GREMLIN Database
DHSO - Sorbitol dehydrogenase
UniProt: Q06004 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 353 (305)
Sequences: 52862 (36583)
Seq/√Len: 2094.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
329_Q332_D2.9431.00
40_M149_Y2.8411.00
38_K77_A2.7761.00
40_M75_E2.6941.00
36_L77_A2.6321.00
35_V140_V2.6261.00
15_H23_E2.5701.00
193_K219_T2.5151.00
148_S151_E2.4731.00
91_R143_I2.3701.00
90_D142_L2.3531.00
87_K90_D2.3461.00
325_Y336_R2.3061.00
72_C128_A2.2861.00
232_E235_T2.2821.00
38_K75_E2.2241.00
150_E324_Q2.1691.00
27_V132_Y2.1531.00
211_E215_K2.1491.00
38_K132_Y2.1251.00
15_H21_K2.1171.00
175_T198_G2.0791.00
176_I192_A2.0491.00
308_E312_S2.0461.00
85_Q137_Q2.0461.00
181_M202_V2.0321.00
323_D336_R2.0221.00
210_L214_K2.0071.00
171_Q174_S1.9941.00
33_D82_S1.9871.00
189_V218_A1.9801.00
13_V23_E1.9651.00
324_Q350_Y1.9641.00
32_H81_S1.9611.00
166_A195_F1.9571.00
31_N34_E1.9511.00
326_S329_Q1.9501.00
72_C94_V1.9041.00
146_S311_A1.8911.00
91_R149_Y1.8831.00
73_A149_Y1.8701.00
32_H82_S1.8641.00
29_D78_A1.8211.00
211_E214_K1.8011.00
335_E339_Q1.7981.00
174_S267_K1.7901.00
158_F187_M1.7891.00
177_A242_V1.7431.00
36_L134_K1.7351.00
177_A203_T1.7251.00
166_A305_K1.7241.00
77_A132_Y1.7201.00
53_T338_L1.7101.00
332_D335_E1.7011.00
207_P211_E1.6921.00
339_Q342_N1.6861.00
325_Y333_A1.6651.00
194_A314_I1.6641.00
243_D263_R1.6611.00
201_I242_V1.6471.00
143_I149_Y1.6361.00
204_D210_L1.6211.00
80_G83_V1.6061.00
210_L221_I1.5941.00
332_D336_R1.5921.00
267_K292_D1.5811.00
262_V268_L1.5781.00
179_M258_A1.5581.00
207_P223_N1.5491.00
86_F142_L1.5231.00
12_A330_T1.5191.00
220_H236_I1.5181.00
227_Q232_E1.5131.00
212_A215_K1.5041.00
168_T244_V1.5001.00
223_N226_E1.5001.00
143_I152_A1.4921.00
34_E136_R1.4811.00
228_D231_E1.4811.00
262_V291_I1.4791.00
10_K24_T1.4751.00
30_I134_K1.4741.00
79_V88_V1.4691.00
267_K294_Y1.4651.00
129_F334_M1.4601.00
207_P226_E1.4541.00
150_E350_Y1.4441.00
78_A88_V1.4271.00
91_R145_D1.4261.00
262_V266_G1.4261.00
86_F90_D1.4251.00
198_G220_H1.4151.00
36_L132_Y1.4131.00
10_K131_Q1.4061.00
39_V72_C1.4051.00
75_E91_R1.3831.00
33_D136_R1.3511.00
10_K328_E1.3501.00
30_I36_L1.3481.00
52_Y334_M1.3461.00
34_E134_K1.3391.00
245_A258_A1.3381.00
189_V202_V1.3101.00
76_I86_F1.3101.00
331_Q335_E1.2971.00
12_A22_I1.2911.00
245_A262_V1.2901.00
322_T336_R1.2831.00
41_A150_E1.2811.00
35_V86_F1.2801.00
36_L78_A1.2651.00
11_A25_L1.2651.00
41_A350_Y1.2611.00
231_E235_T1.2581.00
198_G219_T1.2361.00
175_T201_I1.2341.00
336_R342_N1.2301.00
205_L210_L1.2181.00
75_E149_Y1.2121.00
205_L224_I1.2101.00
188_A246_W1.2081.00
308_E311_A1.2071.00
155_I310_L1.2041.00
162_I166_A1.1851.00
179_M203_T1.1831.00
194_A309_F1.1631.00
86_F140_V1.1541.00
40_M91_R1.1391.00
214_K221_I1.1351.00
30_I34_E1.1301.00
170_L197_A1.1251.00
27_V36_L1.1221.00
210_L223_N1.1171.00
190_A316_D1.1161.00
202_V218_A1.1061.00
207_P210_L1.1001.00
175_T243_D1.0901.00
12_A327_L1.0871.00
16_N19_E1.0751.00
135_M140_V1.0751.00
305_K308_E1.0751.00
39_V133_I1.0711.00
37_I74_G1.0691.00
77_A88_V1.0671.00
33_D137_Q1.0561.00
232_E236_I1.0521.00
330_T349_V1.0421.00
168_T269_A1.0381.00
174_S243_D1.0331.00
44_I333_A1.0251.00
151_E316_D1.0251.00
9_M27_V1.0161.00
52_Y338_L1.0141.00
45_C70_H1.0111.00
45_C71_E1.0041.00
41_A149_Y0.9991.00
212_A344_C0.9971.00
22_I328_E0.9961.00
161_G191_A0.9961.00
260_A285_F0.9911.00
326_S350_Y0.9901.00
166_A302_T0.9901.00
309_F314_I0.9891.00
53_T56_R0.9881.00
304_P308_E0.9841.00
163_H302_T0.9791.00
37_I92_V0.9761.00
40_M73_A0.9721.00
228_D232_E0.9711.00
249_A254_A0.9651.00
201_I220_H0.9641.00
42_V128_A0.9621.00
147_L152_A0.9531.00
161_G188_A0.9461.00
226_E232_E0.9431.00
170_L174_S0.9391.00
230_L260_A0.9301.00
192_A197_A0.9271.00
214_K220_H0.9251.00
42_V129_F0.9201.00
129_F330_T0.9191.00
41_A348_M0.9151.00
181_M204_D0.9151.00
189_V200_I0.9141.00
13_V25_L0.9121.00
178_I188_A0.9121.00
79_V83_V0.9101.00
336_R347_V0.9091.00
158_F306_G0.9061.00
164_A271_V0.9051.00
237_T241_G0.9001.00
84_D137_Q0.8981.00
13_V67_I0.8971.00
49_L337_A0.8951.00
83_V137_Q0.8931.00
286_I293_I0.8931.00
178_I192_A0.8911.00
27_V78_A0.8871.00
247_E250_G0.8831.00
129_F349_V0.8811.00
256_Q260_A0.8791.00
335_E338_L0.8781.00
66_F126_D0.8761.00
233_I242_V0.8681.00
25_L126_D0.8661.00
87_K142_L0.8661.00
33_D80_G0.8651.00
205_L225_R0.8651.00
206_E209_R0.8641.00
285_F289_N0.8631.00
179_M245_A0.8621.00
175_T242_V0.8611.00
230_L257_S0.8581.00
43_G71_E0.8551.00
191_A306_G0.8551.00
181_M213_A0.8531.00
162_I305_K0.8521.00
38_K131_Q0.8471.00
208_L211_E0.8411.00
177_A261_S0.8411.00
15_H19_E0.8401.00
181_M189_V0.8401.00
201_I222_I0.8401.00
29_D36_L0.8381.00
186_L212_A0.8361.00
206_E223_N0.8351.00
203_T224_I0.8331.00
11_A67_I0.8321.00
257_S260_A0.8321.00
209_R344_C0.8241.00
72_C133_I0.8221.00
164_A246_W0.8201.00
27_V77_A0.8181.00
337_A347_V0.8171.00
317_T320_L0.8161.00
204_D221_I0.8141.00
305_K309_F0.8051.00
174_S244_V0.8031.00
12_A20_I0.7911.00
145_D311_A0.7901.00
230_L234_K0.7891.00
93_A307_I0.7861.00
33_D81_S0.7851.00
202_V213_A0.7841.00
44_I337_A0.7841.00
165_A192_A0.7811.00
45_C48_D0.7811.00
9_M28_P0.7801.00
325_Y329_Q0.7771.00
10_K22_I0.7751.00
159_S302_T0.7721.00
237_T240_R0.7711.00
213_A218_A0.7711.00
265_G290_E0.7691.00
12_A331_Q0.7671.00
161_G187_M0.7621.00
191_A309_F0.7491.00
201_I236_I0.7471.00
229_A257_S0.7451.00
31_N134_K0.7431.00
147_L310_L0.7411.00
205_L213_A0.7391.00
161_G184_V0.7391.00
166_A191_A0.7331.00
176_I197_A0.7311.00
94_V135_M0.7301.00
228_D257_S0.7291.00
22_I327_L0.7251.00
309_F313_G0.7251.00
245_A268_L0.7231.00
201_I233_I0.7231.00
195_F305_K0.7221.00
170_L244_V0.7221.00
30_I78_A0.7201.00
164_A188_A0.7191.00
230_L261_S0.7191.00
47_S70_H0.7151.00
44_I129_F0.7151.00
9_M131_Q0.7121.00
92_V140_V0.7111.00
79_V87_K0.7101.00
231_E234_K0.7071.00
258_A268_L0.7071.00
163_H290_E0.7061.00
309_F312_S0.7031.00
248_T271_V0.7001.00
286_I291_I0.6991.00
179_M254_A0.6981.00
73_A153_A0.6941.00
336_R339_Q0.6931.00
30_I80_G0.6931.00
25_L67_I0.6921.00
270_I293_I0.6901.00
141_F304_P0.6901.00
325_Y349_V0.6891.00
282_N285_F0.6871.00
93_A143_I0.6871.00
9_M130_V0.6831.00
192_A200_I0.6821.00
215_K316_D0.6821.00
35_V137_Q0.6801.00
323_D332_D0.6791.00
242_V245_A0.6791.00
157_P183_P0.6731.00
169_K267_K0.6711.00
307_I311_A0.6711.00
14_M19_E0.6711.00
169_K294_Y0.6671.00
160_V184_V0.6621.00
286_I295_G0.6601.00
240_R263_R0.6601.00
200_I219_T0.6591.00
321_V324_Q0.6591.00
325_Y347_V0.6581.00
91_R146_S0.6561.00
244_V269_A0.6561.00
198_G201_I0.6561.00
234_K237_T0.6541.00
197_A200_I0.6491.00
137_Q140_V0.6491.00
18_R335_E0.6481.00
156_E160_V0.6481.00
161_G165_A0.6471.00
175_T240_R0.6471.00
323_D347_V0.6461.00
238_N241_G0.6461.00
90_D145_D0.6461.00
264_R289_N0.6451.00
197_A244_V0.6441.00
46_G50_H0.6411.00
178_I202_V0.6381.00
35_V76_I0.6351.00
141_F307_I0.6351.00
85_Q142_L0.6341.00
233_I261_S0.6331.00
73_A143_I0.6331.00
162_I306_G0.6301.00
204_D223_N0.6291.00
256_Q278_E0.6281.00
141_F303_Y0.6261.00
73_A91_R0.6251.00
212_A216_M0.6241.00
144_P311_A0.6231.00
128_A133_I0.6211.00
255_L268_L0.6211.00
37_I94_V0.6171.00
45_C157_P0.6161.00
336_R343_E0.6161.00
173_G198_G0.6161.00
303_Y307_I0.6131.00
334_M338_L0.6121.00
189_V216_M0.6111.00
162_I309_F0.6101.00
167_R292_D0.6091.00
204_D224_I0.6081.00
256_Q285_F0.6071.00
41_A73_A0.6041.00
210_L224_I0.6031.00
41_A324_Q0.6031.00
169_K292_D0.6031.00
247_E268_L0.6031.00
193_K200_I0.6021.00
40_M350_Y0.6021.00
16_N21_K0.6021.00
93_A156_E0.6011.00
251_N254_A0.6001.00
168_T267_K0.5961.00
85_Q88_V0.5941.00
28_P134_K0.5941.00
188_A271_V0.5921.00
204_D213_A0.5911.00
191_A195_F0.5891.00
242_V261_S0.5861.00
30_I82_S0.5861.00
47_S51_Y0.5861.00
148_S152_A0.5841.00
278_E282_N0.5831.00
220_H232_E0.5831.00
203_T222_I0.5831.00
244_V267_K0.5831.00
210_L213_A0.5831.00
252_P256_Q0.5811.00
95_E141_F0.5791.00
186_L320_L0.5791.00
190_A216_M0.5781.00
33_D138_D0.5771.00
212_A320_L0.5771.00
39_V42_V0.5751.00
155_I306_G0.5711.00
245_A261_S0.5701.00
229_A233_I0.5651.00
176_I244_V0.5651.00
247_E272_G0.5621.00
218_A221_I0.5601.00
279_I282_N0.5591.00
63_E66_F0.5581.00
160_V271_V0.5581.00
49_L338_L0.5581.00
301_N304_P0.5551.00
46_G182_G0.5541.00
164_A296_I0.5541.00
222_I236_I0.5531.00
290_E300_A0.5531.00
62_V66_F0.5501.00
269_A296_I0.5491.00
301_N305_K0.5481.00
28_P132_Y0.5471.00
84_D87_K0.5471.00
28_P36_L0.5461.00
162_I302_T0.5461.00
37_I140_V0.5451.00
157_P187_M0.5441.00
177_A245_A0.5441.00
47_S50_H0.5421.00
234_K241_G0.5411.00
19_E52_Y0.5391.00
285_F291_I0.5391.00
343_E347_V0.5391.00
79_V90_D0.5391.00
45_C346_K0.5381.00
254_A258_A0.5381.00
256_Q280_P0.5371.00
94_V140_V0.5321.00
50_H56_R0.5301.00
165_A191_A0.5291.00
27_V134_K0.5271.00
86_F137_Q0.5261.00
42_V349_V0.5261.00
201_I237_T0.5261.00
69_G129_F0.5241.00
189_V213_A0.5221.00
205_L223_N0.5211.00
154_L317_T0.5191.00
222_I232_E0.5191.00
152_A156_E0.5181.00
154_L348_M0.5171.00
37_I72_C0.5151.00
175_T237_T0.5151.00
214_K218_A0.5131.00
187_M191_A0.5131.00
39_V94_V0.5111.00
73_A152_A0.5101.00
94_V128_A0.5091.00
98_V139_F0.5091.00
19_E331_Q0.5071.00
22_I330_T0.5071.00
167_R302_T0.5061.00
339_Q343_E0.5061.00
222_I227_Q0.5051.00
49_L53_T0.5051.00
322_T345_L0.5041.00
30_I33_D0.5041.00
213_A221_I0.5041.00
310_L315_V0.5021.00
313_G316_D0.5021.00
323_D344_C0.5011.00
173_G197_A0.5011.00
67_I127_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m6iA 4 0.9773 100 0.147 Contact Map
4ej6A 1 0.9603 100 0.153 Contact Map
4ilkA 2 0.9547 100 0.157 Contact Map
3ukoA 4 0.9802 100 0.171 Contact Map
4gi2A 2 0.983 100 0.172 Contact Map
1h2bA 4 0.9462 100 0.177 Contact Map
4oh1A 4 0.949 100 0.18 Contact Map
2dq4A 4 0.9547 100 0.18 Contact Map
1f8fA 4 0.9575 100 0.181 Contact Map
1e3jA 4 0.9688 100 0.183 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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