GREMLIN Database
ALDC - Alpha-acetolactate decarboxylase
UniProt: Q04777 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (233)
Sequences: 611 (464)
Seq/√Len: 30.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_L213_C4.8591.00
169_V194_F4.0461.00
170_R197_E3.6351.00
69_E81_P3.3251.00
56_F63_L2.8921.00
135_L170_R2.8051.00
140_Q163_I2.7911.00
139_V205_V2.7071.00
178_T186_A2.6561.00
42_L88_S2.5410.99
46_P84_N2.5340.99
195_I199_R2.5310.99
118_N190_Y2.5110.99
109_T112_D2.4380.99
133_D216_T2.3460.99
137_K211_E2.3460.99
156_E159_K2.3100.99
173_I205_V2.2760.99
46_P65_G2.2560.99
127_F182_A2.2240.99
118_N177_L2.1800.98
65_G70_F2.1740.98
45_I91_C2.1740.98
46_P70_F2.1610.98
138_K167_D2.0590.98
149_K232_D2.0310.97
43_S84_N2.0200.97
37_D149_K1.9770.97
64_I73_L1.9640.97
24_Q27_T1.9430.97
79_A196_D1.9190.96
140_Q165_N1.9140.96
196_D200_N1.8870.96
126_L234_F1.8700.96
26_S30_S1.8420.95
20_S218_S1.8100.95
188_S247_I1.8030.95
39_D57_N1.7990.95
66_F174_V1.7940.95
37_D151_Y1.7840.95
127_F178_T1.7750.94
153_P156_E1.7750.94
138_K165_N1.7700.94
178_T182_A1.7640.94
94_T176_F1.6830.93
58_K146_L1.6480.92
147_Q151_Y1.6350.91
65_G93_F1.6280.91
57_N87_R1.6130.91
73_L141_T1.6060.91
244_A248_E1.5810.90
147_Q150_P1.5740.90
42_L82_V1.5710.90
166_F201_S1.5690.90
135_L168_N1.5620.89
44_E47_K1.5570.89
183_N188_S1.5560.89
72_R86_D1.5290.88
74_R80_T1.5290.88
169_V196_D1.5230.88
50_D95_F1.5020.88
129_A176_F1.4830.87
74_R78_T1.4770.87
42_L70_F1.4550.86
55_T89_P1.4520.86
231_A235_N1.4490.86
56_F82_V1.4160.84
51_F129_A1.4040.84
182_A225_L1.3920.83
181_Y233_F1.3780.82
28_M187_V1.3730.82
131_R199_R1.3310.80
110_R114_E1.3000.79
59_L144_V1.2690.77
35_V236_A1.2610.76
133_D199_R1.2510.76
133_D172_T1.2500.76
153_P246_D1.2420.75
135_L211_E1.2380.75
171_G194_F1.2310.75
36_Y153_P1.2090.73
158_V250_T1.2050.73
159_K249_T1.1960.72
53_I94_T1.1850.72
28_M51_F1.1790.71
22_I220_K1.1550.70
101_T214_T1.1540.70
26_S177_L1.1530.70
173_I192_L1.1400.69
125_N228_P1.1180.67
23_Y40_F1.1150.67
102_H120_M1.1080.67
42_L65_G1.0970.66
73_L79_A1.0900.65
143_T154_M1.0890.65
41_E60_D1.0880.65
45_I152_V1.0700.64
131_R216_T1.0700.64
63_L143_T1.0600.63
37_D58_K1.0290.61
69_E199_R1.0280.61
142_R206_F1.0240.60
182_A186_A1.0200.60
115_K132_I1.0190.60
56_F143_T1.0160.60
41_E44_E1.0110.59
94_T220_K1.0030.59
147_Q157_A0.9930.58
143_T247_I0.9890.58
152_V160_T0.9820.57
186_A225_L0.9810.57
193_H204_H0.9760.57
56_F72_R0.9700.56
21_Q224_N0.9670.56
63_L88_S0.9630.56
92_S186_A0.9600.55
126_L221_M0.9600.55
25_V39_D0.9510.55
174_V215_V0.9440.54
110_R208_Y0.9400.54
142_R161_Q0.9400.54
28_M247_I0.9390.54
73_L143_T0.9370.53
66_F131_R0.9320.53
147_Q153_P0.9240.52
177_L190_Y0.9210.52
105_D212_D0.9180.52
40_F88_S0.9100.51
113_F208_Y0.9090.51
63_L93_F0.9090.51
60_D146_L0.9030.51
32_L141_T0.8950.50
33_D250_T0.8870.49
55_T72_R0.8820.49
137_K209_V0.8810.49
56_F70_F0.8790.49
191_H204_H0.8750.49
145_E162_P0.8740.48
133_D197_E0.8730.48
38_G164_F0.8680.48
144_V158_V0.8660.48
158_V208_Y0.8660.48
71_Y199_R0.8630.48
69_E162_P0.8600.47
120_M232_D0.8570.47
36_Y59_L0.8510.47
29_T247_I0.8500.47
44_E224_N0.8480.46
232_D235_N0.8470.46
26_S39_D0.8460.46
55_T154_M0.8390.46
30_S238_L0.8350.45
51_F174_V0.8250.45
40_F45_I0.8200.44
47_K177_L0.8200.44
113_F132_I0.8150.44
25_V226_R0.8070.43
192_L218_S0.8030.43
40_F44_E0.7920.42
243_F247_I0.7890.42
213_C248_E0.7850.41
30_S176_F0.7830.41
115_K119_S0.7830.41
44_E48_Y0.7820.41
58_K150_P0.7750.41
97_T200_N0.7740.41
23_Y137_K0.7710.40
142_R189_G0.7700.40
175_G192_L0.7650.40
98_P216_T0.7610.40
83_Q86_D0.7590.39
25_V186_A0.7570.39
53_I87_R0.7560.39
20_S220_K0.7530.39
59_L157_A0.7510.39
124_R137_K0.7490.39
32_L36_Y0.7490.39
23_Y224_N0.7480.39
48_Y55_T0.7450.38
99_D219_Q0.7450.38
90_F186_A0.7400.38
168_N174_V0.7360.38
38_G190_Y0.7340.38
158_V206_F0.7320.37
146_L200_N0.7310.37
115_K212_D0.7260.37
24_Q184_G0.7220.37
83_Q195_I0.7190.36
143_T202_G0.7120.36
23_Y55_T0.7090.36
170_R173_I0.7090.36
116_E169_V0.7090.36
35_V39_D0.7060.35
23_Y219_Q0.7040.35
141_T144_V0.7040.35
245_K249_T0.7030.35
124_R213_C0.7030.35
186_A226_R0.6990.35
55_T77_G0.6950.35
189_G205_V0.6930.34
120_M131_R0.6910.34
226_R230_T0.6910.34
144_V147_Q0.6900.34
108_M112_D0.6870.34
24_Q150_P0.6840.34
140_Q207_D0.6840.34
168_N237_N0.6830.34
103_K214_T0.6810.34
139_V210_L0.6810.34
35_V56_F0.6800.34
50_D133_D0.6800.34
166_F169_V0.6770.33
157_A160_T0.6710.33
126_L140_Q0.6690.33
45_I197_E0.6650.32
67_D131_R0.6620.32
63_L91_C0.6620.32
53_I92_S0.6600.32
112_D115_K0.6580.32
31_L187_V0.6580.32
30_S35_V0.6580.32
37_D159_K0.6580.32
77_G202_G0.6560.32
179_P189_G0.6530.32
79_A198_G0.6520.32
126_L177_L0.6510.32
103_K213_C0.6480.31
63_L70_F0.6470.31
185_I199_R0.6440.31
38_G150_P0.6440.31
31_L53_I0.6420.31
85_G115_K0.6400.31
211_E231_A0.6400.31
132_I207_D0.6390.31
136_F171_G0.6390.31
131_R219_Q0.6380.31
129_A175_G0.6380.31
72_R145_E0.6380.31
96_F238_L0.6350.30
96_F176_F0.6350.30
98_P126_L0.6330.30
28_M154_M0.6330.30
154_M161_Q0.6320.30
45_I245_K0.6300.30
22_I84_N0.6290.30
30_S94_T0.6280.30
230_T239_D0.6270.30
116_E119_S0.6270.30
104_I215_V0.6250.30
133_D249_T0.6250.30
143_T164_F0.6250.30
28_M129_A0.6250.30
43_S211_E0.6210.29
113_F197_E0.6200.29
152_V157_A0.6200.29
90_F206_F0.6180.29
76_D147_Q0.6180.29
62_E204_H0.6160.29
62_E193_H0.6160.29
161_Q189_G0.6140.29
69_E133_D0.6110.29
97_T205_V0.6090.29
97_T132_I0.6090.29
62_E191_H0.6070.29
23_Y48_Y0.6060.28
115_K229_N0.6060.28
161_Q206_F0.6060.28
152_V242_D0.6030.28
125_N233_F0.6020.28
46_P109_T0.5990.28
220_K225_L0.5950.28
38_G151_Y0.5950.28
117_I192_L0.5930.28
59_L72_R0.5920.28
101_T216_T0.5900.27
111_E124_R0.5870.27
48_Y247_I0.5860.27
118_N121_L0.5850.27
47_K132_I0.5850.27
107_K212_D0.5840.27
131_R233_F0.5800.27
59_L242_D0.5780.27
58_K66_F0.5780.27
47_K119_S0.5780.27
80_T138_K0.5770.27
161_Q164_F0.5770.27
96_F129_A0.5760.27
230_T241_P0.5760.27
141_T164_F0.5760.27
93_F155_V0.5730.26
241_P245_K0.5700.26
221_M227_L0.5690.26
63_L86_D0.5690.26
66_F199_R0.5670.26
104_I210_L0.5660.26
99_D218_S0.5650.26
176_F192_L0.5610.26
35_V233_F0.5600.26
44_E237_N0.5590.26
47_K103_K0.5590.26
197_E212_D0.5580.25
27_T92_S0.5570.25
109_T209_V0.5550.25
77_G164_F0.5540.25
85_G168_N0.5520.25
60_D74_R0.5510.25
175_G193_H0.5500.25
175_G204_H0.5500.25
187_V233_F0.5500.25
38_G152_V0.5480.25
65_G133_D0.5440.25
60_D75_S0.5430.25
26_S218_S0.5420.25
31_L142_R0.5410.24
28_M181_Y0.5390.24
25_V29_T0.5390.24
64_I141_T0.5370.24
36_Y128_Y0.5350.24
188_S221_M0.5340.24
25_V28_M0.5340.24
177_L234_F0.5320.24
181_Y185_I0.5310.24
243_F250_T0.5310.24
103_K111_E0.5310.24
68_G130_I0.5290.24
166_F199_R0.5280.24
109_T137_K0.5280.24
60_D72_R0.5270.24
51_F66_F0.5260.24
27_T190_Y0.5260.24
160_T217_I0.5250.24
21_Q222_N0.5240.23
37_D117_I0.5240.23
36_Y57_N0.5210.23
172_T185_I0.5190.23
70_F82_V0.5180.23
170_R205_V0.5180.23
25_V40_F0.5170.23
112_D209_V0.5170.23
49_G172_T0.5160.23
62_E175_G0.5130.23
60_D134_G0.5130.23
72_R77_G0.5130.23
63_L216_T0.5110.23
55_T144_V0.5110.23
33_D218_S0.5100.23
46_P165_N0.5090.23
76_D79_A0.5060.22
36_Y157_A0.5030.22
22_I109_T0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bt2A 2 0.9294 100 0.074 Contact Map
1xv2A 2 0.9098 100 0.103 Contact Map
2dt4A 3 0.5373 83.5 0.947 Contact Map
3hwuA 3 0.5373 65 0.955 Contact Map
3htnA 3 0.5373 64.9 0.955 Contact Map
2h6lA 3 0.5373 51.9 0.958 Contact Map
2hx0A 3 0.5059 47.5 0.959 Contact Map
2p6yA 3 0.4784 42.8 0.96 Contact Map
1hx6A 3 0.5686 12.5 0.969 Contact Map
4g6tB 1 0.2667 11.3 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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