GREMLIN Database
GTAB - UTP--glucose-1-phosphate uridylyltransferase
UniProt: Q05852 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 292 (233)
Sequences: 22294 (13704)
Seq/√Len: 897.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_R218_E3.4611.00
35_K43_E2.8611.00
174_D186_K2.7381.00
174_D187_N2.6281.00
39_Q67_H2.5831.00
108_K112_H2.4921.00
176_L182_R2.4891.00
176_L184_Q2.4821.00
52_D98_D2.4531.00
6_K52_D2.3591.00
161_Q200_N2.3571.00
7_A50_I2.2811.00
125_P210_T2.2471.00
216_Y240_I2.2441.00
184_Q244_F2.1981.00
161_Q247_D2.1751.00
7_A45_A2.0881.00
57_T61_K2.0801.00
52_D100_H2.0641.00
61_K65_E2.0491.00
149_Y156_I2.0401.00
152_T244_F2.0391.00
193_P196_T2.0221.00
216_Y236_K2.0051.00
159_V245_A1.9991.00
176_L186_K1.9821.00
42_I53_I1.9681.00
115_W118_R1.9111.00
153_L244_F1.8091.00
236_K240_I1.8091.00
148_E246_Y1.7961.00
102_I116_C1.7571.00
235_Q239_E1.7551.00
125_P150_E1.7511.00
114_V128_V1.7361.00
62_R66_D1.7101.00
148_E152_T1.6911.00
236_K239_E1.6881.00
45_A129_L1.6871.00
8_I117_A1.6751.00
11_A55_I1.6661.00
143_R147_D1.6621.00
253_Y263_T1.6591.00
201_L247_D1.6461.00
175_P201_L1.6181.00
187_N235_Q1.6161.00
166_E169_R1.6141.00
25_M31_P1.5941.00
39_Q43_E1.5941.00
185_V245_A1.5551.00
19_L23_K1.5391.00
154_S210_T1.5381.00
54_I120_F1.4991.00
25_M63_A1.4951.00
232_D235_Q1.4931.00
191_K197_A1.4881.00
29_M63_A1.4761.00
65_E103_R1.4441.00
125_P208_V1.4191.00
63_A66_D1.4161.00
144_Q147_D1.4051.00
147_D151_K1.4041.00
61_K103_R1.4021.00
185_V243_V1.4011.00
173_I185_V1.4011.00
36_P39_Q1.3861.00
53_I97_A1.3821.00
100_H120_F1.3821.00
212_E215_M1.3741.00
112_H116_C1.3501.00
154_S242_R1.3461.00
189_V198_P1.3411.00
159_V173_I1.3331.00
261_F265_T1.3281.00
251_K267_E1.3271.00
138_E143_R1.3261.00
46_V97_A1.3031.00
156_I159_V1.2901.00
121_I126_F1.2731.00
177_T182_R1.2551.00
54_I102_I1.2511.00
126_F211_P1.2381.00
257_E260_G1.2321.00
154_S158_G1.2151.00
184_Q242_R1.2091.00
158_G161_Q1.1991.00
125_P211_P1.1841.00
115_W218_E1.1821.00
216_Y219_E1.1791.00
255_V264_T1.1761.00
216_Y233_A1.1691.00
127_A208_V1.1611.00
156_I160_Q1.1601.00
159_V201_L1.1521.00
145_L158_G1.1431.00
174_D189_V1.1351.00
14_L107_P1.1331.00
215_M219_E1.1311.00
144_Q148_E1.1301.00
39_Q71_S1.1161.00
174_D199_S1.1111.00
149_Y208_V1.0981.00
262_I266_L1.0951.00
130_L205_G1.0941.00
112_H115_W1.0921.00
260_G263_T1.0911.00
253_Y267_E1.0801.00
155_S159_V1.0801.00
215_M218_E1.0791.00
54_I117_A1.0721.00
148_E151_K1.0691.00
157_I160_Q1.0651.00
219_E236_K1.0621.00
18_F30_L1.0511.00
175_P183_Y1.0511.00
128_V209_F1.0461.00
233_A236_K1.0421.00
175_P245_A1.0381.00
34_D40_Y1.0351.00
57_T103_R1.0251.00
183_Y247_D1.0201.00
29_M67_H1.0191.00
209_F234_I1.0191.00
8_I126_F1.0161.00
155_S161_Q1.0141.00
50_I127_A1.0091.00
57_T65_E1.0081.00
12_A56_V1.0061.00
177_T183_Y0.9931.00
37_T255_V0.9931.00
60_S63_A0.9921.00
57_T64_I0.9891.00
171_G190_E0.9811.00
145_L208_V0.9781.00
69_D101_Y0.9751.00
222_V225_G0.9741.00
57_T101_Y0.9661.00
153_L242_R0.9631.00
115_W217_L0.9621.00
138_E144_Q0.9601.00
124_E211_P0.9571.00
148_E244_F0.9471.00
147_D150_E0.9441.00
38_I68_F0.9311.00
43_E46_V0.9311.00
154_S241_Q0.9311.00
266_L269_A0.9301.00
219_E240_I0.9251.00
231_T235_Q0.9231.00
168_H191_K0.9171.00
54_I100_H0.9161.00
6_K124_E0.9131.00
38_I55_I0.9111.00
136_Q251_K0.9051.00
155_S209_F0.9041.00
259_L263_T0.9021.00
18_F22_T0.8981.00
187_N196_T0.8961.00
155_S160_Q0.8911.00
183_Y186_K0.8881.00
31_P36_P0.8831.00
65_E101_Y0.8801.00
127_A146_M0.8731.00
155_S158_G0.8691.00
5_R124_E0.8641.00
172_I202_A0.8621.00
262_I265_T0.8621.00
136_Q271_Q0.8521.00
9_I131_G0.8431.00
62_R65_E0.8431.00
36_P67_H0.8401.00
137_A251_K0.8381.00
5_R150_E0.8351.00
6_K54_I0.8321.00
35_K39_Q0.8321.00
196_T199_S0.8321.00
35_K40_Y0.8281.00
48_A143_R0.8281.00
118_R214_F0.8261.00
263_T266_L0.8241.00
169_R260_G0.8211.00
42_I68_F0.8151.00
265_T269_A0.8141.00
38_I64_I0.8091.00
133_D252_R0.8071.00
203_I207_Y0.8001.00
253_Y264_T0.7981.00
263_T267_E0.7921.00
234_I243_V0.7901.00
6_K122_G0.7841.00
237_L241_Q0.7761.00
22_T30_L0.7751.00
33_V40_Y0.7741.00
110_L130_L0.7711.00
149_Y210_T0.7641.00
123_D211_P0.7641.00
267_E270_M0.7611.00
47_E138_E0.7581.00
66_D69_D0.7541.00
37_T41_I0.7541.00
186_K189_V0.7531.00
10_P130_L0.7501.00
28_E131_G0.7471.00
65_E69_D0.7441.00
157_I161_Q0.7361.00
148_E156_I0.7341.00
168_H193_P0.7321.00
152_T182_R0.7321.00
227_E230_L0.7311.00
169_R191_K0.7291.00
6_K121_I0.7271.00
102_I105_K0.7201.00
212_E241_Q0.7191.00
122_G211_P0.7191.00
145_L246_Y0.7111.00
129_L142_L0.7101.00
44_E48_A0.7081.00
50_I146_M0.7071.00
8_I56_V0.7041.00
36_P40_Y0.7031.00
21_A25_M0.7021.00
156_I244_F0.7011.00
51_E98_D0.7001.00
212_E216_Y0.6921.00
33_V265_T0.6921.00
26_P63_A0.6891.00
97_A101_Y0.6841.00
30_L261_F0.6801.00
155_S243_V0.6791.00
40_Y43_E0.6791.00
160_Q204_L0.6781.00
146_M150_E0.6771.00
46_V53_I0.6751.00
266_L270_M0.6741.00
223_G226_G0.6741.00
7_A53_I0.6741.00
188_F203_I0.6731.00
155_S237_L0.6711.00
118_R126_F0.6691.00
121_I214_F0.6611.00
40_Y268_F0.6611.00
225_G229_Q0.6581.00
114_V213_I0.6571.00
244_F247_D0.6521.00
46_V51_E0.6521.00
102_I117_A0.6491.00
69_D72_P0.6471.00
42_I99_I0.6451.00
55_I68_F0.6451.00
156_I161_Q0.6431.00
154_S161_Q0.6371.00
189_V196_T0.6361.00
220_Q228_I0.6351.00
21_A258_K0.6321.00
142_L145_L0.6321.00
96_L99_I0.6301.00
152_T156_I0.6291.00
146_M149_Y0.6281.00
56_V113_A0.6271.00
47_E143_R0.6221.00
154_S159_V0.6221.00
9_I129_L0.6221.00
102_I120_F0.6211.00
159_V162_V0.6211.00
154_S160_Q0.6201.00
124_E210_T0.6191.00
189_V192_P0.6181.00
144_Q246_Y0.6171.00
134_I264_T0.6161.00
107_P112_H0.6111.00
167_T172_I0.6101.00
201_L245_A0.6031.00
8_I54_I0.6021.00
42_I55_I0.6021.00
42_I97_A0.6001.00
115_W228_I0.6001.00
262_I269_A0.5991.00
58_G107_P0.5951.00
100_H103_R0.5951.00
211_P214_F0.5911.00
159_V247_D0.5911.00
145_L156_I0.5901.00
221_Q228_I0.5881.00
15_G27_K0.5881.00
39_Q68_F0.5871.00
43_E71_S0.5861.00
10_P110_L0.5841.00
216_Y237_L0.5821.00
221_Q227_E0.5771.00
220_Q236_K0.5761.00
166_E170_Y0.5761.00
46_V71_S0.5751.00
56_V117_A0.5751.00
146_M208_V0.5751.00
130_L133_D0.5721.00
112_H228_I0.5711.00
17_R27_K0.5701.00
143_R146_M0.5691.00
149_Y152_T0.5681.00
6_K126_F0.5641.00
45_A127_A0.5631.00
40_Y44_E0.5621.00
32_I265_T0.5611.00
21_A30_L0.5591.00
169_R257_E0.5571.00
212_E240_I0.5561.00
212_E242_R0.5521.00
232_D236_K0.5521.00
9_I41_I0.5511.00
173_I245_A0.5511.00
109_G229_Q0.5491.00
157_I173_I0.5491.00
101_Y104_Q0.5491.00
167_T170_Y0.5471.00
44_E206_R0.5441.00
222_V228_I0.5401.00
145_L149_Y0.5391.00
258_K262_I0.5371.00
154_S212_E0.5361.00
213_I237_L0.5341.00
161_Q201_L0.5331.00
235_Q238_N0.5311.00
55_I99_I0.5281.00
118_R215_M0.5281.00
185_V188_F0.5251.00
204_L252_R0.5241.00
57_T62_R0.5231.00
51_E96_L0.5221.00
8_I114_V0.5221.00
21_A24_A0.5201.00
106_E112_H0.5191.00
27_K132_D0.5181.00
43_E47_E0.5171.00
129_L206_R0.5151.00
177_T184_Q0.5141.00
135_V204_L0.5141.00
234_I237_L0.5131.00
197_A200_N0.5121.00
125_P149_Y0.5111.00
41_I44_E0.5091.00
154_S157_I0.5061.00
31_P34_D0.5061.00
117_A120_F0.5021.00
127_A142_L0.5021.00
247_D250_G0.5011.00
220_Q233_A0.5011.00
46_V96_L0.5001.00
154_S244_F0.5001.00
170_Y254_D0.5001.00
109_G232_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jukA 3 0.8938 100 0.332 Contact Map
2e3dA 3 0.9692 100 0.333 Contact Map
2pa4A 3 0.9932 100 0.339 Contact Map
2ux8A 4 0.9795 100 0.345 Contact Map
1iimA 3 0.887 100 0.37 Contact Map
1lvwA 3 0.887 100 0.373 Contact Map
4ho4A 3 0.8801 100 0.378 Contact Map
3brkX 2 0.8836 100 0.384 Contact Map
1mc3A 3 0.8836 100 0.385 Contact Map
4ecmA 3 0.8288 100 0.392 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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