DPAA - BACSU - GREMLIN Contacts

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DPAA - Dipicolinate synthase subunit A

UniProt:	Q04809	Sequences: MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTGAVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSGISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVLGLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICINTIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTAGQILANVLSKLLAEIQAEEGK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	297 (285)
Sequences:	426 (339)
Seq/√Len:	20.1

BACSU - DPAA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
165_T	242_L	5.200	1.00
203_T	220_I	4.594	1.00
173_F	217_I	3.630	1.00
142_M	146_Q	3.386	1.00
148_T	215_I	3.184	1.00
157_V	217_I	2.955	0.99
277_G	281_A	2.954	0.99
239_I	249_T	2.888	0.99
160_L	220_I	2.838	0.99
183_G	201_F	2.825	0.99
100_F	284_L	2.800	0.99
144_A	240_L	2.767	0.99
135_P	151_T	2.758	0.99
172_T	176_L	2.690	0.98
165_T	169_I	2.661	0.98
227_Q	256_K	2.661	0.98
169_I	217_I	2.660	0.98
144_A	217_I	2.639	0.98
140_T	217_I	2.626	0.98
158_A	213_I	2.584	0.98
184_A	190_L	2.474	0.97
169_I	173_F	2.336	0.96
135_P	276_A	2.294	0.96
186_S	189_H	2.232	0.95
225_L	230_L	2.221	0.95
190_L	202_H	2.180	0.94
19_I	280_L	2.179	0.94
141_I	172_T	2.179	0.94
216_C	225_L	2.169	0.94
65_V	123_F	2.142	0.94
169_I	242_L	2.123	0.93
162_L	196_M	2.117	0.93
101_S	121_K	2.100	0.93
27_Q	252_K	2.075	0.92
157_V	173_F	2.055	0.92
216_C	233_M	2.049	0.92
251_F	261_A	2.025	0.91
140_T	144_A	1.998	0.91
93_T	117_R	1.988	0.91
156_Q	179_N	1.975	0.90
66_S	121_K	1.950	0.90
141_I	176_L	1.901	0.89
249_T	259_I	1.895	0.88
133_S	168_T	1.868	0.88
280_L	288_L	1.803	0.86
141_I	175_A	1.784	0.85
143_L	262_L	1.778	0.85
184_A	193_I	1.760	0.84
135_P	271_V	1.629	0.79
184_A	189_H	1.625	0.79
132_N	268_P	1.613	0.79
6_K	31_Y	1.602	0.78
19_I	277_G	1.594	0.78
145_I	148_T	1.584	0.77
159_V	239_I	1.549	0.76
189_H	193_I	1.539	0.75
143_L	147_H	1.531	0.75
104_S	109_E	1.521	0.74
185_R	189_H	1.513	0.74
207_K	232_S	1.511	0.74
157_V	178_A	1.506	0.74
195_E	275_T	1.491	0.73
7_I	76_T	1.428	0.69
249_T	261_A	1.426	0.69
239_I	251_F	1.403	0.68
230_L	233_M	1.401	0.68
213_I	225_L	1.397	0.68
104_S	121_K	1.385	0.67
101_S	104_S	1.378	0.67
22_K	277_G	1.373	0.66
220_I	224_I	1.356	0.65
162_L	167_M	1.350	0.65
144_A	215_I	1.329	0.64
183_G	203_T	1.313	0.63
8_A	62_I	1.313	0.63
147_H	260_K	1.308	0.62
264_A	267_L	1.295	0.62
123_F	280_L	1.294	0.62
30_I	169_I	1.284	0.61
20_I	30_I	1.270	0.60
198_L	249_T	1.264	0.60
170_A	198_L	1.252	0.59
250_D	254_A	1.250	0.59
9_V	23_L	1.246	0.59
253_Y	256_K	1.239	0.58
66_S	266_G	1.224	0.57
214_D	234_T	1.221	0.57
242_L	264_A	1.214	0.57
156_Q	212_D	1.210	0.56
151_T	191_A	1.207	0.56
140_T	240_L	1.204	0.56
53_I	173_F	1.196	0.55
171_R	195_E	1.188	0.55
140_T	242_L	1.170	0.54
45_A	284_L	1.164	0.53
210_V	233_M	1.151	0.52
137_V	168_T	1.148	0.52
111_I	115_A	1.147	0.52
160_L	166_G	1.133	0.51
32_L	38_L	1.132	0.51
69_T	104_S	1.132	0.51
253_Y	257_Q	1.131	0.51
93_T	216_C	1.121	0.50
123_F	128_I	1.115	0.50
49_N	81_E	1.106	0.50
54_P	173_F	1.092	0.49
190_L	193_I	1.088	0.48
126_D	129_A	1.087	0.48
68_T	107_Y	1.083	0.48
101_S	123_F	1.081	0.48
179_N	199_V	1.081	0.48
63_L	277_G	1.076	0.48
219_T	244_S	1.075	0.48
197_G	206_L	1.074	0.47
247_G	265_P	1.072	0.47
218_N	244_S	1.068	0.47
63_L	67_A	1.067	0.47
63_L	99_I	1.065	0.47
63_L	108_L	1.057	0.46
210_V	229_V	1.054	0.46
220_I	227_Q	1.046	0.46
213_I	216_C	1.045	0.46
134_I	153_H	1.037	0.45
250_D	259_I	1.034	0.45
74_V	187_S	1.026	0.44
241_D	247_G	1.024	0.44
66_S	89_H	1.019	0.44
132_N	136_T	1.015	0.44
162_L	198_L	1.015	0.44
70_G	156_Q	1.007	0.43
126_D	164_R	1.005	0.43
239_I	261_A	1.004	0.43
241_D	249_T	0.998	0.43
184_A	242_L	0.997	0.42
75_S	141_I	0.989	0.42
149_D	270_I	0.988	0.42
14_A	18_E	0.981	0.41
65_V	266_G	0.981	0.41
135_P	250_D	0.981	0.41
36_D	49_N	0.976	0.41
137_V	141_I	0.975	0.41
67_A	121_K	0.974	0.41
251_F	259_I	0.973	0.41
227_Q	231_S	0.973	0.41
193_I	197_G	0.972	0.41
132_N	218_N	0.966	0.41
175_A	184_A	0.965	0.40
130_I	192_R	0.963	0.40
151_T	271_V	0.963	0.40
214_D	236_K	0.954	0.40
9_V	45_A	0.952	0.40
50_I	53_I	0.951	0.40
151_T	272_A	0.951	0.40
186_S	288_L	0.947	0.39
159_V	178_A	0.942	0.39
226_N	229_V	0.933	0.38
100_F	287_L	0.932	0.38
230_L	257_Q	0.927	0.38
86_K	284_L	0.926	0.38
151_T	276_A	0.924	0.38
137_V	162_L	0.920	0.38
157_V	203_T	0.917	0.38
60_S	288_L	0.912	0.37
142_M	145_I	0.911	0.37
181_K	200_P	0.902	0.37
129_A	135_P	0.889	0.36
10_I	74_V	0.888	0.36
250_D	261_A	0.886	0.36
98_V	288_L	0.881	0.35
254_A	258_G	0.880	0.35
119_L	224_I	0.875	0.35
58_I	230_L	0.875	0.35
99_I	112_A	0.874	0.35
30_I	62_I	0.873	0.35
155_S	239_I	0.867	0.35
245_R	263_L	0.866	0.34
80_N	187_S	0.865	0.34
245_R	265_P	0.862	0.34
250_D	272_A	0.862	0.34
240_L	265_P	0.858	0.34
218_N	243_A	0.858	0.34
100_F	120_V	0.856	0.34
251_F	263_L	0.854	0.34
39_D	93_T	0.854	0.34
216_C	230_L	0.854	0.34
71_E	116_K	0.851	0.34
67_A	277_G	0.851	0.34
141_I	184_A	0.841	0.33
138_E	247_G	0.841	0.33
103_I	123_F	0.839	0.33
241_D	265_P	0.830	0.32
19_I	62_I	0.829	0.32
67_A	101_S	0.827	0.32
149_D	274_K	0.826	0.32
61_I	169_I	0.824	0.32
155_S	214_D	0.821	0.32
70_G	113_A	0.821	0.32
77_V	242_L	0.818	0.32
141_I	174_A	0.813	0.31
22_K	266_G	0.812	0.31
280_L	286_K	0.808	0.31
181_K	213_I	0.804	0.31
142_M	271_V	0.803	0.31
106_A	171_R	0.802	0.31
195_E	249_T	0.802	0.31
72_G	166_G	0.794	0.30
190_L	203_T	0.793	0.30
75_S	230_L	0.791	0.30
45_A	137_V	0.789	0.30
117_R	173_F	0.788	0.30
151_T	242_L	0.784	0.30
73_V	82_E	0.783	0.30
12_G	272_A	0.783	0.30
112_A	117_R	0.783	0.30
24_T	45_A	0.782	0.30
145_I	284_L	0.781	0.30
98_V	284_L	0.780	0.30
41_G	280_L	0.778	0.29
46_V	110_N	0.777	0.29
192_R	195_E	0.776	0.29
158_A	216_C	0.775	0.29
207_K	228_T	0.774	0.29
15_R	138_E	0.774	0.29
239_I	259_I	0.760	0.29
99_I	110_N	0.760	0.29
241_D	251_F	0.760	0.29
109_E	121_K	0.759	0.28
208_E	229_V	0.757	0.28
180_V	237_T	0.757	0.28
134_I	279_I	0.755	0.28
40_H	43_T	0.753	0.28
162_L	182_V	0.753	0.28
108_L	133_S	0.752	0.28
131_Y	153_H	0.751	0.28
224_I	248_G	0.746	0.28
30_I	194_T	0.746	0.28
10_I	97_C	0.744	0.28
80_N	83_V	0.741	0.28
222_S	288_L	0.739	0.27
218_N	221_P	0.739	0.27
227_Q	252_K	0.734	0.27
65_V	83_V	0.734	0.27
77_V	165_T	0.731	0.27
128_I	280_L	0.730	0.27
86_K	112_A	0.728	0.27
193_I	200_P	0.727	0.27
93_T	173_F	0.727	0.27
8_A	58_I	0.724	0.27
83_V	190_L	0.723	0.27
62_I	94_P	0.723	0.27
122_L	284_L	0.722	0.27
159_V	166_G	0.721	0.27
82_E	156_Q	0.720	0.26
193_I	266_G	0.718	0.26
58_I	193_I	0.713	0.26
139_G	272_A	0.710	0.26
143_L	286_K	0.710	0.26
280_L	283_V	0.710	0.26
158_A	220_I	0.708	0.26
263_L	270_I	0.705	0.26
126_D	130_I	0.700	0.25
126_D	192_R	0.698	0.25
210_V	237_T	0.696	0.25
163_G	221_P	0.692	0.25
157_V	215_I	0.689	0.25
10_I	112_A	0.688	0.25
112_A	119_L	0.685	0.25
105_N	121_K	0.684	0.25
24_T	141_I	0.680	0.24
17_L	32_L	0.680	0.24
18_E	21_R	0.679	0.24
105_N	193_I	0.678	0.24
265_P	270_I	0.677	0.24
168_T	192_R	0.677	0.24
36_D	79_S	0.674	0.24
19_I	281_A	0.673	0.24
32_L	42_F	0.672	0.24
7_I	24_T	0.672	0.24
199_V	224_I	0.672	0.24
34_G	254_A	0.672	0.24
148_T	242_L	0.669	0.24
254_A	257_Q	0.669	0.24
34_G	217_I	0.664	0.24
25_E	210_V	0.663	0.24
95_A	112_A	0.660	0.24
65_V	117_R	0.660	0.24
190_L	200_P	0.658	0.23
11_G	164_R	0.658	0.23
91_D	115_A	0.656	0.23
129_A	170_A	0.655	0.23
126_D	274_K	0.653	0.23
193_I	215_I	0.652	0.23
144_A	157_V	0.652	0.23
9_V	152_I	0.648	0.23
227_Q	257_Q	0.647	0.23
7_I	44_G	0.645	0.23
133_S	215_I	0.645	0.23
227_Q	255_E	0.644	0.23
218_N	268_P	0.644	0.23
123_F	202_H	0.643	0.23
16_Q	121_K	0.643	0.23
23_L	283_V	0.641	0.23
62_I	210_V	0.641	0.23
10_I	290_E	0.639	0.23
135_P	191_A	0.638	0.23
68_T	71_E	0.635	0.22
144_A	154_G	0.630	0.22
121_K	157_V	0.630	0.22
160_L	225_L	0.628	0.22
7_I	130_I	0.628	0.22
163_G	244_S	0.627	0.22
67_A	133_S	0.623	0.22
80_N	162_L	0.623	0.22
136_T	268_P	0.619	0.22
191_A	272_A	0.618	0.22
105_N	217_I	0.612	0.21
168_T	196_M	0.611	0.21
181_K	199_V	0.610	0.21
145_I	192_R	0.608	0.21
63_L	104_S	0.608	0.21
7_I	176_L	0.607	0.21
56_Q	92_R	0.607	0.21
155_S	264_A	0.603	0.21
272_A	276_A	0.603	0.21
81_E	255_E	0.602	0.21
68_T	280_L	0.601	0.21
62_I	118_K	0.597	0.21
27_Q	227_Q	0.597	0.21
9_V	62_I	0.594	0.21
110_N	113_A	0.594	0.21
22_K	278_Q	0.593	0.21
96_H	222_S	0.593	0.21
61_I	69_T	0.592	0.20
45_A	200_P	0.591	0.20
99_I	220_I	0.591	0.20
121_K	158_A	0.590	0.20
25_E	223_M	0.589	0.20
6_K	100_F	0.585	0.20
72_G	195_E	0.584	0.20
247_G	263_L	0.582	0.20
12_G	164_R	0.582	0.20
175_A	208_E	0.579	0.20
238_L	262_L	0.578	0.20
132_N	244_S	0.578	0.20
245_R	266_G	0.577	0.20
203_T	224_I	0.576	0.20
72_G	108_L	0.575	0.20
134_I	168_T	0.573	0.20
119_L	270_I	0.572	0.20
113_A	208_E	0.571	0.20
119_L	141_I	0.571	0.20
89_H	205_E	0.571	0.20
178_A	241_D	0.570	0.20
110_N	124_E	0.569	0.20
159_V	270_I	0.568	0.20
138_E	161_G	0.568	0.20
241_D	261_A	0.568	0.20
254_A	261_A	0.567	0.19
137_V	210_V	0.566	0.19
24_T	143_L	0.565	0.19
97_C	166_G	0.563	0.19
26_Q	285_S	0.563	0.19
36_D	48_C	0.562	0.19
158_A	175_A	0.561	0.19
121_K	165_T	0.559	0.19
178_A	197_G	0.559	0.19
205_E	208_E	0.559	0.19
22_K	281_A	0.558	0.19
48_C	52_E	0.555	0.19
53_I	112_A	0.554	0.19
21_R	236_K	0.550	0.19
67_A	160_L	0.549	0.19
151_T	177_G	0.548	0.19
35_F	127_D	0.544	0.19
122_L	133_S	0.544	0.19
37_Q	117_R	0.544	0.19
167_M	184_A	0.543	0.19
190_L	212_D	0.543	0.19
24_T	27_Q	0.539	0.18
132_N	161_G	0.539	0.18
36_D	125_R	0.537	0.18
76_T	82_E	0.533	0.18
51_D	99_I	0.532	0.18
166_G	274_K	0.528	0.18
157_V	169_I	0.527	0.18
152_I	159_V	0.527	0.18
108_L	258_G	0.527	0.18
136_T	145_I	0.526	0.18
218_N	248_G	0.525	0.18
123_F	186_S	0.525	0.18
168_T	265_P	0.524	0.18
53_I	217_I	0.523	0.18
228_T	236_K	0.523	0.18
136_T	218_N	0.522	0.18
247_G	251_F	0.520	0.18
136_T	176_L	0.519	0.18
12_G	34_G	0.519	0.18
95_A	253_Y	0.519	0.18
144_A	280_L	0.517	0.18
88_D	202_H	0.516	0.17
103_I	122_L	0.515	0.17
30_I	165_T	0.515	0.17
47_K	284_L	0.515	0.17
152_I	267_L	0.514	0.17
221_P	243_A	0.514	0.17
166_G	192_R	0.514	0.17
117_R	216_C	0.514	0.17
125_R	290_E	0.514	0.17
171_R	185_R	0.513	0.17
70_G	74_V	0.513	0.17
155_S	215_I	0.512	0.17
5_L	101_S	0.512	0.17
9_V	20_I	0.510	0.17
48_C	95_A	0.510	0.17
37_Q	44_G	0.509	0.17
43_T	137_V	0.508	0.17
220_I	290_E	0.508	0.17
61_I	107_Y	0.508	0.17
154_G	230_L	0.507	0.17
13_D	269_G	0.506	0.17
144_A	152_I	0.505	0.17
67_A	72_G	0.505	0.17
29_D	228_T	0.505	0.17
128_I	257_Q	0.503	0.17
130_I	287_L	0.503	0.17
76_T	128_I	0.502	0.17
7_I	73_V	0.500	0.17
37_Q	157_V	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3d4oA	4	0.9798	100	0.621	Contact Map
2rirA	4	0.9899	100	0.662	Contact Map
1x13A	2	0.9125	99.9	0.776	Contact Map
3x2fA	4	0.963	99.9	0.783	Contact Map
3h9uA	5	0.9562	99.8	0.795	Contact Map
3p2yA	2	0.9125	99.8	0.796	Contact Map
2qrjA	1	0.862	99.8	0.798	Contact Map
2j6iA	2	0.8956	99.8	0.809	Contact Map
2eezA	5	0.8586	99.7	0.817	Contact Map
1pjcA	5	0.9158	99.7	0.817	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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