GTAB - BACSU - GREMLIN Contacts

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GTAB - UTP--glucose-1-phosphate uridylyltransferase

UniProt:	Q05852	Sequences: MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEEAVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYIRQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQQVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	292 (233)
Sequences:	22294 (13704)
Seq/√Len:	897.8

ECOLI - GALU GALF RMLA2 RMLA1 GLMU GLGC
BACSU - GTAB YNGB RMLA YTDA RFBF GLGC GLMU GLGD
HALSA - Q9HSV0 Q9HQQ4 Q9HSZ9 Q9HSZ8 Q9HS61 Q9HSW4
SULSO - Q7LXE7 Q97U06 Q97VX4 Q97XG0 Q97ZD1 Q7LXK9 Q980H9 Q7LXG3 Q980D4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
118_R	218_E	3.461	1.00
35_K	43_E	2.861	1.00
174_D	186_K	2.738	1.00
174_D	187_N	2.628	1.00
39_Q	67_H	2.583	1.00
108_K	112_H	2.492	1.00
176_L	182_R	2.489	1.00
176_L	184_Q	2.482	1.00
52_D	98_D	2.453	1.00
6_K	52_D	2.359	1.00
161_Q	200_N	2.357	1.00
7_A	50_I	2.281	1.00
125_P	210_T	2.247	1.00
216_Y	240_I	2.244	1.00
184_Q	244_F	2.198	1.00
161_Q	247_D	2.175	1.00
7_A	45_A	2.088	1.00
57_T	61_K	2.080	1.00
52_D	100_H	2.064	1.00
61_K	65_E	2.049	1.00
149_Y	156_I	2.040	1.00
152_T	244_F	2.039	1.00
193_P	196_T	2.022	1.00
216_Y	236_K	2.005	1.00
159_V	245_A	1.999	1.00
176_L	186_K	1.982	1.00
42_I	53_I	1.968	1.00
115_W	118_R	1.911	1.00
153_L	244_F	1.809	1.00
236_K	240_I	1.809	1.00
148_E	246_Y	1.796	1.00
102_I	116_C	1.757	1.00
235_Q	239_E	1.755	1.00
125_P	150_E	1.751	1.00
114_V	128_V	1.736	1.00
62_R	66_D	1.710	1.00
148_E	152_T	1.691	1.00
236_K	239_E	1.688	1.00
45_A	129_L	1.687	1.00
8_I	117_A	1.675	1.00
11_A	55_I	1.666	1.00
143_R	147_D	1.662	1.00
253_Y	263_T	1.659	1.00
201_L	247_D	1.646	1.00
175_P	201_L	1.618	1.00
187_N	235_Q	1.616	1.00
166_E	169_R	1.614	1.00
25_M	31_P	1.594	1.00
39_Q	43_E	1.594	1.00
185_V	245_A	1.555	1.00
19_L	23_K	1.539	1.00
154_S	210_T	1.538	1.00
54_I	120_F	1.499	1.00
25_M	63_A	1.495	1.00
232_D	235_Q	1.493	1.00
191_K	197_A	1.488	1.00
29_M	63_A	1.476	1.00
65_E	103_R	1.444	1.00
125_P	208_V	1.419	1.00
63_A	66_D	1.416	1.00
144_Q	147_D	1.405	1.00
147_D	151_K	1.404	1.00
61_K	103_R	1.402	1.00
185_V	243_V	1.401	1.00
173_I	185_V	1.401	1.00
36_P	39_Q	1.386	1.00
53_I	97_A	1.382	1.00
100_H	120_F	1.382	1.00
212_E	215_M	1.374	1.00
112_H	116_C	1.350	1.00
154_S	242_R	1.346	1.00
189_V	198_P	1.341	1.00
159_V	173_I	1.333	1.00
261_F	265_T	1.328	1.00
251_K	267_E	1.327	1.00
138_E	143_R	1.326	1.00
46_V	97_A	1.303	1.00
156_I	159_V	1.290	1.00
121_I	126_F	1.273	1.00
177_T	182_R	1.255	1.00
54_I	102_I	1.251	1.00
126_F	211_P	1.238	1.00
257_E	260_G	1.232	1.00
154_S	158_G	1.215	1.00
184_Q	242_R	1.209	1.00
158_G	161_Q	1.199	1.00
125_P	211_P	1.184	1.00
115_W	218_E	1.182	1.00
216_Y	219_E	1.179	1.00
255_V	264_T	1.176	1.00
216_Y	233_A	1.169	1.00
127_A	208_V	1.161	1.00
156_I	160_Q	1.160	1.00
159_V	201_L	1.152	1.00
145_L	158_G	1.143	1.00
174_D	189_V	1.135	1.00
14_L	107_P	1.133	1.00
215_M	219_E	1.131	1.00
144_Q	148_E	1.130	1.00
39_Q	71_S	1.116	1.00
174_D	199_S	1.111	1.00
149_Y	208_V	1.098	1.00
262_I	266_L	1.095	1.00
130_L	205_G	1.094	1.00
112_H	115_W	1.092	1.00
260_G	263_T	1.091	1.00
253_Y	267_E	1.080	1.00
155_S	159_V	1.080	1.00
215_M	218_E	1.079	1.00
54_I	117_A	1.072	1.00
148_E	151_K	1.069	1.00
157_I	160_Q	1.065	1.00
219_E	236_K	1.062	1.00
18_F	30_L	1.051	1.00
175_P	183_Y	1.051	1.00
128_V	209_F	1.046	1.00
233_A	236_K	1.042	1.00
175_P	245_A	1.038	1.00
34_D	40_Y	1.035	1.00
57_T	103_R	1.025	1.00
183_Y	247_D	1.020	1.00
29_M	67_H	1.019	1.00
209_F	234_I	1.019	1.00
8_I	126_F	1.016	1.00
155_S	161_Q	1.014	1.00
50_I	127_A	1.009	1.00
57_T	65_E	1.008	1.00
12_A	56_V	1.006	1.00
177_T	183_Y	0.993	1.00
37_T	255_V	0.993	1.00
60_S	63_A	0.992	1.00
57_T	64_I	0.989	1.00
171_G	190_E	0.981	1.00
145_L	208_V	0.978	1.00
69_D	101_Y	0.975	1.00
222_V	225_G	0.974	1.00
57_T	101_Y	0.966	1.00
153_L	242_R	0.963	1.00
115_W	217_L	0.962	1.00
138_E	144_Q	0.960	1.00
124_E	211_P	0.957	1.00
148_E	244_F	0.947	1.00
147_D	150_E	0.944	1.00
38_I	68_F	0.931	1.00
43_E	46_V	0.931	1.00
154_S	241_Q	0.931	1.00
266_L	269_A	0.930	1.00
219_E	240_I	0.925	1.00
231_T	235_Q	0.923	1.00
168_H	191_K	0.917	1.00
54_I	100_H	0.916	1.00
6_K	124_E	0.913	1.00
38_I	55_I	0.911	1.00
136_Q	251_K	0.905	1.00
155_S	209_F	0.904	1.00
259_L	263_T	0.902	1.00
18_F	22_T	0.898	1.00
187_N	196_T	0.896	1.00
155_S	160_Q	0.891	1.00
183_Y	186_K	0.888	1.00
31_P	36_P	0.883	1.00
65_E	101_Y	0.880	1.00
127_A	146_M	0.873	1.00
155_S	158_G	0.869	1.00
5_R	124_E	0.864	1.00
172_I	202_A	0.862	1.00
262_I	265_T	0.862	1.00
136_Q	271_Q	0.852	1.00
9_I	131_G	0.843	1.00
62_R	65_E	0.843	1.00
36_P	67_H	0.840	1.00
137_A	251_K	0.838	1.00
5_R	150_E	0.835	1.00
6_K	54_I	0.832	1.00
35_K	39_Q	0.832	1.00
196_T	199_S	0.832	1.00
35_K	40_Y	0.828	1.00
48_A	143_R	0.828	1.00
118_R	214_F	0.826	1.00
263_T	266_L	0.824	1.00
169_R	260_G	0.821	1.00
42_I	68_F	0.815	1.00
265_T	269_A	0.814	1.00
38_I	64_I	0.809	1.00
133_D	252_R	0.807	1.00
203_I	207_Y	0.800	1.00
253_Y	264_T	0.798	1.00
263_T	267_E	0.792	1.00
234_I	243_V	0.790	1.00
6_K	122_G	0.784	1.00
237_L	241_Q	0.776	1.00
22_T	30_L	0.775	1.00
33_V	40_Y	0.774	1.00
110_L	130_L	0.771	1.00
149_Y	210_T	0.764	1.00
123_D	211_P	0.764	1.00
267_E	270_M	0.761	1.00
47_E	138_E	0.758	1.00
66_D	69_D	0.754	1.00
37_T	41_I	0.754	1.00
186_K	189_V	0.753	1.00
10_P	130_L	0.750	1.00
28_E	131_G	0.747	1.00
65_E	69_D	0.744	1.00
157_I	161_Q	0.736	1.00
148_E	156_I	0.734	1.00
168_H	193_P	0.732	1.00
152_T	182_R	0.732	1.00
227_E	230_L	0.731	1.00
169_R	191_K	0.729	1.00
6_K	121_I	0.727	1.00
102_I	105_K	0.720	1.00
212_E	241_Q	0.719	1.00
122_G	211_P	0.719	1.00
145_L	246_Y	0.711	1.00
129_L	142_L	0.710	1.00
44_E	48_A	0.708	1.00
50_I	146_M	0.707	1.00
8_I	56_V	0.704	1.00
36_P	40_Y	0.703	1.00
21_A	25_M	0.702	1.00
156_I	244_F	0.701	1.00
51_E	98_D	0.700	1.00
212_E	216_Y	0.692	1.00
33_V	265_T	0.692	1.00
26_P	63_A	0.689	1.00
97_A	101_Y	0.684	1.00
30_L	261_F	0.680	1.00
155_S	243_V	0.679	1.00
40_Y	43_E	0.679	1.00
160_Q	204_L	0.678	1.00
146_M	150_E	0.677	1.00
46_V	53_I	0.675	1.00
266_L	270_M	0.674	1.00
223_G	226_G	0.674	1.00
7_A	53_I	0.674	1.00
188_F	203_I	0.673	1.00
155_S	237_L	0.671	1.00
118_R	126_F	0.669	1.00
121_I	214_F	0.661	1.00
40_Y	268_F	0.661	1.00
225_G	229_Q	0.658	1.00
114_V	213_I	0.657	1.00
244_F	247_D	0.652	1.00
46_V	51_E	0.652	1.00
102_I	117_A	0.649	1.00
69_D	72_P	0.647	1.00
42_I	99_I	0.645	1.00
55_I	68_F	0.645	1.00
156_I	161_Q	0.643	1.00
154_S	161_Q	0.637	1.00
189_V	196_T	0.636	1.00
220_Q	228_I	0.635	1.00
21_A	258_K	0.632	1.00
142_L	145_L	0.632	1.00
96_L	99_I	0.630	1.00
152_T	156_I	0.629	1.00
146_M	149_Y	0.628	1.00
56_V	113_A	0.627	1.00
47_E	143_R	0.622	1.00
154_S	159_V	0.622	1.00
9_I	129_L	0.622	1.00
102_I	120_F	0.621	1.00
159_V	162_V	0.621	1.00
154_S	160_Q	0.620	1.00
124_E	210_T	0.619	1.00
189_V	192_P	0.618	1.00
144_Q	246_Y	0.617	1.00
134_I	264_T	0.616	1.00
107_P	112_H	0.611	1.00
167_T	172_I	0.610	1.00
201_L	245_A	0.603	1.00
8_I	54_I	0.602	1.00
42_I	55_I	0.602	1.00
42_I	97_A	0.600	1.00
115_W	228_I	0.600	1.00
262_I	269_A	0.599	1.00
58_G	107_P	0.595	1.00
100_H	103_R	0.595	1.00
211_P	214_F	0.591	1.00
159_V	247_D	0.591	1.00
145_L	156_I	0.590	1.00
221_Q	228_I	0.588	1.00
15_G	27_K	0.588	1.00
39_Q	68_F	0.587	1.00
43_E	71_S	0.586	1.00
10_P	110_L	0.584	1.00
216_Y	237_L	0.582	1.00
221_Q	227_E	0.577	1.00
220_Q	236_K	0.576	1.00
166_E	170_Y	0.576	1.00
46_V	71_S	0.575	1.00
56_V	117_A	0.575	1.00
146_M	208_V	0.575	1.00
130_L	133_D	0.572	1.00
112_H	228_I	0.571	1.00
17_R	27_K	0.570	1.00
143_R	146_M	0.569	1.00
149_Y	152_T	0.568	1.00
6_K	126_F	0.564	1.00
45_A	127_A	0.563	1.00
40_Y	44_E	0.562	1.00
32_I	265_T	0.561	1.00
21_A	30_L	0.559	1.00
169_R	257_E	0.557	1.00
212_E	240_I	0.556	1.00
212_E	242_R	0.552	1.00
232_D	236_K	0.552	1.00
9_I	41_I	0.551	1.00
173_I	245_A	0.551	1.00
109_G	229_Q	0.549	1.00
157_I	173_I	0.549	1.00
101_Y	104_Q	0.549	1.00
167_T	170_Y	0.547	1.00
44_E	206_R	0.544	1.00
222_V	228_I	0.540	1.00
145_L	149_Y	0.539	1.00
258_K	262_I	0.537	1.00
154_S	212_E	0.536	1.00
213_I	237_L	0.534	1.00
161_Q	201_L	0.533	1.00
235_Q	238_N	0.531	1.00
55_I	99_I	0.528	1.00
118_R	215_M	0.528	1.00
185_V	188_F	0.525	1.00
204_L	252_R	0.524	1.00
57_T	62_R	0.523	1.00
51_E	96_L	0.522	1.00
8_I	114_V	0.522	1.00
21_A	24_A	0.520	1.00
106_E	112_H	0.519	1.00
27_K	132_D	0.518	1.00
43_E	47_E	0.517	1.00
129_L	206_R	0.515	1.00
177_T	184_Q	0.514	1.00
135_V	204_L	0.514	1.00
234_I	237_L	0.513	1.00
197_A	200_N	0.512	1.00
125_P	149_Y	0.511	1.00
41_I	44_E	0.509	1.00
154_S	157_I	0.506	1.00
31_P	34_D	0.506	1.00
117_A	120_F	0.502	1.00
127_A	142_L	0.502	1.00
247_D	250_G	0.501	1.00
220_Q	233_A	0.501	1.00
46_V	96_L	0.500	1.00
154_S	244_F	0.500	1.00
170_Y	254_D	0.500	1.00
109_G	232_D	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3jukA	3	0.8938	100	0.332	Contact Map
2e3dA	3	0.9692	100	0.333	Contact Map
2pa4A	3	0.9932	100	0.339	Contact Map
2ux8A	4	0.9795	100	0.345	Contact Map
1iimA	3	0.887	100	0.37	Contact Map
1lvwA	3	0.887	100	0.373	Contact Map
4ho4A	3	0.8801	100	0.378	Contact Map
3brkX	2	0.8836	100	0.384	Contact Map
1mc3A	3	0.8836	100	0.385	Contact Map
4ecmA	3	0.8288	100	0.392	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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