SYV - BACSU - GREMLIN Contacts

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SYV - Valine--tRNA ligase

UniProt:	Q05873	Sequences: METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSVVIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLREEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVREVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIEIATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAVKITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAGVLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRFEKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLDTWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERPFKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSYEKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQLADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMRLLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNIRSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTAVVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDEEREKEKDYVAKRDAVQKRMAELKG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	880 (788)
Sequences:	8687 (4759)
Seq/√Len:	169.5

ECOLI - SYV SYI SYM
BACSU - SYV SYI SYL SYM
HALSA - SYV SYI SYL SYM
SULSO - SYV SYI SYL2 SYL1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
23_D	27_K	5.089	1.00
73_K	78_Y	5.029	1.00
314_Y	329_D	5.000	1.00
317_M	325_K	3.990	1.00
29_K	32_E	3.982	1.00
119_E	122_K	3.842	1.00
115_K	118_E	3.817	1.00
169_K	502_E	3.805	1.00
524_R	530_L	3.718	1.00
246_I	263_G	3.536	1.00
249_T	258_E	3.514	1.00
302_N	306_T	3.417	1.00
26_L	136_A	3.401	1.00
313_Q	329_D	3.347	1.00
477_Y	500_G	3.202	1.00
613_T	724_A	3.029	1.00
200_Q	343_M	2.975	1.00
233_V	250_V	2.969	1.00
542_K	566_Y	2.968	1.00
609_K	720_D	2.967	1.00
13_D	16_A	2.961	1.00
76_Q	623_T	2.919	1.00
678_D	682_R	2.890	1.00
211_A	258_E	2.885	1.00
373_D	377_E	2.864	1.00
386_N	511_D	2.767	1.00
112_G	115_K	2.694	1.00
165_K	168_E	2.684	1.00
309_E	315_Q	2.632	1.00
328_K	332_E	2.632	1.00
290_G	295_L	2.630	1.00
614_R	645_D	2.604	1.00
217_I	275_A	2.576	1.00
423_H	426_T	2.566	1.00
621_H	637_H	2.540	1.00
328_K	331_Q	2.524	1.00
200_Q	341_D	2.521	1.00
211_A	249_T	2.517	1.00
615_L	679_Q	2.487	1.00
768_E	771_R	2.479	1.00
624_Q	628_R	2.460	1.00
383_E	393_E	2.456	1.00
198_D	343_M	2.436	1.00
40_E	78_Y	2.433	1.00
307_M	311_A	2.429	1.00
182_D	352_S	2.410	1.00
617_E	724_A	2.409	1.00
480_D	510_K	2.390	1.00
207_S	216_S	2.380	1.00
424_K	443_E	2.371	1.00
623_T	711_W	2.348	1.00
96_K	99_A	2.346	1.00
24_F	28_G	2.343	1.00
107_S	110_D	2.337	1.00
233_V	275_A	2.323	1.00
68_I	553_A	2.319	1.00
251_I	256_N	2.300	1.00
329_D	333_A	2.289	1.00
521_E	565_S	2.289	1.00
583_S	695_I	2.270	1.00
521_E	567_E	2.209	1.00
32_E	145_S	2.207	1.00
385_V	497_I	2.188	1.00
417_R	444_Q	2.161	1.00
24_F	697_Q	2.156	1.00
369_Q	373_D	2.154	1.00
33_A	704_E	2.129	1.00
325_K	328_K	2.128	1.00
165_K	169_K	2.124	1.00
155_L	461_S	2.116	1.00
611_I	676_V	2.115	1.00
374_A	505_G	2.115	1.00
70_T	80_V	2.113	1.00
22_Y	690_F	2.101	1.00
511_D	629_Y	2.100	1.00
367_R	370_P	2.100	1.00
684_L	692_T	2.097	1.00
129_D	132_R	2.092	1.00
202_A	341_D	2.090	1.00
232_A	262_V	2.083	1.00
161_E	165_K	2.081	1.00
620_E	624_Q	2.074	1.00
161_E	433_L	2.058	1.00
390_D	393_E	2.056	1.00
36_D	39_K	2.055	1.00
594_T	597_E	2.053	1.00
185_T	352_S	2.052	1.00
376_I	397_L	2.035	1.00
623_T	627_D	2.026	1.00
329_D	332_E	2.009	1.00
239_D	269_M	2.003	1.00
211_A	251_I	2.002	1.00
73_K	76_Q	1.995	1.00
132_R	136_A	1.982	1.00
182_D	185_T	1.980	1.00
198_D	345_S	1.978	1.00
72_M	627_D	1.955	1.00
764_A	768_E	1.940	1.00
104_E	119_E	1.928	1.00
734_I	738_R	1.925	1.00
234_A	278_I	1.916	1.00
72_M	76_Q	1.913	1.00
100_K	126_E	1.910	1.00
378_L	384_K	1.892	1.00
771_R	775_E	1.889	1.00
374_A	377_E	1.875	1.00
73_K	627_D	1.848	1.00
209_P	335_V	1.844	1.00
468_V	474_K	1.840	1.00
376_I	401_E	1.820	1.00
157_K	467_D	1.793	1.00
186_K	304_D	1.790	1.00
266_Y	289_L	1.784	1.00
238_E	265_D	1.783	1.00
308_N	311_A	1.783	1.00
331_Q	339_I	1.713	1.00
318_D	321_E	1.707	1.00
251_I	258_E	1.699	1.00
100_K	119_E	1.693	1.00
433_L	437_E	1.688	1.00
176_E	362_T	1.677	1.00
287_F	291_N	1.675	1.00
634_V	687_F	1.674	1.00
54_R	130_F	1.669	1.00
489_I	514_I	1.668	1.00
576_A	688_M	1.666	1.00
630_E	633_E	1.664	1.00
618_T	637_H	1.655	1.00
765_S	768_E	1.651	1.00
168_E	433_L	1.650	1.00
28_G	704_E	1.650	1.00
71_R	689_P	1.642	1.00
182_D	349_S	1.618	1.00
174_R	362_T	1.617	1.00
619_I	683_L	1.615	1.00
23_D	26_L	1.611	1.00
148_R	154_G	1.607	1.00
118_E	122_K	1.603	1.00
538_D	542_K	1.594	1.00
385_V	507_R	1.586	1.00
720_D	723_A	1.584	1.00
313_Q	325_K	1.584	1.00
254_I	329_D	1.581	1.00
682_R	709_S	1.576	1.00
705_S	708_V	1.570	1.00
266_Y	278_I	1.564	1.00
250_V	261_I	1.563	1.00
209_P	251_I	1.559	1.00
164_V	168_E	1.551	1.00
471_E	474_K	1.544	1.00
72_M	623_T	1.539	1.00
20_D	694_E	1.539	1.00
377_E	383_E	1.531	1.00
726_D	769_A	1.525	1.00
388_V	511_D	1.524	1.00
44_V	70_T	1.516	1.00
75_M	682_R	1.513	1.00
615_L	619_I	1.511	1.00
217_I	261_I	1.509	1.00
42_Y	481_V	1.505	1.00
538_D	541_D	1.503	1.00
288_E	291_N	1.499	1.00
197_K	353_G	1.495	1.00
262_V	289_L	1.494	1.00
143_D	146_R	1.492	1.00
63_T	135_W	1.490	1.00
710_Q	713_A	1.487	1.00
324_K	328_K	1.482	1.00
619_I	679_Q	1.482	1.00
184_A	354_A	1.481	1.00
41_P	79_D	1.477	1.00
614_R	728_K	1.468	1.00
312_L	315_Q	1.458	1.00
370_P	373_D	1.452	1.00
185_T	349_S	1.450	1.00
79_D	475_R	1.442	1.00
425_E	441_N	1.440	1.00
246_I	293_H	1.439	1.00
616_N	619_I	1.439	1.00
443_E	446_T	1.436	1.00
434_E	437_E	1.434	1.00
603_E	664_A	1.432	1.00
63_T	140_L	1.427	1.00
75_M	685_H	1.417	1.00
206_M	330_L	1.416	1.00
617_E	721_T	1.415	1.00
753_E	782_V	1.412	1.00
378_L	501_I	1.408	1.00
218_E	337_F	1.403	1.00
657_P	669_T	1.402	1.00
137_K	541_D	1.400	1.00
199_V	348_H	1.397	1.00
128_A	149_F	1.395	1.00
394_K	398_H	1.393	1.00
186_K	303_E	1.392	1.00
393_E	397_L	1.385	1.00
626_A	687_F	1.378	1.00
207_S	337_F	1.376	1.00
424_K	441_N	1.375	1.00
235_V	246_I	1.369	1.00
642_I	680_T	1.368	1.00
693_E	705_S	1.363	1.00
209_P	216_S	1.362	1.00
184_A	352_S	1.356	1.00
215_G	244_H	1.356	1.00
661_E	665_A	1.355	1.00
666_K	670_R	1.354	1.00
21_R	694_E	1.351	1.00
300_V	307_M	1.350	1.00
423_H	438_D	1.349	1.00
172_I	408_I	1.321	1.00
737_V	778_T	1.316	1.00
722_E	726_D	1.315	1.00
727_M	730_L	1.311	1.00
133_S	136_A	1.305	1.00
780_P	783_L	1.298	1.00
162_V	503_F	1.298	1.00
317_M	321_E	1.297	1.00
231_T	298_I	1.294	1.00
608_D	650_Y	1.293	1.00
205_H	338_K	1.292	1.00
734_I	737_V	1.291	1.00
481_V	511_D	1.291	1.00
249_T	260_P	1.289	1.00
668_T	672_I	1.287	1.00
626_A	634_V	1.281	1.00
209_P	214_S	1.280	1.00
366_V	408_I	1.280	1.00
384_K	506_E	1.279	1.00
234_A	262_V	1.276	1.00
469_T	473_F	1.275	1.00
542_K	570_E	1.274	1.00
122_K	125_E	1.273	1.00
582_A	647_C	1.270	1.00
426_T	438_D	1.266	1.00
764_A	787_T	1.264	1.00
684_L	688_M	1.263	1.00
106_K	110_D	1.262	1.00
88_H	151_L	1.262	1.00
397_L	401_E	1.260	1.00
208_Y	230_D	1.258	1.00
606_V	726_D	1.258	1.00
753_E	784_K	1.257	1.00
456_A	499_Q	1.256	1.00
539_V	548_L	1.256	1.00
21_R	697_Q	1.254	1.00
387_F	489_I	1.254	1.00
19_K	137_K	1.246	1.00
196_Y	345_S	1.240	1.00
285_N	288_E	1.238	1.00
614_R	617_E	1.237	1.00
306_T	318_D	1.235	1.00
307_M	322_C	1.235	1.00
620_E	714_V	1.235	1.00
325_K	329_D	1.233	1.00
212_D	248_K	1.232	1.00
30_F	708_V	1.231	1.00
615_L	676_V	1.231	1.00
210_L	213_G	1.228	1.00
576_A	691_L	1.228	1.00
721_T	725_A	1.228	1.00
620_E	716_P	1.225	1.00
264_D	289_L	1.225	1.00
423_H	428_E	1.223	1.00
349_S	352_S	1.220	1.00
625_L	637_H	1.219	1.00
235_V	261_I	1.219	1.00
79_D	476_Y	1.217	1.00
383_E	397_L	1.216	1.00
210_L	214_S	1.214	1.00
232_A	278_I	1.212	1.00
100_K	103_E	1.201	1.00
681_M	695_I	1.199	1.00
132_R	145_S	1.198	1.00
567_E	570_E	1.191	1.00
36_D	79_D	1.190	1.00
612_L	675_Y	1.190	1.00
139_G	690_F	1.189	1.00
236_H	239_D	1.187	1.00
236_H	269_M	1.186	1.00
321_E	325_K	1.186	1.00
30_F	705_S	1.185	1.00
432_G	435_A	1.176	1.00
174_R	422_Y	1.174	1.00
765_S	769_A	1.173	1.00
54_R	134_Q	1.170	1.00
613_T	617_E	1.169	1.00
723_A	730_L	1.167	1.00
111_L	115_K	1.166	1.00
703_G	709_S	1.162	1.00
132_R	147_E	1.161	1.00
166_L	499_Q	1.161	1.00
217_I	233_V	1.161	1.00
205_H	218_E	1.158	1.00
149_F	152_D	1.156	1.00
302_N	308_N	1.155	1.00
17_V	20_D	1.155	1.00
679_Q	682_R	1.155	1.00
614_R	724_A	1.152	1.00
367_R	405_D	1.152	1.00
654_A	669_T	1.151	1.00
613_T	719_T	1.148	1.00
16_A	20_D	1.142	1.00
228_L	307_M	1.142	1.00
484_T	493_V	1.139	1.00
430_Y	442_W	1.137	1.00
57_L	533_G	1.135	1.00
728_K	731_V	1.135	1.00
38_T	79_D	1.131	1.00
481_V	513_L	1.126	1.00
620_E	719_T	1.120	1.00
585_F	654_A	1.119	1.00
473_F	504_T	1.119	1.00
219_I	233_V	1.119	1.00
308_N	315_Q	1.115	1.00
210_L	215_G	1.115	1.00
681_M	706_I	1.114	1.00
622_V	634_V	1.113	1.00
672_I	676_V	1.111	1.00
166_L	502_E	1.111	1.00
289_L	292_R	1.110	1.00
19_K	23_D	1.110	1.00
619_I	623_T	1.109	1.00
235_V	263_G	1.109	1.00
257_R	298_I	1.109	1.00
20_D	23_D	1.106	1.00
550_Y	635_G	1.105	1.00
611_I	641_F	1.103	1.00
722_E	725_A	1.099	1.00
76_Q	627_D	1.098	1.00
24_F	693_E	1.098	1.00
115_K	119_E	1.095	1.00
125_E	151_L	1.094	1.00
42_Y	69_V	1.092	1.00
238_E	269_M	1.089	1.00
608_D	668_T	1.083	1.00
235_V	275_A	1.081	1.00
276_V	289_L	1.081	1.00
16_A	19_K	1.080	1.00
55_L	138_L	1.080	1.00
278_I	289_L	1.079	1.00
135_W	140_L	1.077	1.00
551_F	572_T	1.073	1.00
386_N	390_D	1.072	1.00
736_S	739_N	1.071	1.00
438_D	441_N	1.070	1.00
685_H	707_T	1.068	1.00
317_M	322_C	1.067	1.00
321_E	324_K	1.067	1.00
210_L	250_V	1.067	1.00
619_I	712_P	1.063	1.00
616_N	719_T	1.062	1.00
579_I	642_I	1.061	1.00
379_Q	400_M	1.057	0.99
229_G	300_V	1.057	0.99
234_A	289_L	1.056	0.99
400_M	497_I	1.055	0.99
611_I	646_F	1.054	0.99
582_A	651_I	1.052	0.99
663_E	666_K	1.051	0.99
739_N	743_E	1.051	0.99
306_T	321_E	1.049	0.99
604_K	668_T	1.048	0.99
660_G	665_A	1.044	0.99
618_T	641_F	1.044	0.99
18_E	545_A	1.043	0.99
466_P	469_T	1.042	0.99
349_S	354_A	1.042	0.99
586_A	646_F	1.041	0.99
621_H	624_Q	1.040	0.99
48_P	155_L	1.040	0.99
622_V	637_H	1.040	0.99
623_T	713_A	1.040	0.99
771_R	785_I	1.038	0.99
314_Y	325_K	1.037	0.99
530_L	533_G	1.034	0.99
195_I	350_E	1.032	0.99
82_W	142_L	1.028	0.99
309_E	312_L	1.028	0.99
202_A	339_I	1.027	0.99
26_L	29_K	1.026	0.99
387_F	512_V	1.024	0.99
237_P	263_G	1.021	0.99
65_L	483_V	1.019	0.99
155_L	458_W	1.019	0.99
625_L	633_E	1.017	0.99
662_D	665_A	1.015	0.99
46_I	142_L	1.015	0.99
554_T	635_G	1.013	0.99
135_W	142_L	1.010	0.99
617_E	621_H	1.010	0.99
507_R	510_K	1.009	0.99
310_N	315_Q	1.007	0.99
57_L	518_I	1.006	0.99
46_I	63_T	1.006	0.99
203_F	271_F	1.006	0.99
735_R	739_N	1.003	0.99
605_S	665_A	1.002	0.99
109_Y	112_G	1.001	0.99
755_Y	786_G	1.000	0.99
234_A	264_D	0.998	0.99
619_I	714_V	0.995	0.99
800_V	803_A	0.994	0.99
216_S	337_F	0.994	0.99
604_K	612_L	0.993	0.99
29_K	145_S	0.991	0.99
86_M	132_R	0.990	0.99
314_Y	317_M	0.989	0.99
301_M	307_M	0.988	0.99
679_Q	683_L	0.987	0.99
726_D	730_L	0.987	0.99
378_L	507_R	0.984	0.99
148_R	155_L	0.980	0.99
538_D	566_Y	0.980	0.99
185_T	354_A	0.976	0.99
604_K	672_I	0.975	0.99
83_L	462_T	0.974	0.99
197_K	348_H	0.971	0.99
723_A	726_D	0.971	0.99
792_V	795_A	0.969	0.99
377_E	384_K	0.967	0.99
300_V	308_N	0.965	0.99
398_H	401_E	0.962	0.99
39_K	78_Y	0.962	0.99
660_G	663_E	0.959	0.99
188_A	407_C	0.958	0.99
228_L	326_L	0.958	0.99
245_L	248_K	0.957	0.99
387_F	514_I	0.957	0.99
438_D	442_W	0.956	0.99
64_T	68_I	0.956	0.99
291_N	297_R	0.953	0.99
400_M	494_S	0.952	0.99
583_S	677_L	0.951	0.99
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464_G	504_T	0.949	0.99
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204_Y	227_M	0.944	0.99
211_A	214_S	0.942	0.99
311_A	315_Q	0.940	0.99
755_Y	784_K	0.940	0.99
125_E	129_D	0.938	0.99
681_M	692_T	0.936	0.99
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46_I	135_W	0.934	0.99
207_S	218_E	0.934	0.99
649_W	731_V	0.933	0.99
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62_D	515_H	0.931	0.99
303_E	359_Y	0.931	0.99
28_G	705_S	0.930	0.99
236_H	265_D	0.928	0.99
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55_L	59_H	0.927	0.99
753_E	781_S	0.925	0.99
284_P	288_E	0.925	0.99
267_V	271_F	0.925	0.99
352_S	423_H	0.924	0.99
76_Q	713_A	0.924	0.99
327_V	339_I	0.921	0.99
158_A	465_W	0.921	0.99
464_G	467_D	0.921	0.99
15_A	541_D	0.920	0.99
762_E	765_S	0.920	0.99
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657_P	665_A	0.917	0.99
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423_H	430_Y	0.903	0.98
254_I	330_L	0.903	0.98
616_N	716_P	0.903	0.98
252_L	259_I	0.903	0.98
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129_D	133_S	0.902	0.98
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669_T	672_I	0.896	0.98
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126_E	130_F	0.891	0.98
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278_I	290_G	0.873	0.98
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693_E	697_Q	0.870	0.98
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254_I	333_A	0.843	0.97
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732_E	736_S	0.840	0.97
732_E	735_R	0.839	0.97
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254_I	326_L	0.836	0.97
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537_M	541_D	0.833	0.97
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459_P	500_G	0.610	0.87
210_L	217_I	0.610	0.87
550_Y	688_M	0.610	0.87
633_E	637_H	0.610	0.87
22_Y	137_K	0.610	0.87
106_K	115_K	0.610	0.87
593_M	596_D	0.609	0.87
749_S	779_N	0.609	0.87
240_E	269_M	0.609	0.87
210_L	216_S	0.608	0.87
383_E	394_K	0.607	0.87
167_Y	431_V	0.607	0.87
175_G	365_F	0.607	0.87
105_G	108_R	0.606	0.87
62_D	483_V	0.606	0.87
28_G	697_Q	0.605	0.86
583_S	698_H	0.604	0.86
345_S	348_H	0.603	0.86
726_D	770_N	0.603	0.86
34_G	37_Q	0.603	0.86
533_G	536_P	0.603	0.86
62_D	66_Q	0.602	0.86
208_Y	233_V	0.602	0.86
282_H	299_L	0.601	0.86
212_D	249_T	0.601	0.86
208_Y	259_I	0.600	0.86
464_G	469_T	0.600	0.86
465_W	468_V	0.600	0.86
613_T	616_N	0.600	0.86
752_V	781_S	0.600	0.86
101_L	111_L	0.599	0.86
68_I	687_F	0.597	0.86
433_L	436_P	0.595	0.86
723_A	729_L	0.595	0.86
266_Y	271_F	0.595	0.86
798_A	801_S	0.594	0.85
732_E	801_S	0.594	0.85
465_W	469_T	0.593	0.85
403_I	498_F	0.592	0.85
247_G	293_H	0.592	0.85
585_F	673_L	0.591	0.85
202_A	327_V	0.590	0.85
526_M	532_N	0.590	0.85
425_E	439_S	0.590	0.85
231_T	290_G	0.590	0.85
595_Y	598_L	0.590	0.85
398_H	402_N	0.589	0.85
486_Y	516_G	0.589	0.85
659_Y	666_K	0.588	0.85
180_N	356_V	0.586	0.85
534_V	566_Y	0.585	0.85
736_S	740_I	0.584	0.84
688_M	691_L	0.584	0.84
136_A	144_Y	0.584	0.84
733_L	737_V	0.584	0.84
486_Y	514_I	0.584	0.84
638_L	680_T	0.583	0.84
638_L	683_L	0.582	0.84
183_P	354_A	0.582	0.84
737_V	780_P	0.582	0.84
520_D	532_N	0.582	0.84
206_M	252_L	0.581	0.84
662_D	666_K	0.581	0.84
431_V	436_P	0.580	0.84
379_Q	387_F	0.580	0.84
517_L	525_K	0.578	0.84
604_K	608_D	0.578	0.84
299_L	303_E	0.577	0.84
423_H	429_L	0.577	0.84
756_I	803_A	0.575	0.84
94_Q	120_T	0.575	0.84
677_L	695_I	0.574	0.83
96_K	127_Y	0.574	0.83
426_T	440_E	0.574	0.83
386_N	510_K	0.573	0.83
770_N	773_Y	0.572	0.83
670_R	674_A	0.572	0.83
422_Y	445_D	0.572	0.83
431_V	437_E	0.572	0.83
422_Y	429_L	0.572	0.83
307_M	326_L	0.571	0.83
213_G	248_K	0.571	0.83
730_L	770_N	0.571	0.83
797_T	800_V	0.571	0.83
678_D	702_Q	0.569	0.83
200_Q	342_H	0.569	0.83
185_T	426_T	0.568	0.83
273_S	278_I	0.568	0.83
697_Q	701_H	0.568	0.83
130_F	134_Q	0.568	0.83
299_L	308_N	0.568	0.83
113_R	116_F	0.568	0.83
146_R	152_D	0.567	0.83
583_S	586_A	0.566	0.83
469_T	475_R	0.564	0.82
344_H	348_H	0.564	0.82
594_T	598_L	0.564	0.82
82_W	140_L	0.563	0.82
158_A	464_G	0.563	0.82
741_R	747_P	0.562	0.82
169_K	505_G	0.562	0.82
236_H	266_Y	0.562	0.82
685_H	705_S	0.562	0.82
347_G	358_P	0.562	0.82
485_G	514_I	0.561	0.82
237_P	246_I	0.560	0.82
262_V	292_R	0.560	0.82
427_G	433_L	0.559	0.82
162_V	460_F	0.559	0.82
618_T	638_L	0.559	0.82
35_S	79_D	0.558	0.82
314_Y	322_C	0.558	0.82
219_I	253_P	0.557	0.82
385_V	512_V	0.557	0.82
22_Y	707_T	0.557	0.82
751_Q	779_N	0.556	0.82
618_T	634_V	0.556	0.82
424_K	438_D	0.556	0.82
379_Q	385_V	0.555	0.81
311_A	314_Y	0.555	0.81
9_P	698_H	0.554	0.81
759_S	763_I	0.554	0.81
57_L	535_D	0.554	0.81
237_P	266_Y	0.554	0.81
363_Q	407_C	0.554	0.81
696_W	703_G	0.553	0.81
675_Y	678_D	0.553	0.81
185_T	423_H	0.552	0.81
240_E	243_K	0.552	0.81
676_V	680_T	0.552	0.81
40_E	76_Q	0.551	0.81
251_I	255_V	0.551	0.81
95_A	184_A	0.551	0.81
723_A	731_V	0.551	0.81
363_Q	411_Q	0.551	0.81
33_A	708_V	0.551	0.81
41_P	78_Y	0.551	0.81
372_A	401_E	0.550	0.81
68_I	631_F	0.550	0.81
798_A	803_A	0.550	0.81
605_S	668_T	0.550	0.81
260_P	293_H	0.550	0.81
423_H	440_E	0.549	0.81
585_F	651_I	0.549	0.81
126_E	133_S	0.549	0.81
211_A	250_V	0.549	0.81
605_S	654_A	0.549	0.81
435_A	438_D	0.548	0.81
61_W	562_L	0.548	0.81
768_E	785_I	0.547	0.80
208_Y	219_I	0.547	0.80
301_M	357_E	0.546	0.80
26_L	133_S	0.546	0.80
330_L	335_V	0.546	0.80
663_E	667_K	0.544	0.80
57_L	548_L	0.543	0.80
600_L	603_E	0.543	0.80
327_V	341_D	0.542	0.80
299_L	302_N	0.542	0.80
227_M	333_A	0.542	0.80
689_P	707_T	0.542	0.80
464_G	468_V	0.541	0.80
586_A	674_A	0.540	0.80
675_Y	712_P	0.540	0.80
157_K	433_L	0.539	0.80
424_K	430_Y	0.538	0.79
45_V	463_M	0.538	0.79
300_V	310_N	0.538	0.79
600_L	671_S	0.538	0.79
74_R	80_V	0.537	0.79
646_F	680_T	0.537	0.79
539_V	569_V	0.537	0.79
518_I	533_G	0.537	0.79
146_R	472_D	0.536	0.79
331_Q	334_G	0.536	0.79
468_V	473_F	0.536	0.79
57_L	537_M	0.536	0.79
230_D	277_K	0.536	0.79
255_V	313_Q	0.536	0.79
459_P	462_T	0.536	0.79
767_L	783_L	0.535	0.79
51_V	97_V	0.535	0.79
536_P	539_V	0.535	0.79
260_P	296_E	0.531	0.79
179_I	356_V	0.531	0.79
35_S	475_R	0.531	0.79
557_S	632_G	0.531	0.79
613_T	721_T	0.531	0.79
213_G	243_K	0.531	0.79
794_K	798_A	0.530	0.78
19_K	541_D	0.530	0.78
601_S	604_K	0.529	0.78
738_R	742_S	0.529	0.78
60_A	534_V	0.529	0.78
34_G	74_R	0.529	0.78
35_S	710_Q	0.529	0.78
39_K	76_Q	0.528	0.78
78_Y	627_D	0.528	0.78
733_L	767_L	0.528	0.78
681_M	699_L	0.528	0.78
271_F	342_H	0.528	0.78
379_Q	393_E	0.528	0.78
65_L	553_A	0.528	0.78
60_A	64_T	0.527	0.78
656_L	660_G	0.527	0.78
262_V	295_L	0.526	0.78
42_Y	629_Y	0.526	0.78
469_T	474_K	0.526	0.78
607_A	653_M	0.525	0.78
665_A	669_T	0.524	0.78
38_T	41_P	0.524	0.78
327_V	331_Q	0.524	0.78
92_A	350_E	0.524	0.78
427_G	443_E	0.524	0.78
757_K	760_T	0.524	0.78
55_L	535_D	0.524	0.78
567_E	571_S	0.524	0.78
758_T	764_A	0.524	0.78
793_D	803_A	0.523	0.77
34_G	475_R	0.522	0.77
163_F	173_Y	0.522	0.77
495_R	509_F	0.521	0.77
619_I	622_V	0.521	0.77
603_E	668_T	0.520	0.77
599_D	671_S	0.519	0.77
792_V	802_G	0.518	0.77
558_P	632_G	0.518	0.77
607_A	727_M	0.517	0.77
372_A	400_M	0.517	0.77
633_E	636_R	0.517	0.77
352_S	355_V	0.517	0.77
172_I	366_V	0.517	0.77
425_E	428_E	0.516	0.77
209_P	213_G	0.516	0.77
617_E	620_E	0.516	0.77
423_H	436_P	0.516	0.77
799_V	803_A	0.516	0.77
674_A	678_D	0.515	0.76
33_A	145_S	0.515	0.76
379_Q	396_Y	0.515	0.76
704_E	709_S	0.515	0.76
179_I	188_A	0.514	0.76
795_A	800_V	0.514	0.76
37_Q	475_R	0.514	0.76
604_K	609_K	0.513	0.76
775_E	780_P	0.513	0.76
42_Y	480_D	0.513	0.76
18_E	137_K	0.513	0.76
615_L	683_L	0.513	0.76
298_I	308_N	0.512	0.76
737_V	752_V	0.512	0.76
306_T	309_E	0.512	0.76
201_G	342_H	0.512	0.76
794_K	797_T	0.512	0.76
722_E	762_E	0.512	0.76
213_G	216_S	0.511	0.76
33_A	476_Y	0.511	0.76
431_V	435_A	0.511	0.76
724_A	727_M	0.511	0.76
17_V	694_E	0.510	0.76
252_L	257_R	0.510	0.76
188_A	411_Q	0.510	0.76
663_E	670_R	0.509	0.76
797_T	803_A	0.509	0.76
41_P	475_R	0.509	0.76
609_K	613_T	0.508	0.75
795_A	802_G	0.508	0.75
460_F	463_M	0.508	0.75
371_L	502_E	0.507	0.75
579_I	695_I	0.507	0.75
580_W	691_L	0.506	0.75
75_M	686_P	0.505	0.75
86_M	147_E	0.505	0.75
486_Y	489_I	0.505	0.75
177_Y	361_S	0.504	0.75
231_T	278_I	0.504	0.75
378_L	385_V	0.503	0.75
526_M	534_V	0.501	0.74
84_P	142_L	0.501	0.74
593_M	667_K	0.501	0.74
302_N	307_M	0.500	0.74
644_D	648_D	0.500	0.74
135_W	144_Y	0.500	0.74
762_E	766_R	0.500	0.74

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1gaxA	1	0.9659	100	0.125	Contact Map
1ffyA	1	0.9273	100	0.202	Contact Map
1ileA	1	0.8364	100	0.278	Contact Map
1wz2A	1	0.9102	100	0.309	Contact Map
1wkbA	1	0.7477	100	0.386	Contact Map
2v0cA	1	0.6955	100	0.388	Contact Map
4arcA	1	0.7523	100	0.403	Contact Map
3ziuA	1	0.6432	100	0.52	Contact Map
4qreA	1	0.5727	100	0.627	Contact Map
1rqgA	2	0.608	100	0.627	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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