GREMLIN Database
AK1 - Aspartokinase 1
UniProt: Q04795 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 404 (385)
Sequences: 4790 (2757)
Seq/√Len: 140.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_V135_A4.3551.00
96_K134_D4.1371.00
145_T149_D3.9141.00
358_K399_V3.8811.00
388_D391_P3.6531.00
138_V165_L3.4221.00
37_V169_V3.3681.00
166_G174_I3.1321.00
208_L345_V2.8701.00
40_V83_S2.7971.00
100_L129_V2.7701.00
361_S365_E2.7491.00
27_K93_N2.7301.00
199_V246_T2.6931.00
323_Q327_M2.6711.00
87_T97_A2.6441.00
20_K93_N2.6071.00
173_Y232_R2.5681.00
24_G93_N2.5451.00
22_A86_F2.5371.00
181_E238_S2.5251.00
232_R244_L2.5021.00
338_N386_E2.4811.00
272_T316_G2.4641.00
267_H389_M2.4411.00
27_K95_V2.3901.00
98_A134_D2.3741.00
21_L24_G2.3501.00
291_K295_N2.3401.00
342_V396_L2.2231.00
83_S139_A2.1961.00
26_I38_V2.1881.00
111_D145_T2.1681.00
11_T14_K2.1421.00
51_A54_S2.1381.00
203_T225_M2.1031.00
269_K390_V2.0531.00
349_I354_G2.0401.00
56_L71_Q2.0321.00
198_P241_K2.0141.00
28_E239_N1.9391.00
109_T151_T1.9211.00
27_K135_A1.9071.00
56_L75_L1.8971.00
193_N398_E1.8941.00
11_T44_G1.8381.00
76_S150_T1.8361.00
170_D227_A1.8261.00
91_L96_K1.8201.00
124_E128_S1.8061.00
19_R86_F1.8051.00
228_K247_S1.7931.00
366_K391_P1.7911.00
319_T335_V1.7881.00
269_K386_E1.7741.00
40_V86_F1.7601.00
26_I90_L1.7561.00
45_R51_A1.7351.00
165_L169_V1.7321.00
175_D232_R1.7281.00
163_A174_I1.7181.00
385_H388_D1.7001.00
72_D114_T1.6961.00
224_A231_I1.6951.00
27_K90_L1.6901.00
123_P127_F1.6761.00
316_G337_R1.6741.00
24_G27_K1.6511.00
363_L392_A1.6491.00
327_M330_G1.6491.00
37_V138_V1.6471.00
391_P394_N1.6471.00
365_E399_V1.6441.00
102_G105_A1.6221.00
197_L200_V1.6201.00
45_R214_K1.6111.00
23_L93_N1.6091.00
287_T294_A1.6021.00
98_A136_V1.5761.00
125_R129_V1.5571.00
178_T233_V1.5461.00
369_P373_S1.5421.00
295_N328_D1.5301.00
181_E184_M1.5091.00
286_Q310_I1.4831.00
29_A175_D1.4811.00
265_I393_V1.4771.00
126_L136_V1.4571.00
89_M93_N1.4481.00
71_Q75_L1.4441.00
44_G53_D1.4291.00
109_T143_G1.4271.00
57_G60_Y1.4251.00
8_F25_H1.4201.00
25_H239_N1.4061.00
103_A150_T1.4011.00
323_Q335_V1.3921.00
359_I382_V1.3811.00
362_A399_V1.3811.00
324_R328_D1.3671.00
45_R54_S1.3601.00
366_K395_A1.3461.00
18_G21_L1.3411.00
118_I164_A1.3401.00
340_A389_M1.3351.00
359_I396_L1.3291.00
20_K92_D1.3281.00
34_Y172_E1.3261.00
69_R149_D1.3241.00
316_G386_E1.3201.00
302_F383_L1.3191.00
77_C81_I1.3091.00
67_S91_L1.2981.00
24_G28_E1.2871.00
274_F322_A1.2841.00
14_K44_G1.2801.00
21_L236_T1.2741.00
100_L136_V1.2691.00
4_I34_Y1.2661.00
292_A325_I1.2631.00
29_A32_E1.2611.00
28_E32_E1.2531.00
181_E235_S1.2381.00
57_G61_G1.2371.00
39_V165_L1.2331.00
175_D234_R1.2271.00
186_A267_H1.2181.00
128_S131_A1.2171.00
185_T397_H1.2161.00
342_V392_A1.2101.00
272_T319_T1.2081.00
121_M125_R1.2041.00
19_R89_M1.2041.00
279_K284_N1.1991.00
342_V393_V1.1911.00
128_S132_N1.1901.00
35_K131_A1.1871.00
58_L62_D1.1841.00
116_A151_T1.1811.00
174_I224_A1.1741.00
390_V394_N1.1701.00
90_L95_V1.1681.00
23_L89_M1.1610.99
6_Q29_A1.1490.99
126_L165_L1.1490.99
26_I135_A1.1480.99
110_N116_A1.1460.99
15_D18_G1.1450.99
362_A395_A1.1400.99
96_K133_H1.1370.99
113_H116_A1.1310.99
296_A328_D1.1300.99
12_S236_T1.1240.99
3_I172_E1.1200.99
74_L84_V1.1120.99
103_A144_A1.1070.99
23_L27_K1.1040.99
270_D316_G1.1020.99
108_L146_E1.0990.99
181_E240_D1.0970.99
29_A36_V1.0940.99
90_L137_V1.0940.99
324_R327_M1.0920.99
25_H236_T1.0920.99
200_V263_T1.0880.99
127_F131_A1.0790.99
276_V289_V1.0780.99
190_V393_V1.0750.99
320_E337_R1.0740.99
111_D147_K1.0710.99
361_S399_V1.0700.99
22_A26_I1.0670.99
76_S80_T1.0660.99
107_F161_S1.0650.99
338_N385_H1.0640.99
199_V244_L1.0630.99
286_Q305_I1.0590.99
371_L385_H1.0570.99
301_D313_T1.0540.99
277_P332_D1.0530.99
173_Y244_L1.0500.99
44_G51_A1.0450.99
127_F170_D1.0430.99
87_T91_L1.0360.99
18_G236_T1.0360.99
292_A296_A1.0350.99
59_L63_Q1.0350.99
11_T45_R1.0330.99
274_F314_V1.0320.99
88_S91_L1.0300.99
296_A321_T1.0280.99
275_K311_V1.0230.99
216_I245_V1.0170.99
272_T337_R1.0120.99
51_A81_I1.0110.99
273_Q371_L1.0100.99
186_A393_V1.0100.99
167_A229_V1.0080.99
59_L74_L1.0080.99
42_A52_T1.0060.99
16_D20_K1.0060.99
321_T329_M1.0050.98
59_L71_Q0.9920.98
349_I355_V0.9860.98
11_T178_T0.9800.98
125_R128_S0.9800.98
113_H145_T0.9730.98
298_I325_I0.9570.98
109_T113_H0.9540.98
63_Q92_D0.9510.98
108_L144_A0.9480.98
87_T99_A0.9450.98
119_I146_E0.9430.98
56_L60_Y0.9320.98
98_A129_V0.9310.98
268_V271_V0.9280.97
26_I86_F0.9270.97
102_G139_A0.9260.97
129_V134_D0.9210.97
301_D341_K0.9160.97
344_A359_I0.9160.97
340_A386_E0.9140.97
145_T151_T0.9090.97
6_Q175_D0.9070.97
342_V384_V0.9050.97
83_S99_A0.9010.97
328_D331_Y0.9010.97
26_I137_V0.9000.97
68_P114_T0.8970.97
3_I35_K0.8970.97
37_V136_V0.8970.97
284_N369_P0.8940.97
20_K89_M0.8930.97
354_G377_H0.8850.97
269_K389_M0.8850.97
211_Q343_S0.8830.97
286_Q303_F0.8830.97
279_K285_V0.8830.97
184_M194_A0.8830.97
13_V40_V0.8810.97
110_N113_H0.8800.97
4_I173_Y0.8790.96
37_V165_L0.8700.96
343_S381_W0.8690.96
37_V130_L0.8670.96
350_M377_H0.8660.96
326_L329_M0.8650.96
86_F137_V0.8640.96
102_G138_V0.8620.96
180_V215_V0.8590.96
18_G237_Y0.8580.96
161_S165_L0.8580.96
293_M300_V0.8560.96
356_T360_V0.8560.96
29_A34_Y0.8560.96
199_V248_H0.8510.96
302_F381_W0.8480.96
111_D116_A0.8470.96
315_A318_K0.8410.95
3_I34_Y0.8410.95
19_R43_M0.8380.95
336_T371_L0.8380.95
368_I392_A0.8380.95
109_T116_A0.8340.95
73_L99_A0.8310.95
191_V393_V0.8280.95
326_L330_G0.8250.95
398_E401_E0.8230.95
338_N387_A0.8200.95
261_L355_V0.8180.95
192_E394_N0.8170.95
59_L62_D0.8170.95
101_T139_A0.8160.95
306_T311_V0.8160.95
101_T105_A0.8160.95
72_D152_T0.8150.95
186_A191_V0.8110.95
286_Q300_V0.8090.94
13_V82_S0.8030.94
289_V310_I0.8010.94
366_K388_D0.8000.94
201_T204_E0.7970.94
370_I373_S0.7950.94
369_P374_A0.7950.94
35_K134_D0.7940.94
341_K381_W0.7930.94
21_L25_H0.7910.94
35_K133_H0.7890.94
269_K340_A0.7890.94
110_N117_K0.7880.94
3_I6_Q0.7860.94
84_V88_S0.7840.93
129_V136_V0.7840.93
218_P223_I0.7820.93
267_H393_V0.7810.93
23_L86_F0.7810.93
290_F300_V0.7770.93
108_L119_I0.7750.93
321_T324_R0.7740.93
190_V267_H0.7740.93
339_C383_L0.7670.93
184_M216_I0.7650.93
278_A307_P0.7640.93
159_D179_D0.7640.93
344_A380_I0.7630.93
221_V231_I0.7620.92
86_F90_L0.7620.92
264_G345_V0.7600.92
318_K321_T0.7570.92
53_D155_R0.7550.92
219_R222_E0.7540.92
186_A265_I0.7490.92
115_N318_K0.7480.92
23_L90_L0.7480.92
368_I391_P0.7470.92
11_T51_A0.7430.92
216_I231_I0.7400.91
11_T15_D0.7390.91
216_I220_A0.7380.91
91_L97_A0.7380.91
291_K361_S0.7370.91
199_V250_S0.7360.91
287_T291_K0.7360.91
357_S364_S0.7350.91
364_S369_P0.7340.91
221_V245_V0.7330.91
102_G142_Q0.7300.91
108_L122_K0.7300.91
327_M332_D0.7220.90
285_V310_I0.7200.90
277_P334_M0.7190.90
201_T247_S0.7160.90
37_V161_S0.7150.90
363_L368_I0.7140.90
99_A139_A0.7130.90
66_I71_Q0.7130.90
62_D92_D0.7120.90
97_A137_V0.7110.90
284_N305_I0.7100.90
108_L120_E0.7070.89
293_M312_Y0.7040.89
72_D143_G0.7040.89
311_V372_Q0.7010.89
15_D43_M0.6980.89
44_G214_K0.6980.89
362_A366_K0.6960.89
271_V315_A0.6960.89
80_T150_T0.6960.89
272_T314_V0.6950.89
270_D317_N0.6930.88
321_T328_D0.6920.88
302_F374_A0.6920.88
8_F12_S0.6900.88
326_L333_P0.6880.88
293_M298_I0.6860.88
359_I380_I0.6850.88
7_K10_G0.6840.88
110_N115_N0.6840.88
298_I321_T0.6820.88
183_V215_V0.6820.88
336_T385_H0.6820.88
290_F299_S0.6790.87
62_D88_S0.6790.87
136_V139_A0.6780.87
21_L237_Y0.6770.87
384_V389_M0.6760.87
320_E323_Q0.6750.87
339_C371_L0.6740.87
81_I84_V0.6730.87
349_I377_H0.6720.87
83_S137_V0.6710.87
336_T339_C0.6710.87
199_V249_H0.6700.87
220_A223_I0.6690.87
176_I183_V0.6670.86
183_V205_I0.6670.86
281_G284_N0.6670.86
360_V370_I0.6620.86
322_A326_L0.6620.86
361_S364_S0.6590.86
283_Y286_Q0.6590.86
368_I395_A0.6590.86
80_T101_T0.6570.86
292_A329_M0.6570.86
183_V243_T0.6560.86
101_T150_T0.6550.85
190_V269_K0.6550.85
341_K383_L0.6520.85
271_V301_D0.6520.85
235_S238_S0.6510.85
289_V326_L0.6490.85
8_F13_V0.6490.85
108_L148_G0.6460.85
271_V313_T0.6460.85
293_M319_T0.6440.85
100_L105_A0.6440.85
195_K199_V0.6420.84
14_K237_Y0.6410.84
28_E240_D0.6380.84
289_V333_P0.6350.84
8_F29_A0.6350.84
286_Q369_P0.6350.84
167_A227_A0.6340.84
354_G369_P0.6330.84
222_E226_Q0.6320.83
178_T215_V0.6320.83
96_K132_N0.6300.83
160_T220_A0.6290.83
17_K20_K0.6280.83
286_Q373_S0.6280.83
97_A135_A0.6280.83
290_F310_I0.6270.83
185_T195_K0.6270.83
284_N299_S0.6270.83
58_L63_Q0.6260.83
80_T83_S0.6260.83
298_I322_A0.6250.83
369_P372_Q0.6250.83
273_Q311_V0.6250.83
18_G22_A0.6240.83
62_D89_M0.6240.83
161_S223_I0.6240.83
281_G286_Q0.6230.83
5_V171_A0.6220.82
387_A391_P0.6220.82
186_A397_H0.6210.82
288_E329_M0.6210.82
122_K127_F0.6200.82
13_V43_M0.6200.82
182_G196_P0.6180.82
277_P308_S0.6170.82
220_A224_A0.6150.82
290_F303_F0.6150.82
284_N310_I0.6140.82
395_A399_V0.6140.82
71_Q114_T0.6120.81
298_I314_V0.6110.81
176_I215_V0.6110.81
108_L125_R0.6110.81
101_T144_A0.6090.81
105_A126_L0.6080.81
8_F175_D0.6070.81
14_K18_G0.6070.81
68_P321_T0.6060.81
104_Q129_V0.6060.81
289_V329_M0.6060.81
124_E127_F0.6050.81
363_L382_V0.6020.80
14_K43_M0.6020.80
107_F121_M0.6010.80
77_C80_T0.6000.80
370_I374_A0.5990.80
391_P395_A0.5980.80
372_Q383_L0.5980.80
234_R239_N0.5980.80
65_A320_E0.5970.80
89_M92_D0.5930.79
178_T236_T0.5930.79
22_A38_V0.5930.79
195_K260_R0.5930.79
217_S231_I0.5900.79
160_T217_S0.5860.79
156_G220_A0.5860.79
157_G179_D0.5860.79
275_K334_M0.5840.78
176_I214_K0.5820.78
112_Q115_N0.5820.78
296_A325_I0.5810.78
12_S178_T0.5800.78
32_E358_K0.5790.78
355_V380_I0.5790.78
267_H342_V0.5790.78
185_T194_A0.5780.78
129_V132_N0.5780.78
304_N374_A0.5780.78
358_K362_A0.5780.78
290_F301_D0.5780.78
41_S52_T0.5770.77
45_R53_D0.5770.77
354_G357_S0.5760.77
392_A395_A0.5760.77
279_K307_P0.5760.77
107_F110_N0.5760.77
217_S223_I0.5760.77
8_F239_N0.5750.77
12_S176_I0.5740.77
85_V104_Q0.5730.77
6_Q25_H0.5720.77
300_V303_F0.5720.77
72_D113_H0.5710.77
4_I29_A0.5700.77
104_Q144_A0.5680.76
385_H395_A0.5680.76
184_M196_P0.5660.76
384_V392_A0.5650.76
207_N210_Y0.5650.76
12_S215_V0.5640.76
20_K24_G0.5620.76
267_H340_A0.5610.76
263_T266_A0.5610.76
207_N360_V0.5600.75
366_K392_A0.5590.75
113_H149_D0.5580.75
87_T137_V0.5560.75
320_E327_M0.5560.75
22_A236_T0.5550.75
224_A227_A0.5530.74
40_V82_S0.5530.74
327_M331_Y0.5530.74
80_T103_A0.5520.74
365_E387_A0.5520.74
349_I356_T0.5520.74
72_D154_G0.5500.74
283_Y369_P0.5490.74
289_V312_Y0.5470.74
36_V166_G0.5470.74
130_L136_V0.5460.74
202_Y230_P0.5460.74
6_Q236_T0.5450.73
162_A174_I0.5440.73
216_I233_V0.5440.73
72_D116_A0.5430.73
52_T78_G0.5420.73
131_A250_S0.5420.73
123_P168_A0.5410.73
205_I211_Q0.5410.73
270_D386_E0.5410.73
279_K309_E0.5410.73
302_F313_T0.5410.73
356_T373_S0.5410.73
120_E123_P0.5380.72
260_R263_T0.5380.72
108_L145_T0.5380.72
337_R391_P0.5370.72
3_I127_F0.5370.72
59_L66_I0.5330.72
73_L150_T0.5330.72
357_S361_S0.5330.72
116_A143_G0.5330.72
284_N307_P0.5320.72
206_C305_I0.5310.72
273_Q336_T0.5300.71
226_Q260_R0.5290.71
365_E398_E0.5280.71
163_A224_A0.5280.71
139_A150_T0.5280.71
51_A58_L0.5270.71
72_D151_T0.5270.71
83_S101_T0.5260.71
111_D146_E0.5250.71
13_V22_A0.5250.71
119_I122_K0.5240.71
246_T249_H0.5230.70
360_V369_P0.5210.70
279_K283_Y0.5210.70
384_V394_N0.5210.70
64_S67_S0.5210.70
358_K401_E0.5200.70
72_D109_T0.5190.70
282_Q285_V0.5190.70
293_M322_A0.5180.70
141_F158_S0.5180.70
111_D119_I0.5160.69
262_I265_I0.5160.69
175_D235_S0.5150.69
178_T189_R0.5140.69
274_F298_I0.5130.69
178_T264_G0.5100.68
230_P244_L0.5090.68
4_I175_D0.5090.68
275_K309_E0.5080.68
113_H151_T0.5080.68
356_T377_H0.5070.68
61_G64_S0.5070.68
164_A219_R0.5030.67
306_T309_E0.5030.67
282_Q288_E0.5000.67
300_V309_E0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j0wA 2 0.9505 100 0.234 Contact Map
2cdqA 2 0.9653 100 0.246 Contact Map
3l76A 2 0.9629 100 0.25 Contact Map
3ab4A 7 0.9233 100 0.251 Contact Map
3c1mA 3 0.9653 100 0.264 Contact Map
3tviA 2 0.9604 100 0.274 Contact Map
4ab7A 3 0.8639 100 0.642 Contact Map
1ybdA 5 0.5347 100 0.707 Contact Map
2a1fA 5 0.5545 100 0.708 Contact Map
2j4jA 5 0.5124 100 0.709 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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