GREMLIN Database
SYV - Valine--tRNA ligase
UniProt: Q05873 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 880 (788)
Sequences: 8687 (4759)
Seq/√Len: 169.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_D27_K5.0891.00
73_K78_Y5.0291.00
314_Y329_D5.0001.00
317_M325_K3.9901.00
29_K32_E3.9821.00
119_E122_K3.8421.00
115_K118_E3.8171.00
169_K502_E3.8051.00
524_R530_L3.7181.00
246_I263_G3.5361.00
249_T258_E3.5141.00
302_N306_T3.4171.00
26_L136_A3.4011.00
313_Q329_D3.3471.00
477_Y500_G3.2021.00
613_T724_A3.0291.00
200_Q343_M2.9751.00
233_V250_V2.9691.00
542_K566_Y2.9681.00
609_K720_D2.9671.00
13_D16_A2.9611.00
76_Q623_T2.9191.00
678_D682_R2.8901.00
211_A258_E2.8851.00
373_D377_E2.8641.00
386_N511_D2.7671.00
112_G115_K2.6941.00
165_K168_E2.6841.00
309_E315_Q2.6321.00
328_K332_E2.6321.00
290_G295_L2.6301.00
614_R645_D2.6041.00
217_I275_A2.5761.00
423_H426_T2.5661.00
621_H637_H2.5401.00
328_K331_Q2.5241.00
200_Q341_D2.5211.00
211_A249_T2.5171.00
615_L679_Q2.4871.00
768_E771_R2.4791.00
624_Q628_R2.4601.00
383_E393_E2.4561.00
198_D343_M2.4361.00
40_E78_Y2.4331.00
307_M311_A2.4291.00
182_D352_S2.4101.00
617_E724_A2.4091.00
480_D510_K2.3901.00
207_S216_S2.3801.00
424_K443_E2.3711.00
623_T711_W2.3481.00
96_K99_A2.3461.00
24_F28_G2.3431.00
107_S110_D2.3371.00
233_V275_A2.3231.00
68_I553_A2.3191.00
251_I256_N2.3001.00
329_D333_A2.2891.00
521_E565_S2.2891.00
583_S695_I2.2701.00
521_E567_E2.2091.00
32_E145_S2.2071.00
385_V497_I2.1881.00
417_R444_Q2.1611.00
24_F697_Q2.1561.00
369_Q373_D2.1541.00
33_A704_E2.1291.00
325_K328_K2.1281.00
165_K169_K2.1241.00
155_L461_S2.1161.00
611_I676_V2.1151.00
374_A505_G2.1151.00
70_T80_V2.1131.00
22_Y690_F2.1011.00
511_D629_Y2.1001.00
367_R370_P2.1001.00
684_L692_T2.0971.00
129_D132_R2.0921.00
202_A341_D2.0901.00
232_A262_V2.0831.00
161_E165_K2.0811.00
620_E624_Q2.0741.00
161_E433_L2.0581.00
390_D393_E2.0561.00
36_D39_K2.0551.00
594_T597_E2.0531.00
185_T352_S2.0521.00
376_I397_L2.0351.00
623_T627_D2.0261.00
329_D332_E2.0091.00
239_D269_M2.0031.00
211_A251_I2.0021.00
73_K76_Q1.9951.00
132_R136_A1.9821.00
182_D185_T1.9801.00
198_D345_S1.9781.00
72_M627_D1.9551.00
764_A768_E1.9401.00
104_E119_E1.9281.00
734_I738_R1.9251.00
234_A278_I1.9161.00
72_M76_Q1.9131.00
100_K126_E1.9101.00
378_L384_K1.8921.00
771_R775_E1.8891.00
374_A377_E1.8751.00
73_K627_D1.8481.00
209_P335_V1.8441.00
468_V474_K1.8401.00
376_I401_E1.8201.00
157_K467_D1.7931.00
186_K304_D1.7901.00
266_Y289_L1.7841.00
238_E265_D1.7831.00
308_N311_A1.7831.00
331_Q339_I1.7131.00
318_D321_E1.7071.00
251_I258_E1.6991.00
100_K119_E1.6931.00
433_L437_E1.6881.00
176_E362_T1.6771.00
287_F291_N1.6751.00
634_V687_F1.6741.00
54_R130_F1.6691.00
489_I514_I1.6681.00
576_A688_M1.6661.00
630_E633_E1.6641.00
618_T637_H1.6551.00
765_S768_E1.6511.00
168_E433_L1.6501.00
28_G704_E1.6501.00
71_R689_P1.6421.00
182_D349_S1.6181.00
174_R362_T1.6171.00
619_I683_L1.6151.00
23_D26_L1.6111.00
148_R154_G1.6071.00
118_E122_K1.6031.00
538_D542_K1.5941.00
385_V507_R1.5861.00
720_D723_A1.5841.00
313_Q325_K1.5841.00
254_I329_D1.5811.00
682_R709_S1.5761.00
705_S708_V1.5701.00
266_Y278_I1.5641.00
250_V261_I1.5631.00
209_P251_I1.5591.00
164_V168_E1.5511.00
471_E474_K1.5441.00
72_M623_T1.5391.00
20_D694_E1.5391.00
377_E383_E1.5311.00
726_D769_A1.5251.00
388_V511_D1.5241.00
44_V70_T1.5161.00
75_M682_R1.5131.00
615_L619_I1.5111.00
217_I261_I1.5091.00
42_Y481_V1.5051.00
538_D541_D1.5031.00
288_E291_N1.4991.00
197_K353_G1.4951.00
262_V289_L1.4941.00
143_D146_R1.4921.00
63_T135_W1.4901.00
710_Q713_A1.4871.00
324_K328_K1.4821.00
619_I679_Q1.4821.00
184_A354_A1.4811.00
41_P79_D1.4771.00
614_R728_K1.4681.00
312_L315_Q1.4581.00
370_P373_D1.4521.00
185_T349_S1.4501.00
79_D475_R1.4421.00
425_E441_N1.4401.00
246_I293_H1.4391.00
616_N619_I1.4391.00
443_E446_T1.4361.00
434_E437_E1.4341.00
603_E664_A1.4321.00
63_T140_L1.4271.00
75_M685_H1.4171.00
206_M330_L1.4161.00
617_E721_T1.4151.00
753_E782_V1.4121.00
378_L501_I1.4081.00
218_E337_F1.4031.00
657_P669_T1.4021.00
137_K541_D1.4001.00
199_V348_H1.3971.00
128_A149_F1.3951.00
394_K398_H1.3931.00
186_K303_E1.3921.00
393_E397_L1.3851.00
626_A687_F1.3781.00
207_S337_F1.3761.00
424_K441_N1.3751.00
235_V246_I1.3691.00
642_I680_T1.3681.00
693_E705_S1.3631.00
209_P216_S1.3621.00
184_A352_S1.3561.00
215_G244_H1.3561.00
661_E665_A1.3551.00
666_K670_R1.3541.00
21_R694_E1.3511.00
300_V307_M1.3501.00
423_H438_D1.3491.00
172_I408_I1.3211.00
737_V778_T1.3161.00
722_E726_D1.3151.00
727_M730_L1.3111.00
133_S136_A1.3051.00
780_P783_L1.2981.00
162_V503_F1.2981.00
317_M321_E1.2971.00
231_T298_I1.2941.00
608_D650_Y1.2931.00
205_H338_K1.2921.00
734_I737_V1.2911.00
481_V511_D1.2911.00
249_T260_P1.2891.00
668_T672_I1.2871.00
626_A634_V1.2811.00
209_P214_S1.2801.00
366_V408_I1.2801.00
384_K506_E1.2791.00
234_A262_V1.2761.00
469_T473_F1.2751.00
542_K570_E1.2741.00
122_K125_E1.2731.00
582_A647_C1.2701.00
426_T438_D1.2661.00
764_A787_T1.2641.00
684_L688_M1.2631.00
106_K110_D1.2621.00
88_H151_L1.2621.00
397_L401_E1.2601.00
208_Y230_D1.2581.00
606_V726_D1.2581.00
753_E784_K1.2571.00
456_A499_Q1.2561.00
539_V548_L1.2561.00
21_R697_Q1.2541.00
387_F489_I1.2541.00
19_K137_K1.2461.00
196_Y345_S1.2401.00
285_N288_E1.2381.00
614_R617_E1.2371.00
306_T318_D1.2351.00
307_M322_C1.2351.00
620_E714_V1.2351.00
325_K329_D1.2331.00
212_D248_K1.2321.00
30_F708_V1.2311.00
615_L676_V1.2311.00
210_L213_G1.2281.00
576_A691_L1.2281.00
721_T725_A1.2281.00
620_E716_P1.2251.00
264_D289_L1.2251.00
423_H428_E1.2231.00
349_S352_S1.2201.00
625_L637_H1.2191.00
235_V261_I1.2191.00
79_D476_Y1.2171.00
383_E397_L1.2161.00
210_L214_S1.2141.00
232_A278_I1.2121.00
100_K103_E1.2011.00
681_M695_I1.1991.00
132_R145_S1.1981.00
567_E570_E1.1911.00
36_D79_D1.1901.00
612_L675_Y1.1901.00
139_G690_F1.1891.00
236_H239_D1.1871.00
236_H269_M1.1861.00
321_E325_K1.1861.00
30_F705_S1.1851.00
432_G435_A1.1761.00
174_R422_Y1.1741.00
765_S769_A1.1731.00
54_R134_Q1.1701.00
613_T617_E1.1691.00
723_A730_L1.1671.00
111_L115_K1.1661.00
703_G709_S1.1621.00
132_R147_E1.1611.00
166_L499_Q1.1611.00
217_I233_V1.1611.00
205_H218_E1.1581.00
149_F152_D1.1561.00
302_N308_N1.1551.00
17_V20_D1.1551.00
679_Q682_R1.1551.00
614_R724_A1.1521.00
367_R405_D1.1521.00
654_A669_T1.1511.00
613_T719_T1.1481.00
16_A20_D1.1421.00
228_L307_M1.1421.00
484_T493_V1.1391.00
430_Y442_W1.1371.00
57_L533_G1.1351.00
728_K731_V1.1351.00
38_T79_D1.1311.00
481_V513_L1.1261.00
620_E719_T1.1201.00
585_F654_A1.1191.00
473_F504_T1.1191.00
219_I233_V1.1191.00
308_N315_Q1.1151.00
210_L215_G1.1151.00
681_M706_I1.1141.00
622_V634_V1.1131.00
672_I676_V1.1111.00
166_L502_E1.1111.00
289_L292_R1.1101.00
19_K23_D1.1101.00
619_I623_T1.1091.00
235_V263_G1.1091.00
257_R298_I1.1091.00
20_D23_D1.1061.00
550_Y635_G1.1051.00
611_I641_F1.1031.00
722_E725_A1.0991.00
76_Q627_D1.0981.00
24_F693_E1.0981.00
115_K119_E1.0951.00
125_E151_L1.0941.00
42_Y69_V1.0921.00
238_E269_M1.0891.00
608_D668_T1.0831.00
235_V275_A1.0811.00
276_V289_L1.0811.00
16_A19_K1.0801.00
55_L138_L1.0801.00
278_I289_L1.0791.00
135_W140_L1.0771.00
551_F572_T1.0731.00
386_N390_D1.0721.00
736_S739_N1.0711.00
438_D441_N1.0701.00
685_H707_T1.0681.00
317_M322_C1.0671.00
321_E324_K1.0671.00
210_L250_V1.0671.00
619_I712_P1.0631.00
616_N719_T1.0621.00
579_I642_I1.0611.00
379_Q400_M1.0570.99
229_G300_V1.0570.99
234_A289_L1.0560.99
400_M497_I1.0550.99
611_I646_F1.0540.99
582_A651_I1.0520.99
663_E666_K1.0510.99
739_N743_E1.0510.99
306_T321_E1.0490.99
604_K668_T1.0480.99
660_G665_A1.0440.99
618_T641_F1.0440.99
18_E545_A1.0430.99
466_P469_T1.0420.99
349_S354_A1.0420.99
586_A646_F1.0410.99
621_H624_Q1.0400.99
48_P155_L1.0400.99
622_V637_H1.0400.99
623_T713_A1.0400.99
771_R785_I1.0380.99
314_Y325_K1.0370.99
530_L533_G1.0340.99
195_I350_E1.0320.99
82_W142_L1.0280.99
309_E312_L1.0280.99
202_A339_I1.0270.99
26_L29_K1.0260.99
387_F512_V1.0240.99
237_P263_G1.0210.99
65_L483_V1.0190.99
155_L458_W1.0190.99
625_L633_E1.0170.99
662_D665_A1.0150.99
46_I142_L1.0150.99
554_T635_G1.0130.99
135_W142_L1.0100.99
617_E621_H1.0100.99
507_R510_K1.0090.99
310_N315_Q1.0070.99
57_L518_I1.0060.99
46_I63_T1.0060.99
203_F271_F1.0060.99
735_R739_N1.0030.99
605_S665_A1.0020.99
109_Y112_G1.0010.99
755_Y786_G1.0000.99
234_A264_D0.9980.99
619_I714_V0.9950.99
800_V803_A0.9940.99
216_S337_F0.9940.99
604_K612_L0.9930.99
29_K145_S0.9910.99
86_M132_R0.9900.99
314_Y317_M0.9890.99
301_M307_M0.9880.99
679_Q683_L0.9870.99
726_D730_L0.9870.99
378_L507_R0.9840.99
148_R155_L0.9800.99
538_D566_Y0.9800.99
185_T354_A0.9760.99
604_K672_I0.9750.99
83_L462_T0.9740.99
197_K348_H0.9710.99
723_A726_D0.9710.99
792_V795_A0.9690.99
377_E384_K0.9670.99
300_V308_N0.9650.99
398_H401_E0.9620.99
39_K78_Y0.9620.99
660_G663_E0.9590.99
188_A407_C0.9580.99
228_L326_L0.9580.99
245_L248_K0.9570.99
387_F514_I0.9570.99
438_D442_W0.9560.99
64_T68_I0.9560.99
291_N297_R0.9530.99
400_M494_S0.9520.99
583_S677_L0.9510.99
24_F705_S0.9500.99
464_G504_T0.9490.99
72_M626_A0.9440.99
204_Y227_M0.9440.99
211_A214_S0.9420.99
311_A315_Q0.9400.99
755_Y784_K0.9400.99
125_E129_D0.9380.99
681_M692_T0.9360.99
106_K111_L0.9340.99
46_I135_W0.9340.99
207_S218_E0.9340.99
649_W731_V0.9330.99
387_F396_Y0.9320.99
62_D515_H0.9310.99
303_E359_Y0.9310.99
28_G705_S0.9300.99
236_H265_D0.9280.99
164_V433_L0.9270.99
55_L59_H0.9270.99
753_E781_S0.9250.99
284_P288_E0.9250.99
267_V271_F0.9250.99
352_S423_H0.9240.99
76_Q713_A0.9240.99
327_V339_I0.9210.99
158_A465_W0.9210.99
464_G467_D0.9210.99
15_A541_D0.9200.99
762_E765_S0.9200.99
423_H442_W0.9190.99
657_P665_A0.9170.99
374_A378_L0.9070.98
423_H430_Y0.9030.98
254_I330_L0.9030.98
616_N716_P0.9030.98
252_L259_I0.9030.98
477_Y506_E0.9030.98
129_D133_S0.9020.98
68_I626_A0.9010.98
210_L248_K0.8980.98
90_G94_Q0.8980.98
163_F172_I0.8970.98
669_T672_I0.8960.98
518_I562_L0.8950.98
612_L718_H0.8950.98
564_F569_V0.8950.98
180_N358_P0.8930.98
368_M371_L0.8930.98
352_S426_T0.8920.98
126_E130_F0.8910.98
727_M731_V0.8890.98
386_N628_R0.8880.98
336_L339_I0.8860.98
301_M359_Y0.8780.98
617_E719_T0.8780.98
715_V718_H0.8770.98
182_D354_A0.8770.98
429_L432_G0.8760.98
423_H439_S0.8760.98
184_A349_S0.8750.98
69_V481_V0.8750.98
278_I290_G0.8730.98
171_L371_L0.8730.98
281_A300_V0.8720.98
423_H441_N0.8710.98
693_E697_Q0.8700.98
39_K79_D0.8690.98
353_G529_S0.8680.98
98_E116_F0.8650.98
605_S608_D0.8620.98
94_Q98_E0.8610.98
162_V453_F0.8600.98
281_A297_R0.8600.98
772_S775_E0.8590.98
266_Y285_N0.8580.98
481_V629_Y0.8580.98
43_S480_D0.8570.98
227_M252_L0.8560.98
74_R141_G0.8520.98
506_E510_K0.8520.98
616_N718_H0.8510.98
379_Q397_L0.8500.98
459_P477_Y0.8500.98
685_H692_T0.8500.98
231_T296_E0.8490.98
451_T454_S0.8480.98
30_F704_E0.8470.98
616_N620_E0.8450.98
426_T439_S0.8450.98
97_V120_T0.8450.98
423_H427_G0.8440.97
254_I333_A0.8430.97
411_Q447_D0.8430.97
250_V259_I0.8420.97
37_Q79_D0.8420.97
301_M319_R0.8400.97
732_E736_S0.8400.97
732_E735_R0.8390.97
735_R738_R0.8380.97
396_Y512_V0.8370.97
426_T432_G0.8370.97
254_I326_L0.8360.97
182_D423_H0.8350.97
616_N715_V0.8330.97
537_M541_D0.8330.97
215_G243_K0.8330.97
43_S463_M0.8320.97
153_E157_K0.8310.97
236_H267_V0.8290.97
288_E292_R0.8280.97
322_C326_L0.8250.97
474_K506_E0.8250.97
734_I739_N0.8240.97
8_M698_H0.8240.97
30_F141_G0.8220.97
566_Y570_E0.8220.97
677_L699_L0.8220.97
729_L766_R0.8210.97
227_M254_I0.8200.97
764_A785_I0.8190.97
725_A728_K0.8190.97
625_L634_V0.8180.97
264_D288_E0.8170.97
771_R783_L0.8170.97
159_V449_L0.8120.97
171_L370_P0.8120.97
205_H220_A0.8100.97
353_G530_L0.8090.97
618_T622_V0.8080.97
501_I507_R0.8070.97
535_D538_D0.8070.97
621_H625_L0.8050.97
368_M403_I0.8030.97
243_K246_I0.8010.97
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737_V752_V0.5120.76
306_T309_E0.5120.76
201_G342_H0.5120.76
794_K797_T0.5120.76
722_E762_E0.5120.76
213_G216_S0.5110.76
33_A476_Y0.5110.76
431_V435_A0.5110.76
724_A727_M0.5110.76
17_V694_E0.5100.76
252_L257_R0.5100.76
188_A411_Q0.5100.76
663_E670_R0.5090.76
797_T803_A0.5090.76
41_P475_R0.5090.76
609_K613_T0.5080.75
795_A802_G0.5080.75
460_F463_M0.5080.75
371_L502_E0.5070.75
579_I695_I0.5070.75
580_W691_L0.5060.75
75_M686_P0.5050.75
86_M147_E0.5050.75
486_Y489_I0.5050.75
177_Y361_S0.5040.75
231_T278_I0.5040.75
378_L385_V0.5030.75
526_M534_V0.5010.74
84_P142_L0.5010.74
593_M667_K0.5010.74
302_N307_M0.5000.74
644_D648_D0.5000.74
135_W144_Y0.5000.74
762_E766_R0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gaxA 1 0.9659 100 0.125 Contact Map
1ffyA 1 0.9273 100 0.202 Contact Map
1ileA 1 0.8364 100 0.278 Contact Map
1wz2A 1 0.9102 100 0.309 Contact Map
1wkbA 1 0.7477 100 0.386 Contact Map
2v0cA 1 0.6955 100 0.388 Contact Map
4arcA 1 0.7523 100 0.403 Contact Map
3ziuA 1 0.6432 100 0.52 Contact Map
4qreA 1 0.5727 100 0.627 Contact Map
1rqgA 2 0.608 100 0.627 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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