DHAS - BACSU - GREMLIN Contacts

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DHAS - Aspartate-semialdehyde dehydrogenase

UniProt:	Q04797	Sequences: MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAGTKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRMDENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVSGAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFEEMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAPGVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSVQIAESLKKLNLV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	346 (330)
Sequences:	3172 (1583)
Seq/√Len:	87.1

ECOLI - DHAS USG ARGC
BACSU - DHAS ARGC
HALSA - Q9HPX0
SULSO - Q97ZL8 Q97WN3 ARGC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
140_E	144_K	4.572	1.00
162_A	195_K	4.099	1.00
46_K	53_E	3.799	1.00
117_D	231_H	3.571	1.00
159_V	199_I	3.068	1.00
27_R	338_E	3.004	1.00
268_I	316_F	2.965	1.00
203_A	244_L	2.957	1.00
154_S	253_S	2.932	1.00
142_I	258_I	2.909	1.00
59_A	82_L	2.860	1.00
279_T	300_D	2.816	1.00
8_A	67_V	2.815	1.00
149_N	259_D	2.802	1.00
283_D	286_Q	2.781	1.00
40_K	58_E	2.652	1.00
213_N	220_M	2.592	1.00
145_A	271_L	2.480	1.00
145_A	267_D	2.434	1.00
6_H	33_T	2.410	1.00
46_K	55_T	2.375	1.00
116_A	231_H	2.331	1.00
64_F	86_A	2.304	1.00
208_D	217_F	2.277	1.00
35_T	57_Q	2.205	1.00
48_T	53_E	2.187	1.00
80_Q	99_A	2.170	1.00
254_V	320_V	2.108	1.00
25_E	50_K	2.060	1.00
110_V	136_V	2.051	1.00
135_M	254_V	1.977	1.00
299_N	326_L	1.940	1.00
146_Y	263_A	1.938	1.00
6_H	32_D	1.913	1.00
261_D	308_K	1.870	1.00
197_Y	291_M	1.860	1.00
105_N	122_N	1.827	1.00
290_P	304_G	1.827	1.00
10_V	59_A	1.819	1.00
327_K	335_Q	1.818	1.00
164_N	168_K	1.816	1.00
83_A	124_I	1.792	1.00
19_Q	22_K	1.785	1.00
20_M	71_L	1.778	1.00
117_D	120_E	1.772	1.00
28_N	50_K	1.746	1.00
265_V	306_I	1.741	1.00
206_Q	287_Q	1.739	1.00
280_L	306_I	1.726	1.00
85_E	89_R	1.704	1.00
209_K	217_F	1.702	1.00
176_A	181_E	1.696	1.00
81_A	85_E	1.689	1.00
115_E	339_S	1.684	1.00
150_K	257_E	1.667	1.00
85_E	88_K	1.657	1.00
149_N	257_E	1.653	1.00
168_K	171_Y	1.641	1.00
269_K	306_I	1.626	1.00
267_D	270_N	1.624	1.00
270_N	274_E	1.598	1.00
5_L	341_K	1.597	1.00
142_I	268_I	1.583	1.00
312_R	315_G	1.567	1.00
147_G	259_D	1.563	1.00
298_K	302_F	1.554	1.00
82_L	85_E	1.534	1.00
203_A	292_P	1.533	1.00
162_A	166_A	1.482	0.99
22_K	26_D	1.480	0.99
31_M	34_L	1.471	0.99
152_I	255_Y	1.470	0.99
6_H	35_T	1.468	0.99
171_Y	247_Q	1.467	0.99
92_I	340_L	1.466	0.99
26_D	326_L	1.455	0.99
13_T	56_V	1.449	0.99
36_L	47_V	1.445	0.99
153_V	252_E	1.422	0.99
6_H	67_V	1.419	0.99
5_L	69_I	1.400	0.99
23_T	331_W	1.396	0.99
33_T	57_Q	1.380	0.99
232_M	235_L	1.370	0.99
283_D	288_L	1.367	0.99
70_A	91_A	1.347	0.99
270_N	273_K	1.341	0.99
143_R	232_M	1.339	0.99
265_V	308_K	1.337	0.99
34_L	54_L	1.328	0.99
135_M	252_E	1.320	0.99
61_P	81_A	1.319	0.99
43_A	55_T	1.316	0.99
174_T	201_F	1.315	0.99
269_K	280_L	1.314	0.99
272_L	318_L	1.306	0.99
137_A	275_A	1.297	0.99
83_A	93_V	1.295	0.99
261_D	314_N	1.294	0.99
256_I	318_L	1.290	0.99
275_A	278_V	1.283	0.98
31_M	49_F	1.282	0.98
168_K	172_S	1.265	0.98
272_L	280_L	1.264	0.98
23_T	334_V	1.261	0.98
86_A	93_V	1.256	0.98
281_Q	294_D	1.251	0.98
84_P	88_K	1.234	0.98
35_T	67_V	1.232	0.98
169_E	173_Q	1.231	0.98
238_A	311_D	1.212	0.98
113_V	137_A	1.197	0.98
246_I	251_S	1.181	0.97
29_F	337_A	1.174	0.97
178_L	201_F	1.173	0.97
134_Q	322_S	1.169	0.97
171_Y	175_Q	1.168	0.97
184_E	187_I	1.167	0.97
69_I	337_A	1.165	0.97
72_F	83_A	1.163	0.97
261_D	313_A	1.161	0.97
272_L	278_V	1.160	0.97
72_F	86_A	1.160	0.97
65_E	89_R	1.159	0.97
19_Q	248_T	1.154	0.97
118_L	339_S	1.153	0.97
236_Q	313_A	1.136	0.97
55_T	58_E	1.134	0.97
255_Y	317_H	1.125	0.97
13_T	38_S	1.120	0.96
195_K	204_I	1.120	0.96
140_E	143_R	1.107	0.96
173_Q	198_Q	1.107	0.96
248_T	296_V	1.105	0.96
251_S	292_P	1.101	0.96
167_V	247_Q	1.100	0.96
299_N	331_W	1.100	0.96
140_E	230_M	1.100	0.96
146_Y	267_D	1.100	0.96
210_F	284_P	1.098	0.96
21_L	36_L	1.094	0.96
42_S	45_T	1.094	0.96
67_V	91_A	1.087	0.96
197_Y	294_D	1.080	0.96
153_V	254_V	1.071	0.95
281_Q	288_L	1.069	0.95
61_P	89_R	1.065	0.95
148_L	256_I	1.064	0.95
87_V	124_I	1.063	0.95
249_G	324_N	1.063	0.95
211_Q	220_M	1.063	0.95
339_S	342_K	1.059	0.95
238_A	317_H	1.053	0.95
183_I	187_I	1.051	0.95
146_Y	271_L	1.051	0.95
7_V	29_F	1.045	0.95
143_R	147_G	1.041	0.95
175_Q	179_N	1.036	0.94
220_M	224_N	1.035	0.94
134_Q	321_V	1.033	0.94
139_L	256_I	1.029	0.94
279_T	302_F	1.028	0.94
112_E	327_K	1.028	0.94
24_L	31_M	1.021	0.94
96_N	127_N	1.019	0.94
112_E	335_Q	1.014	0.94
174_T	178_L	1.013	0.94
145_A	260_R	1.010	0.94
249_G	296_V	1.009	0.94
60_S	63_S	1.008	0.94
226_T	235_L	1.003	0.93
23_T	326_L	1.001	0.93
150_K	311_D	1.000	0.93
207_I	222_M	1.000	0.93
284_P	288_L	1.000	0.93
162_A	204_I	1.000	0.93
172_S	176_A	0.994	0.93
213_N	310_L	0.990	0.93
139_L	151_V	0.986	0.93
258_I	263_A	0.973	0.92
15_A	167_V	0.972	0.92
227_K	235_L	0.971	0.92
56_V	59_A	0.970	0.92
115_E	119_H	0.969	0.92
264_T	308_K	0.966	0.92
206_Q	210_F	0.964	0.92
265_V	269_K	0.962	0.92
69_I	94_I	0.958	0.92
238_A	255_Y	0.955	0.92
227_K	233_P	0.949	0.91
102_M	224_N	0.947	0.91
31_M	54_L	0.945	0.91
138_A	318_L	0.941	0.91
215_Y	220_M	0.936	0.91
135_M	153_V	0.935	0.91
264_T	267_D	0.935	0.91
18_Q	45_T	0.932	0.91
251_S	319_W	0.931	0.91
27_R	299_N	0.930	0.91
134_Q	324_N	0.927	0.90
39_S	42_S	0.927	0.90
61_P	85_E	0.927	0.90
248_T	325_L	0.923	0.90
136_V	230_M	0.922	0.90
248_T	324_N	0.922	0.90
118_L	125_I	0.912	0.90
257_E	315_G	0.901	0.89
23_T	26_D	0.892	0.89
211_Q	224_N	0.887	0.88
60_S	85_E	0.887	0.88
25_E	49_F	0.881	0.88
148_L	235_L	0.876	0.88
129_N	221_K	0.873	0.88
58_E	63_S	0.872	0.88
43_A	58_E	0.872	0.88
135_M	222_M	0.869	0.87
38_S	42_S	0.868	0.87
306_I	316_F	0.867	0.87
211_Q	217_F	0.864	0.87
9_V	36_L	0.864	0.87
35_T	66_G	0.859	0.87
208_D	216_T	0.857	0.87
269_K	273_K	0.856	0.87
138_A	301_V	0.854	0.86
249_G	295_A	0.854	0.86
76_G	98_S	0.853	0.86
21_L	54_L	0.851	0.86
266_E	269_K	0.849	0.86
80_Q	103_D	0.849	0.86
236_Q	311_D	0.845	0.86
311_D	317_H	0.844	0.86
37_L	67_V	0.840	0.86
291_M	294_D	0.836	0.85
142_I	316_F	0.832	0.85
177_I	198_Q	0.831	0.85
111_P	133_I	0.830	0.85
147_G	258_I	0.828	0.85
258_I	268_I	0.827	0.85
87_V	123_G	0.824	0.84
103_D	122_N	0.824	0.84
48_T	51_G	0.823	0.84
22_K	25_E	0.819	0.84
59_A	78_V	0.816	0.84
98_S	217_F	0.815	0.84
146_Y	264_T	0.814	0.84
174_T	200_A	0.811	0.84
25_E	48_T	0.810	0.83
71_L	333_S	0.810	0.83
143_R	258_I	0.801	0.83
139_L	148_L	0.801	0.83
13_T	42_S	0.796	0.82
222_M	241_C	0.796	0.82
223_I	310_L	0.795	0.82
9_V	20_M	0.792	0.82
272_L	275_A	0.792	0.82
138_A	141_P	0.790	0.82
57_Q	63_S	0.787	0.82
167_V	248_T	0.786	0.82
135_M	151_V	0.783	0.81
183_I	186_E	0.782	0.81
220_M	310_L	0.781	0.81
261_D	264_T	0.780	0.81
203_A	242_V	0.778	0.81
13_T	39_S	0.775	0.81
220_M	223_I	0.770	0.80
131_S	155_T	0.768	0.80
269_K	282_D	0.761	0.79
75_G	79_S	0.761	0.79
71_L	337_A	0.760	0.79
260_R	267_D	0.759	0.79
18_Q	47_V	0.759	0.79
47_V	54_L	0.753	0.79
74_A	97_T	0.750	0.78
149_N	314_N	0.749	0.78
263_A	268_I	0.748	0.78
176_A	184_E	0.745	0.78
210_F	217_F	0.745	0.78
210_F	216_T	0.744	0.78
131_S	222_M	0.742	0.78
257_E	312_R	0.742	0.78
92_I	123_G	0.741	0.78
71_L	94_I	0.741	0.78
176_A	183_I	0.740	0.78
33_T	52_Q	0.737	0.77
288_L	291_M	0.736	0.77
138_A	151_V	0.735	0.77
151_V	239_A	0.735	0.77
159_V	167_V	0.735	0.77
138_A	320_V	0.730	0.77
177_I	183_I	0.726	0.76
143_R	259_D	0.725	0.76
109_V	339_S	0.722	0.76
266_E	270_N	0.722	0.76
166_A	195_K	0.721	0.76
197_Y	204_I	0.716	0.75
91_A	123_G	0.711	0.75
258_I	261_D	0.708	0.74
281_Q	302_F	0.707	0.74
130_C	221_K	0.706	0.74
10_V	37_L	0.705	0.74
153_V	222_M	0.704	0.74
204_I	291_M	0.702	0.74
113_V	140_E	0.701	0.74
79_S	100_F	0.701	0.74
204_I	289_Y	0.700	0.74
197_Y	289_Y	0.699	0.73
265_V	268_I	0.698	0.73
9_V	24_L	0.695	0.73
20_M	334_V	0.693	0.73
198_Q	293_A	0.691	0.73
11_G	14_G	0.690	0.72
210_F	289_Y	0.689	0.72
255_Y	311_D	0.686	0.72
297_G	323_D	0.684	0.72
37_L	64_F	0.683	0.72
195_K	199_I	0.682	0.72
240_T	317_H	0.682	0.72
246_I	319_W	0.681	0.71
197_Y	287_Q	0.680	0.71
256_I	272_L	0.679	0.71
152_I	238_A	0.679	0.71
154_S	255_Y	0.676	0.71
76_G	80_Q	0.674	0.71
306_I	318_L	0.673	0.71
5_L	32_D	0.671	0.70
134_Q	252_E	0.671	0.70
146_Y	259_D	0.669	0.70
326_L	331_W	0.669	0.70
254_V	318_L	0.669	0.70
37_L	57_Q	0.667	0.70
177_I	180_K	0.666	0.70
111_P	336_I	0.665	0.70
113_V	136_V	0.664	0.70
5_L	31_M	0.661	0.69
218_E	221_K	0.659	0.69
182_E	185_P	0.658	0.69
137_A	335_Q	0.658	0.69
118_L	340_L	0.658	0.69
40_K	60_S	0.654	0.68
300_D	331_W	0.653	0.68
58_E	61_P	0.648	0.68
208_D	211_Q	0.647	0.68
60_S	81_A	0.646	0.67
35_T	62_E	0.646	0.67
62_E	65_E	0.645	0.67
8_A	70_A	0.645	0.67
240_T	253_S	0.644	0.67
35_T	65_E	0.642	0.67
251_S	321_V	0.640	0.67
263_A	308_K	0.640	0.67
273_K	280_L	0.638	0.66
101_R	161_G	0.637	0.66
36_L	54_L	0.636	0.66
36_L	57_Q	0.631	0.66
296_V	324_N	0.631	0.66
161_G	221_K	0.630	0.66
37_L	63_S	0.630	0.66
135_M	226_T	0.629	0.65
77_S	80_Q	0.627	0.65
67_V	70_A	0.624	0.65
221_K	229_I	0.624	0.65
63_S	66_G	0.624	0.65
130_C	161_G	0.623	0.65
61_P	82_L	0.621	0.64
265_V	280_L	0.620	0.64
277_G	327_K	0.619	0.64
62_E	89_R	0.619	0.64
139_L	321_V	0.618	0.64
71_L	99_A	0.615	0.64
151_V	256_I	0.615	0.64
182_E	187_I	0.615	0.64
7_V	31_M	0.613	0.63
129_N	161_G	0.613	0.63
81_A	84_P	0.613	0.63
142_I	256_I	0.611	0.63
15_A	248_T	0.610	0.63
84_P	93_V	0.609	0.63
144_K	275_A	0.608	0.63
10_V	70_A	0.608	0.63
205_P	208_D	0.608	0.63
277_G	335_Q	0.607	0.63
39_S	78_V	0.606	0.63
271_L	275_A	0.604	0.62
80_Q	217_F	0.602	0.62
6_H	66_G	0.600	0.62
200_A	247_Q	0.599	0.62
131_S	134_Q	0.597	0.61
8_A	37_L	0.594	0.61
151_V	237_V	0.593	0.61
171_Y	177_I	0.593	0.61
284_P	287_Q	0.592	0.61
138_A	275_A	0.592	0.61
218_E	250_H	0.591	0.61
263_A	316_F	0.590	0.60
145_A	265_V	0.588	0.60
153_V	173_Q	0.586	0.60
137_A	327_K	0.585	0.60
60_S	82_L	0.583	0.60
255_Y	312_R	0.582	0.59
59_A	67_V	0.581	0.59
205_P	216_T	0.579	0.59
175_Q	181_E	0.578	0.59
105_N	121_H	0.578	0.59
70_A	83_A	0.577	0.59
46_K	56_V	0.577	0.59
74_A	79_S	0.576	0.59
265_V	316_F	0.574	0.58
10_V	72_F	0.574	0.58
310_L	317_H	0.572	0.58
175_Q	178_L	0.571	0.58
8_A	59_A	0.571	0.58
106_T	122_N	0.570	0.58
196_H	287_Q	0.569	0.58
152_I	253_S	0.567	0.57
92_I	121_H	0.567	0.57
7_V	71_L	0.567	0.57
258_I	316_F	0.567	0.57
201_F	247_Q	0.567	0.57
215_Y	238_A	0.565	0.57
74_A	78_V	0.565	0.57
38_S	56_V	0.563	0.57
112_E	115_E	0.563	0.57
73_S	79_S	0.561	0.57
294_D	302_F	0.561	0.57
29_F	34_L	0.560	0.57
101_R	130_C	0.559	0.56
84_P	87_V	0.559	0.56
238_A	310_L	0.559	0.56
45_T	56_V	0.557	0.56
171_Y	174_T	0.556	0.56
143_R	148_L	0.556	0.56
183_I	198_Q	0.554	0.56
25_E	51_G	0.554	0.56
235_L	318_L	0.553	0.56
162_A	207_I	0.551	0.55
129_N	218_E	0.550	0.55
161_G	243_R	0.549	0.55
136_V	226_T	0.547	0.55
73_S	100_F	0.547	0.55
145_A	263_A	0.545	0.55
20_M	325_L	0.542	0.54
255_Y	310_L	0.542	0.54
150_K	315_G	0.540	0.54
236_Q	312_R	0.540	0.54
134_Q	320_V	0.540	0.54
150_K	255_Y	0.540	0.54
31_M	36_L	0.540	0.54
217_F	224_N	0.540	0.54
9_V	71_L	0.539	0.54
103_D	106_T	0.539	0.54
73_S	96_N	0.534	0.53
146_Y	260_R	0.534	0.53
6_H	68_N	0.533	0.53
295_A	322_S	0.533	0.53
176_A	179_N	0.531	0.53
14_G	39_S	0.531	0.53
55_T	59_A	0.530	0.52
135_M	239_A	0.528	0.52
158_A	248_T	0.528	0.52
223_I	239_A	0.527	0.52
76_G	208_D	0.525	0.52
159_V	195_K	0.524	0.52
19_Q	23_T	0.524	0.52
295_A	302_F	0.523	0.52
77_S	99_A	0.522	0.51
177_I	181_E	0.521	0.51
63_S	86_A	0.520	0.51
58_E	82_L	0.519	0.51
172_S	186_E	0.514	0.50
131_S	199_I	0.513	0.50
71_L	334_V	0.513	0.50
101_R	218_E	0.511	0.50
171_Y	178_L	0.511	0.50
136_V	151_V	0.511	0.50
130_C	243_R	0.510	0.50
100_F	106_T	0.510	0.50
10_V	82_L	0.510	0.50
19_Q	331_W	0.510	0.50
24_L	49_F	0.510	0.50
221_K	243_R	0.509	0.50
175_Q	180_K	0.509	0.50
157_Q	218_E	0.508	0.50
146_Y	308_K	0.508	0.50
77_S	209_K	0.507	0.49
127_N	221_K	0.505	0.49
27_R	30_E	0.504	0.49
161_G	218_E	0.504	0.49
204_I	208_D	0.504	0.49
37_L	86_A	0.504	0.49
92_I	125_I	0.504	0.49
64_F	91_A	0.503	0.49
135_M	237_V	0.502	0.49
72_F	93_V	0.501	0.49
172_S	175_Q	0.500	0.48
130_C	329_A	0.500	0.48

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2yv3A	2	0.948	100	0.242	Contact Map
2r00A	2	0.9624	100	0.259	Contact Map
3pzrA	2	0.9769	100	0.262	Contact Map
3uw3A	2	0.9595	100	0.262	Contact Map
3tz6A	2	0.9393	100	0.264	Contact Map
1t4bA	2	0.9711	100	0.272	Contact Map
2hjsA	2	0.9566	100	0.274	Contact Map
4r3nA	2	0.9682	100	0.275	Contact Map
4dplA	4	0.8699	100	0.371	Contact Map
2ep5A	4	0.8786	100	0.373	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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