ILVX - BACSU - GREMLIN Contacts

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ILVX - Acetolactate synthase

UniProt:	Q04789	Sequences: MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVFDALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEGDPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASAGQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVGMKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLEQADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINHIEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVTVTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGDGGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYAESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMKTKAL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	570 (533)
Sequences:	14315 (9055)
Seq/√Len:	392.2

ECOLI - ILVB GCL ILVG ILVI OXC POXB MEND
BACSU - ILVX ILVB IOLD YDAP MEND
HALSA - MEND
SULSO - Q7LXT8 Q97ZB3 Q97UP3 Q97U16 Q980V7 Q97V62 Q97XR3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
506_K	509_E	4.915	1.00
476_N	541_D	3.784	1.00
382_E	525_A	3.668	1.00
64_A	94_G	3.612	1.00
235_K	256_E	3.471	1.00
516_L	530_Q	3.364	1.00
229_A	333_N	3.207	1.00
30_T	76_K	3.041	1.00
520_S	523_Q	3.014	1.00
517_R	543_P	2.915	1.00
201_S	338_D	2.863	1.00
229_A	329_P	2.789	1.00
386_A	529_R	2.700	1.00
73_L	439_K	2.661	1.00
326_G	331_T	2.646	1.00
25_V	51_G	2.581	1.00
217_V	230_V	2.557	1.00
254_D	411_Y	2.551	1.00
516_L	538_V	2.510	1.00
514_T	536_G	2.498	1.00
382_E	385_N	2.424	1.00
519_E	523_Q	2.423	1.00
31_H	53_E	2.414	1.00
284_I	328_I	2.376	1.00
25_V	50_K	2.360	1.00
432_A	446_S	2.317	1.00
203_A	305_I	2.317	1.00
278_A	281_V	2.276	1.00
516_L	527_V	2.275	1.00
82_V	91_L	2.245	1.00
385_N	525_A	2.152	1.00
503_D	506_K	2.132	1.00
514_T	530_Q	2.130	1.00
517_R	541_D	2.127	1.00
454_L	511_F	2.120	1.00
77_P	159_S	2.104	1.00
307_L	331_T	2.102	1.00
439_K	442_E	2.099	1.00
89_S	93_T	2.047	1.00
283_T	286_Y	2.031	1.00
18_E	46_A	2.026	1.00
106_V	155_F	2.025	1.00
57_A	63_A	2.024	1.00
206_K	322_L	1.996	1.00
95_L	107_A	1.990	1.00
507_Y	510_S	1.976	1.00
215_V	234_L	1.939	1.00
206_K	280_V	1.932	1.00
109_A	167_F	1.920	1.00
129_A	132_Q	1.911	1.00
206_K	303_T	1.869	1.00
388_D	391_V	1.856	1.00
150_A	168_V	1.849	1.00
505_V	515_G	1.848	1.00
207_I	282_L	1.843	1.00
236_K	336_E	1.843	1.00
518_V	527_V	1.836	1.00
77_P	106_V	1.833	1.00
22_D	26_E	1.826	1.00
453_F	457_A	1.803	1.00
68_Q	72_R	1.798	1.00
436_S	469_P	1.790	1.00
234_L	241_F	1.780	1.00
464_V	513_A	1.769	1.00
202_A	205_A	1.744	1.00
232_K	236_K	1.742	1.00
205_A	209_T	1.732	1.00
197_D	334_H	1.730	1.00
126_D	129_A	1.727	1.00
236_K	340_V	1.726	1.00
18_E	49_D	1.720	1.00
384_R	409_R	1.720	1.00
529_R	533_N	1.714	1.00
196_A	199_A	1.713	1.00
525_A	529_R	1.711	1.00
514_T	538_V	1.704	1.00
474_V	539_I	1.697	1.00
531_G	540_I	1.679	1.00
523_Q	526_D	1.673	1.00
392_T	435_A	1.669	1.00
14_N	22_D	1.660	1.00
215_V	282_L	1.656	1.00
215_V	239_L	1.654	1.00
231_R	235_K	1.636	1.00
396_D	448_S	1.635	1.00
494_T	498_D	1.627	1.00
381_K	385_N	1.593	1.00
228_K	232_K	1.580	1.00
143_D	146_N	1.576	1.00
519_E	543_P	1.573	1.00
427_V	431_W	1.570	1.00
396_D	452_G	1.568	1.00
34_G	54_I	1.559	1.00
139_V	168_V	1.542	1.00
509_E	514_T	1.539	1.00
44_F	54_I	1.537	1.00
383_L	447_V	1.535	1.00
22_D	25_V	1.527	1.00
135_T	167_F	1.521	1.00
74_T	438_V	1.501	1.00
436_S	468_A	1.489	1.00
241_F	251_L	1.488	1.00
505_V	517_R	1.482	1.00
136_K	164_G	1.477	1.00
417_M	435_A	1.477	1.00
284_I	307_L	1.476	1.00
199_A	202_A	1.475	1.00
20_V	170_F	1.474	1.00
238_Q	258_Q	1.474	1.00
314_I	325_I	1.473	1.00
526_D	530_Q	1.471	1.00
494_T	497_V	1.467	1.00
378_E	521_P	1.466	1.00
210_A	213_P	1.465	1.00
463_A	513_A	1.456	1.00
23_C	152_T	1.455	1.00
207_I	280_V	1.454	1.00
277_Q	354_D	1.436	1.00
415_T	442_E	1.436	1.00
386_A	525_A	1.433	1.00
460_L	513_A	1.424	1.00
391_V	443_K	1.423	1.00
526_D	529_R	1.411	1.00
20_V	151_V	1.407	1.00
91_L	107_A	1.403	1.00
108_L	170_F	1.402	1.00
378_E	382_E	1.402	1.00
463_A	470_I	1.400	1.00
144_V	177_E	1.397	1.00
473_I	528_L	1.392	1.00
62_N	459_E	1.390	1.00
473_I	540_I	1.390	1.00
57_A	66_M	1.369	1.00
382_E	386_A	1.364	1.00
457_A	507_Y	1.360	1.00
204_I	335_I	1.357	1.00
106_V	158_A	1.343	1.00
232_K	336_E	1.341	1.00
349_Q	353_S	1.341	1.00
233_L	237_V	1.339	1.00
356_K	359_M	1.339	1.00
280_V	305_I	1.339	1.00
388_D	443_K	1.335	1.00
204_I	338_D	1.334	1.00
27_Q	155_F	1.334	1.00
95_L	105_V	1.332	1.00
210_A	280_V	1.331	1.00
114_R	173_D	1.330	1.00
77_P	155_F	1.328	1.00
303_T	321_D	1.326	1.00
53_E	466_L	1.321	1.00
445_V	532_M	1.315	1.00
21_V	50_K	1.308	1.00
379_I	542_V	1.298	1.00
471_V	531_G	1.289	1.00
389_D	411_Y	1.288	1.00
473_I	542_V	1.287	1.00
31_H	437_L	1.285	1.00
88_A	109_A	1.285	1.00
433_I	463_A	1.281	1.00
284_I	332_I	1.277	1.00
387_V	445_V	1.277	1.00
200_I	338_D	1.272	1.00
425_L	455_F	1.268	1.00
437_L	468_A	1.268	1.00
214_V	278_A	1.267	1.00
201_S	205_A	1.266	1.00
64_A	91_L	1.261	1.00
469_P	536_G	1.261	1.00
392_T	439_K	1.257	1.00
141_V	147_I	1.255	1.00
27_Q	152_T	1.254	1.00
507_Y	511_F	1.253	1.00
146_N	149_E	1.249	1.00
329_P	333_N	1.247	1.00
505_V	509_E	1.243	1.00
436_S	443_K	1.243	1.00
478_S	501_N	1.242	1.00
233_L	332_I	1.236	1.00
354_D	358_Y	1.232	1.00
233_L	336_E	1.232	1.00
315_D	320_P	1.230	1.00
356_K	360_H	1.227	1.00
231_R	252_S	1.224	1.00
374_A	542_V	1.223	1.00
195_A	331_T	1.222	1.00
151_V	168_V	1.220	1.00
22_D	50_K	1.213	1.00
443_K	532_M	1.210	1.00
149_E	153_N	1.209	1.00
446_S	472_H	1.208	1.00
68_Q	97_T	1.203	1.00
230_V	332_I	1.203	1.00
55_I	437_L	1.198	1.00
351_I	355_L	1.195	1.00
524_L	542_V	1.193	1.00
374_A	379_I	1.191	1.00
355_L	359_M	1.185	1.00
469_P	535_E	1.185	1.00
508_A	513_A	1.183	1.00
15_R	18_E	1.182	1.00
70_V	438_V	1.182	1.00
17_A	46_A	1.181	1.00
506_K	510_S	1.176	1.00
33_F	70_V	1.171	1.00
327_D	330_S	1.168	1.00
357_Q	361_E	1.168	1.00
513_A	539_I	1.163	1.00
71_G	104_P	1.160	1.00
16_G	147_I	1.160	1.00
23_C	151_V	1.158	1.00
202_A	206_K	1.152	1.00
204_I	339_A	1.151	1.00
392_T	444_V	1.149	1.00
334_H	337_H	1.147	1.00
243_E	259_Y	1.145	1.00
30_T	53_E	1.145	1.00
330_S	333_N	1.144	1.00
221_G	230_V	1.141	1.00
92_A	130_L	1.141	1.00
461_E	465_R	1.140	1.00
139_V	153_N	1.136	1.00
353_S	357_Q	1.134	1.00
508_A	539_I	1.133	1.00
527_V	540_I	1.133	1.00
231_R	251_L	1.130	1.00
32_V	47_L	1.130	1.00
29_V	79_V	1.129	1.00
115_A	173_D	1.127	1.00
389_D	412_E	1.127	1.00
248_A	253_R	1.125	1.00
96_L	422_M	1.123	1.00
171_P	174_V	1.120	1.00
19_L	179_T	1.119	1.00
229_A	336_E	1.116	1.00
232_K	235_K	1.115	1.00
353_S	356_K	1.115	1.00
235_K	258_Q	1.110	1.00
260_F	274_L	1.109	1.00
139_V	150_A	1.108	1.00
215_V	233_L	1.102	1.00
197_D	338_D	1.100	1.00
213_P	279_D	1.099	1.00
348_E	352_L	1.094	1.00
299_N	302_R	1.091	1.00
80_V	91_L	1.091	1.00
92_A	134_I	1.088	1.00
68_Q	103_D	1.087	1.00
436_S	440_P	1.087	1.00
194_P	334_H	1.086	1.00
195_A	334_H	1.086	1.00
203_A	324_L	1.084	1.00
15_R	178_V	1.082	1.00
495_S	498_D	1.077	1.00
229_A	232_K	1.076	1.00
99_N	165_A	1.072	1.00
516_L	540_I	1.071	1.00
273_L	277_Q	1.068	1.00
212_L	277_Q	1.067	1.00
73_L	435_A	1.064	1.00
157_I	166_A	1.055	1.00
208_Q	342_V	1.055	1.00
436_S	444_V	1.053	1.00
524_L	528_L	1.052	1.00
232_K	333_N	1.048	1.00
204_I	208_Q	1.047	1.00
514_T	534_A	1.046	1.00
390_H	442_E	1.046	1.00
141_V	150_A	1.042	1.00
89_S	130_L	1.041	1.00
495_S	499_F	1.039	1.00
62_N	456_S	1.039	1.00
130_L	134_I	1.038	1.00
19_L	148_P	1.036	1.00
69_A	73_L	1.033	1.00
217_V	221_G	1.032	1.00
203_A	322_L	1.032	1.00
508_A	515_G	1.031	1.00
393_V	408_F	1.030	1.00
114_R	177_E	1.028	1.00
208_Q	340_V	1.028	1.00
135_T	138_S	1.028	1.00
283_T	288_P	1.024	1.00
46_A	49_D	1.023	1.00
215_V	230_V	1.023	1.00
40_I	43_V	1.023	1.00
64_A	80_V	1.022	1.00
515_G	539_I	1.022	1.00
234_L	251_L	1.017	1.00
228_K	231_R	1.014	1.00
269_Q	273_L	1.013	1.00
31_H	55_I	1.011	1.00
436_S	441_G	1.010	1.00
251_L	256_E	1.010	1.00
117_R	140_E	1.009	1.00
351_I	358_Y	1.007	1.00
530_Q	533_N	1.007	1.00
233_L	339_A	1.005	1.00
82_V	107_A	1.005	1.00
55_I	466_L	1.002	1.00
214_V	242_V	0.996	1.00
234_L	258_Q	0.995	1.00
14_N	178_V	0.993	1.00
320_P	323_E	0.992	1.00
518_V	523_Q	0.992	1.00
471_V	538_V	0.990	1.00
20_V	108_L	0.986	1.00
443_K	471_V	0.986	1.00
494_T	499_F	0.982	1.00
242_V	260_F	0.982	1.00
387_V	393_V	0.979	1.00
32_V	79_V	0.979	1.00
518_V	524_L	0.979	1.00
354_D	357_Q	0.978	1.00
478_S	543_P	0.975	1.00
80_V	107_A	0.974	1.00
428_A	446_S	0.972	1.00
330_S	334_H	0.968	1.00
159_S	163_A	0.966	1.00
236_K	341_K	0.964	1.00
474_V	504_I	0.961	1.00
460_L	539_I	0.960	1.00
138_S	167_F	0.958	1.00
375_H	548_D	0.958	1.00
208_Q	339_A	0.957	1.00
210_A	279_D	0.957	1.00
534_A	538_V	0.956	1.00
457_A	511_F	0.953	1.00
531_G	538_V	0.949	1.00
453_F	474_V	0.947	1.00
95_L	131_F	0.945	1.00
209_T	303_T	0.944	1.00
505_V	541_D	0.942	1.00
436_S	536_G	0.942	1.00
429_L	453_F	0.941	1.00
137_Y	157_I	0.940	1.00
128_A	138_S	0.939	1.00
209_T	280_V	0.939	1.00
394_T	444_V	0.933	1.00
137_Y	150_A	0.932	1.00
20_V	43_V	0.930	1.00
471_V	540_I	0.930	1.00
380_V	447_V	0.927	1.00
111_N	169_S	0.926	1.00
460_L	472_H	0.925	1.00
231_R	256_E	0.923	1.00
64_A	105_V	0.923	1.00
394_T	446_S	0.923	1.00
43_V	170_F	0.919	1.00
194_P	330_S	0.919	1.00
229_A	332_I	0.916	1.00
76_K	159_S	0.915	1.00
475_W	544_V	0.913	1.00
527_V	531_G	0.913	1.00
324_L	331_T	0.913	1.00
471_V	532_M	0.913	1.00
232_K	340_V	0.910	1.00
66_M	463_A	0.908	1.00
102_G	162_Q	0.907	1.00
227_I	231_R	0.907	1.00
214_V	281_V	0.907	1.00
513_A	537_P	0.905	1.00
88_A	131_F	0.902	1.00
214_V	275_L	0.901	1.00
461_E	511_F	0.899	1.00
359_M	362_G	0.899	1.00
463_A	472_H	0.895	1.00
197_D	201_S	0.894	1.00
358_Y	361_E	0.893	1.00
18_E	22_D	0.892	1.00
47_L	52_P	0.892	1.00
198_D	201_S	0.888	1.00
379_I	475_W	0.887	1.00
467_K	535_E	0.887	1.00
386_A	528_L	0.887	1.00
453_F	539_I	0.886	1.00
307_L	324_L	0.883	1.00
14_N	19_L	0.883	1.00
357_Q	360_H	0.876	1.00
352_L	356_K	0.875	1.00
203_A	206_K	0.874	1.00
412_E	415_T	0.874	1.00
484_A	498_D	0.872	1.00
45_D	48_Q	0.868	1.00
384_R	408_F	0.867	1.00
463_A	537_P	0.867	1.00
16_G	144_V	0.867	1.00
378_E	524_L	0.866	1.00
89_S	96_L	0.866	1.00
523_Q	527_V	0.859	1.00
72_R	103_D	0.858	1.00
106_V	159_S	0.858	1.00
355_L	358_Y	0.857	1.00
350_K	354_D	0.857	1.00
129_A	133_P	0.857	1.00
153_N	157_I	0.855	1.00
206_K	305_I	0.855	1.00
79_V	106_V	0.853	1.00
23_C	27_Q	0.851	1.00
205_A	342_V	0.848	1.00
496_A	499_F	0.848	1.00
434_G	438_V	0.845	1.00
137_Y	154_A	0.842	1.00
358_Y	362_G	0.841	1.00
69_A	431_W	0.837	1.00
128_A	140_E	0.837	1.00
447_V	475_W	0.837	1.00
92_A	131_F	0.836	1.00
203_A	331_T	0.835	1.00
404_M	447_V	0.834	1.00
451_G	480_Y	0.833	1.00
203_A	280_V	0.828	1.00
391_V	445_V	0.826	1.00
205_A	208_Q	0.826	1.00
470_I	537_P	0.825	1.00
158_A	166_A	0.824	1.00
93_T	424_T	0.824	1.00
237_V	339_A	0.821	1.00
215_V	284_I	0.818	1.00
263_I	275_L	0.817	1.00
226_A	229_A	0.817	1.00
298_I	302_R	0.816	1.00
42_A	176_N	0.814	1.00
23_C	26_E	0.814	1.00
73_L	417_M	0.814	1.00
382_E	524_L	0.812	1.00
380_V	475_W	0.810	1.00
212_L	279_D	0.808	1.00
31_H	70_V	0.807	1.00
253_R	259_Y	0.804	1.00
390_H	412_E	0.804	1.00
386_A	532_M	0.803	1.00
509_E	515_G	0.801	1.00
465_R	500_G	0.799	1.00
478_S	546_Y	0.798	1.00
314_I	323_E	0.797	1.00
15_R	46_A	0.794	1.00
476_N	543_P	0.793	1.00
527_V	530_Q	0.790	1.00
464_V	537_P	0.787	1.00
200_I	334_H	0.786	1.00
280_V	303_T	0.786	1.00
311_I	325_I	0.786	1.00
170_F	175_V	0.783	1.00
136_K	166_A	0.783	1.00
144_V	148_P	0.781	1.00
36_P	56_V	0.780	1.00
530_Q	534_A	0.779	1.00
24_L	79_V	0.777	1.00
222_G	250_T	0.776	1.00
30_T	70_V	0.776	1.00
384_R	411_Y	0.776	1.00
217_V	243_E	0.776	1.00
156_R	160_A	0.775	1.00
202_A	322_L	0.775	1.00
445_V	473_I	0.773	1.00
83_T	123_Q	0.772	1.00
27_Q	159_S	0.771	1.00
217_V	241_F	0.770	1.00
225_E	414_L	0.768	1.00
29_V	155_F	0.768	1.00
208_Q	337_H	0.767	1.00
471_V	535_E	0.765	1.00
137_Y	153_N	0.764	1.00
503_D	517_R	0.763	1.00
57_A	62_N	0.763	1.00
254_D	389_D	0.762	1.00
195_A	200_I	0.762	1.00
221_G	250_T	0.760	1.00
213_P	239_L	0.759	1.00
433_I	468_A	0.754	1.00
522_D	526_D	0.754	1.00
400_H	452_G	0.752	1.00
96_L	134_I	0.751	1.00
118_L	124_S	0.751	1.00
395_C	418_I	0.750	1.00
137_Y	166_A	0.750	1.00
65_F	424_T	0.749	1.00
81_L	108_L	0.749	1.00
293_P	296_W	0.748	1.00
73_L	438_V	0.746	1.00
208_Q	338_D	0.746	1.00
515_G	541_D	0.745	1.00
95_L	134_I	0.745	1.00
140_E	169_S	0.741	1.00
306_H	320_P	0.740	1.00
219_M	246_Q	0.740	1.00
429_L	472_H	0.740	1.00
71_G	105_V	0.738	1.00
380_V	408_F	0.737	1.00
35_I	91_L	0.734	1.00
387_V	391_V	0.733	1.00
374_A	521_P	0.733	1.00
454_L	457_A	0.733	1.00
392_T	442_E	0.733	1.00
70_V	76_K	0.732	1.00
61_Q	90_N	0.731	1.00
252_S	411_Y	0.731	1.00
192_L	327_D	0.730	1.00
334_H	338_D	0.730	1.00
40_I	44_F	0.728	1.00
282_L	307_L	0.726	1.00
447_V	473_I	0.725	1.00
333_N	337_H	0.723	1.00
432_A	470_I	0.722	1.00
351_I	362_G	0.721	1.00
503_D	509_E	0.721	1.00
40_I	81_L	0.718	1.00
350_K	353_S	0.716	1.00
18_E	50_K	0.715	1.00
136_K	157_I	0.715	1.00
71_G	103_D	0.710	1.00
25_V	30_T	0.710	1.00
395_C	416_L	0.710	1.00
32_V	81_L	0.710	1.00
454_L	502_I	0.710	1.00
82_V	109_A	0.710	1.00
33_F	66_M	0.708	1.00
473_I	524_L	0.707	1.00
226_A	329_P	0.706	1.00
472_H	513_A	0.705	1.00
26_E	185_R	0.705	1.00
103_D	427_V	0.702	1.00
396_D	428_A	0.702	1.00
333_N	336_E	0.699	1.00
355_L	362_G	0.698	1.00
53_E	440_P	0.697	1.00
429_L	448_S	0.696	1.00
30_T	51_G	0.694	1.00
252_S	256_E	0.694	1.00
484_A	488_L	0.693	1.00
454_L	504_I	0.692	1.00
109_A	169_S	0.691	0.99
43_V	175_V	0.691	0.99
245_Y	405_S	0.689	0.99
144_V	179_T	0.689	0.99
251_L	259_Y	0.689	0.99
443_K	469_P	0.688	0.99
111_N	117_R	0.686	0.99
98_A	105_V	0.684	0.99
128_A	132_Q	0.682	0.99
213_P	280_V	0.681	0.99
227_I	413_P	0.679	0.99
216_L	283_T	0.678	0.99
394_T	417_M	0.677	0.99
453_F	504_I	0.676	0.99
352_L	355_L	0.675	0.99
395_C	404_M	0.675	0.99
518_V	540_I	0.675	0.99
446_S	452_G	0.673	0.99
463_A	468_A	0.673	0.99
64_A	107_A	0.673	0.99
136_K	160_A	0.671	0.99
82_V	88_A	0.670	0.99
243_E	253_R	0.670	0.99
199_A	203_A	0.669	0.99
58_R	465_R	0.669	0.99
479_T	484_A	0.668	0.99
464_V	500_G	0.664	0.99
513_A	536_G	0.663	0.99
445_V	471_V	0.663	0.99
331_T	334_H	0.661	0.99
337_H	340_V	0.661	0.99
90_N	93_T	0.660	0.99
114_R	142_Q	0.660	0.99
184_V	187_V	0.660	0.99
215_V	241_F	0.658	0.99
89_S	92_A	0.658	0.99
144_V	174_V	0.657	0.99
199_A	324_L	0.657	0.99
195_A	330_S	0.656	0.99
45_D	49_D	0.655	0.99
379_I	473_I	0.654	0.99
314_I	320_P	0.652	0.99
207_I	237_V	0.651	0.99
99_N	136_K	0.650	0.99
464_V	512_G	0.649	0.99
394_T	435_A	0.649	0.99
153_N	156_R	0.649	0.99
43_V	81_L	0.647	0.99
206_K	209_T	0.646	0.99
200_I	335_I	0.646	0.99
469_P	537_P	0.644	0.99
238_Q	257_D	0.644	0.99
220_K	308_D	0.642	0.99
234_L	237_V	0.641	0.99
374_A	520_S	0.641	0.99
249_G	253_R	0.640	0.99
148_P	152_T	0.640	0.99
390_H	443_K	0.637	0.99
224_P	327_D	0.636	0.99
69_A	434_G	0.635	0.99
430_P	459_E	0.634	0.99
429_L	459_E	0.633	0.99
503_D	541_D	0.632	0.99
264_G	267_R	0.631	0.99
283_T	304_I	0.627	0.99
114_R	171_P	0.625	0.99
141_V	171_P	0.624	0.99
195_A	326_G	0.624	0.99
516_L	534_A	0.624	0.99
157_I	162_Q	0.624	0.99
31_H	76_K	0.623	0.99
100_T	422_M	0.623	0.99
131_F	167_F	0.622	0.99
150_A	153_N	0.622	0.99
211_K	350_K	0.621	0.99
194_P	197_D	0.621	0.99
89_S	125_L	0.620	0.99
136_K	162_Q	0.620	0.99
257_D	356_K	0.617	0.99
433_I	462_T	0.617	0.99
216_L	244_T	0.616	0.99
65_F	97_T	0.616	0.99
236_K	339_A	0.616	0.99
42_A	175_V	0.615	0.99
527_V	538_V	0.615	0.99
122_H	423_Q	0.614	0.99
502_I	510_S	0.613	0.99
16_G	19_L	0.612	0.99
237_V	258_Q	0.611	0.99
273_L	276_E	0.610	0.99
70_V	74_T	0.608	0.99
498_D	546_Y	0.608	0.99
59_H	90_N	0.607	0.99
448_S	456_S	0.607	0.99
230_V	234_L	0.606	0.99
391_V	442_E	0.606	0.99
535_E	538_V	0.606	0.99
457_A	510_S	0.605	0.99
40_I	110_G	0.603	0.99
32_V	52_P	0.601	0.99
417_M	427_V	0.600	0.99
104_P	158_A	0.599	0.99
211_K	279_D	0.598	0.99
520_S	526_D	0.598	0.99
222_G	414_L	0.598	0.99
111_N	140_E	0.597	0.99
106_V	168_V	0.595	0.99
231_R	412_E	0.594	0.98
139_V	166_A	0.593	0.98
25_V	52_P	0.593	0.98
372_D	520_S	0.593	0.98
35_I	480_Y	0.592	0.98
448_S	472_H	0.592	0.98
336_E	340_V	0.591	0.98
248_A	410_S	0.590	0.98
191_K	196_A	0.589	0.98
96_L	125_L	0.589	0.98
437_L	466_L	0.589	0.98
260_F	271_G	0.589	0.98
379_I	524_L	0.588	0.98
14_N	18_E	0.588	0.98
387_V	408_F	0.587	0.98
400_H	475_W	0.587	0.98
394_T	428_A	0.587	0.98
471_V	536_G	0.587	0.98
229_A	233_L	0.586	0.98
435_A	444_V	0.583	0.98
70_V	78_G	0.581	0.98
331_T	335_I	0.581	0.98
432_A	444_V	0.579	0.98
192_L	196_A	0.579	0.98
216_L	286_Y	0.578	0.98
155_F	159_S	0.575	0.98
146_N	150_A	0.575	0.98
226_A	328_I	0.574	0.98
109_A	127_N	0.574	0.98
212_L	351_I	0.574	0.98
480_Y	483_V	0.572	0.98
328_I	333_N	0.571	0.98
483_V	487_Q	0.571	0.98
454_L	458_M	0.570	0.98
114_R	174_V	0.569	0.98
66_M	437_L	0.567	0.98
377_L	548_D	0.566	0.98
383_L	473_I	0.564	0.98
77_P	158_A	0.563	0.98
154_A	168_V	0.562	0.98
380_V	404_M	0.562	0.98
187_V	190_P	0.561	0.98
378_E	525_A	0.560	0.98
231_R	234_L	0.560	0.98
258_Q	352_L	0.560	0.98
157_I	160_A	0.559	0.98
365_V	368_D	0.559	0.98
429_L	463_A	0.558	0.98
173_D	177_E	0.557	0.98
313_D	316_H	0.557	0.98
108_L	168_V	0.556	0.98
372_D	521_P	0.556	0.98
106_V	166_A	0.556	0.98
200_I	324_L	0.556	0.98
464_V	467_K	0.554	0.98
108_L	151_V	0.551	0.98
272_D	276_E	0.550	0.98
216_L	281_V	0.550	0.98
73_L	392_T	0.550	0.98
395_C	428_A	0.550	0.98
114_R	143_D	0.549	0.97
91_L	109_A	0.549	0.97
462_T	468_A	0.549	0.97
127_N	167_F	0.549	0.97
38_A	83_T	0.548	0.97
484_A	546_Y	0.548	0.97
214_V	274_L	0.547	0.97
373_R	545_D	0.545	0.97
502_I	507_Y	0.545	0.97
23_C	148_P	0.545	0.97
74_T	434_G	0.545	0.97
26_E	181_T	0.544	0.97
395_C	398_G	0.544	0.97
296_W	318_Y	0.543	0.97
37_G	83_T	0.542	0.97
64_A	95_L	0.541	0.97
144_V	147_I	0.541	0.97
53_E	437_L	0.540	0.97
253_R	409_R	0.540	0.97
351_I	354_D	0.540	0.97
30_T	74_T	0.540	0.97
55_I	462_T	0.540	0.97
54_I	496_A	0.540	0.97
453_F	472_H	0.540	0.97
472_H	539_I	0.539	0.97
308_D	313_D	0.539	0.97
518_V	526_D	0.538	0.97
232_K	337_H	0.537	0.97
338_D	341_K	0.537	0.97
448_S	452_G	0.536	0.97
370_K	522_D	0.536	0.97
246_Q	420_N	0.535	0.97
528_L	532_M	0.535	0.97
97_T	101_E	0.535	0.97
58_R	461_E	0.535	0.97
198_D	202_A	0.534	0.97
63_A	80_V	0.534	0.97
208_Q	211_K	0.534	0.97
467_K	536_G	0.532	0.97
380_V	384_R	0.532	0.97
21_V	47_L	0.530	0.97
99_N	135_T	0.530	0.97
392_T	417_M	0.530	0.97
19_L	181_T	0.530	0.97
509_E	516_L	0.529	0.97
91_L	94_G	0.529	0.97
72_R	101_E	0.528	0.97
376_P	403_W	0.527	0.97
396_D	446_S	0.527	0.97
460_L	464_V	0.527	0.97
290_E	293_P	0.526	0.97
243_E	248_A	0.526	0.97
459_E	462_T	0.526	0.97
68_Q	431_W	0.526	0.97
249_G	415_T	0.524	0.97
404_M	416_L	0.524	0.97
23_C	155_F	0.524	0.97
461_E	502_I	0.523	0.97
71_G	77_P	0.523	0.97
476_N	504_I	0.523	0.97
238_Q	341_K	0.520	0.97
516_L	526_D	0.520	0.97
338_D	342_V	0.520	0.97
156_R	159_S	0.519	0.96
199_A	322_L	0.519	0.96
429_L	457_A	0.519	0.96
339_A	342_V	0.519	0.96
364_Q	367_A	0.518	0.96
79_V	108_L	0.517	0.96
503_D	510_S	0.517	0.96
145_K	180_N	0.515	0.96
520_S	524_L	0.515	0.96
471_V	534_A	0.515	0.96
530_Q	538_V	0.515	0.96
38_A	486_Q	0.514	0.96
35_I	57_A	0.513	0.96
425_L	483_V	0.513	0.96
79_V	155_F	0.512	0.96
305_I	322_L	0.512	0.96
16_G	177_E	0.511	0.96
228_K	235_K	0.511	0.96
488_L	549_N	0.510	0.96
192_L	330_S	0.509	0.96
412_E	442_E	0.508	0.96
33_F	437_L	0.507	0.96
514_T	535_E	0.507	0.96
367_A	381_K	0.507	0.96
71_G	78_G	0.507	0.96
162_Q	310_I	0.506	0.96
502_I	511_F	0.506	0.96
238_Q	352_L	0.506	0.96
495_S	500_G	0.505	0.96
29_V	77_P	0.504	0.96
148_P	151_V	0.504	0.96
39_K	84_S	0.504	0.96
303_T	322_L	0.503	0.96
497_V	500_G	0.502	0.96
387_V	532_M	0.502	0.96
196_A	330_S	0.502	0.96
222_G	227_I	0.501	0.96
208_Q	341_K	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4rjjA	5	0.9737	100	0.163	Contact Map
1ozhA	4	0.9596	100	0.168	Contact Map
2ihtA	4	0.9421	100	0.181	Contact Map
1ybhA	4	0.9825	100	0.182	Contact Map
2panA	3	0.9772	100	0.186	Contact Map
1t9bA	2	0.9807	100	0.188	Contact Map
3eyaA	5	0.9211	100	0.19	Contact Map
2uz1A	4	0.9491	100	0.191	Contact Map
2pgnA	4	0.9509	100	0.193	Contact Map
2x7jA	4	0.9754	100	0.201	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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