GREMLIN Database
DPAA - Dipicolinate synthase subunit A
UniProt: Q04809 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (285)
Sequences: 426 (339)
Seq/√Len: 20.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_T242_L5.2001.00
203_T220_I4.5941.00
173_F217_I3.6301.00
142_M146_Q3.3861.00
148_T215_I3.1841.00
157_V217_I2.9550.99
277_G281_A2.9540.99
239_I249_T2.8880.99
160_L220_I2.8380.99
183_G201_F2.8250.99
100_F284_L2.8000.99
144_A240_L2.7670.99
135_P151_T2.7580.99
172_T176_L2.6900.98
165_T169_I2.6610.98
227_Q256_K2.6610.98
169_I217_I2.6600.98
144_A217_I2.6390.98
140_T217_I2.6260.98
158_A213_I2.5840.98
184_A190_L2.4740.97
169_I173_F2.3360.96
135_P276_A2.2940.96
186_S189_H2.2320.95
225_L230_L2.2210.95
190_L202_H2.1800.94
19_I280_L2.1790.94
141_I172_T2.1790.94
216_C225_L2.1690.94
65_V123_F2.1420.94
169_I242_L2.1230.93
162_L196_M2.1170.93
101_S121_K2.1000.93
27_Q252_K2.0750.92
157_V173_F2.0550.92
216_C233_M2.0490.92
251_F261_A2.0250.91
140_T144_A1.9980.91
93_T117_R1.9880.91
156_Q179_N1.9750.90
66_S121_K1.9500.90
141_I176_L1.9010.89
249_T259_I1.8950.88
133_S168_T1.8680.88
280_L288_L1.8030.86
141_I175_A1.7840.85
143_L262_L1.7780.85
184_A193_I1.7600.84
135_P271_V1.6290.79
184_A189_H1.6250.79
132_N268_P1.6130.79
6_K31_Y1.6020.78
19_I277_G1.5940.78
145_I148_T1.5840.77
159_V239_I1.5490.76
189_H193_I1.5390.75
143_L147_H1.5310.75
104_S109_E1.5210.74
185_R189_H1.5130.74
207_K232_S1.5110.74
157_V178_A1.5060.74
195_E275_T1.4910.73
7_I76_T1.4280.69
249_T261_A1.4260.69
239_I251_F1.4030.68
230_L233_M1.4010.68
213_I225_L1.3970.68
104_S121_K1.3850.67
101_S104_S1.3780.67
22_K277_G1.3730.66
220_I224_I1.3560.65
162_L167_M1.3500.65
144_A215_I1.3290.64
183_G203_T1.3130.63
8_A62_I1.3130.63
147_H260_K1.3080.62
264_A267_L1.2950.62
123_F280_L1.2940.62
30_I169_I1.2840.61
20_I30_I1.2700.60
198_L249_T1.2640.60
170_A198_L1.2520.59
250_D254_A1.2500.59
9_V23_L1.2460.59
253_Y256_K1.2390.58
66_S266_G1.2240.57
214_D234_T1.2210.57
242_L264_A1.2140.57
156_Q212_D1.2100.56
151_T191_A1.2070.56
140_T240_L1.2040.56
53_I173_F1.1960.55
171_R195_E1.1880.55
140_T242_L1.1700.54
45_A284_L1.1640.53
210_V233_M1.1510.52
137_V168_T1.1480.52
111_I115_A1.1470.52
160_L166_G1.1330.51
32_L38_L1.1320.51
69_T104_S1.1320.51
253_Y257_Q1.1310.51
93_T216_C1.1210.50
123_F128_I1.1150.50
49_N81_E1.1060.50
54_P173_F1.0920.49
190_L193_I1.0880.48
126_D129_A1.0870.48
68_T107_Y1.0830.48
101_S123_F1.0810.48
179_N199_V1.0810.48
63_L277_G1.0760.48
219_T244_S1.0750.48
197_G206_L1.0740.47
247_G265_P1.0720.47
218_N244_S1.0680.47
63_L67_A1.0670.47
63_L99_I1.0650.47
63_L108_L1.0570.46
210_V229_V1.0540.46
220_I227_Q1.0460.46
213_I216_C1.0450.46
134_I153_H1.0370.45
250_D259_I1.0340.45
74_V187_S1.0260.44
241_D247_G1.0240.44
66_S89_H1.0190.44
132_N136_T1.0150.44
162_L198_L1.0150.44
70_G156_Q1.0070.43
126_D164_R1.0050.43
239_I261_A1.0040.43
241_D249_T0.9980.43
184_A242_L0.9970.42
75_S141_I0.9890.42
149_D270_I0.9880.42
14_A18_E0.9810.41
65_V266_G0.9810.41
135_P250_D0.9810.41
36_D49_N0.9760.41
137_V141_I0.9750.41
67_A121_K0.9740.41
251_F259_I0.9730.41
227_Q231_S0.9730.41
193_I197_G0.9720.41
132_N218_N0.9660.41
175_A184_A0.9650.40
130_I192_R0.9630.40
151_T271_V0.9630.40
214_D236_K0.9540.40
9_V45_A0.9520.40
50_I53_I0.9510.40
151_T272_A0.9510.40
186_S288_L0.9470.39
159_V178_A0.9420.39
226_N229_V0.9330.38
100_F287_L0.9320.38
230_L257_Q0.9270.38
86_K284_L0.9260.38
151_T276_A0.9240.38
137_V162_L0.9200.38
157_V203_T0.9170.38
60_S288_L0.9120.37
142_M145_I0.9110.37
181_K200_P0.9020.37
129_A135_P0.8890.36
10_I74_V0.8880.36
250_D261_A0.8860.36
98_V288_L0.8810.35
254_A258_G0.8800.35
119_L224_I0.8750.35
58_I230_L0.8750.35
99_I112_A0.8740.35
30_I62_I0.8730.35
155_S239_I0.8670.35
245_R263_L0.8660.34
80_N187_S0.8650.34
245_R265_P0.8620.34
250_D272_A0.8620.34
240_L265_P0.8580.34
218_N243_A0.8580.34
100_F120_V0.8560.34
251_F263_L0.8540.34
39_D93_T0.8540.34
216_C230_L0.8540.34
71_E116_K0.8510.34
67_A277_G0.8510.34
141_I184_A0.8410.33
138_E247_G0.8410.33
103_I123_F0.8390.33
241_D265_P0.8300.32
19_I62_I0.8290.32
67_A101_S0.8270.32
149_D274_K0.8260.32
61_I169_I0.8240.32
155_S214_D0.8210.32
70_G113_A0.8210.32
77_V242_L0.8180.32
141_I174_A0.8130.31
22_K266_G0.8120.31
280_L286_K0.8080.31
181_K213_I0.8040.31
142_M271_V0.8030.31
106_A171_R0.8020.31
195_E249_T0.8020.31
72_G166_G0.7940.30
190_L203_T0.7930.30
75_S230_L0.7910.30
45_A137_V0.7890.30
117_R173_F0.7880.30
151_T242_L0.7840.30
73_V82_E0.7830.30
12_G272_A0.7830.30
112_A117_R0.7830.30
24_T45_A0.7820.30
145_I284_L0.7810.30
98_V284_L0.7800.30
41_G280_L0.7780.29
46_V110_N0.7770.29
192_R195_E0.7760.29
158_A216_C0.7750.29
207_K228_T0.7740.29
15_R138_E0.7740.29
239_I259_I0.7600.29
99_I110_N0.7600.29
241_D251_F0.7600.29
109_E121_K0.7590.28
208_E229_V0.7570.28
180_V237_T0.7570.28
134_I279_I0.7550.28
40_H43_T0.7530.28
162_L182_V0.7530.28
108_L133_S0.7520.28
131_Y153_H0.7510.28
224_I248_G0.7460.28
30_I194_T0.7460.28
10_I97_C0.7440.28
80_N83_V0.7410.28
222_S288_L0.7390.27
218_N221_P0.7390.27
227_Q252_K0.7340.27
65_V83_V0.7340.27
77_V165_T0.7310.27
128_I280_L0.7300.27
86_K112_A0.7280.27
193_I200_P0.7270.27
93_T173_F0.7270.27
8_A58_I0.7240.27
83_V190_L0.7230.27
62_I94_P0.7230.27
122_L284_L0.7220.27
159_V166_G0.7210.27
82_E156_Q0.7200.26
193_I266_G0.7180.26
58_I193_I0.7130.26
139_G272_A0.7100.26
143_L286_K0.7100.26
280_L283_V0.7100.26
158_A220_I0.7080.26
263_L270_I0.7050.26
126_D130_I0.7000.25
126_D192_R0.6980.25
210_V237_T0.6960.25
163_G221_P0.6920.25
157_V215_I0.6890.25
10_I112_A0.6880.25
112_A119_L0.6850.25
105_N121_K0.6840.25
24_T141_I0.6800.24
17_L32_L0.6800.24
18_E21_R0.6790.24
105_N193_I0.6780.24
265_P270_I0.6770.24
168_T192_R0.6770.24
36_D79_S0.6740.24
19_I281_A0.6730.24
32_L42_F0.6720.24
7_I24_T0.6720.24
199_V224_I0.6720.24
34_G254_A0.6720.24
148_T242_L0.6690.24
254_A257_Q0.6690.24
34_G217_I0.6640.24
25_E210_V0.6630.24
95_A112_A0.6600.24
65_V117_R0.6600.24
190_L200_P0.6580.23
11_G164_R0.6580.23
91_D115_A0.6560.23
129_A170_A0.6550.23
126_D274_K0.6530.23
193_I215_I0.6520.23
144_A157_V0.6520.23
9_V152_I0.6480.23
227_Q257_Q0.6470.23
7_I44_G0.6450.23
133_S215_I0.6450.23
227_Q255_E0.6440.23
218_N268_P0.6440.23
123_F202_H0.6430.23
16_Q121_K0.6430.23
23_L283_V0.6410.23
62_I210_V0.6410.23
10_I290_E0.6390.23
135_P191_A0.6380.23
68_T71_E0.6350.22
144_A154_G0.6300.22
121_K157_V0.6300.22
160_L225_L0.6280.22
7_I130_I0.6280.22
163_G244_S0.6270.22
67_A133_S0.6230.22
80_N162_L0.6230.22
136_T268_P0.6190.22
191_A272_A0.6180.22
105_N217_I0.6120.21
168_T196_M0.6110.21
181_K199_V0.6100.21
145_I192_R0.6080.21
63_L104_S0.6080.21
7_I176_L0.6070.21
56_Q92_R0.6070.21
155_S264_A0.6030.21
272_A276_A0.6030.21
81_E255_E0.6020.21
68_T280_L0.6010.21
62_I118_K0.5970.21
27_Q227_Q0.5970.21
9_V62_I0.5940.21
110_N113_A0.5940.21
22_K278_Q0.5930.21
96_H222_S0.5930.21
61_I69_T0.5920.20
45_A200_P0.5910.20
99_I220_I0.5910.20
121_K158_A0.5900.20
25_E223_M0.5890.20
6_K100_F0.5850.20
72_G195_E0.5840.20
247_G263_L0.5820.20
12_G164_R0.5820.20
175_A208_E0.5790.20
238_L262_L0.5780.20
132_N244_S0.5780.20
245_R266_G0.5770.20
203_T224_I0.5760.20
72_G108_L0.5750.20
134_I168_T0.5730.20
119_L270_I0.5720.20
113_A208_E0.5710.20
119_L141_I0.5710.20
89_H205_E0.5710.20
178_A241_D0.5700.20
110_N124_E0.5690.20
159_V270_I0.5680.20
138_E161_G0.5680.20
241_D261_A0.5680.20
254_A261_A0.5670.19
137_V210_V0.5660.19
24_T143_L0.5650.19
97_C166_G0.5630.19
26_Q285_S0.5630.19
36_D48_C0.5620.19
158_A175_A0.5610.19
121_K165_T0.5590.19
178_A197_G0.5590.19
205_E208_E0.5590.19
22_K281_A0.5580.19
48_C52_E0.5550.19
53_I112_A0.5540.19
21_R236_K0.5500.19
67_A160_L0.5490.19
151_T177_G0.5480.19
35_F127_D0.5440.19
122_L133_S0.5440.19
37_Q117_R0.5440.19
167_M184_A0.5430.19
190_L212_D0.5430.19
24_T27_Q0.5390.18
132_N161_G0.5390.18
36_D125_R0.5370.18
76_T82_E0.5330.18
51_D99_I0.5320.18
166_G274_K0.5280.18
157_V169_I0.5270.18
152_I159_V0.5270.18
108_L258_G0.5270.18
136_T145_I0.5260.18
218_N248_G0.5250.18
123_F186_S0.5250.18
168_T265_P0.5240.18
53_I217_I0.5230.18
228_T236_K0.5230.18
136_T218_N0.5220.18
247_G251_F0.5200.18
136_T176_L0.5190.18
12_G34_G0.5190.18
95_A253_Y0.5190.18
144_A280_L0.5170.18
88_D202_H0.5160.17
103_I122_L0.5150.17
30_I165_T0.5150.17
47_K284_L0.5150.17
152_I267_L0.5140.17
221_P243_A0.5140.17
166_G192_R0.5140.17
117_R216_C0.5140.17
125_R290_E0.5140.17
171_R185_R0.5130.17
70_G74_V0.5130.17
155_S215_I0.5120.17
5_L101_S0.5120.17
9_V20_I0.5100.17
48_C95_A0.5100.17
37_Q44_G0.5090.17
43_T137_V0.5080.17
220_I290_E0.5080.17
61_I107_Y0.5080.17
154_G230_L0.5070.17
13_D269_G0.5060.17
144_A152_I0.5050.17
67_A72_G0.5050.17
29_D228_T0.5050.17
128_I257_Q0.5030.17
130_I287_L0.5030.17
76_T128_I0.5020.17
7_I73_V0.5000.17
37_Q157_V0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d4oA 4 0.9798 100 0.621 Contact Map
2rirA 4 0.9899 100 0.662 Contact Map
1x13A 2 0.9125 99.9 0.776 Contact Map
3x2fA 4 0.963 99.9 0.783 Contact Map
3h9uA 5 0.9562 99.8 0.795 Contact Map
3p2yA 2 0.9125 99.8 0.796 Contact Map
2qrjA 1 0.862 99.8 0.798 Contact Map
2j6iA 2 0.8956 99.8 0.809 Contact Map
2eezA 5 0.8586 99.7 0.817 Contact Map
1pjcA 5 0.9158 99.7 0.817 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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