GREMLIN Database
FOLC - Folylpolyglutamate synthase
UniProt: Q05865 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 430 (399)
Sequences: 5307 (4140)
Seq/√Len: 207.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_N182_E3.9601.00
82_N94_D3.7741.00
164_V273_A3.7021.00
213_E217_H3.3921.00
46_V56_V3.3841.00
151_R186_E3.3411.00
62_M274_A3.1621.00
191_I197_I3.1581.00
169_G321_E3.0971.00
304_E426_R3.0471.00
96_E137_H2.9311.00
170_H173_M2.8891.00
181_E205_E2.7451.00
162_L273_A2.6701.00
213_E216_R2.5681.00
395_D398_D2.5641.00
179_T182_E2.5171.00
345_A354_M2.4791.00
92_I132_Y2.4691.00
350_P353_N2.4421.00
65_E296_K2.3051.00
103_Q135_E2.3051.00
93_S96_E2.2671.00
301_G422_I2.2521.00
47_A146_T2.2381.00
31_M157_V2.2301.00
49_T171_D2.2151.00
60_R64_Q2.2141.00
316_G419_L2.2051.00
56_V72_T2.1881.00
80_T91_P2.1501.00
63_L141_F2.1071.00
139_V142_V2.0201.00
103_Q131_L2.0021.00
366_H393_S1.9621.00
340_S366_H1.9541.00
80_T94_D1.9331.00
81_F125_M1.8981.00
131_L135_E1.8801.00
305_L311_P1.8721.00
148_L175_I1.8301.00
61_S293_G1.8241.00
40_K134_A1.7911.00
99_A135_E1.7751.00
341_V362_A1.7271.00
65_E292_S1.7241.00
287_D291_R1.7091.00
56_V143_I1.6921.00
208_Q212_H1.6921.00
73_F126_T1.6891.00
29_Q33_R1.6811.00
165_I191_I1.6811.00
43_A158_V1.6751.00
300_P304_E1.6361.00
393_S402_F1.6331.00
41_I142_V1.6321.00
305_L313_Y1.6271.00
96_E99_A1.6251.00
286_S289_A1.6241.00
340_S364_A1.6191.00
170_H180_I1.6181.00
30_L119_P1.6151.00
27_M127_A1.6121.00
323_V354_M1.6071.00
292_S296_K1.5951.00
32_A36_H1.5901.00
162_L198_V1.5891.00
55_T166_T1.5741.00
351_Y376_S1.5571.00
324_E357_R1.5531.00
348_D374_R1.5481.00
69_T88_N1.5461.00
82_N91_P1.5451.00
364_A391_S1.5331.00
222_Q276_W1.5191.00
79_I423_S1.5091.00
193_E217_H1.4981.00
58_F297_A1.4951.00
369_S378_A1.4901.00
326_L414_L1.4901.00
197_I219_A1.4861.00
338_R411_E1.4831.00
130_F144_F1.4831.00
55_T164_V1.4801.00
355_I385_S1.4751.00
144_F158_V1.4741.00
182_E185_G1.4721.00
207_L223_S1.4621.00
62_M293_G1.4601.00
342_V403_I1.4491.00
212_H216_R1.4411.00
312_V400_I1.4271.00
340_S406_K1.4121.00
59_I143_I1.4101.00
59_I274_A1.4051.00
98_T102_N1.3931.00
325_K328_E1.3921.00
303_L329_T1.3881.00
415_I425_I1.3781.00
303_L313_Y1.3711.00
47_A190_I1.3691.00
191_I219_A1.3671.00
377_L380_D1.3661.00
100_L132_Y1.3631.00
200_A269_L1.3561.00
399_V403_I1.3441.00
25_G28_K1.3401.00
50_N322_G1.3371.00
371_D424_D1.3321.00
30_L127_A1.3291.00
58_F270_S1.3261.00
77_Y84_R1.3181.00
352_Q384_A1.3181.00
167_S321_E1.3171.00
382_Y386_E1.3151.00
13_H121_E1.3101.00
57_A297_A1.3071.00
342_V413_V1.2991.00
339_I412_I1.2961.00
396_P425_I1.2921.00
330_M414_L1.2921.00
320_E353_N1.2871.00
60_R72_T1.2871.00
72_T86_S1.2861.00
29_Q32_A1.2831.00
68_Y140_D1.2801.00
81_F97_W1.2771.00
66_A289_A1.2771.00
100_L131_L1.2741.00
185_G213_E1.2681.00
345_A351_Y1.2471.00
79_I426_R1.2471.00
211_R215_E1.2411.00
188_A213_E1.2381.00
261_T328_E1.2371.00
207_L211_R1.2331.00
57_A299_W1.2321.00
194_G218_A1.2291.00
71_G133_F1.2191.00
255_R295_V1.2181.00
199_T221_F1.2121.00
407_K413_V1.2091.00
152_F186_E1.2091.00
163_T195_I1.2031.00
193_E218_A1.2021.00
214_A221_F1.2011.00
342_V399_V1.1971.00
267_A294_L1.1841.00
164_V269_L1.1791.00
39_K159_E1.1791.00
293_G297_A1.1761.00
167_S202_T1.1731.00
77_Y121_E1.1681.00
173_M178_N1.1681.00
78_I423_S1.1661.00
42_R161_L1.1621.00
129_A144_F1.1561.00
45_H156_N1.1561.00
201_V265_Q1.1541.00
196_P220_P1.1531.00
130_F158_V1.1491.00
198_V269_L1.1461.00
60_R86_S1.1441.00
366_H406_K1.1401.00
260_G263_Q1.1331.00
323_V327_A1.1321.00
199_T207_L1.1281.00
331_K361_I1.1171.00
64_Q88_N1.1171.00
159_E195_I1.1161.00
95_E99_A1.1141.00
211_R223_S1.1121.00
261_T332_Q1.1061.00
391_S402_F1.1051.00
59_I273_A1.1051.00
87_V139_V1.1021.00
165_I210_I1.0981.00
69_T137_H1.0941.00
327_A357_R1.0931.00
368_A399_V1.0921.00
63_L274_A1.0921.00
44_F141_F1.0911.00
387_I390_K1.0901.00
366_H402_F1.0881.00
10_S13_H1.0881.00
321_E324_E1.0831.00
339_I362_A1.0821.00
367_F390_K1.0821.00
68_Y141_F1.0801.00
383_D386_E1.0801.00
223_S226_D1.0721.00
92_I96_E1.0651.00
121_E125_M1.0581.00
198_V276_W1.0551.00
141_F283_A1.0531.00
85_I132_Y1.0501.00
378_A392_W1.0491.00
253_D256_T1.0481.00
312_V404_E1.0471.00
340_S411_E1.0461.00
101_V128_C1.0451.00
289_A293_G1.0421.00
254_I257_S1.0391.00
188_A210_I1.0341.00
96_E132_Y1.0311.00
34_L131_L1.0291.00
54_S263_Q1.0271.00
191_I214_A1.0261.00
191_I210_I1.0211.00
314_L422_I1.0171.00
206_A210_I1.0131.00
97_W128_C1.0091.00
344_S370_F1.0071.00
337_S410_N1.0021.00
104_M107_H0.9991.00
59_I164_V0.9991.00
151_R185_G0.9981.00
160_P192_K0.9971.00
341_V414_L0.9971.00
338_R364_A0.9951.00
60_R143_I0.9951.00
402_F406_K0.9851.00
174_N348_D0.9851.00
169_G324_E0.9841.00
403_I413_V0.9831.00
61_S297_A0.9821.00
73_F154_S0.9771.00
370_F421_F0.9741.00
96_E135_E0.9711.00
402_F405_S0.9711.00
208_Q211_R0.9681.00
358_L416_T0.9631.00
44_F277_L0.9601.00
242_F267_A0.9601.00
223_S227_A0.9530.99
132_Y137_H0.9520.99
338_R363_H0.9500.99
86_S91_P0.9470.99
71_G139_V0.9460.99
347_K380_D0.9410.99
262_H325_K0.9410.99
92_I97_W0.9360.99
66_A285_I0.9340.99
59_I270_S0.9320.99
191_I217_H0.9310.99
272_L275_E0.9260.99
185_G212_H0.9260.99
299_W419_L0.9250.99
151_R213_E0.9250.99
66_A286_S0.9240.99
343_F355_I0.9230.99
400_I425_I0.9220.99
36_H39_K0.9150.99
327_A331_K0.9130.99
62_M294_L0.9110.99
87_V137_H0.9090.99
222_Q272_L0.9040.99
198_V273_A0.9010.99
376_S380_D0.9000.99
63_L143_I0.8960.99
263_Q266_N0.8940.99
323_V357_R0.8930.99
380_D383_D0.8890.99
256_T267_A0.8890.99
100_L128_C0.8880.99
181_E206_A0.8850.99
351_Y384_A0.8790.99
367_F378_A0.8780.99
58_F267_A0.8770.99
199_T223_S0.8750.99
173_M350_P0.8750.99
254_I291_R0.8740.99
305_L308_E0.8740.99
288_E292_S0.8740.99
294_L297_A0.8720.99
58_F257_S0.8710.99
20_V23_G0.8710.99
320_E324_E0.8700.99
206_A209_V0.8680.99
258_L263_Q0.8680.99
278_N287_D0.8670.99
50_N319_N0.8640.99
341_V416_T0.8630.99
167_S200_A0.8620.99
311_P412_I0.8610.99
369_S375_A0.8560.99
154_S186_E0.8540.99
323_V358_L0.8530.99
346_L420_Y0.8510.99
100_L135_E0.8490.99
85_I92_I0.8430.99
55_T270_S0.8400.99
204_P208_Q0.8390.99
31_M127_A0.8350.99
336_N412_I0.8330.99
344_S368_A0.8310.99
146_T190_I0.8310.99
394_E398_D0.8300.99
240_E244_F0.8280.99
60_R89_G0.8260.99
160_P195_I0.8240.98
320_E350_P0.8220.98
43_A142_V0.8210.98
164_V198_V0.8200.98
77_Y83_E0.8190.98
313_Y412_I0.8190.98
41_I139_V0.8180.98
271_I290_L0.8170.98
171_D319_N0.8140.98
55_T269_L0.8080.98
165_I197_I0.8070.98
211_R221_F0.8060.98
141_F161_L0.8050.98
61_S65_E0.8050.98
100_L103_Q0.8030.98
258_L297_A0.8020.98
169_G320_E0.8000.98
188_A191_I0.7990.98
156_N192_K0.7970.98
20_V120_T0.7970.98
58_F294_L0.7960.98
251_Y254_I0.7960.98
341_V365_I0.7950.98
312_V413_V0.7950.98
382_Y392_W0.7930.98
65_E293_G0.7910.98
64_Q89_G0.7890.98
160_P163_T0.7870.98
31_M38_E0.7850.98
225_H228_C0.7820.98
290_L293_G0.7810.98
322_G325_K0.7770.98
57_A61_S0.7770.98
424_D427_K0.7750.98
43_A144_F0.7730.98
45_H192_K0.7670.98
251_Y275_E0.7650.98
376_S384_A0.7640.98
20_V148_L0.7610.97
256_T294_L0.7610.97
23_G27_M0.7590.97
20_V175_I0.7590.97
64_Q70_V0.7580.97
72_T143_I0.7540.97
323_V326_L0.7530.97
180_I205_E0.7530.97
317_A322_G0.7490.97
33_R107_H0.7480.97
62_M290_L0.7460.97
324_E328_E0.7440.97
370_F375_A0.7440.97
34_L104_M0.7430.97
342_V415_I0.7430.97
181_E209_V0.7420.97
262_H303_L0.7410.97
97_W125_M0.7410.97
326_L416_T0.7390.97
199_T210_I0.7380.97
367_F382_Y0.7380.97
11_W15_R0.7370.97
346_L370_F0.7320.97
178_N181_E0.7320.97
364_A389_N0.7300.97
393_S398_D0.7290.97
364_A406_K0.7280.97
82_N97_W0.7250.97
336_N339_I0.7250.97
165_I189_G0.7240.97
343_F416_T0.7240.97
15_R124_I0.7210.97
62_M66_A0.7210.97
163_T197_I0.7200.96
366_H403_I0.7190.96
173_M182_E0.7170.96
372_F420_Y0.7170.96
379_K392_W0.7160.96
228_C268_A0.7160.96
245_K250_C0.7130.96
317_A414_L0.7120.96
340_S407_K0.7120.96
285_I289_A0.7110.96
367_F392_W0.7100.96
45_H155_T0.7080.96
120_T123_E0.7070.96
202_T206_A0.7070.96
81_F85_I0.7060.96
369_S394_E0.7060.96
44_F274_A0.7010.96
337_S412_I0.6970.96
199_T269_L0.6970.96
243_S253_D0.6960.96
22_P26_R0.6940.96
122_F147_G0.6940.96
16_L21_K0.6940.96
292_S295_V0.6910.96
307_Q311_P0.6900.96
27_M154_S0.6880.95
287_D290_L0.6840.95
267_A297_A0.6840.95
244_F272_L0.6830.95
212_H215_E0.6830.95
211_R226_D0.6820.95
306_V314_L0.6800.95
352_Q356_K0.6800.95
21_K26_R0.6750.95
45_H160_P0.6740.95
131_L134_A0.6740.95
362_A414_L0.6740.95
59_I63_L0.6740.95
321_E325_K0.6730.95
31_M37_P0.6700.95
81_F121_E0.6700.95
85_I133_F0.6690.95
92_I100_L0.6680.95
47_A168_I0.6640.95
104_M128_C0.6640.95
23_G26_R0.6630.94
369_S377_L0.6630.94
103_Q107_H0.6630.94
10_S14_G0.6600.94
351_Y381_L0.6600.94
26_R117_G0.6590.94
163_T190_I0.6570.94
380_D384_A0.6570.94
87_V132_Y0.6560.94
353_N357_R0.6550.94
164_V270_S0.6540.94
152_F185_G0.6530.94
326_L330_M0.6470.94
337_S411_E0.6460.94
63_L70_V0.6460.94
11_W105_K0.6450.94
162_L277_L0.6440.94
180_I206_A0.6430.94
334_F412_I0.6420.93
62_M271_I0.6410.93
85_I125_M0.6400.93
379_K383_D0.6400.93
401_K405_S0.6390.93
382_Y390_K0.6390.93
73_F84_R0.6370.93
28_K159_E0.6350.93
408_G411_E0.6340.93
181_E208_Q0.6340.93
314_L415_I0.6340.93
421_F425_I0.6330.93
81_F84_R0.6320.93
102_N105_K0.6300.93
244_F271_I0.6290.93
313_Y329_T0.6270.93
29_Q114_T0.6260.93
73_F129_A0.6250.93
403_I407_K0.6250.93
160_P196_P0.6250.93
42_R141_F0.6230.92
307_Q310_P0.6220.92
300_P426_R0.6200.92
362_A365_I0.6190.92
202_T265_Q0.6180.92
129_A133_F0.6180.92
314_L426_R0.6180.92
102_N106_P0.6170.92
312_V415_I0.6160.92
49_T169_G0.6150.92
401_K404_E0.6140.92
38_E157_V0.6120.92
184_A208_Q0.6110.92
156_N190_I0.6100.92
372_F375_A0.6100.92
237_P240_E0.6090.92
34_L107_H0.6080.92
224_L265_Q0.6060.91
342_V368_A0.6030.91
49_T319_N0.6020.91
30_L124_I0.6020.91
379_K382_Y0.6020.91
188_A209_V0.6010.91
262_H322_G0.6000.91
85_I129_A0.5960.91
94_D97_W0.5940.91
46_V273_A0.5930.90
24_L27_M0.5910.90
174_N347_K0.5910.90
77_Y125_M0.5890.90
340_S413_V0.5890.90
306_V310_P0.5880.90
271_I275_E0.5880.90
173_M183_I0.5860.90
203_Q206_A0.5830.90
291_R295_V0.5820.90
368_A396_P0.5820.90
71_G85_I0.5810.90
353_N356_K0.5800.90
225_H229_V0.5790.89
79_I427_K0.5790.89
11_W14_G0.5780.89
397_D401_K0.5780.89
200_A265_Q0.5770.89
202_T210_I0.5760.89
340_S403_I0.5760.89
198_V222_Q0.5750.89
370_F420_Y0.5750.89
224_L228_C0.5740.89
398_D401_K0.5720.89
346_L376_S0.5710.89
367_F381_L0.5710.89
267_A293_G0.5700.89
386_E390_K0.5690.89
339_I363_H0.5680.89
66_A290_L0.5640.88
195_I220_P0.5640.88
173_M179_T0.5640.88
130_F157_V0.5630.88
69_T87_V0.5620.88
307_Q404_E0.5620.88
18_F21_K0.5590.88
367_F385_S0.5580.88
165_I190_I0.5560.87
46_V146_T0.5540.87
189_G192_K0.5530.87
345_A376_S0.5530.87
63_L68_Y0.5520.87
184_A209_V0.5510.87
191_I213_E0.5500.87
346_L372_F0.5500.87
148_L186_E0.5490.87
217_H220_P0.5480.87
163_T196_P0.5480.87
238_A241_Q0.5460.87
378_A382_Y0.5440.86
85_I97_W0.5440.86
60_R70_V0.5430.86
99_A103_Q0.5420.86
182_E186_E0.5420.86
31_M36_H0.5410.86
303_L326_L0.5410.86
27_M31_M0.5410.86
396_P421_F0.5410.86
167_S201_V0.5380.86
368_A421_F0.5360.86
146_T186_E0.5360.86
180_I203_Q0.5350.85
344_S378_A0.5350.85
274_A278_N0.5350.85
41_I134_A0.5340.85
307_Q312_V0.5330.85
27_M126_T0.5320.85
63_L277_L0.5320.85
197_I221_F0.5320.85
84_R121_E0.5310.85
214_A219_A0.5310.85
390_K393_S0.5300.85
78_I422_I0.5300.85
162_L276_W0.5290.85
59_I62_M0.5290.85
146_T158_V0.5260.84
272_L276_W0.5250.84
170_H182_E0.5240.84
165_I188_A0.5240.84
170_H175_I0.5220.84
195_I219_A0.5210.84
311_P334_F0.5200.84
104_M131_L0.5200.84
45_H163_T0.5200.84
61_S64_Q0.5200.84
15_R18_F0.5200.84
184_A188_A0.5190.84
44_F59_I0.5190.84
343_F367_F0.5180.84
354_M357_R0.5180.84
309_H409_S0.5180.84
341_V358_L0.5180.84
56_V74_T0.5170.83
343_F385_S0.5170.83
191_I209_V0.5160.83
241_Q253_D0.5150.83
330_M339_I0.5150.83
73_F125_M0.5140.83
159_E163_T0.5130.83
288_E291_R0.5120.83
199_T202_T0.5120.83
14_G18_F0.5110.83
58_F258_L0.5110.83
126_T157_V0.5100.83
271_I294_L0.5100.83
69_T140_D0.5090.83
393_S399_V0.5090.83
361_I414_L0.5080.82
69_T139_V0.5080.82
146_T163_T0.5070.82
165_I186_E0.5060.82
122_F126_T0.5060.82
229_V245_K0.5050.82
249_K275_E0.5050.82
205_E208_Q0.5040.82
343_F354_M0.5030.82
83_E423_S0.5010.82
317_A416_T0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vosA 1 0.9814 100 0.226 Contact Map
1jbwA 1 0.9465 100 0.245 Contact Map
1o5zA 1 0.9465 100 0.263 Contact Map
3nrsA 1 0.914 100 0.311 Contact Map
1w78A 1 0.9465 100 0.329 Contact Map
1e8cA 1 0.893 100 0.505 Contact Map
4bubA 1 0.8767 100 0.506 Contact Map
4c12A 2 0.8884 100 0.522 Contact Map
2wtzA 1 0.8953 100 0.524 Contact Map
3zm6A 1 0.8419 100 0.539 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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