ALDC - BACSU - GREMLIN Contacts

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ALDC - Alpha-acetolactate decarboxylase

UniProt:	Q04777	Sequences: MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSEIPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTHKIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKTQPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTISQKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	255 (233)
Sequences:	611 (464)
Seq/√Len:	30.4

BACSU - ALDC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
210_L	213_C	4.859	1.00
169_V	194_F	4.046	1.00
170_R	197_E	3.635	1.00
69_E	81_P	3.325	1.00
56_F	63_L	2.892	1.00
135_L	170_R	2.805	1.00
140_Q	163_I	2.791	1.00
139_V	205_V	2.707	1.00
178_T	186_A	2.656	1.00
42_L	88_S	2.541	0.99
46_P	84_N	2.534	0.99
195_I	199_R	2.531	0.99
118_N	190_Y	2.511	0.99
109_T	112_D	2.438	0.99
133_D	216_T	2.346	0.99
137_K	211_E	2.346	0.99
156_E	159_K	2.310	0.99
173_I	205_V	2.276	0.99
46_P	65_G	2.256	0.99
127_F	182_A	2.224	0.99
118_N	177_L	2.180	0.98
65_G	70_F	2.174	0.98
45_I	91_C	2.174	0.98
46_P	70_F	2.161	0.98
138_K	167_D	2.059	0.98
149_K	232_D	2.031	0.97
43_S	84_N	2.020	0.97
37_D	149_K	1.977	0.97
64_I	73_L	1.964	0.97
24_Q	27_T	1.943	0.97
79_A	196_D	1.919	0.96
140_Q	165_N	1.914	0.96
196_D	200_N	1.887	0.96
126_L	234_F	1.870	0.96
26_S	30_S	1.842	0.95
20_S	218_S	1.810	0.95
188_S	247_I	1.803	0.95
39_D	57_N	1.799	0.95
66_F	174_V	1.794	0.95
37_D	151_Y	1.784	0.95
127_F	178_T	1.775	0.94
153_P	156_E	1.775	0.94
138_K	165_N	1.770	0.94
178_T	182_A	1.764	0.94
94_T	176_F	1.683	0.93
58_K	146_L	1.648	0.92
147_Q	151_Y	1.635	0.91
65_G	93_F	1.628	0.91
57_N	87_R	1.613	0.91
73_L	141_T	1.606	0.91
244_A	248_E	1.581	0.90
147_Q	150_P	1.574	0.90
42_L	82_V	1.571	0.90
166_F	201_S	1.569	0.90
135_L	168_N	1.562	0.89
44_E	47_K	1.557	0.89
183_N	188_S	1.556	0.89
72_R	86_D	1.529	0.88
74_R	80_T	1.529	0.88
169_V	196_D	1.523	0.88
50_D	95_F	1.502	0.88
129_A	176_F	1.483	0.87
74_R	78_T	1.477	0.87
42_L	70_F	1.455	0.86
55_T	89_P	1.452	0.86
231_A	235_N	1.449	0.86
56_F	82_V	1.416	0.84
51_F	129_A	1.404	0.84
182_A	225_L	1.392	0.83
181_Y	233_F	1.378	0.82
28_M	187_V	1.373	0.82
131_R	199_R	1.331	0.80
110_R	114_E	1.300	0.79
59_L	144_V	1.269	0.77
35_V	236_A	1.261	0.76
133_D	199_R	1.251	0.76
133_D	172_T	1.250	0.76
153_P	246_D	1.242	0.75
135_L	211_E	1.238	0.75
171_G	194_F	1.231	0.75
36_Y	153_P	1.209	0.73
158_V	250_T	1.205	0.73
159_K	249_T	1.196	0.72
53_I	94_T	1.185	0.72
28_M	51_F	1.179	0.71
22_I	220_K	1.155	0.70
101_T	214_T	1.154	0.70
26_S	177_L	1.153	0.70
173_I	192_L	1.140	0.69
125_N	228_P	1.118	0.67
23_Y	40_F	1.115	0.67
102_H	120_M	1.108	0.67
42_L	65_G	1.097	0.66
73_L	79_A	1.090	0.65
143_T	154_M	1.089	0.65
41_E	60_D	1.088	0.65
45_I	152_V	1.070	0.64
131_R	216_T	1.070	0.64
63_L	143_T	1.060	0.63
37_D	58_K	1.029	0.61
69_E	199_R	1.028	0.61
142_R	206_F	1.024	0.60
182_A	186_A	1.020	0.60
115_K	132_I	1.019	0.60
56_F	143_T	1.016	0.60
41_E	44_E	1.011	0.59
94_T	220_K	1.003	0.59
147_Q	157_A	0.993	0.58
143_T	247_I	0.989	0.58
152_V	160_T	0.982	0.57
186_A	225_L	0.981	0.57
193_H	204_H	0.976	0.57
56_F	72_R	0.970	0.56
21_Q	224_N	0.967	0.56
63_L	88_S	0.963	0.56
92_S	186_A	0.960	0.55
126_L	221_M	0.960	0.55
25_V	39_D	0.951	0.55
174_V	215_V	0.944	0.54
110_R	208_Y	0.940	0.54
142_R	161_Q	0.940	0.54
28_M	247_I	0.939	0.54
73_L	143_T	0.937	0.53
66_F	131_R	0.932	0.53
147_Q	153_P	0.924	0.52
177_L	190_Y	0.921	0.52
105_D	212_D	0.918	0.52
40_F	88_S	0.910	0.51
113_F	208_Y	0.909	0.51
63_L	93_F	0.909	0.51
60_D	146_L	0.903	0.51
32_L	141_T	0.895	0.50
33_D	250_T	0.887	0.49
55_T	72_R	0.882	0.49
137_K	209_V	0.881	0.49
56_F	70_F	0.879	0.49
191_H	204_H	0.875	0.49
145_E	162_P	0.874	0.48
133_D	197_E	0.873	0.48
38_G	164_F	0.868	0.48
144_V	158_V	0.866	0.48
158_V	208_Y	0.866	0.48
71_Y	199_R	0.863	0.48
69_E	162_P	0.860	0.47
120_M	232_D	0.857	0.47
36_Y	59_L	0.851	0.47
29_T	247_I	0.850	0.47
44_E	224_N	0.848	0.46
232_D	235_N	0.847	0.46
26_S	39_D	0.846	0.46
55_T	154_M	0.839	0.46
30_S	238_L	0.835	0.45
51_F	174_V	0.825	0.45
40_F	45_I	0.820	0.44
47_K	177_L	0.820	0.44
113_F	132_I	0.815	0.44
25_V	226_R	0.807	0.43
192_L	218_S	0.803	0.43
40_F	44_E	0.792	0.42
243_F	247_I	0.789	0.42
213_C	248_E	0.785	0.41
30_S	176_F	0.783	0.41
115_K	119_S	0.783	0.41
44_E	48_Y	0.782	0.41
58_K	150_P	0.775	0.41
97_T	200_N	0.774	0.41
23_Y	137_K	0.771	0.40
142_R	189_G	0.770	0.40
175_G	192_L	0.765	0.40
98_P	216_T	0.761	0.40
83_Q	86_D	0.759	0.39
25_V	186_A	0.757	0.39
53_I	87_R	0.756	0.39
20_S	220_K	0.753	0.39
59_L	157_A	0.751	0.39
124_R	137_K	0.749	0.39
32_L	36_Y	0.749	0.39
23_Y	224_N	0.748	0.39
48_Y	55_T	0.745	0.38
99_D	219_Q	0.745	0.38
90_F	186_A	0.740	0.38
168_N	174_V	0.736	0.38
38_G	190_Y	0.734	0.38
158_V	206_F	0.732	0.37
146_L	200_N	0.731	0.37
115_K	212_D	0.726	0.37
24_Q	184_G	0.722	0.37
83_Q	195_I	0.719	0.36
143_T	202_G	0.712	0.36
23_Y	55_T	0.709	0.36
170_R	173_I	0.709	0.36
116_E	169_V	0.709	0.36
35_V	39_D	0.706	0.35
23_Y	219_Q	0.704	0.35
141_T	144_V	0.704	0.35
245_K	249_T	0.703	0.35
124_R	213_C	0.703	0.35
186_A	226_R	0.699	0.35
55_T	77_G	0.695	0.35
189_G	205_V	0.693	0.34
120_M	131_R	0.691	0.34
226_R	230_T	0.691	0.34
144_V	147_Q	0.690	0.34
108_M	112_D	0.687	0.34
24_Q	150_P	0.684	0.34
140_Q	207_D	0.684	0.34
168_N	237_N	0.683	0.34
103_K	214_T	0.681	0.34
139_V	210_L	0.681	0.34
35_V	56_F	0.680	0.34
50_D	133_D	0.680	0.34
166_F	169_V	0.677	0.33
157_A	160_T	0.671	0.33
126_L	140_Q	0.669	0.33
45_I	197_E	0.665	0.32
67_D	131_R	0.662	0.32
63_L	91_C	0.662	0.32
53_I	92_S	0.660	0.32
112_D	115_K	0.658	0.32
31_L	187_V	0.658	0.32
30_S	35_V	0.658	0.32
37_D	159_K	0.658	0.32
77_G	202_G	0.656	0.32
179_P	189_G	0.653	0.32
79_A	198_G	0.652	0.32
126_L	177_L	0.651	0.32
103_K	213_C	0.648	0.31
63_L	70_F	0.647	0.31
185_I	199_R	0.644	0.31
38_G	150_P	0.644	0.31
31_L	53_I	0.642	0.31
85_G	115_K	0.640	0.31
211_E	231_A	0.640	0.31
132_I	207_D	0.639	0.31
136_F	171_G	0.639	0.31
131_R	219_Q	0.638	0.31
129_A	175_G	0.638	0.31
72_R	145_E	0.638	0.31
96_F	238_L	0.635	0.30
96_F	176_F	0.635	0.30
98_P	126_L	0.633	0.30
28_M	154_M	0.633	0.30
154_M	161_Q	0.632	0.30
45_I	245_K	0.630	0.30
22_I	84_N	0.629	0.30
30_S	94_T	0.628	0.30
230_T	239_D	0.627	0.30
116_E	119_S	0.627	0.30
104_I	215_V	0.625	0.30
133_D	249_T	0.625	0.30
143_T	164_F	0.625	0.30
28_M	129_A	0.625	0.30
43_S	211_E	0.621	0.29
113_F	197_E	0.620	0.29
152_V	157_A	0.620	0.29
90_F	206_F	0.618	0.29
76_D	147_Q	0.618	0.29
62_E	204_H	0.616	0.29
62_E	193_H	0.616	0.29
161_Q	189_G	0.614	0.29
69_E	133_D	0.611	0.29
97_T	205_V	0.609	0.29
97_T	132_I	0.609	0.29
62_E	191_H	0.607	0.29
23_Y	48_Y	0.606	0.28
115_K	229_N	0.606	0.28
161_Q	206_F	0.606	0.28
152_V	242_D	0.603	0.28
125_N	233_F	0.602	0.28
46_P	109_T	0.599	0.28
220_K	225_L	0.595	0.28
38_G	151_Y	0.595	0.28
117_I	192_L	0.593	0.28
59_L	72_R	0.592	0.28
101_T	216_T	0.590	0.27
111_E	124_R	0.587	0.27
48_Y	247_I	0.586	0.27
118_N	121_L	0.585	0.27
47_K	132_I	0.585	0.27
107_K	212_D	0.584	0.27
131_R	233_F	0.580	0.27
59_L	242_D	0.578	0.27
58_K	66_F	0.578	0.27
47_K	119_S	0.578	0.27
80_T	138_K	0.577	0.27
161_Q	164_F	0.577	0.27
96_F	129_A	0.576	0.27
230_T	241_P	0.576	0.27
141_T	164_F	0.576	0.27
93_F	155_V	0.573	0.26
241_P	245_K	0.570	0.26
221_M	227_L	0.569	0.26
63_L	86_D	0.569	0.26
66_F	199_R	0.567	0.26
104_I	210_L	0.566	0.26
99_D	218_S	0.565	0.26
176_F	192_L	0.561	0.26
35_V	233_F	0.560	0.26
44_E	237_N	0.559	0.26
47_K	103_K	0.559	0.26
197_E	212_D	0.558	0.25
27_T	92_S	0.557	0.25
109_T	209_V	0.555	0.25
77_G	164_F	0.554	0.25
85_G	168_N	0.552	0.25
60_D	74_R	0.551	0.25
175_G	193_H	0.550	0.25
175_G	204_H	0.550	0.25
187_V	233_F	0.550	0.25
38_G	152_V	0.548	0.25
65_G	133_D	0.544	0.25
60_D	75_S	0.543	0.25
26_S	218_S	0.542	0.25
31_L	142_R	0.541	0.24
28_M	181_Y	0.539	0.24
25_V	29_T	0.539	0.24
64_I	141_T	0.537	0.24
36_Y	128_Y	0.535	0.24
188_S	221_M	0.534	0.24
25_V	28_M	0.534	0.24
177_L	234_F	0.532	0.24
181_Y	185_I	0.531	0.24
243_F	250_T	0.531	0.24
103_K	111_E	0.531	0.24
68_G	130_I	0.529	0.24
166_F	199_R	0.528	0.24
109_T	137_K	0.528	0.24
60_D	72_R	0.527	0.24
51_F	66_F	0.526	0.24
27_T	190_Y	0.526	0.24
160_T	217_I	0.525	0.24
21_Q	222_N	0.524	0.23
37_D	117_I	0.524	0.23
36_Y	57_N	0.521	0.23
172_T	185_I	0.519	0.23
70_F	82_V	0.518	0.23
170_R	205_V	0.518	0.23
25_V	40_F	0.517	0.23
112_D	209_V	0.517	0.23
49_G	172_T	0.516	0.23
62_E	175_G	0.513	0.23
60_D	134_G	0.513	0.23
72_R	77_G	0.513	0.23
63_L	216_T	0.511	0.23
55_T	144_V	0.511	0.23
33_D	218_S	0.510	0.23
46_P	165_N	0.509	0.23
76_D	79_A	0.506	0.22
36_Y	157_A	0.503	0.22
22_I	109_T	0.500	0.22

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4bt2A	2	0.9294	100	0.074	Contact Map
1xv2A	2	0.9098	100	0.103	Contact Map
2dt4A	3	0.5373	83.5	0.947	Contact Map
3hwuA	3	0.5373	65	0.955	Contact Map
3htnA	3	0.5373	64.9	0.955	Contact Map
2h6lA	3	0.5373	51.9	0.958	Contact Map
2hx0A	3	0.5059	47.5	0.959	Contact Map
2p6yA	3	0.4784	42.8	0.96	Contact Map
1hx6A	3	0.5686	12.5	0.969	Contact Map
4g6tB	1	0.2667	11.3	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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