GREMLIN Database
CHEB - Chemotaxis response regulator protein-glutamate methylesterase
UniProt: Q05522 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 357 (336)
Sequences: 3000 (2330)
Seq/√Len: 127.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
323_Y330_V4.5941.00
304_M309_N3.7481.00
169_C277_V3.5331.00
61_N64_D3.2651.00
219_I235_V3.1971.00
21_L27_I3.1951.00
302_K306_T3.1191.00
337_E347_S3.0381.00
35_N59_V2.9081.00
171_G270_A2.7971.00
305_L336_H2.7691.00
222_K225_K2.7321.00
31_G46_L2.6791.00
222_K228_E2.6041.00
314_A330_V2.5821.00
214_N220_Q2.5621.00
275_R303_D2.4611.00
327_K331_K2.4411.00
313_I344_I2.4351.00
242_K259_N2.3581.00
226_D256_V2.2951.00
244_I255_V2.2681.00
70_I74_N2.2181.00
314_A335_I2.2091.00
330_V338_I2.1831.00
287_A304_M2.1801.00
37_E59_V2.1501.00
7_V39_A2.0561.00
201_M206_T2.0301.00
170_I183_V2.0191.00
207_A211_D2.0161.00
259_N267_K2.0141.00
44_E72_I1.9731.00
228_E236_Y1.9431.00
3_R28_E1.9291.00
220_Q234_C1.9151.00
301_L312_A1.9111.00
316_S320_C1.8731.00
184_I217_S1.8281.00
53_L65_T1.8061.00
319_S340_H1.8031.00
316_S340_H1.8001.00
247_I256_V1.7951.00
314_A338_I1.7891.00
34_R38_E1.7771.00
329_A335_I1.7441.00
18_S32_T1.7371.00
66_L77_V1.6861.00
194_P230_A1.6621.00
323_Y327_K1.6621.00
40_L65_T1.6501.00
236_Y255_V1.6301.00
347_S350_S1.6231.00
43_I51_I1.6181.00
183_V290_M1.6151.00
60_M64_D1.6141.00
222_K234_C1.6121.00
55_V79_M1.6011.00
120_Q124_R1.5961.00
117_I121_L1.5801.00
328_A331_K1.5771.00
182_K342_E1.5701.00
51_I75_L1.5661.00
196_V230_A1.5551.00
88_K91_T1.5471.00
253_L281_T1.5441.00
277_V285_K1.5281.00
315_E320_C1.5231.00
315_E318_E1.5071.00
339_K344_I1.5061.00
271_D300_G1.5031.00
285_K304_M1.4851.00
298_T332_A1.4721.00
112_L116_K1.4671.00
329_A334_L1.4571.00
298_T334_L1.4441.00
310_V336_H1.4291.00
89_E93_N1.4231.00
206_T223_E1.4081.00
302_K334_L1.3971.00
93_N97_I1.3891.00
32_T42_K1.3811.00
172_T290_M1.3791.00
245_S258_D1.3711.00
314_A323_Y1.3671.00
68_K72_I1.3621.00
43_I48_P1.3621.00
263_P275_R1.3551.00
319_S342_E1.3501.00
188_P349_T1.3491.00
289_I301_L1.3481.00
120_Q123_E1.3441.00
231_L234_C1.3371.00
41_K45_L1.3291.00
53_L66_L1.3231.00
166_Q284_E1.3171.00
31_G42_K1.3131.00
340_H343_D1.3121.00
112_L121_L1.3021.00
211_D215_H1.3011.00
123_E127_A1.2951.00
323_Y338_I1.2901.00
65_T69_I1.2881.00
189_K218_D1.2821.00
183_V344_I1.2731.00
93_N96_E1.2681.00
198_V273_L1.2651.00
116_K119_E1.2641.00
312_A334_L1.2621.00
121_L124_R1.2601.00
17_I80_V1.2591.00
179_A341_V1.2481.00
167_I196_V1.2481.00
116_K120_Q1.2451.00
67_R97_I1.2391.00
68_K71_E1.2381.00
117_I120_Q1.2311.00
85_E104_T1.2240.99
38_E42_K1.2220.99
123_E128_A1.2110.99
191_L348_I1.2070.99
301_L329_A1.2010.99
197_V235_V1.1970.99
4_V50_V1.1940.99
43_I75_L1.1820.99
230_A246_V1.1750.99
91_T102_F1.1680.99
320_C323_Y1.1680.99
79_M84_T1.1650.99
303_D306_T1.1640.99
335_I338_I1.1550.99
37_E41_K1.1550.99
124_R128_A1.1520.99
120_Q128_A1.1500.99
298_T329_A1.1490.99
312_A329_A1.1400.99
187_L191_L1.1390.99
117_I123_E1.1320.99
125_V130_L1.1280.99
128_A132_G1.1250.99
289_I312_A1.1190.99
339_K347_S1.1190.99
24_E118_K1.1150.99
40_L43_I1.1100.99
124_R129_G1.1100.99
301_L334_L1.1070.99
288_V348_I1.0940.99
11_A14_R1.0870.99
108_G111_S1.0740.99
184_I235_V1.0700.99
6_V17_I1.0660.99
196_V244_I1.0650.99
124_R130_L1.0640.99
290_M344_I1.0630.99
67_R93_N1.0630.99
187_L195_V1.0580.98
211_D214_N1.0560.98
119_E123_E1.0560.98
114_L117_I1.0540.98
42_K45_L1.0540.98
41_K44_E1.0520.98
168_V348_I1.0480.98
117_I124_R1.0480.98
197_V237_I1.0450.98
121_L125_V1.0430.98
42_K46_L1.0370.98
47_K73_Y1.0360.98
298_T328_A1.0320.98
312_A332_A1.0310.98
302_K332_A1.0290.98
24_E27_I1.0280.98
310_V337_E1.0280.98
84_T91_T1.0280.98
78_I100_F1.0270.98
5_L31_G1.0240.98
168_V191_L1.0190.98
129_G132_G1.0170.98
301_L332_A1.0140.98
186_K345_A1.0110.98
36_G65_T1.0110.98
295_S299_A1.0090.98
266_H269_S1.0070.98
229_A252_G1.0050.98
125_V128_A0.9990.98
120_Q127_A0.9980.98
343_D346_A0.9950.98
33_A42_K0.9950.98
118_K124_R0.9900.98
180_L197_V0.9900.98
57_M60_M0.9880.98
241_G259_N0.9870.98
124_R127_A0.9830.98
147_I151_V0.9830.98
172_T180_L0.9800.98
51_I69_I0.9730.97
225_K228_E0.9670.97
8_D57_M0.9630.97
111_S115_Y0.9630.97
222_K236_Y0.9590.97
120_Q125_V0.9510.97
55_V90_C0.9510.97
96_E181_Q0.9500.97
289_I332_A0.9470.97
116_K121_L0.9430.97
301_L335_I0.9420.97
274_F289_I0.9360.97
54_D57_M0.9330.97
9_D57_M0.9250.96
30_I46_L0.9230.96
84_T87_G0.9200.96
330_V335_I0.9190.96
6_V18_S0.9190.96
116_K123_E0.9190.96
125_V129_G0.9180.96
63_T97_I0.9170.96
4_V21_L0.9170.96
26_Q118_K0.9080.96
112_L117_I0.9060.96
289_I329_A0.9050.96
9_D54_D0.9010.96
43_I46_L0.9000.96
18_S22_T0.8980.96
243_N267_K0.8900.96
243_N257_L0.8860.96
127_A130_L0.8860.96
122_V125_V0.8750.95
55_V84_T0.8660.95
332_A335_I0.8620.95
126_V129_G0.8540.95
220_Q231_L0.8500.94
289_I300_G0.8500.94
4_V27_I0.8450.94
183_V348_I0.8440.94
299_A332_A0.8420.94
91_T101_D0.8420.94
31_G48_P0.8410.94
37_E68_K0.8400.94
289_I335_I0.8390.94
70_I100_F0.8370.94
118_K121_L0.8340.94
182_K186_K0.8330.94
36_G177_P0.8290.94
14_R32_T0.8260.93
339_K343_D0.8260.93
224_A227_G0.8250.93
228_E234_C0.8240.93
195_V219_I0.8230.93
79_M102_F0.8220.93
146_P149_R0.8190.93
191_L195_V0.8180.93
123_E126_V0.8180.93
121_L127_A0.8170.93
278_G300_G0.8160.93
119_E124_R0.8160.93
57_M62_G0.8150.93
128_A133_K0.8150.93
121_L128_A0.8110.93
313_I339_K0.8110.93
21_L29_V0.8060.93
312_A336_H0.8010.92
327_K330_V0.7990.92
53_L77_V0.7960.92
271_D289_I0.7940.92
274_F287_A0.7930.92
245_S260_H0.7910.92
54_D58_P0.7890.92
9_D62_G0.7860.92
40_L72_I0.7850.92
15_K19_D0.7850.92
8_D105_K0.7750.91
116_K124_R0.7740.91
191_L219_I0.7740.91
129_G133_K0.7710.91
167_I277_V0.7700.91
27_I50_V0.7690.91
125_V131_S0.7650.91
180_L209_L0.7620.90
21_L117_I0.7610.90
149_R152_V0.7600.90
329_A332_A0.7600.90
172_T185_P0.7590.90
47_K75_L0.7520.90
299_A306_T0.7520.90
59_V65_T0.7500.90
53_L69_I0.7450.89
36_G59_V0.7450.89
122_V126_V0.7430.89
145_E149_R0.7420.89
111_S116_K0.7420.89
303_D307_A0.7420.89
148_V151_V0.7400.89
54_D105_K0.7360.89
305_L334_L0.7360.89
298_T312_A0.7350.89
169_C273_L0.7330.89
191_L349_T0.7270.88
202_P240_G0.7250.88
114_L118_K0.7240.88
130_L133_K0.7210.88
224_A244_I0.7190.88
209_L237_I0.7180.88
342_E345_A0.7150.87
56_E61_N0.7140.87
299_A302_K0.7140.87
196_V246_V0.7120.87
51_I65_T0.7110.87
54_D62_G0.7110.87
184_I197_V0.7110.87
242_K267_K0.7100.87
123_E133_K0.7090.87
116_K122_V0.7070.87
147_I150_A0.7070.87
64_D68_K0.7060.87
146_P151_V0.7050.87
116_K125_V0.7040.87
3_R30_I0.7030.87
207_A225_K0.7020.86
241_G267_K0.7000.86
202_P206_T0.6970.86
6_V52_T0.6950.86
186_K346_A0.6920.86
127_A132_G0.6920.86
118_K125_V0.6900.85
264_S269_S0.6890.85
182_K345_A0.6850.85
123_E131_S0.6810.85
279_K303_D0.6800.85
63_T67_R0.6780.84
37_E40_L0.6770.84
22_T28_E0.6760.84
245_S256_V0.6750.84
195_V235_V0.6720.84
281_T285_K0.6720.84
52_T80_V0.6670.84
51_I77_V0.6670.84
264_S271_D0.6670.84
323_Y335_I0.6650.83
145_E148_V0.6640.83
122_V129_G0.6630.83
121_L129_G0.6630.83
313_I347_S0.6630.83
19_D22_T0.6600.83
117_I122_V0.6590.83
187_L348_I0.6590.83
7_V51_I0.6570.83
111_S120_Q0.6570.83
169_C196_V0.6550.82
246_V253_L0.6550.82
278_G285_K0.6540.82
43_I47_K0.6540.82
63_T94_C0.6530.82
317_E320_C0.6520.82
58_P62_G0.6500.82
173_S176_G0.6490.82
246_V281_T0.6460.82
169_C285_K0.6430.81
124_R132_G0.6390.81
202_P223_E0.6380.81
263_P272_Y0.6380.81
114_L120_Q0.6370.81
245_S279_K0.6370.81
339_K346_A0.6360.81
5_L43_I0.6350.80
56_E83_Q0.6350.80
196_V255_V0.6320.80
194_P236_Y0.6280.80
206_T240_G0.6280.80
114_L124_R0.6270.80
6_V29_V0.6250.79
125_V132_G0.6200.79
117_I125_V0.6190.79
180_L185_P0.6190.79
112_L118_K0.6170.79
343_D347_S0.6170.79
66_L79_M0.6160.78
346_A350_S0.6160.78
87_G91_T0.6160.78
203_E241_G0.6150.78
8_D14_R0.6150.78
114_L121_L0.6140.78
171_G289_I0.6140.78
54_D81_S0.6130.78
129_G134_R0.6130.78
66_L97_I0.6120.78
126_V133_K0.6120.78
40_L68_K0.6110.78
3_R46_L0.6080.78
36_G40_L0.6070.77
70_I73_Y0.6050.77
169_C304_M0.6030.77
117_I127_A0.6020.77
74_N100_F0.6020.77
263_P266_H0.6010.77
181_Q185_P0.6010.77
117_I128_A0.6000.77
50_V100_F0.5990.76
185_P216_L0.5990.76
340_H345_A0.5990.76
115_Y119_E0.5980.76
9_D58_P0.5940.76
18_S29_V0.5930.76
337_E350_S0.5930.76
286_V348_I0.5910.76
107_S110_I0.5860.75
146_P150_A0.5840.75
239_P257_L0.5840.75
290_M339_K0.5840.75
46_L52_T0.5820.74
36_G60_M0.5770.74
212_R223_E0.5770.74
52_T79_M0.5740.73
70_I75_L0.5710.73
120_Q126_V0.5700.73
274_F304_M0.5660.72
90_C93_N0.5640.72
127_A131_S0.5640.72
243_N261_D0.5620.72
128_A131_S0.5600.72
266_H272_Y0.5600.72
160_K163_T0.5580.71
84_T88_K0.5580.71
110_I120_Q0.5580.71
70_I76_P0.5570.71
43_I65_T0.5570.71
224_A239_P0.5570.71
320_C327_K0.5550.71
14_R34_R0.5540.71
249_N254_Q0.5540.71
114_L128_A0.5530.71
207_A223_E0.5530.71
226_D257_L0.5520.71
131_S135_K0.5510.70
318_E340_H0.5500.70
15_K18_S0.5490.70
229_A254_Q0.5480.70
6_V21_L0.5480.70
271_D299_A0.5480.70
143_R146_P0.5480.70
12_F102_F0.5460.70
305_L335_I0.5450.70
110_I114_L0.5450.70
313_I337_E0.5450.70
189_K219_I0.5430.69
298_T302_K0.5400.69
100_F120_Q0.5400.69
323_Y328_A0.5380.69
40_L69_I0.5380.69
198_V266_H0.5360.68
247_I254_Q0.5360.68
126_V130_L0.5360.68
64_D67_R0.5350.68
273_L277_V0.5330.68
169_C244_I0.5320.68
199_Q205_F0.5320.68
56_E87_G0.5320.68
5_L33_A0.5310.68
144_P150_A0.5310.68
199_Q209_L0.5300.67
109_S112_L0.5300.67
40_L53_L0.5300.67
198_V267_K0.5280.67
116_K128_A0.5280.67
92_I208_S0.5270.67
120_Q131_S0.5270.67
124_R131_S0.5260.67
295_S332_A0.5260.67
34_R42_K0.5260.67
114_L119_E0.5250.67
167_I285_K0.5240.67
277_V280_L0.5230.66
42_K48_P0.5220.66
120_Q132_G0.5220.66
328_A332_A0.5220.66
119_E122_V0.5210.66
83_Q90_C0.5200.66
123_E132_G0.5190.66
258_D261_D0.5190.66
243_N266_H0.5180.66
13_M17_I0.5180.66
35_N38_E0.5180.66
52_T78_I0.5180.66
62_G105_K0.5170.66
40_L44_E0.5150.65
187_L219_I0.5150.65
126_V132_G0.5150.65
313_I338_I0.5140.65
194_P228_E0.5100.64
55_V83_Q0.5100.64
110_I115_Y0.5080.64
59_V69_I0.5080.64
53_L97_I0.5080.64
302_K305_L0.5080.64
131_S134_R0.5070.64
112_L124_R0.5060.64
36_G57_M0.5050.64
168_V288_V0.5050.64
249_N252_G0.5050.64
217_S235_V0.5040.64
92_I95_L0.5030.63
126_V131_S0.5030.63
123_E130_L0.5020.63
178_R181_Q0.5010.63
289_I298_T0.5010.63
317_E327_K0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a2oA 1 0.9384 100 0.186 Contact Map
1chdA 1 0.5462 100 0.458 Contact Map
3sftA 1 0.5294 100 0.459 Contact Map
4g97A 1 0.3613 100 0.664 Contact Map
4ldzA 2 0.5434 100 0.665 Contact Map
4gvpA 1 0.5658 100 0.667 Contact Map
3n0rA 1 0.3389 100 0.667 Contact Map
3c3wA 2 0.5658 100 0.67 Contact Map
1yioA 1 0.549 100 0.671 Contact Map
1a04A 1 0.5518 100 0.681 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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