CHEB - BACSU - GREMLIN Contacts

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CHEB - Chemotaxis response regulator protein-glutamate methylesterase

UniProt:	Q05522	Sequences: MIRVLVVDDSAFMRKMISDFLTEEKQIEVIGTARNGEEALKKIELLKPDVITLDVEMPVMNGTDTLRKIIEIYNLPVIMVSSQTEKGKECTINCLEIGAFDFITKPSGSISLDLYKIKEQLVERVVAAGLSGKRKRPVSQTVRPEPIVRAVVKPELSKPKPGTGRQIVCIGTSTGGPRALQKVIPKLPKDLNAPVVVVQHMPEGFTASLADRLNHLSDIQVKEAKDGEAALNGCVYIAPGGKNISVIKNSEGLQVVLDNHDTPSRHKPSADYLFRSVGKLTDYEKVAVIMTGMGSDGTAGLKDMLTAGNVKAIAESEESCVVYGMPKAAVKAGLIHEIKHVEDIAASITSCVKKERV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	357 (336)
Sequences:	3000 (2330)
Seq/√Len:	127.1

ECOLI - CHEB
BACSU - CHEB
HALSA - CHEB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
323_Y	330_V	4.594	1.00
304_M	309_N	3.748	1.00
169_C	277_V	3.533	1.00
61_N	64_D	3.265	1.00
219_I	235_V	3.197	1.00
21_L	27_I	3.195	1.00
302_K	306_T	3.119	1.00
337_E	347_S	3.038	1.00
35_N	59_V	2.908	1.00
171_G	270_A	2.797	1.00
305_L	336_H	2.769	1.00
222_K	225_K	2.732	1.00
31_G	46_L	2.679	1.00
222_K	228_E	2.604	1.00
314_A	330_V	2.582	1.00
214_N	220_Q	2.562	1.00
275_R	303_D	2.461	1.00
327_K	331_K	2.441	1.00
313_I	344_I	2.435	1.00
242_K	259_N	2.358	1.00
226_D	256_V	2.295	1.00
244_I	255_V	2.268	1.00
70_I	74_N	2.218	1.00
314_A	335_I	2.209	1.00
330_V	338_I	2.183	1.00
287_A	304_M	2.180	1.00
37_E	59_V	2.150	1.00
7_V	39_A	2.056	1.00
201_M	206_T	2.030	1.00
170_I	183_V	2.019	1.00
207_A	211_D	2.016	1.00
259_N	267_K	2.014	1.00
44_E	72_I	1.973	1.00
228_E	236_Y	1.943	1.00
3_R	28_E	1.929	1.00
220_Q	234_C	1.915	1.00
301_L	312_A	1.911	1.00
316_S	320_C	1.873	1.00
184_I	217_S	1.828	1.00
53_L	65_T	1.806	1.00
319_S	340_H	1.803	1.00
316_S	340_H	1.800	1.00
247_I	256_V	1.795	1.00
314_A	338_I	1.789	1.00
34_R	38_E	1.777	1.00
329_A	335_I	1.744	1.00
18_S	32_T	1.737	1.00
66_L	77_V	1.686	1.00
194_P	230_A	1.662	1.00
323_Y	327_K	1.662	1.00
40_L	65_T	1.650	1.00
236_Y	255_V	1.630	1.00
347_S	350_S	1.623	1.00
43_I	51_I	1.618	1.00
183_V	290_M	1.615	1.00
60_M	64_D	1.614	1.00
222_K	234_C	1.612	1.00
55_V	79_M	1.601	1.00
120_Q	124_R	1.596	1.00
117_I	121_L	1.580	1.00
328_A	331_K	1.577	1.00
182_K	342_E	1.570	1.00
51_I	75_L	1.566	1.00
196_V	230_A	1.555	1.00
88_K	91_T	1.547	1.00
253_L	281_T	1.544	1.00
277_V	285_K	1.528	1.00
315_E	320_C	1.523	1.00
315_E	318_E	1.507	1.00
339_K	344_I	1.506	1.00
271_D	300_G	1.503	1.00
285_K	304_M	1.485	1.00
298_T	332_A	1.472	1.00
112_L	116_K	1.467	1.00
329_A	334_L	1.457	1.00
298_T	334_L	1.444	1.00
310_V	336_H	1.429	1.00
89_E	93_N	1.423	1.00
206_T	223_E	1.408	1.00
302_K	334_L	1.397	1.00
93_N	97_I	1.389	1.00
32_T	42_K	1.381	1.00
172_T	290_M	1.379	1.00
245_S	258_D	1.371	1.00
314_A	323_Y	1.367	1.00
68_K	72_I	1.362	1.00
43_I	48_P	1.362	1.00
263_P	275_R	1.355	1.00
319_S	342_E	1.350	1.00
188_P	349_T	1.349	1.00
289_I	301_L	1.348	1.00
120_Q	123_E	1.344	1.00
231_L	234_C	1.337	1.00
41_K	45_L	1.329	1.00
53_L	66_L	1.323	1.00
166_Q	284_E	1.317	1.00
31_G	42_K	1.313	1.00
340_H	343_D	1.312	1.00
112_L	121_L	1.302	1.00
211_D	215_H	1.301	1.00
123_E	127_A	1.295	1.00
323_Y	338_I	1.290	1.00
65_T	69_I	1.288	1.00
189_K	218_D	1.282	1.00
183_V	344_I	1.273	1.00
93_N	96_E	1.268	1.00
198_V	273_L	1.265	1.00
116_K	119_E	1.264	1.00
312_A	334_L	1.262	1.00
121_L	124_R	1.260	1.00
17_I	80_V	1.259	1.00
179_A	341_V	1.248	1.00
167_I	196_V	1.248	1.00
116_K	120_Q	1.245	1.00
67_R	97_I	1.239	1.00
68_K	71_E	1.238	1.00
117_I	120_Q	1.231	1.00
85_E	104_T	1.224	0.99
38_E	42_K	1.222	0.99
123_E	128_A	1.211	0.99
191_L	348_I	1.207	0.99
301_L	329_A	1.201	0.99
197_V	235_V	1.197	0.99
4_V	50_V	1.194	0.99
43_I	75_L	1.182	0.99
230_A	246_V	1.175	0.99
91_T	102_F	1.168	0.99
320_C	323_Y	1.168	0.99
79_M	84_T	1.165	0.99
303_D	306_T	1.164	0.99
335_I	338_I	1.155	0.99
37_E	41_K	1.155	0.99
124_R	128_A	1.152	0.99
120_Q	128_A	1.150	0.99
298_T	329_A	1.149	0.99
312_A	329_A	1.140	0.99
187_L	191_L	1.139	0.99
117_I	123_E	1.132	0.99
125_V	130_L	1.128	0.99
128_A	132_G	1.125	0.99
289_I	312_A	1.119	0.99
339_K	347_S	1.119	0.99
24_E	118_K	1.115	0.99
40_L	43_I	1.110	0.99
124_R	129_G	1.110	0.99
301_L	334_L	1.107	0.99
288_V	348_I	1.094	0.99
11_A	14_R	1.087	0.99
108_G	111_S	1.074	0.99
184_I	235_V	1.070	0.99
6_V	17_I	1.066	0.99
196_V	244_I	1.065	0.99
124_R	130_L	1.064	0.99
290_M	344_I	1.063	0.99
67_R	93_N	1.063	0.99
187_L	195_V	1.058	0.98
211_D	214_N	1.056	0.98
119_E	123_E	1.056	0.98
114_L	117_I	1.054	0.98
42_K	45_L	1.054	0.98
41_K	44_E	1.052	0.98
168_V	348_I	1.048	0.98
117_I	124_R	1.048	0.98
197_V	237_I	1.045	0.98
121_L	125_V	1.043	0.98
42_K	46_L	1.037	0.98
47_K	73_Y	1.036	0.98
298_T	328_A	1.032	0.98
312_A	332_A	1.031	0.98
302_K	332_A	1.029	0.98
24_E	27_I	1.028	0.98
310_V	337_E	1.028	0.98
84_T	91_T	1.028	0.98
78_I	100_F	1.027	0.98
5_L	31_G	1.024	0.98
168_V	191_L	1.019	0.98
129_G	132_G	1.017	0.98
301_L	332_A	1.014	0.98
186_K	345_A	1.011	0.98
36_G	65_T	1.011	0.98
295_S	299_A	1.009	0.98
266_H	269_S	1.007	0.98
229_A	252_G	1.005	0.98
125_V	128_A	0.999	0.98
120_Q	127_A	0.998	0.98
343_D	346_A	0.995	0.98
33_A	42_K	0.995	0.98
118_K	124_R	0.990	0.98
180_L	197_V	0.990	0.98
57_M	60_M	0.988	0.98
241_G	259_N	0.987	0.98
124_R	127_A	0.983	0.98
147_I	151_V	0.983	0.98
172_T	180_L	0.980	0.98
51_I	69_I	0.973	0.97
225_K	228_E	0.967	0.97
8_D	57_M	0.963	0.97
111_S	115_Y	0.963	0.97
222_K	236_Y	0.959	0.97
120_Q	125_V	0.951	0.97
55_V	90_C	0.951	0.97
96_E	181_Q	0.950	0.97
289_I	332_A	0.947	0.97
116_K	121_L	0.943	0.97
301_L	335_I	0.942	0.97
274_F	289_I	0.936	0.97
54_D	57_M	0.933	0.97
9_D	57_M	0.925	0.96
30_I	46_L	0.923	0.96
84_T	87_G	0.920	0.96
330_V	335_I	0.919	0.96
6_V	18_S	0.919	0.96
116_K	123_E	0.919	0.96
125_V	129_G	0.918	0.96
63_T	97_I	0.917	0.96
4_V	21_L	0.917	0.96
26_Q	118_K	0.908	0.96
112_L	117_I	0.906	0.96
289_I	329_A	0.905	0.96
9_D	54_D	0.901	0.96
43_I	46_L	0.900	0.96
18_S	22_T	0.898	0.96
243_N	267_K	0.890	0.96
243_N	257_L	0.886	0.96
127_A	130_L	0.886	0.96
122_V	125_V	0.875	0.95
55_V	84_T	0.866	0.95
332_A	335_I	0.862	0.95
126_V	129_G	0.854	0.95
220_Q	231_L	0.850	0.94
289_I	300_G	0.850	0.94
4_V	27_I	0.845	0.94
183_V	348_I	0.844	0.94
299_A	332_A	0.842	0.94
91_T	101_D	0.842	0.94
31_G	48_P	0.841	0.94
37_E	68_K	0.840	0.94
289_I	335_I	0.839	0.94
70_I	100_F	0.837	0.94
118_K	121_L	0.834	0.94
182_K	186_K	0.833	0.94
36_G	177_P	0.829	0.94
14_R	32_T	0.826	0.93
339_K	343_D	0.826	0.93
224_A	227_G	0.825	0.93
228_E	234_C	0.824	0.93
195_V	219_I	0.823	0.93
79_M	102_F	0.822	0.93
146_P	149_R	0.819	0.93
191_L	195_V	0.818	0.93
123_E	126_V	0.818	0.93
121_L	127_A	0.817	0.93
278_G	300_G	0.816	0.93
119_E	124_R	0.816	0.93
57_M	62_G	0.815	0.93
128_A	133_K	0.815	0.93
121_L	128_A	0.811	0.93
313_I	339_K	0.811	0.93
21_L	29_V	0.806	0.93
312_A	336_H	0.801	0.92
327_K	330_V	0.799	0.92
53_L	77_V	0.796	0.92
271_D	289_I	0.794	0.92
274_F	287_A	0.793	0.92
245_S	260_H	0.791	0.92
54_D	58_P	0.789	0.92
9_D	62_G	0.786	0.92
40_L	72_I	0.785	0.92
15_K	19_D	0.785	0.92
8_D	105_K	0.775	0.91
116_K	124_R	0.774	0.91
191_L	219_I	0.774	0.91
129_G	133_K	0.771	0.91
167_I	277_V	0.770	0.91
27_I	50_V	0.769	0.91
125_V	131_S	0.765	0.91
180_L	209_L	0.762	0.90
21_L	117_I	0.761	0.90
149_R	152_V	0.760	0.90
329_A	332_A	0.760	0.90
172_T	185_P	0.759	0.90
47_K	75_L	0.752	0.90
299_A	306_T	0.752	0.90
59_V	65_T	0.750	0.90
53_L	69_I	0.745	0.89
36_G	59_V	0.745	0.89
122_V	126_V	0.743	0.89
145_E	149_R	0.742	0.89
111_S	116_K	0.742	0.89
303_D	307_A	0.742	0.89
148_V	151_V	0.740	0.89
54_D	105_K	0.736	0.89
305_L	334_L	0.736	0.89
298_T	312_A	0.735	0.89
169_C	273_L	0.733	0.89
191_L	349_T	0.727	0.88
202_P	240_G	0.725	0.88
114_L	118_K	0.724	0.88
130_L	133_K	0.721	0.88
224_A	244_I	0.719	0.88
209_L	237_I	0.718	0.88
342_E	345_A	0.715	0.87
56_E	61_N	0.714	0.87
299_A	302_K	0.714	0.87
196_V	246_V	0.712	0.87
51_I	65_T	0.711	0.87
54_D	62_G	0.711	0.87
184_I	197_V	0.711	0.87
242_K	267_K	0.710	0.87
123_E	133_K	0.709	0.87
116_K	122_V	0.707	0.87
147_I	150_A	0.707	0.87
64_D	68_K	0.706	0.87
146_P	151_V	0.705	0.87
116_K	125_V	0.704	0.87
3_R	30_I	0.703	0.87
207_A	225_K	0.702	0.86
241_G	267_K	0.700	0.86
202_P	206_T	0.697	0.86
6_V	52_T	0.695	0.86
186_K	346_A	0.692	0.86
127_A	132_G	0.692	0.86
118_K	125_V	0.690	0.85
264_S	269_S	0.689	0.85
182_K	345_A	0.685	0.85
123_E	131_S	0.681	0.85
279_K	303_D	0.680	0.85
63_T	67_R	0.678	0.84
37_E	40_L	0.677	0.84
22_T	28_E	0.676	0.84
245_S	256_V	0.675	0.84
195_V	235_V	0.672	0.84
281_T	285_K	0.672	0.84
52_T	80_V	0.667	0.84
51_I	77_V	0.667	0.84
264_S	271_D	0.667	0.84
323_Y	335_I	0.665	0.83
145_E	148_V	0.664	0.83
122_V	129_G	0.663	0.83
121_L	129_G	0.663	0.83
313_I	347_S	0.663	0.83
19_D	22_T	0.660	0.83
117_I	122_V	0.659	0.83
187_L	348_I	0.659	0.83
7_V	51_I	0.657	0.83
111_S	120_Q	0.657	0.83
169_C	196_V	0.655	0.82
246_V	253_L	0.655	0.82
278_G	285_K	0.654	0.82
43_I	47_K	0.654	0.82
63_T	94_C	0.653	0.82
317_E	320_C	0.652	0.82
58_P	62_G	0.650	0.82
173_S	176_G	0.649	0.82
246_V	281_T	0.646	0.82
169_C	285_K	0.643	0.81
124_R	132_G	0.639	0.81
202_P	223_E	0.638	0.81
263_P	272_Y	0.638	0.81
114_L	120_Q	0.637	0.81
245_S	279_K	0.637	0.81
339_K	346_A	0.636	0.81
5_L	43_I	0.635	0.80
56_E	83_Q	0.635	0.80
196_V	255_V	0.632	0.80
194_P	236_Y	0.628	0.80
206_T	240_G	0.628	0.80
114_L	124_R	0.627	0.80
6_V	29_V	0.625	0.79
125_V	132_G	0.620	0.79
117_I	125_V	0.619	0.79
180_L	185_P	0.619	0.79
112_L	118_K	0.617	0.79
343_D	347_S	0.617	0.79
66_L	79_M	0.616	0.78
346_A	350_S	0.616	0.78
87_G	91_T	0.616	0.78
203_E	241_G	0.615	0.78
8_D	14_R	0.615	0.78
114_L	121_L	0.614	0.78
171_G	289_I	0.614	0.78
54_D	81_S	0.613	0.78
129_G	134_R	0.613	0.78
66_L	97_I	0.612	0.78
126_V	133_K	0.612	0.78
40_L	68_K	0.611	0.78
3_R	46_L	0.608	0.78
36_G	40_L	0.607	0.77
70_I	73_Y	0.605	0.77
169_C	304_M	0.603	0.77
117_I	127_A	0.602	0.77
74_N	100_F	0.602	0.77
263_P	266_H	0.601	0.77
181_Q	185_P	0.601	0.77
117_I	128_A	0.600	0.77
50_V	100_F	0.599	0.76
185_P	216_L	0.599	0.76
340_H	345_A	0.599	0.76
115_Y	119_E	0.598	0.76
9_D	58_P	0.594	0.76
18_S	29_V	0.593	0.76
337_E	350_S	0.593	0.76
286_V	348_I	0.591	0.76
107_S	110_I	0.586	0.75
146_P	150_A	0.584	0.75
239_P	257_L	0.584	0.75
290_M	339_K	0.584	0.75
46_L	52_T	0.582	0.74
36_G	60_M	0.577	0.74
212_R	223_E	0.577	0.74
52_T	79_M	0.574	0.73
70_I	75_L	0.571	0.73
120_Q	126_V	0.570	0.73
274_F	304_M	0.566	0.72
90_C	93_N	0.564	0.72
127_A	131_S	0.564	0.72
243_N	261_D	0.562	0.72
128_A	131_S	0.560	0.72
266_H	272_Y	0.560	0.72
160_K	163_T	0.558	0.71
84_T	88_K	0.558	0.71
110_I	120_Q	0.558	0.71
70_I	76_P	0.557	0.71
43_I	65_T	0.557	0.71
224_A	239_P	0.557	0.71
320_C	327_K	0.555	0.71
14_R	34_R	0.554	0.71
249_N	254_Q	0.554	0.71
114_L	128_A	0.553	0.71
207_A	223_E	0.553	0.71
226_D	257_L	0.552	0.71
131_S	135_K	0.551	0.70
318_E	340_H	0.550	0.70
15_K	18_S	0.549	0.70
229_A	254_Q	0.548	0.70
6_V	21_L	0.548	0.70
271_D	299_A	0.548	0.70
143_R	146_P	0.548	0.70
12_F	102_F	0.546	0.70
305_L	335_I	0.545	0.70
110_I	114_L	0.545	0.70
313_I	337_E	0.545	0.70
189_K	219_I	0.543	0.69
298_T	302_K	0.540	0.69
100_F	120_Q	0.540	0.69
323_Y	328_A	0.538	0.69
40_L	69_I	0.538	0.69
198_V	266_H	0.536	0.68
247_I	254_Q	0.536	0.68
126_V	130_L	0.536	0.68
64_D	67_R	0.535	0.68
273_L	277_V	0.533	0.68
169_C	244_I	0.532	0.68
199_Q	205_F	0.532	0.68
56_E	87_G	0.532	0.68
5_L	33_A	0.531	0.68
144_P	150_A	0.531	0.68
199_Q	209_L	0.530	0.67
109_S	112_L	0.530	0.67
40_L	53_L	0.530	0.67
198_V	267_K	0.528	0.67
116_K	128_A	0.528	0.67
92_I	208_S	0.527	0.67
120_Q	131_S	0.527	0.67
124_R	131_S	0.526	0.67
295_S	332_A	0.526	0.67
34_R	42_K	0.526	0.67
114_L	119_E	0.525	0.67
167_I	285_K	0.524	0.67
277_V	280_L	0.523	0.66
42_K	48_P	0.522	0.66
120_Q	132_G	0.522	0.66
328_A	332_A	0.522	0.66
119_E	122_V	0.521	0.66
83_Q	90_C	0.520	0.66
123_E	132_G	0.519	0.66
258_D	261_D	0.519	0.66
243_N	266_H	0.518	0.66
13_M	17_I	0.518	0.66
35_N	38_E	0.518	0.66
52_T	78_I	0.518	0.66
62_G	105_K	0.517	0.66
40_L	44_E	0.515	0.65
187_L	219_I	0.515	0.65
126_V	132_G	0.515	0.65
313_I	338_I	0.514	0.65
194_P	228_E	0.510	0.64
55_V	83_Q	0.510	0.64
110_I	115_Y	0.508	0.64
59_V	69_I	0.508	0.64
53_L	97_I	0.508	0.64
302_K	305_L	0.508	0.64
131_S	134_R	0.507	0.64
112_L	124_R	0.506	0.64
36_G	57_M	0.505	0.64
168_V	288_V	0.505	0.64
249_N	252_G	0.505	0.64
217_S	235_V	0.504	0.64
92_I	95_L	0.503	0.63
126_V	131_S	0.503	0.63
123_E	130_L	0.502	0.63
178_R	181_Q	0.501	0.63
289_I	298_T	0.501	0.63
317_E	327_K	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a2oA	1	0.9384	100	0.186	Contact Map
1chdA	1	0.5462	100	0.458	Contact Map
3sftA	1	0.5294	100	0.459	Contact Map
4g97A	1	0.3613	100	0.664	Contact Map
4ldzA	2	0.5434	100	0.665	Contact Map
4gvpA	1	0.5658	100	0.667	Contact Map
3n0rA	1	0.3389	100	0.667	Contact Map
3c3wA	2	0.5658	100	0.67	Contact Map
1yioA	1	0.549	100	0.671	Contact Map
1a04A	1	0.5518	100	0.681	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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