GREMLIN Database
DPAB - Dipicolinate synthase subunit B
UniProt: Q04810 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 200 (190)
Sequences: 368 (241)
Seq/√Len: 17.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_I115_A5.4951.00
71_I77_A4.9121.00
126_V178_T4.3041.00
128_G154_I3.4561.00
63_E69_E3.3440.99
28_E32_N3.3420.99
54_E57_E3.0720.99
43_F110_P2.9700.99
12_G89_M2.9570.99
146_M191_I2.9300.99
31_V37_V2.8980.98
36_E68_Y2.7910.98
72_D76_K2.7050.97
134_A168_M2.6930.97
140_T144_R2.6510.97
8_R36_E2.6160.97
84_L123_R2.4740.96
49_N55_G2.4700.96
88_C126_V2.3920.95
168_M192_L2.2480.93
46_K72_D2.1730.91
139_G143_M2.1000.90
99_M142_L2.0680.89
160_D163_K1.9620.86
181_K188_L1.9070.85
90_V179_I1.7760.80
80_L143_M1.7710.80
8_R38_R1.7540.79
152_F185_H1.7060.77
26_Q29_E1.6670.76
12_G98_S1.6620.75
28_E61_K1.6530.75
24_F62_I1.6230.74
128_G172_M1.6070.73
90_V175_L1.5460.70
94_L99_M1.5120.68
12_G111_V1.4910.67
63_E70_A1.4790.66
12_G40_V1.4600.65
174_L188_L1.4560.65
11_F23_V1.4490.65
154_I175_L1.4400.64
27_I62_I1.4250.63
139_G146_M1.4200.63
38_R86_L1.4040.62
128_G170_A1.3930.62
99_M129_I1.3690.60
71_I80_L1.3640.60
24_F61_K1.3460.59
17_H58_W1.3440.59
156_F192_L1.2950.56
178_T188_L1.2860.55
74_I113_M1.2580.54
131_T142_L1.2570.54
91_I127_L1.2440.53
171_K193_V1.2340.52
13_L27_I1.2270.52
149_K166_N1.2090.51
6_G35_A1.2010.50
117_A138_N1.1840.49
127_L130_S1.1780.49
131_T134_A1.1640.48
140_T143_M1.1460.47
11_F92_A1.1310.46
171_K174_L1.0910.44
24_F58_W1.0880.43
9_I88_C1.0690.42
80_L85_P1.0650.42
27_I151_I1.0560.41
118_T125_V1.0480.41
40_V80_L1.0410.41
52_F114_A1.0360.40
145_L153_F1.0280.40
40_V89_M1.0270.40
94_L98_S1.0260.40
31_V66_T1.0140.39
92_A188_L1.0120.39
92_A175_L1.0070.39
181_K186_Q0.9850.37
86_L170_A0.9800.37
100_S105_A0.9790.37
126_V179_I0.9790.37
33_E176_P0.9700.36
59_V62_I0.9630.36
157_G168_M0.9570.36
51_R67_G0.9510.35
15_G49_N0.9510.35
131_T189_Q0.9500.35
9_I12_G0.9460.35
134_A169_V0.9400.35
71_I76_K0.9390.35
91_I109_S0.9360.35
80_L118_T0.9340.34
39_P62_I0.9270.34
41_V70_A0.9080.33
41_V45_V0.9060.33
88_C179_I0.9050.33
105_A109_S0.9040.33
148_T166_N0.9000.33
138_N151_I0.8980.33
96_G138_N0.8970.32
28_E64_D0.8840.32
56_A60_K0.8810.32
14_T113_M0.8790.32
11_F90_V0.8760.31
85_P143_M0.8680.31
29_E33_E0.8680.31
177_Q185_H0.8630.31
94_L143_M0.8610.31
102_L115_A0.8570.30
169_V172_M0.8560.30
36_E57_E0.8540.30
85_P117_A0.8470.30
101_K143_M0.8380.29
20_Y58_W0.8380.29
22_A160_D0.8330.29
112_L137_L0.8260.29
61_K142_L0.8250.29
41_V147_S0.8240.29
175_L188_L0.8230.29
122_N150_N0.8220.29
13_L139_G0.8200.29
119_I150_N0.8150.28
115_A177_Q0.8120.28
178_T181_K0.8120.28
118_T143_M0.8080.28
22_A175_L0.8050.28
56_A71_I0.8040.28
89_M98_S0.8020.28
130_S145_L0.7990.28
49_N57_E0.7970.27
117_A161_P0.7950.27
97_N101_K0.7860.27
134_A192_L0.7850.27
110_P136_G0.7800.27
7_K184_M0.7780.27
157_G193_V0.7680.26
37_V193_V0.7580.26
59_V63_E0.7570.26
41_V72_D0.7570.26
42_T102_L0.7530.25
36_E142_L0.7530.25
18_C52_F0.7510.25
20_Y24_F0.7510.25
166_N186_Q0.7440.25
106_M143_M0.7430.25
134_A153_F0.7410.25
44_N48_T0.7370.25
13_L131_T0.7300.24
103_A161_P0.7280.24
17_H100_S0.7210.24
12_G94_L0.7210.24
90_V126_V0.7180.24
22_A127_L0.7170.24
42_T94_L0.7140.24
66_T136_G0.7120.24
89_M129_I0.7110.23
136_G166_N0.7020.23
4_L35_A0.7010.23
6_G31_V0.7000.23
96_G104_N0.7000.23
112_L115_A0.7000.23
53_G165_P0.6980.23
46_K70_A0.6950.23
29_E32_N0.6920.23
76_K84_L0.6890.23
146_M156_F0.6880.22
15_G169_V0.6870.22
130_S137_L0.6830.22
97_N143_M0.6810.22
50_T112_L0.6790.22
25_P100_S0.6770.22
30_L162_F0.6750.22
137_L172_M0.6740.22
35_A126_V0.6700.22
27_I156_F0.6680.22
9_I30_L0.6680.22
142_L188_L0.6670.22
125_V135_L0.6660.22
106_M147_S0.6660.22
48_T75_V0.6620.21
41_V59_V0.6600.21
86_L89_M0.6580.21
13_L191_I0.6530.21
8_R68_Y0.6530.21
122_N160_D0.6500.21
24_F53_G0.6480.21
79_P103_A0.6430.21
115_A131_T0.6400.21
143_M147_S0.6400.21
28_E188_L0.6330.20
117_A151_I0.6330.20
46_K172_M0.6320.20
83_K169_V0.6310.20
104_N138_N0.6300.20
11_F125_V0.6300.20
112_L157_G0.6280.20
79_P83_K0.6270.20
30_L175_L0.6270.20
60_K64_D0.6260.20
31_V65_L0.6250.20
115_A125_V0.6230.20
35_A88_C0.6220.20
58_W171_K0.6210.20
137_L148_T0.6200.20
53_G185_H0.6160.20
140_T148_T0.6150.20
13_L32_N0.6140.20
97_N106_M0.6140.20
94_L139_G0.6140.20
15_G44_N0.6110.19
158_Q187_Q0.6110.19
32_N163_K0.6070.19
19_T134_A0.6050.19
99_M193_V0.6030.19
17_H172_M0.6020.19
128_G139_G0.6010.19
107_T130_S0.5980.19
38_R80_L0.5980.19
7_K180_E0.5950.19
121_N142_L0.5940.19
27_I37_V0.5920.19
42_T46_K0.5890.19
9_I98_S0.5870.18
42_T176_P0.5820.18
40_V84_L0.5820.18
17_H45_V0.5770.18
41_V62_I0.5770.18
57_E174_L0.5770.18
9_I75_V0.5740.18
61_K149_K0.5740.18
27_I34_G0.5740.18
159_D167_S0.5740.18
153_F165_P0.5730.18
14_T112_L0.5720.18
165_P189_Q0.5700.18
89_M183_L0.5700.18
28_E36_E0.5680.18
29_E177_Q0.5670.18
17_H105_A0.5670.18
22_A118_T0.5660.18
97_N107_T0.5650.18
125_V171_K0.5630.18
80_L105_A0.5620.18
42_T49_N0.5560.17
94_L142_L0.5550.17
104_N166_N0.5530.17
160_D173_D0.5510.17
58_W118_T0.5510.17
107_T112_L0.5460.17
59_V70_A0.5450.17
26_Q177_Q0.5450.17
88_C147_S0.5440.17
137_L143_M0.5440.17
86_L119_I0.5400.17
41_V140_T0.5390.17
97_N134_A0.5380.17
24_F139_G0.5360.17
57_E171_K0.5350.17
38_R169_V0.5350.17
187_Q190_P0.5340.17
42_T106_M0.5320.17
49_N66_T0.5320.17
85_P88_C0.5310.17
9_I56_A0.5310.17
14_T130_S0.5270.16
21_E40_V0.5230.16
20_Y117_A0.5230.16
80_L86_L0.5230.16
9_I20_Y0.5220.16
20_Y100_S0.5220.16
140_T147_S0.5220.16
45_V165_P0.5210.16
44_N150_N0.5210.16
88_C183_L0.5200.16
56_A162_F0.5190.16
68_Y99_M0.5150.16
94_L127_L0.5120.16
111_V157_G0.5110.16
10_G86_L0.5080.16
51_R181_K0.5050.16
4_L26_Q0.5040.16
80_L100_S0.5040.16
135_L139_G0.5030.16
104_N150_N0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lqkA 5 0.975 100 0.586 Contact Map
3mcuA 5 0.94 100 0.597 Contact Map
1p3y1 6 0.805 100 0.679 Contact Map
1sbzA 6 0.905 100 0.714 Contact Map
4zavA 6 0.96 100 0.719 Contact Map
1qzuA 3 0.76 100 0.719 Contact Map
4rhfA 6 0.94 100 0.719 Contact Map
1mvlA 3 0.79 100 0.734 Contact Map
3qjgA 5 0.79 99.9 0.749 Contact Map
2ejbA 6 0.855 99.9 0.752 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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