GREMLIN Database
YMXG - Uncharacterized zinc protease YmxG
UniProt: Q04805 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 409 (393)
Sequences: 16551 (12758)
Seq/√Len: 643.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
328_S332_E4.4281.00
317_T320_T4.0981.00
168_G172_R3.6971.00
268_R330_E3.5921.00
320_T324_D3.4971.00
113_E117_K3.4221.00
380_N383_R3.2011.00
383_R386_G3.1271.00
339_K377_N3.0251.00
15_L192_I2.9951.00
306_Q309_Q2.9411.00
319_A323_R2.9041.00
328_S381_L2.8451.00
272_D276_D2.8381.00
250_R390_Q2.7741.00
169_D173_Q2.7571.00
96_N199_D2.7461.00
57_S108_H2.7441.00
124_Y164_A2.6181.00
258_N285_S2.6171.00
142_L240_G2.6051.00
60_S63_E2.5031.00
41_I170_S2.3301.00
327_T330_E2.3251.00
197_I201_E2.2521.00
272_D277_K2.2261.00
381_L385_N2.2241.00
8_Q201_E2.2121.00
322_K389_R2.2031.00
188_V196_F2.1671.00
173_Q177_D2.1641.00
104_D108_H2.1631.00
257_L388_A2.1621.00
277_K313_T2.0951.00
117_K120_K2.0821.00
312_E316_E2.0501.00
30_I184_V2.0381.00
272_D317_T2.0241.00
386_G390_Q1.9991.00
260_V326_I1.9951.00
90_V98_A1.9871.00
58_T100_D1.9581.00
313_T316_E1.9541.00
167_N170_S1.9511.00
382_E386_G1.9201.00
325_G385_N1.8931.00
298_I314_I1.8411.00
78_F85_C1.8321.00
141_L144_K1.8101.00
250_R386_G1.8091.00
28_V186_I1.7971.00
45_S174_Y1.7951.00
274_R281_Y1.7861.00
277_K309_Q1.7771.00
253_D387_L1.7561.00
308_Q312_E1.7401.00
371_E374_N1.7401.00
160_E164_A1.7241.00
195_S198_K1.7151.00
159_T162_T1.7121.00
319_A322_K1.7121.00
59_K104_D1.6991.00
58_T104_D1.6891.00
331_L381_L1.6831.00
309_Q312_E1.6801.00
88_A98_A1.6721.00
124_Y160_E1.6611.00
332_E335_K1.6601.00
67_S97_Y1.6601.00
96_N202_K1.6591.00
40_E170_S1.6551.00
84_T179_Y1.6461.00
112_D115_E1.6411.00
374_N377_N1.6291.00
128_K160_E1.6281.00
68_F73_G1.6241.00
385_N389_R1.6141.00
332_E336_E1.6031.00
239_L315_Q1.6001.00
382_E385_N1.5931.00
198_K201_E1.5911.00
256_V379_V1.5661.00
16_E352_K1.5611.00
59_K67_S1.5511.00
12_R185_V1.5351.00
286_Y297_T1.5291.00
107_F206_S1.5281.00
198_K202_K1.5271.00
71_I97_Y1.5151.00
316_E320_T1.5001.00
57_S110_T1.4831.00
170_S173_Q1.4731.00
56_T104_D1.4571.00
172_R176_H1.4561.00
173_Q176_H1.4321.00
253_D383_R1.4181.00
48_L111_F1.4081.00
14_V185_V1.4061.00
169_D172_R1.3971.00
38_T41_I1.3881.00
300_G310_L1.3851.00
374_N378_A1.3771.00
268_R317_T1.3751.00
321_L326_I1.3561.00
47_F116_L1.3541.00
253_D379_V1.3481.00
371_E375_E1.3481.00
241_F315_Q1.3481.00
19_P191_N1.3451.00
82_E152_L1.3451.00
97_Y100_D1.3441.00
17_N193_S1.3381.00
284_Y299_Y1.3331.00
11_V186_I1.3241.00
103_A204_F1.3241.00
249_E383_R1.3221.00
31_G183_R1.3191.00
367_K371_E1.3191.00
235_A307_L1.3131.00
46_H50_H1.3121.00
273_V280_A1.2871.00
116_L168_G1.2831.00
58_T108_H1.2831.00
11_V184_V1.2801.00
96_N195_S1.2781.00
199_D203_W1.2781.00
116_L171_L1.2671.00
386_G389_R1.2641.00
249_E375_E1.2601.00
195_S199_D1.2561.00
44_I166_F1.2511.00
96_N203_W1.2331.00
189_A353_M1.2321.00
335_K376_L1.2321.00
254_L387_L1.2161.00
29_W357_G1.2161.00
271_Q276_D1.2091.00
221_F224_E1.2061.00
120_K163_L1.2061.00
192_I196_F1.2051.00
28_V184_V1.2031.00
199_D202_K1.1961.00
181_P207_Y1.1881.00
300_G314_I1.1861.00
54_K119_E1.1811.00
35_R292_D1.1811.00
186_I200_V1.1781.00
201_E205_G1.1781.00
272_D313_T1.1751.00
113_E168_G1.1731.00
26_I188_V1.1681.00
109_S175_M1.1671.00
99_L199_D1.1581.00
258_N296_L1.1461.00
280_A283_V1.1361.00
120_K124_Y1.1361.00
302_T310_L1.1331.00
94_H97_Y1.1221.00
375_E378_A1.1221.00
365_K371_E1.1181.00
257_L387_L1.1121.00
194_D197_I1.1111.00
71_I94_H1.1101.00
30_I106_F1.1081.00
67_S70_R1.1081.00
250_R391_L1.1071.00
92_D191_N1.1011.00
34_S156_I1.0951.00
100_D203_W1.0951.00
12_R360_E1.0941.00
188_V192_I1.0871.00
63_E66_E1.0831.00
47_F120_K1.0761.00
265_M270_F1.0751.00
280_A300_G1.0741.00
15_L196_F1.0731.00
103_A107_F1.0721.00
115_E118_K1.0691.00
51_M171_L1.0671.00
252_Y375_E1.0621.00
46_H49_E1.0571.00
64_I105_M1.0571.00
32_T174_Y1.0571.00
39_P154_Y1.0541.00
348_S351_S1.0521.00
370_D374_N1.0471.00
48_L171_L1.0451.00
14_V360_E1.0411.00
182_D210_K1.0411.00
127_I157_L1.0391.00
326_I331_L1.0331.00
339_K373_I1.0331.00
243_G287_H1.0291.00
194_D198_K1.0281.00
63_E67_S1.0261.00
125_E128_K1.0261.00
22_R191_N1.0251.00
102_L105_M1.0241.00
185_V360_E1.0231.00
68_F75_V1.0181.00
311_S315_Q1.0161.00
25_A89_K1.0151.00
220_E224_E1.0101.00
259_N334_S1.0091.00
24_V190_G1.0041.00
50_H119_E1.0001.00
340_G344_L0.9971.00
257_L384_V0.9961.00
343_M373_I0.9901.00
245_E248_H0.9891.00
228_R231_E0.9881.00
368_T371_E0.9871.00
146_T295_M0.9801.00
40_E162_T0.9801.00
221_F225_K0.9791.00
52_F109_S0.9741.00
315_Q319_A0.9721.00
131_E160_E0.9721.00
56_T109_S0.9661.00
260_V334_S0.9551.00
331_L335_K0.9551.00
24_V92_D0.9531.00
124_Y128_K0.9521.00
117_K121_N0.9491.00
393_T396_Y0.9481.00
111_F116_L0.9281.00
219_P223_T0.9281.00
99_L200_V0.9271.00
124_Y163_L0.9271.00
43_G158_G0.9251.00
46_H126_E0.9241.00
95_A199_D0.9211.00
239_L311_S0.9181.00
273_V313_T0.9171.00
86_Y179_Y0.9161.00
88_A102_L0.9141.00
50_H79_T0.9121.00
51_M116_L0.9121.00
372_I376_L0.9101.00
273_V283_V0.9011.00
184_V207_Y0.8971.00
323_R389_R0.8951.00
11_V181_P0.8911.00
316_E319_A0.8881.00
119_E122_V0.8881.00
335_K377_N0.8881.00
388_A392_F0.8841.00
96_N100_D0.8841.00
64_I101_V0.8811.00
326_I381_L0.8811.00
254_L391_L0.8791.00
103_A203_W0.8781.00
142_L238_C0.8731.00
46_H79_T0.8721.00
271_Q275_E0.8701.00
26_I88_A0.8701.00
41_I177_D0.8661.00
16_E189_A0.8651.00
49_E79_T0.8631.00
285_S296_L0.8621.00
373_I377_N0.8611.00
59_K100_D0.8571.00
252_Y379_V0.8561.00
29_W85_C0.8551.00
222_H225_K0.8521.00
200_V203_W0.8521.00
313_T317_T0.8521.00
95_A196_F0.8511.00
219_P225_K0.8501.00
182_D209_A0.8471.00
240_G297_T0.8471.00
255_I372_I0.8441.00
27_G85_C0.8421.00
256_V331_L0.8411.00
31_G291_E0.8381.00
260_V268_R0.8341.00
81_K143_S0.8331.00
127_I163_L0.8321.00
309_Q313_T0.8311.00
50_H126_E0.8301.00
324_D385_N0.8261.00
12_R31_G0.8241.00
67_S71_I0.8221.00
249_E253_D0.8221.00
7_C13_I0.8211.00
180_T210_K0.8171.00
133_A136_D0.8141.00
335_K339_K0.8101.00
329_K333_N0.8081.00
13_I197_I0.8051.00
148_G153_G0.8021.00
28_V106_F0.8011.00
174_Y178_Y0.7991.00
317_T321_L0.7961.00
329_K332_E0.7921.00
270_F275_E0.7921.00
283_V314_I0.7901.00
236_H301_G0.7881.00
47_F123_V0.7871.00
44_I48_L0.7811.00
180_T183_R0.7801.00
279_L306_Q0.7791.00
327_T381_L0.7781.00
42_N162_T0.7761.00
325_G381_L0.7751.00
50_H76_N0.7741.00
196_F200_V0.7721.00
187_S356_N0.7651.00
50_H53_F0.7641.00
114_N118_K0.7641.00
365_K368_T0.7601.00
52_F105_M0.7591.00
121_N124_Y0.7591.00
47_F171_L0.7591.00
41_I166_F0.7581.00
308_Q311_S0.7571.00
67_S101_V0.7551.00
303_G306_Q0.7521.00
258_N262_G0.7511.00
73_G90_V0.7501.00
99_L203_W0.7481.00
46_H123_V0.7481.00
59_K64_I0.7481.00
123_V163_L0.7411.00
283_V298_I0.7401.00
331_L379_V0.7371.00
37_E43_G0.7361.00
339_K343_M0.7341.00
32_T36_H0.7341.00
138_V238_C0.7311.00
149_N153_G0.7291.00
78_F83_Y0.7251.00
237_L300_G0.7251.00
320_T325_G0.7251.00
270_F274_R0.7251.00
244_L391_L0.7251.00
15_L200_V0.7251.00
141_L145_A0.7241.00
262_G285_S0.7211.00
370_D373_I0.7201.00
28_V204_F0.7191.00
322_K325_G0.7181.00
249_E378_A0.7161.00
9_N205_G0.7131.00
268_R327_T0.7131.00
103_A206_S0.7121.00
169_D176_H0.7101.00
116_L166_F0.7101.00
50_H123_V0.7091.00
24_V188_V0.7081.00
257_L321_L0.7081.00
77_A86_Y0.7051.00
269_L283_V0.7021.00
162_T165_S0.7011.00
49_E53_F0.7011.00
174_Y179_Y0.7001.00
220_E223_T0.6971.00
34_S37_E0.6961.00
107_F207_Y0.6951.00
334_S338_M0.6951.00
219_P224_E0.6911.00
357_G361_L0.6911.00
337_Q340_G0.6901.00
15_L188_V0.6881.00
179_Y183_R0.6871.00
119_E123_V0.6851.00
9_N181_P0.6851.00
123_V126_E0.6841.00
259_N337_Q0.6811.00
111_F175_M0.6781.00
326_I385_N0.6741.00
182_D211_G0.6721.00
261_L318_L0.6711.00
51_M54_K0.6701.00
236_H299_Y0.6701.00
54_K115_E0.6691.00
260_V330_E0.6691.00
38_T177_D0.6681.00
387_L391_L0.6661.00
259_N338_M0.6651.00
355_R359_N0.6641.00
161_E165_S0.6641.00
162_T166_F0.6641.00
64_I68_F0.6621.00
176_H210_K0.6611.00
32_T178_Y0.6611.00
49_E77_A0.6591.00
171_L175_M0.6581.00
278_G281_Y0.6551.00
50_H77_A0.6551.00
49_E126_E0.6531.00
150_H153_G0.6531.00
146_T240_G0.6531.00
388_A391_L0.6501.00
187_S353_M0.6481.00
59_K101_V0.6481.00
66_E69_D0.6481.00
244_L248_H0.6471.00
41_I44_I0.6461.00
145_A148_G0.6421.00
18_N349_T0.6411.00
253_D257_L0.6341.00
187_S360_E0.6321.00
81_K156_I0.6321.00
18_N189_A0.6311.00
19_P22_R0.6301.00
139_H143_S0.6271.00
220_E225_K0.6261.00
314_I317_T0.6251.00
33_G43_G0.6231.00
256_V334_S0.6221.00
18_N22_R0.6221.00
24_V192_I0.6211.00
232_T235_A0.6211.00
52_F86_Y0.6191.00
322_K385_N0.6191.00
56_T110_T0.6181.00
193_S196_F0.6171.00
41_I45_S0.6171.00
56_T59_K0.6171.00
234_Q301_G0.6171.00
237_L307_L0.6151.00
248_H391_L0.6151.00
66_E70_R0.6151.00
102_L106_F0.6141.00
256_V338_M0.6141.00
22_R92_D0.6111.00
73_G98_A0.6101.00
239_L398_L0.6091.00
79_T126_E0.6091.00
219_P222_H0.6081.00
375_E379_V0.6071.00
161_E164_A0.6071.00
342_L372_I0.6061.00
307_L311_S0.6051.00
58_T110_T0.6051.00
56_T108_H0.6051.00
34_S81_K0.6041.00
79_T84_T0.6031.00
43_G46_H0.6021.00
301_G304_A0.6021.00
24_V95_A0.6011.00
279_L310_L0.6011.00
147_Y295_M0.5991.00
31_G185_V0.5981.00
367_K370_D0.5961.00
254_L257_L0.5951.00
279_L309_Q0.5931.00
50_H122_V0.5931.00
282_S301_G0.5921.00
264_S267_S0.5911.00
54_K118_K0.5891.00
137_I141_L0.5881.00
187_S357_G0.5881.00
147_Y293_S0.5871.00
273_V314_I0.5861.00
238_C297_T0.5861.00
331_L384_V0.5851.00
175_M179_Y0.5841.00
116_L120_K0.5841.00
140_D144_K0.5841.00
237_L302_T0.5831.00
325_G388_A0.5831.00
28_V102_L0.5821.00
45_S48_L0.5821.00
139_H238_C0.5811.00
111_F168_G0.5791.00
11_V207_Y0.5781.00
275_E280_A0.5761.00
11_V204_F0.5761.00
141_L226_L0.5761.00
233_E236_H0.5751.00
168_G171_L0.5751.00
122_V126_E0.5741.00
218_K221_F0.5741.00
257_L296_L0.5731.00
273_V279_L0.5721.00
217_E220_E0.5721.00
262_G267_S0.5711.00
130_Y136_D0.5711.00
203_W206_S0.5711.00
18_N352_K0.5711.00
320_T323_R0.5701.00
264_S270_F0.5691.00
196_F199_D0.5681.00
178_Y183_R0.5681.00
338_M376_L0.5671.00
98_A102_L0.5661.00
172_R175_M0.5661.00
335_K381_L0.5661.00
129_M133_A0.5661.00
92_D195_S0.5651.00
302_T305_N0.5651.00
256_V384_V0.5641.00
7_C201_E0.5611.00
48_L174_Y0.5611.00
19_P193_S0.5611.00
27_G87_Y0.5601.00
272_D316_E0.5591.00
125_E129_M0.5591.00
44_I170_S0.5591.00
257_L261_L0.5591.00
250_R253_D0.5581.00
192_I200_V0.5581.00
387_L390_Q0.5571.00
14_V187_S0.5551.00
155_P158_G0.5551.00
241_F318_L0.5541.00
47_F163_L0.5541.00
270_F280_A0.5521.00
29_W187_S0.5511.00
49_E122_V0.5511.00
86_Y102_L0.5491.00
352_K356_N0.5491.00
49_E84_T0.5481.00
15_L193_S0.5471.00
99_L196_F0.5471.00
26_I186_I0.5471.00
178_Y181_P0.5461.00
259_N341_S0.5451.00
60_S64_I0.5441.00
65_A75_V0.5441.00
100_D104_D0.5431.00
130_Y157_L0.5421.00
46_H122_V0.5421.00
322_K393_T0.5421.00
229_K233_E0.5421.00
59_K108_H0.5411.00
128_K131_E0.5411.00
274_R280_A0.5411.00
270_F273_V0.5401.00
78_F354_S0.5391.00
61_A115_E0.5391.00
57_S104_D0.5381.00
91_L94_H0.5381.00
310_L314_I0.5370.99
106_F175_M0.5360.99
16_E356_N0.5360.99
389_R393_T0.5340.99
155_P159_T0.5340.99
237_L311_S0.5320.99
332_E377_N0.5310.99
46_H119_E0.5310.99
49_E123_V0.5310.99
215_G218_K0.5300.99
146_T242_K0.5300.99
37_E41_I0.5300.99
32_T84_T0.5300.99
226_L229_K0.5290.99
318_L322_K0.5290.99
229_K232_T0.5280.99
268_R272_D0.5260.99
252_Y376_L0.5250.99
248_H390_Q0.5240.99
273_V278_G0.5230.99
100_D202_K0.5220.99
101_V104_D0.5220.99
205_G208_E0.5210.99
384_V388_A0.5200.99
234_Q281_Y0.5190.99
181_P208_E0.5180.99
267_S270_F0.5160.99
256_V335_K0.5150.99
88_A91_L0.5150.99
330_E333_N0.5140.99
227_T230_K0.5140.99
231_E235_A0.5140.99
188_V200_V0.5120.99
328_S382_E0.5120.99
27_G353_M0.5120.99
321_L325_G0.5110.99
328_S335_K0.5100.99
280_A310_L0.5080.99
378_A383_R0.5080.99
337_Q341_S0.5060.99
385_N388_A0.5060.99
231_E234_Q0.5060.99
348_S352_K0.5030.99
47_F51_M0.5030.99
30_I84_T0.5030.99
42_N154_Y0.5030.99
235_A238_C0.5020.99
322_K392_F0.5020.99
260_V384_V0.5020.99
119_E158_G0.5020.99
287_H296_L0.5020.99
272_D320_T0.5020.99
347_E351_S0.5020.99
139_H286_Y0.5000.99
197_I200_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hdiA 2 0.9976 100 0.075 Contact Map
3eoqA 2 0.9878 100 0.082 Contact Map
1hr6B 1 0.9976 100 0.119 Contact Map
3amiA 2 0.9927 100 0.13 Contact Map
1hr6A 1 0.9927 100 0.135 Contact Map
1pp9A 1 0.9927 100 0.136 Contact Map
4nnzA 2 0.9389 100 0.138 Contact Map
3gwbA 2 0.9902 100 0.148 Contact Map
1pp9B 2 0.9878 100 0.152 Contact Map
3amjB 1 0.9829 100 0.163 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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