GREMLIN Database
DHAS - Aspartate-semialdehyde dehydrogenase
UniProt: Q04797 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 346 (330)
Sequences: 3172 (1583)
Seq/√Len: 87.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_E144_K4.5721.00
162_A195_K4.0991.00
46_K53_E3.7991.00
117_D231_H3.5711.00
159_V199_I3.0681.00
27_R338_E3.0041.00
268_I316_F2.9651.00
203_A244_L2.9571.00
154_S253_S2.9321.00
142_I258_I2.9091.00
59_A82_L2.8601.00
279_T300_D2.8161.00
8_A67_V2.8151.00
149_N259_D2.8021.00
283_D286_Q2.7811.00
40_K58_E2.6521.00
213_N220_M2.5921.00
145_A271_L2.4801.00
145_A267_D2.4341.00
6_H33_T2.4101.00
46_K55_T2.3751.00
116_A231_H2.3311.00
64_F86_A2.3041.00
208_D217_F2.2771.00
35_T57_Q2.2051.00
48_T53_E2.1871.00
80_Q99_A2.1701.00
254_V320_V2.1081.00
25_E50_K2.0601.00
110_V136_V2.0511.00
135_M254_V1.9771.00
299_N326_L1.9401.00
146_Y263_A1.9381.00
6_H32_D1.9131.00
261_D308_K1.8701.00
197_Y291_M1.8601.00
105_N122_N1.8271.00
290_P304_G1.8271.00
10_V59_A1.8191.00
327_K335_Q1.8181.00
164_N168_K1.8161.00
83_A124_I1.7921.00
19_Q22_K1.7851.00
20_M71_L1.7781.00
117_D120_E1.7721.00
28_N50_K1.7461.00
265_V306_I1.7411.00
206_Q287_Q1.7391.00
280_L306_I1.7261.00
85_E89_R1.7041.00
209_K217_F1.7021.00
176_A181_E1.6961.00
81_A85_E1.6891.00
115_E339_S1.6841.00
150_K257_E1.6671.00
85_E88_K1.6571.00
149_N257_E1.6531.00
168_K171_Y1.6411.00
269_K306_I1.6261.00
267_D270_N1.6241.00
270_N274_E1.5981.00
5_L341_K1.5971.00
142_I268_I1.5831.00
312_R315_G1.5671.00
147_G259_D1.5631.00
298_K302_F1.5541.00
82_L85_E1.5341.00
203_A292_P1.5331.00
162_A166_A1.4820.99
22_K26_D1.4800.99
31_M34_L1.4710.99
152_I255_Y1.4700.99
6_H35_T1.4680.99
171_Y247_Q1.4670.99
92_I340_L1.4660.99
26_D326_L1.4550.99
13_T56_V1.4490.99
36_L47_V1.4450.99
153_V252_E1.4220.99
6_H67_V1.4190.99
5_L69_I1.4000.99
23_T331_W1.3960.99
33_T57_Q1.3800.99
232_M235_L1.3700.99
283_D288_L1.3670.99
70_A91_A1.3470.99
270_N273_K1.3410.99
143_R232_M1.3390.99
265_V308_K1.3370.99
34_L54_L1.3280.99
135_M252_E1.3200.99
61_P81_A1.3190.99
43_A55_T1.3160.99
174_T201_F1.3150.99
269_K280_L1.3140.99
272_L318_L1.3060.99
137_A275_A1.2970.99
83_A93_V1.2950.99
261_D314_N1.2940.99
256_I318_L1.2900.99
275_A278_V1.2830.98
31_M49_F1.2820.98
168_K172_S1.2650.98
272_L280_L1.2640.98
23_T334_V1.2610.98
86_A93_V1.2560.98
281_Q294_D1.2510.98
84_P88_K1.2340.98
35_T67_V1.2320.98
169_E173_Q1.2310.98
238_A311_D1.2120.98
113_V137_A1.1970.98
246_I251_S1.1810.97
29_F337_A1.1740.97
178_L201_F1.1730.97
134_Q322_S1.1690.97
171_Y175_Q1.1680.97
184_E187_I1.1670.97
69_I337_A1.1650.97
72_F83_A1.1630.97
261_D313_A1.1610.97
272_L278_V1.1600.97
72_F86_A1.1600.97
65_E89_R1.1590.97
19_Q248_T1.1540.97
118_L339_S1.1530.97
236_Q313_A1.1360.97
55_T58_E1.1340.97
255_Y317_H1.1250.97
13_T38_S1.1200.96
195_K204_I1.1200.96
140_E143_R1.1070.96
173_Q198_Q1.1070.96
248_T296_V1.1050.96
251_S292_P1.1010.96
167_V247_Q1.1000.96
299_N331_W1.1000.96
140_E230_M1.1000.96
146_Y267_D1.1000.96
210_F284_P1.0980.96
21_L36_L1.0940.96
42_S45_T1.0940.96
67_V91_A1.0870.96
197_Y294_D1.0800.96
153_V254_V1.0710.95
281_Q288_L1.0690.95
61_P89_R1.0650.95
148_L256_I1.0640.95
87_V124_I1.0630.95
249_G324_N1.0630.95
211_Q220_M1.0630.95
339_S342_K1.0590.95
238_A317_H1.0530.95
183_I187_I1.0510.95
146_Y271_L1.0510.95
7_V29_F1.0450.95
143_R147_G1.0410.95
175_Q179_N1.0360.94
220_M224_N1.0350.94
134_Q321_V1.0330.94
139_L256_I1.0290.94
279_T302_F1.0280.94
112_E327_K1.0280.94
24_L31_M1.0210.94
96_N127_N1.0190.94
112_E335_Q1.0140.94
174_T178_L1.0130.94
145_A260_R1.0100.94
249_G296_V1.0090.94
60_S63_S1.0080.94
226_T235_L1.0030.93
23_T326_L1.0010.93
150_K311_D1.0000.93
207_I222_M1.0000.93
284_P288_L1.0000.93
162_A204_I1.0000.93
172_S176_A0.9940.93
213_N310_L0.9900.93
139_L151_V0.9860.93
258_I263_A0.9730.92
15_A167_V0.9720.92
227_K235_L0.9710.92
56_V59_A0.9700.92
115_E119_H0.9690.92
264_T308_K0.9660.92
206_Q210_F0.9640.92
265_V269_K0.9620.92
69_I94_I0.9580.92
238_A255_Y0.9550.92
227_K233_P0.9490.91
102_M224_N0.9470.91
31_M54_L0.9450.91
138_A318_L0.9410.91
215_Y220_M0.9360.91
135_M153_V0.9350.91
264_T267_D0.9350.91
18_Q45_T0.9320.91
251_S319_W0.9310.91
27_R299_N0.9300.91
134_Q324_N0.9270.90
39_S42_S0.9270.90
61_P85_E0.9270.90
248_T325_L0.9230.90
136_V230_M0.9220.90
248_T324_N0.9220.90
118_L125_I0.9120.90
257_E315_G0.9010.89
23_T26_D0.8920.89
211_Q224_N0.8870.88
60_S85_E0.8870.88
25_E49_F0.8810.88
148_L235_L0.8760.88
129_N221_K0.8730.88
58_E63_S0.8720.88
43_A58_E0.8720.88
135_M222_M0.8690.87
38_S42_S0.8680.87
306_I316_F0.8670.87
211_Q217_F0.8640.87
9_V36_L0.8640.87
35_T66_G0.8590.87
208_D216_T0.8570.87
269_K273_K0.8560.87
138_A301_V0.8540.86
249_G295_A0.8540.86
76_G98_S0.8530.86
21_L54_L0.8510.86
266_E269_K0.8490.86
80_Q103_D0.8490.86
236_Q311_D0.8450.86
311_D317_H0.8440.86
37_L67_V0.8400.86
291_M294_D0.8360.85
142_I316_F0.8320.85
177_I198_Q0.8310.85
111_P133_I0.8300.85
147_G258_I0.8280.85
258_I268_I0.8270.85
87_V123_G0.8240.84
103_D122_N0.8240.84
48_T51_G0.8230.84
22_K25_E0.8190.84
59_A78_V0.8160.84
98_S217_F0.8150.84
146_Y264_T0.8140.84
174_T200_A0.8110.84
25_E48_T0.8100.83
71_L333_S0.8100.83
143_R258_I0.8010.83
139_L148_L0.8010.83
13_T42_S0.7960.82
222_M241_C0.7960.82
223_I310_L0.7950.82
9_V20_M0.7920.82
272_L275_A0.7920.82
138_A141_P0.7900.82
57_Q63_S0.7870.82
167_V248_T0.7860.82
135_M151_V0.7830.81
183_I186_E0.7820.81
220_M310_L0.7810.81
261_D264_T0.7800.81
203_A242_V0.7780.81
13_T39_S0.7750.81
220_M223_I0.7700.80
131_S155_T0.7680.80
269_K282_D0.7610.79
75_G79_S0.7610.79
71_L337_A0.7600.79
260_R267_D0.7590.79
18_Q47_V0.7590.79
47_V54_L0.7530.79
74_A97_T0.7500.78
149_N314_N0.7490.78
263_A268_I0.7480.78
176_A184_E0.7450.78
210_F217_F0.7450.78
210_F216_T0.7440.78
131_S222_M0.7420.78
257_E312_R0.7420.78
92_I123_G0.7410.78
71_L94_I0.7410.78
176_A183_I0.7400.78
33_T52_Q0.7370.77
288_L291_M0.7360.77
138_A151_V0.7350.77
151_V239_A0.7350.77
159_V167_V0.7350.77
138_A320_V0.7300.77
177_I183_I0.7260.76
143_R259_D0.7250.76
109_V339_S0.7220.76
266_E270_N0.7220.76
166_A195_K0.7210.76
197_Y204_I0.7160.75
91_A123_G0.7110.75
258_I261_D0.7080.74
281_Q302_F0.7070.74
130_C221_K0.7060.74
10_V37_L0.7050.74
153_V222_M0.7040.74
204_I291_M0.7020.74
113_V140_E0.7010.74
79_S100_F0.7010.74
204_I289_Y0.7000.74
197_Y289_Y0.6990.73
265_V268_I0.6980.73
9_V24_L0.6950.73
20_M334_V0.6930.73
198_Q293_A0.6910.73
11_G14_G0.6900.72
210_F289_Y0.6890.72
255_Y311_D0.6860.72
297_G323_D0.6840.72
37_L64_F0.6830.72
195_K199_I0.6820.72
240_T317_H0.6820.72
246_I319_W0.6810.71
197_Y287_Q0.6800.71
256_I272_L0.6790.71
152_I238_A0.6790.71
154_S255_Y0.6760.71
76_G80_Q0.6740.71
306_I318_L0.6730.71
5_L32_D0.6710.70
134_Q252_E0.6710.70
146_Y259_D0.6690.70
326_L331_W0.6690.70
254_V318_L0.6690.70
37_L57_Q0.6670.70
177_I180_K0.6660.70
111_P336_I0.6650.70
113_V136_V0.6640.70
5_L31_M0.6610.69
218_E221_K0.6590.69
182_E185_P0.6580.69
137_A335_Q0.6580.69
118_L340_L0.6580.69
40_K60_S0.6540.68
300_D331_W0.6530.68
58_E61_P0.6480.68
208_D211_Q0.6470.68
60_S81_A0.6460.67
35_T62_E0.6460.67
62_E65_E0.6450.67
8_A70_A0.6450.67
240_T253_S0.6440.67
35_T65_E0.6420.67
251_S321_V0.6400.67
263_A308_K0.6400.67
273_K280_L0.6380.66
101_R161_G0.6370.66
36_L54_L0.6360.66
36_L57_Q0.6310.66
296_V324_N0.6310.66
161_G221_K0.6300.66
37_L63_S0.6300.66
135_M226_T0.6290.65
77_S80_Q0.6270.65
67_V70_A0.6240.65
221_K229_I0.6240.65
63_S66_G0.6240.65
130_C161_G0.6230.65
61_P82_L0.6210.64
265_V280_L0.6200.64
277_G327_K0.6190.64
62_E89_R0.6190.64
139_L321_V0.6180.64
71_L99_A0.6150.64
151_V256_I0.6150.64
182_E187_I0.6150.64
7_V31_M0.6130.63
129_N161_G0.6130.63
81_A84_P0.6130.63
142_I256_I0.6110.63
15_A248_T0.6100.63
84_P93_V0.6090.63
144_K275_A0.6080.63
10_V70_A0.6080.63
205_P208_D0.6080.63
277_G335_Q0.6070.63
39_S78_V0.6060.63
271_L275_A0.6040.62
80_Q217_F0.6020.62
6_H66_G0.6000.62
200_A247_Q0.5990.62
131_S134_Q0.5970.61
8_A37_L0.5940.61
151_V237_V0.5930.61
171_Y177_I0.5930.61
284_P287_Q0.5920.61
138_A275_A0.5920.61
218_E250_H0.5910.61
263_A316_F0.5900.60
145_A265_V0.5880.60
153_V173_Q0.5860.60
137_A327_K0.5850.60
60_S82_L0.5830.60
255_Y312_R0.5820.59
59_A67_V0.5810.59
205_P216_T0.5790.59
175_Q181_E0.5780.59
105_N121_H0.5780.59
70_A83_A0.5770.59
46_K56_V0.5770.59
74_A79_S0.5760.59
265_V316_F0.5740.58
10_V72_F0.5740.58
310_L317_H0.5720.58
175_Q178_L0.5710.58
8_A59_A0.5710.58
106_T122_N0.5700.58
196_H287_Q0.5690.58
152_I253_S0.5670.57
92_I121_H0.5670.57
7_V71_L0.5670.57
258_I316_F0.5670.57
201_F247_Q0.5670.57
215_Y238_A0.5650.57
74_A78_V0.5650.57
38_S56_V0.5630.57
112_E115_E0.5630.57
73_S79_S0.5610.57
294_D302_F0.5610.57
29_F34_L0.5600.57
101_R130_C0.5590.56
84_P87_V0.5590.56
238_A310_L0.5590.56
45_T56_V0.5570.56
171_Y174_T0.5560.56
143_R148_L0.5560.56
183_I198_Q0.5540.56
25_E51_G0.5540.56
235_L318_L0.5530.56
162_A207_I0.5510.55
129_N218_E0.5500.55
161_G243_R0.5490.55
136_V226_T0.5470.55
73_S100_F0.5470.55
145_A263_A0.5450.55
20_M325_L0.5420.54
255_Y310_L0.5420.54
150_K315_G0.5400.54
236_Q312_R0.5400.54
134_Q320_V0.5400.54
150_K255_Y0.5400.54
31_M36_L0.5400.54
217_F224_N0.5400.54
9_V71_L0.5390.54
103_D106_T0.5390.54
73_S96_N0.5340.53
146_Y260_R0.5340.53
6_H68_N0.5330.53
295_A322_S0.5330.53
176_A179_N0.5310.53
14_G39_S0.5310.53
55_T59_A0.5300.52
135_M239_A0.5280.52
158_A248_T0.5280.52
223_I239_A0.5270.52
76_G208_D0.5250.52
159_V195_K0.5240.52
19_Q23_T0.5240.52
295_A302_F0.5230.52
77_S99_A0.5220.51
177_I181_E0.5210.51
63_S86_A0.5200.51
58_E82_L0.5190.51
172_S186_E0.5140.50
131_S199_I0.5130.50
71_L334_V0.5130.50
101_R218_E0.5110.50
171_Y178_L0.5110.50
136_V151_V0.5110.50
130_C243_R0.5100.50
100_F106_T0.5100.50
10_V82_L0.5100.50
19_Q331_W0.5100.50
24_L49_F0.5100.50
221_K243_R0.5090.50
175_Q180_K0.5090.50
157_Q218_E0.5080.50
146_Y308_K0.5080.50
77_S209_K0.5070.49
127_N221_K0.5050.49
27_R30_E0.5040.49
161_G218_E0.5040.49
204_I208_D0.5040.49
37_L86_A0.5040.49
92_I125_I0.5040.49
64_F91_A0.5030.49
135_M237_V0.5020.49
72_F93_V0.5010.49
172_S175_Q0.5000.48
130_C329_A0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yv3A 2 0.948 100 0.242 Contact Map
2r00A 2 0.9624 100 0.259 Contact Map
3pzrA 2 0.9769 100 0.262 Contact Map
3uw3A 2 0.9595 100 0.262 Contact Map
3tz6A 2 0.9393 100 0.264 Contact Map
1t4bA 2 0.9711 100 0.272 Contact Map
2hjsA 2 0.9566 100 0.274 Contact Map
4r3nA 2 0.9682 100 0.275 Contact Map
4dplA 4 0.8699 100 0.371 Contact Map
2ep5A 4 0.8786 100 0.373 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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