GREMLIN Database
DAPA - 4-hydroxy-tetrahydrodipicolinate synthase
UniProt: Q04796 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (283)
Sequences: 10345 (6786)
Seq/√Len: 403.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_Q230_N3.7791.00
30_D67_E3.2751.00
15_D19_N3.1251.00
117_Y151_R3.1011.00
260_L284_S2.8991.00
26_S67_E2.8101.00
22_F59_A2.7201.00
94_E128_S2.6231.00
26_S63_Y2.6181.00
22_F63_Y2.6161.00
58_I92_K2.5031.00
78_T90_T2.4991.00
222_N230_N2.4781.00
196_I201_G2.4211.00
90_T101_V2.2361.00
230_N233_L2.1641.00
30_D71_R2.0441.00
222_N227_Q2.0131.00
7_S39_S2.0131.00
121_K156_I2.0081.00
150_I178_E1.9991.00
217_Q221_K1.9931.00
221_K225_N1.9791.00
125_A156_I1.9781.00
113_Q145_A1.9691.00
31_Y35_N1.9651.00
113_Q148_T1.9521.00
197_L223_Y1.9501.00
83_T119_H1.9081.00
59_A62_E1.8751.00
38_D221_K1.8731.00
121_K125_A1.8691.00
256_T280_R1.8501.00
21_D24_K1.8421.00
114_E118_Q1.8381.00
143_S171_A1.8381.00
54_T85_D1.8241.00
30_D34_K1.8201.00
114_E151_R1.7861.00
26_S66_K1.7821.00
35_N214_T1.7791.00
215_D237_K1.7661.00
29_I64_T1.7401.00
117_Y121_K1.7131.00
65_V74_V1.6901.00
62_E66_K1.6861.00
59_A63_Y1.6821.00
25_L64_T1.6741.00
132_M161_A1.6591.00
8_T209_S1.6411.00
124_A156_I1.6211.00
24_K27_T1.6041.00
103_L123_I1.6001.00
118_Q121_K1.5931.00
56_E269_R1.5621.00
259_Q266_G1.5591.00
145_A148_T1.5581.00
149_T162_I1.5471.00
42_V64_T1.5451.00
94_E127_T1.5271.00
63_Y67_E1.5201.00
61_F76_A1.5161.00
33_L72_V1.4801.00
281_L284_S1.4751.00
13_P25_L1.4701.00
151_R155_D1.4661.00
233_L237_K1.4611.00
25_L60_L1.4471.00
86_S123_I1.4101.00
277_E281_L1.3681.00
118_Q122_A1.3671.00
218_Q222_N1.3641.00
277_E280_R1.3511.00
11_I258_L1.3501.00
7_S41_V1.3441.00
94_E129_L1.3421.00
256_T260_L1.3351.00
38_D217_Q1.3321.00
247_K282_S1.3241.00
218_Q230_N1.3211.00
90_T127_T1.3181.00
92_K95_E1.3141.00
63_Y66_K1.2931.00
54_T88_K1.2931.00
276_T279_E1.2881.00
80_S86_S1.2811.00
82_N85_D1.2781.00
121_K155_D1.2721.00
58_I88_K1.2661.00
214_T218_Q1.2631.00
174_K178_E1.2601.00
4_G224_T1.2571.00
31_Y263_L1.2551.00
87_I122_A1.2491.00
281_L285_S1.2461.00
176_I185_V1.2411.00
132_M205_V1.2371.00
6_V37_T1.2281.00
75_I100_A1.2271.00
58_I62_E1.2251.00
54_T92_K1.2091.00
223_Y228_T1.2081.00
101_V127_T1.2021.00
122_A270_L1.1871.00
29_I68_V1.1821.00
55_E59_A1.1821.00
61_F93_A1.1751.00
194_L231_A1.1751.00
48_E255_K1.1621.00
259_Q264_D1.1541.00
33_L71_R1.1461.00
184_Y202_R1.1441.00
124_A158_N1.1431.00
43_A60_L1.1431.00
19_N84_K1.1401.00
228_T232_A1.1381.00
220_I224_T1.1331.00
68_V74_V1.1311.00
147_E178_E1.1291.00
65_V99_D1.1211.00
15_D21_D1.1201.00
122_A125_A1.1171.00
62_E92_K1.1121.00
91_K95_E1.0991.00
256_T259_Q1.0971.00
122_A126_E1.0911.00
23_Q26_S1.0801.00
58_I95_E1.0771.00
91_K126_E1.0761.00
22_F26_S1.0641.00
62_E96_A1.0621.00
75_I132_M1.0611.00
14_F52_L1.0601.00
218_Q221_K1.0581.00
229_A232_A1.0541.00
29_I67_E1.0421.00
256_T284_S1.0371.00
78_T93_A1.0371.00
101_V129_L1.0341.00
76_A98_V1.0301.00
8_T32_L1.0231.00
275_L283_L1.0211.00
87_I91_K1.0201.00
174_K243_K1.0161.00
275_L279_E1.0151.00
92_K96_A1.0131.00
198_S228_T1.0091.00
152_L159_V1.0061.00
114_E276_T1.0021.00
4_G202_R1.0001.00
257_A287_I0.9991.00
114_E117_Y0.9981.00
24_K265_V0.9971.00
16_N267_S0.9891.00
6_V217_Q0.9881.00
41_V102_M0.9811.00
150_I179_T0.9741.00
230_N234_I0.9721.00
280_R284_S0.9701.00
54_T89_L0.9691.00
8_T37_T0.9681.00
124_A131_V0.9601.00
101_V131_V0.9561.00
26_S30_D0.9541.00
24_K264_D0.9501.00
87_I126_E0.9471.00
79_G104_V0.9441.00
279_E282_S0.9431.00
28_L258_L0.9401.00
55_E88_K0.9391.00
153_A183_F0.9351.00
16_N265_V0.9351.00
282_S285_S0.9351.00
18_G84_K0.9341.00
10_M32_L0.9311.00
222_N234_I0.9311.00
232_A236_Q0.9311.00
57_K89_L0.9281.00
172_I196_I0.9281.00
118_Q273_V0.9261.00
208_A242_M0.9221.00
33_L68_V0.9191.00
88_K92_K0.9171.00
117_Y155_D0.9171.00
65_V98_V0.9141.00
133_L149_T0.9121.00
259_Q280_R0.9121.00
113_Q151_R0.9101.00
244_E286_T0.9071.00
135_N143_S0.9031.00
117_Y148_T0.9011.00
80_S85_D0.8991.00
105_T142_A0.8971.00
78_T101_V0.8941.00
116_M142_A0.8901.00
38_D220_I0.8891.00
88_K91_K0.8881.00
74_V98_V0.8881.00
65_V96_A0.8871.00
266_G280_R0.8801.00
14_F269_R0.8751.00
146_P178_E0.8751.00
212_A241_I0.8731.00
198_S232_A0.8661.00
197_L220_I0.8631.00
219_M234_I0.8581.00
206_S209_S0.8581.00
29_I63_Y0.8561.00
278_D281_L0.8501.00
186_Y203_G0.8491.00
18_G270_L0.8491.00
37_T213_G0.8471.00
193_T204_V0.8461.00
91_K94_E0.8451.00
124_A159_V0.8421.00
278_D282_S0.8411.00
6_V220_I0.8331.00
42_V60_L0.8321.00
103_L131_V0.8281.00
156_I159_V0.8211.00
10_M40_L0.8201.00
83_T87_I0.8151.00
198_S223_Y0.8111.00
226_G229_A0.8051.00
6_V204_V0.8031.00
187_S196_I0.8001.00
266_G274_P0.7951.00
27_T263_L0.7901.00
259_Q265_V0.7891.00
23_Q27_T0.7881.00
260_L280_R0.7871.00
55_E58_I0.7871.00
146_P171_A0.7841.00
61_F96_A0.7761.00
146_P150_I0.7731.00
117_Y156_I0.7721.00
43_A76_A0.7721.00
18_G267_S0.7721.00
239_L243_K0.7681.00
229_A233_L0.7661.00
52_L60_L0.7661.00
10_M25_L0.7651.00
146_P174_K0.7641.00
61_F98_V0.7631.00
218_Q234_I0.7621.00
212_A238_L0.7591.00
235_H239_L0.7541.00
212_A215_D0.7521.00
25_L29_I0.7521.00
45_T108_Y0.7511.00
6_V209_S0.7501.00
35_N213_G0.7501.00
84_K88_K0.7441.00
93_A98_V0.7401.00
179_T202_R0.7391.00
97_G129_L0.7361.00
215_D218_Q0.7351.00
195_P198_S0.7321.00
39_S75_I0.7301.00
252_A268_V0.7271.00
118_Q270_L0.7261.00
15_D267_S0.7201.00
149_T175_I0.7191.00
15_D18_G0.7171.00
29_I40_L0.7101.00
86_S103_L0.7091.00
40_L68_V0.7081.00
113_Q147_E0.7061.00
20_V25_L0.7041.00
15_D23_Q0.7041.00
134_Y163_K0.7031.00
105_T144_L0.7021.00
219_M223_Y0.7001.00
68_V71_R0.7001.00
58_I89_L0.6991.00
247_K279_E0.6971.00
73_P99_D0.6961.00
174_K177_A0.6931.00
176_I179_T0.6911.00
268_V272_L0.6881.00
172_I185_V0.6881.00
136_V140_T0.6831.00
143_S168_D0.6821.00
43_A52_L0.6810.99
33_L67_E0.6800.99
258_L261_R0.6800.99
214_T261_R0.6780.99
58_I96_A0.6770.99
49_S77_G0.6770.99
144_L149_T0.6750.99
121_K151_R0.6740.99
135_N164_E0.6710.99
32_L35_N0.6700.99
173_T177_A0.6690.99
252_A275_L0.6680.99
20_V60_L0.6680.99
83_T122_A0.6660.99
194_L223_Y0.6650.99
170_E191_A0.6620.99
58_I93_A0.6620.99
78_T103_L0.6620.99
54_T58_I0.6610.99
112_S252_A0.6610.99
133_L144_L0.6600.99
21_D264_D0.6600.99
147_E174_K0.6550.99
115_G273_V0.6540.99
62_E95_E0.6510.99
194_L228_T0.6510.99
61_F65_V0.6510.99
7_S75_I0.6500.99
32_L37_T0.6490.99
68_V72_V0.6490.99
195_P199_V0.6460.99
275_L280_R0.6450.99
267_S274_P0.6420.99
28_L32_L0.6410.99
248_A279_E0.6410.99
10_M64_T0.6370.99
132_M160_V0.6360.99
153_A179_T0.6350.99
176_I202_R0.6350.99
246_F250_N0.6340.99
53_S84_K0.6320.99
31_Y261_R0.6320.99
128_S158_N0.6310.99
258_L263_L0.6310.99
193_T219_M0.6310.99
30_D33_L0.6300.99
225_N230_N0.6290.99
260_L287_I0.6260.99
50_P109_N0.6250.99
179_T182_D0.6210.99
147_E150_I0.6170.99
85_D88_K0.6160.99
222_N225_N0.6130.99
160_V184_Y0.6100.99
177_A236_Q0.6090.99
112_S115_G0.6090.99
282_S286_T0.6070.99
125_A158_N0.6050.99
70_G99_D0.6010.99
173_T235_H0.6000.99
14_F56_E0.5970.99
42_V74_V0.5920.99
173_T199_V0.5910.99
41_V75_I0.5870.99
164_E172_I0.5840.98
22_F67_E0.5830.98
256_T268_V0.5820.98
43_A57_K0.5800.98
20_V63_Y0.5800.98
98_V129_L0.5790.98
172_I176_I0.5780.98
268_V273_V0.5760.98
257_A260_L0.5750.98
233_L236_Q0.5740.98
221_K224_T0.5730.98
249_P253_P0.5730.98
211_I257_A0.5730.98
105_T120_F0.5720.98
148_T151_R0.5720.98
144_L148_T0.5710.98
177_A240_P0.5710.98
36_G217_Q0.5700.98
250_N253_P0.5700.98
112_S248_A0.5690.98
277_E284_S0.5690.98
194_L235_H0.5690.98
195_P235_H0.5680.98
75_I102_M0.5670.98
4_G38_D0.5630.98
45_T134_Y0.5620.98
253_P275_L0.5600.98
169_L192_L0.5550.98
161_A184_Y0.5550.98
127_T158_N0.5540.98
114_E273_V0.5510.98
119_H122_A0.5470.98
65_V69_N0.5460.98
234_I237_K0.5460.98
173_T195_P0.5440.98
90_T123_I0.5420.98
175_I185_V0.5410.97
87_I123_I0.5400.97
257_A283_L0.5360.97
37_T217_Q0.5360.97
168_D171_A0.5360.97
9_A207_V0.5350.97
55_E92_K0.5340.97
110_K138_G0.5320.97
197_L224_T0.5310.97
11_I254_V0.5310.97
94_E126_E0.5290.97
43_A61_F0.5280.97
76_A93_A0.5280.97
248_A276_T0.5270.97
10_M29_I0.5270.97
194_L198_S0.5260.97
132_M184_Y0.5240.97
103_L120_F0.5240.97
211_I254_V0.5230.97
193_T216_M0.5230.97
28_L31_Y0.5200.97
207_V254_V0.5190.97
40_L72_V0.5180.97
152_L156_I0.5180.97
64_T68_V0.5170.97
66_K69_N0.5160.97
9_A206_S0.5140.97
100_A160_V0.5110.96
223_Y231_A0.5090.96
31_Y213_G0.5070.96
208_A212_A0.5050.96
89_L93_A0.5050.96
19_N59_A0.5030.96
211_I258_L0.5030.96
193_T220_I0.5030.96
185_V196_I0.5020.96
53_S88_K0.5020.96
215_D234_I0.5020.96
84_K122_A0.5010.96
51_T83_T0.5010.96
32_L209_S0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eb2A 3 0.9966 100 0.023 Contact Map
4pfmA 2 0.9931 100 0.026 Contact Map
3si9A 3 1 100 0.027 Contact Map
3na8A 3 1 100 0.027 Contact Map
1xkyA 3 0.9966 100 0.028 Contact Map
3qzeA 2 0.9897 100 0.029 Contact Map
4i7wA 3 0.9897 100 0.029 Contact Map
3fluA 3 0.9966 100 0.03 Contact Map
3a5fA 3 0.9897 100 0.033 Contact Map
2ehhA 3 0.9931 100 0.033 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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