_L	0.766	0.61
194_K	198_N	0.765	0.61
38_I	161_Q	0.762	0.60
43_Y	172_E	0.762	0.60
196_K	204_S	0.760	0.60
8_P	50_L	0.759	0.60
194_K	204_S	0.759	0.60
33_L	36_R	0.753	0.60
108_H	170_G	0.752	0.59
208_A	213_S	0.750	0.59
14_D	55_D	0.748	0.59
58_V	63_R	0.744	0.59
32_A	50_L	0.743	0.58
34_A	160_I	0.739	0.58
216_L	223_K	0.725	0.57
203_A	206_A	0.721	0.56
39_L	46_V	0.721	0.56
211_F	214_I	0.716	0.56
15_P	18_T	0.715	0.56
17_A	91_Y	0.715	0.56
86_T	149_S	0.709	0.55
28_T	127_F	0.708	0.55
215_V	223_K	0.700	0.54
210_G	214_I	0.696	0.54
100_T	122_K	0.694	0.53
153_K	156_T	0.694	0.53
206_A	210_G	0.694	0.53
39_L	76_L	0.690	0.53
8_P	51_S	0.690	0.53
14_D	145_I	0.689	0.53
203_A	207_E	0.685	0.52
29_L	33_L	0.685	0.52
96_V	127_F	0.682	0.52
219_D	223_K	0.681	0.52
195_V	201_S	0.681	0.52
27_L	31_I	0.677	0.52
205_N	208_A	0.676	0.51
74_F	174_A	0.672	0.51
122_K	127_F	0.669	0.51
207_E	211_F	0.665	0.50
36_R	53_T	0.665	0.50
217_L	222_Y	0.665	0.50
185_L	192_A	0.663	0.50
6_I	35_L	0.662	0.50
204_S	208_A	0.661	0.50
15_P	31_I	0.661	0.50
68_N	134_A	0.660	0.50
185_L	188_V	0.658	0.50
196_K	199_A	0.655	0.49
199_A	211_F	0.653	0.49
57_Y	60_L	0.653	0.49
190_I	206_A	0.650	0.49
195_V	205_N	0.646	0.48
88_F	108_H	0.645	0.48
90_S	140_T	0.644	0.48
36_R	48_L	0.644	0.48
219_D	222_Y	0.643	0.48
31_I	163_L	0.641	0.48
187_K	190_I	0.641	0.48
28_T	78_I	0.639	0.48
127_F	132_E	0.637	0.47
140_T	170_G	0.635	0.47
72_A	135_M	0.634	0.47
80_V	151_A	0.633	0.47
33_L	53_T	0.632	0.47
71_G	171_L	0.631	0.47
100_T	124_T	0.630	0.47
66_A	70_W	0.628	0.46
220_G	223_K	0.628	0.46
207_E	217_L	0.627	0.46
218_K	221_L	0.626	0.46
68_N	119_D	0.626	0.46
88_F	121_G	0.618	0.45
6_I	171_L	0.618	0.45
183_S	186_Y	0.617	0.45
67_A	75_F	0.614	0.45
201_S	212_D	0.609	0.44
5_F	70_W	0.607	0.44
122_K	126_N	0.606	0.44
197_A	212_D	0.604	0.44
93_Y	126_N	0.603	0.44
31_I	80_V	0.603	0.44
7_D	52_R	0.603	0.44
92_I	124_T	0.603	0.44
182_S	185_L	0.602	0.44
193_F	201_S	0.602	0.44
51_S	174_A	0.601	0.44
32_A	35_L	0.600	0.43
7_D	51_S	0.599	0.43
92_I	101_T	0.598	0.43
31_I	78_I	0.594	0.43
207_E	212_D	0.592	0.43
193_F	204_S	0.590	0.42
10_H	79_H	0.590	0.42
22_L	27_L	0.585	0.42
9_G	79_H	0.582	0.42
34_A	164_A	0.581	0.41
11_G	129_V	0.578	0.41
107_I	140_T	0.577	0.41
21_G	155_K	0.577	0.41
180_T	184_G	0.576	0.41
51_S	75_F	0.573	0.41
97_G	101_T	0.573	0.41
209_K	213_S	0.573	0.41
94_P	124_T	0.572	0.41
14_D	27_L	0.571	0.40
38_I	169_N	0.569	0.40
59_S	128_H	0.567	0.40
97_G	127_F	0.567	0.40
193_F	198_N	0.562	0.40
207_E	210_G	0.560	0.39
108_H	117_F	0.554	0.39
183_S	187_K	0.550	0.38
216_L	221_L	0.550	0.38
36_R	51_S	0.549	0.38
201_S	208_A	0.549	0.38
205_N	210_G	0.548	0.38
208_A	214_I	0.547	0.38
125_A	130_L	0.547	0.38
130_L	139_L	0.545	0.38
75_F	126_N	0.544	0.38
37_T	180_T	0.541	0.37
28_T	32_A	0.539	0.37
197_A	210_G	0.539	0.37
9_G	16_G	0.537	0.37
19_G	155_K	0.537	0.37
17_A	146_D	0.536	0.37
33_L	54_S	0.534	0.37
116_D	121_G	0.532	0.37
217_L	220_G	0.530	0.36
91_Y	139_L	0.528	0.36
194_K	201_S	0.528	0.36
217_L	221_L	0.528	0.36
192_A	202_L	0.527	0.36
195_V	211_F	0.525	0.36
75_F	135_M	0.525	0.36
35_L	172_E	0.525	0.36
193_F	206_A	0.525	0.36
93_Y	125_A	0.524	0.36
207_E	218_K	0.523	0.36
75_F	137_A	0.523	0.36
105_S	170_G	0.522	0.36
172_E	177_L	0.517	0.35
206_A	215_V	0.517	0.35
203_A	213_S	0.517	0.35
11_G	52_R	0.516	0.35
215_V	222_Y	0.515	0.35
19_G	22_L	0.514	0.35
43_Y	168_A	0.513	0.35
147_T	160_I	0.513	0.35
198_N	208_A	0.511	0.34
187_K	192_A	0.510	0.34
215_V	221_L	0.510	0.34
97_G	126_N	0.509	0.34
93_Y	96_V	0.508	0.34
197_A	211_F	0.507	0.34
181_S	188_V	0.507	0.34
201_S	204_S	0.506	0.34
198_N	201_S	0.506	0.34
48_L	121_G	0.504	0.34
7_D	77_S	0.503	0.34
64_T	133_S	0.500	0.33
3_K	49_L	0.500	0.33

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1jwqA	1	0.6824	100	0.262	Contact Map
4rn7A	1	0.6941	100	0.269	Contact Map
1xovA	1	0.9804	100	0.271	Contact Map
4binA	1	0.6863	100	0.274	Contact Map
3ne8A	2	0.7176	100	0.279	Contact Map
4lq6A	1	0.6902	100	0.305	Contact Map
3czxA	2	0.6706	100	0.318	Contact Map
3qayA	1	0.6588	100	0.354	Contact Map
1x60A	1	0.3098	97.2	0.897	Contact Map
1utaA	1	0.2941	96.8	0.903	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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