GREMLIN Database
MURE - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
UniProt: Q03523 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 494 (399)
Sequences: 16265 (11972)
Seq/√Len: 599.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_V312_T3.4621.00
260_Y308_A2.9051.00
179_S182_L2.6981.00
376_V400_A2.6521.00
272_N283_D2.6271.00
432_H443_F2.5351.00
196_V308_A2.3901.00
310_V323_I2.3841.00
194_I312_T2.3721.00
103_Q193_D2.3691.00
319_P322_I2.3651.00
402_E432_H2.3611.00
80_V83_S2.3571.00
210_T213_E2.3331.00
434_I443_F2.3061.00
436_N439_Q2.2751.00
126_K329_E2.2651.00
443_F447_N2.2201.00
56_K60_N2.1871.00
271_K285_V2.1731.00
268_V311_A2.1621.00
339_L347_P2.1551.00
402_E447_N2.1451.00
294_T328_E2.1241.00
241_A266_A2.1221.00
123_I313_C2.1091.00
123_I309_A2.0961.00
283_D292_H2.0941.00
58_V75_V2.0751.00
416_R420_R2.0691.00
295_M306_V2.0641.00
41_V66_V2.0071.00
448_A454_V2.0031.00
360_E364_E2.0011.00
382_G385_D1.9861.00
236_R315_A1.9091.00
443_F446_A1.8981.00
126_K325_E1.8941.00
106_G177_V1.8871.00
209_K213_E1.8781.00
126_K326_A1.8681.00
364_E399_L1.8571.00
373_K452_D1.8541.00
215_R248_Y1.8251.00
129_K171_D1.8251.00
106_G192_Y1.8231.00
394_K398_E1.8001.00
193_D235_K1.7961.00
56_K59_E1.7721.00
222_F237_A1.7631.00
404_I447_N1.7501.00
121_D133_L1.7361.00
80_V84_L1.7151.00
122_E329_E1.7131.00
55_Q59_E1.7101.00
120_V309_A1.6941.00
127_A322_I1.6811.00
120_V312_T1.6801.00
270_A307_L1.6631.00
217_A220_L1.6611.00
306_V327_V1.6411.00
105_I316_A1.6401.00
201_T357_D1.6311.00
219_S252_V1.6291.00
375_F447_N1.6141.00
282_F306_V1.6091.00
120_V313_C1.6091.00
262_I300_Q1.6031.00
281_S292_H1.5931.00
339_L349_I1.5871.00
286_T289_G1.5841.00
466_Q469_N1.5841.00
194_I316_A1.5811.00
115_S302_N1.5711.00
269_M285_V1.5641.00
213_E216_H1.5571.00
163_K167_D1.5561.00
111_N355_T1.5501.00
375_F402_E1.5381.00
373_K402_E1.5371.00
404_I443_F1.5361.00
283_D290_T1.5361.00
460_G465_Q1.5271.00
300_Q364_E1.5171.00
384_R388_K1.5171.00
107_I120_V1.5171.00
121_D125_K1.5161.00
417_A420_R1.5151.00
314_I320_F1.5041.00
127_A318_I1.4991.00
241_A259_T1.4681.00
377_V406_T1.4641.00
215_R245_A1.4621.00
285_V290_T1.4581.00
434_I439_Q1.4531.00
195_A221_L1.4481.00
324_T328_E1.4471.00
313_C323_I1.4441.00
419_L433_S1.4431.00
236_R256_H1.4421.00
382_G461_H1.4411.00
270_A273_I1.4301.00
44_K68_E1.4281.00
225_L235_K1.4071.00
346_F448_A1.4001.00
268_V314_I1.4001.00
385_D388_K1.3971.00
348_V445_I1.3941.00
103_Q172_T1.3911.00
119_M297_L1.3841.00
465_Q469_N1.3831.00
281_S294_T1.3801.00
382_G388_K1.3731.00
236_R258_S1.3691.00
122_E326_A1.3551.00
70_E79_I1.3431.00
286_T314_I1.3391.00
48_V52_D1.3371.00
39_L64_A1.3351.00
172_T316_A1.3221.00
274_S281_S1.3161.00
107_I117_T1.3151.00
124_L316_A1.3101.00
364_E395_I1.3101.00
65_I68_E1.3061.00
282_F303_V1.3001.00
296_S331_H1.2901.00
238_V315_A1.2871.00
124_L174_I1.2831.00
105_I120_V1.2831.00
404_I440_A1.2761.00
300_Q368_D1.2751.00
373_K449_K1.2731.00
114_T333_V1.2711.00
104_L190_C1.2701.00
313_C318_I1.2611.00
119_M330_L1.2601.00
437_R466_Q1.2581.00
200_L215_R1.2561.00
342_Q347_P1.2541.00
194_I315_A1.2531.00
202_Q387_T1.2531.00
416_R433_S1.2501.00
68_E83_S1.2471.00
271_K283_D1.2411.00
259_T267_D1.2391.00
258_S311_A1.2301.00
239_L257_I1.2301.00
197_F200_L1.2281.00
375_F404_I1.2251.00
239_L246_S1.2231.00
325_E329_E1.2201.00
360_E395_I1.2201.00
439_Q442_F1.2171.00
361_N364_E1.2141.00
177_V187_V1.2141.00
191_D235_K1.2041.00
103_Q171_D1.2011.00
256_H315_A1.1951.00
359_L457_A1.1921.00
406_T440_A1.1911.00
337_F349_I1.1901.00
442_F446_A1.1871.00
101_K166_N1.1831.00
116_T198_T1.1821.00
322_I325_E1.1811.00
337_F366_C1.1801.00
124_L172_T1.1721.00
89_V93_A1.1711.00
194_I238_V1.1691.00
226_G234_P1.1661.00
240_N304_Y1.1631.00
219_S249_F1.1581.00
382_G408_D1.1551.00
284_L310_V1.1431.00
212_D216_H1.1421.00
239_L259_T1.1391.00
405_F433_S1.1361.00
405_F419_L1.1281.00
402_E430_Y1.1281.00
345_E450_K1.1201.00
97_Q100_K1.1191.00
373_K401_D1.1181.00
245_A248_Y1.1171.00
268_V286_T1.1151.00
54_A65_I1.1151.00
239_L250_E1.1121.00
39_L66_V1.1051.00
291_K324_T1.1041.00
334_R338_E1.1021.00
111_N357_D1.1001.00
216_H252_V1.0991.00
366_C374_L1.0981.00
120_V196_V1.0971.00
197_F222_F1.0911.00
414_D417_A1.0901.00
85_R89_V1.0711.00
90_L93_A1.0701.00
325_E328_E1.0681.00
390_P421_D1.0661.00
132_G165_M1.0661.00
263_K300_Q1.0601.00
130_R171_D1.0581.00
242_D304_Y1.0561.00
318_I322_I1.0541.00
420_R424_A1.0531.00
302_N305_N1.0461.00
321_E325_E1.0441.00
362_V455_L1.0441.00
359_L378_V1.0441.00
262_I304_Y1.0431.00
339_L342_Q1.0401.00
375_F452_D1.0391.00
279_G294_T1.0371.00
458_G464_Y1.0361.00
185_G217_A1.0351.00
248_Y251_K1.0331.00
258_S315_A1.0331.00
438_E442_F1.0331.00
419_L423_E1.0311.00
220_L223_S1.0311.00
198_T308_A1.0291.00
212_D245_A1.0261.00
110_T203_D1.0211.00
391_K394_K1.0151.00
123_I323_I1.0121.00
119_M306_V1.0071.00
416_R435_A1.0071.00
270_A303_V1.0061.00
124_L318_I1.0041.00
179_S208_H1.0031.00
105_I312_T1.0021.00
393_A422_M1.0021.00
261_G304_Y1.0001.00
354_H359_L0.9991.00
420_R423_E0.9951.00
195_A225_L0.9941.00
202_Q205_L0.9941.00
242_D261_G0.9931.00
282_F293_I0.9921.00
185_G223_S0.9891.00
93_A97_Q0.9891.00
312_T316_A0.9881.00
44_K69_R0.9881.00
338_E350_V0.9861.00
211_M245_A0.9841.00
193_D226_G0.9841.00
241_A247_A0.9821.00
57_A62_A0.9761.00
226_G233_H0.9731.00
123_I326_A0.9681.00
108_T218_K0.9671.00
360_E398_E0.9661.00
417_A421_D0.9641.00
262_I270_A0.9641.00
202_Q211_M0.9581.00
122_E125_K0.9571.00
79_I82_Q0.9531.00
185_G188_H0.9511.00
73_V76_P0.9481.00
363_L399_L0.9451.00
390_P394_K0.9441.00
223_S252_V0.9411.00
407_S435_A0.9391.00
423_E431_Y0.9391.00
346_F451_G0.9381.00
89_V92_D0.9351.00
127_A326_A0.9341.00
439_Q443_F0.9321.00
271_K290_T0.9311.00
404_I434_I0.9281.00
48_V53_F0.9271.00
404_I444_A0.9251.00
240_N243_D0.9241.00
444_A448_A0.9181.00
449_K452_D0.9161.00
180_H207_Y0.9151.00
50_G54_A0.9141.00
129_K172_T0.9111.00
357_D361_N0.9081.00
421_D424_A0.9061.00
101_K163_K0.9061.00
45_G50_G0.9021.00
104_L173_A0.9021.00
261_G264_N0.9011.00
88_S186_R0.9011.00
203_D355_T0.8981.00
54_A58_V0.8981.00
213_E217_A0.8971.00
300_Q304_Y0.8971.00
314_I323_I0.8961.00
238_V311_A0.8931.00
197_F249_F0.8871.00
122_E330_L0.8841.00
353_A457_A0.8821.00
276_T281_S0.8771.00
393_A397_V0.8741.00
41_V87_L0.8741.00
216_H220_L0.8711.00
194_I236_R0.8691.00
215_R219_S0.8691.00
349_I366_C0.8671.00
435_A439_Q0.8661.00
41_V83_S0.8621.00
49_D69_R0.8561.00
259_T266_A0.8511.00
293_I324_T0.8501.00
383_D388_K0.8491.00
58_V65_I0.8481.00
335_G350_V0.8441.00
42_C54_A0.8431.00
404_I432_H0.8381.00
376_V457_A0.8361.00
103_Q316_A0.8351.00
40_F63_A0.8341.00
118_H137_M0.8331.00
126_K322_I0.8331.00
415_P418_I0.8301.00
85_R88_S0.8281.00
432_H447_N0.8261.00
423_E433_S0.8221.00
419_L431_Y0.8211.00
342_Q346_F0.8191.00
65_I75_V0.8151.00
422_M425_G0.8151.00
243_D304_Y0.8091.00
244_E248_Y0.8051.00
88_S92_D0.8041.00
395_I399_L0.8031.00
392_M396_A0.8021.00
297_L330_L0.8021.00
418_I421_D0.8001.00
403_P422_M0.7981.00
42_C67_A0.7961.00
225_L237_A0.7961.00
363_L376_V0.7941.00
434_I440_A0.7891.00
67_A77_V0.7891.00
405_F422_M0.7891.00
116_T309_A0.7851.00
201_T211_M0.7841.00
208_H217_A0.7811.00
418_I422_M0.7811.00
247_A251_K0.7781.00
116_T308_A0.7731.00
310_V314_I0.7721.00
51_H54_A0.7711.00
379_G458_G0.7691.00
177_V192_Y0.7691.00
202_Q357_D0.7611.00
372_G452_D0.7561.00
237_A253_T0.7561.00
220_L224_Q0.7551.00
386_K421_D0.7481.00
121_D131_T0.7461.00
276_T279_G0.7451.00
111_N358_S0.7351.00
378_V422_M0.7341.00
347_P453_V0.7331.00
320_F324_T0.7301.00
49_D52_D0.7301.00
396_A403_P0.7301.00
111_N201_T0.7291.00
117_T133_L0.7271.00
241_A246_S0.7241.00
118_H333_V0.7231.00
122_E126_K0.7221.00
275_I280_T0.7221.00
127_A319_P0.7211.00
248_Y252_V0.7161.00
266_A269_M0.7141.00
78_I82_Q0.7131.00
280_T303_V0.7101.00
104_L175_M0.7101.00
84_L88_S0.7101.00
416_R419_L0.7091.00
131_T170_V0.7091.00
92_D97_Q0.7091.00
370_T453_V0.7071.00
247_A259_T0.7071.00
138_Y145_T0.7071.00
219_S223_S0.7051.00
310_V320_F0.7031.00
337_F365_T0.7011.00
212_D248_Y0.7001.00
237_A255_A0.6941.00
291_K320_F0.6931.00
182_L221_L0.6921.00
87_L90_L0.6911.00
392_M395_I0.6911.00
79_I83_S0.6891.00
52_D69_R0.6891.00
240_N260_Y0.6891.00
250_E259_T0.6881.00
297_L302_N0.6881.00
440_A444_A0.6871.00
102_L166_N0.6831.00
191_D226_G0.6821.00
367_R399_L0.6821.00
200_L211_M0.6811.00
377_V456_I0.6771.00
318_I323_I0.6761.00
380_C462_E0.6751.00
241_A261_G0.6741.00
400_A403_P0.6721.00
375_F448_A0.6711.00
335_G460_G0.6691.00
185_G207_Y0.6651.00
405_F431_Y0.6651.00
284_L307_L0.6631.00
185_G220_L0.6621.00
242_D262_I0.6621.00
342_Q345_E0.6621.00
211_M215_R0.6621.00
188_H224_Q0.6591.00
310_V324_T0.6581.00
215_R249_F0.6571.00
51_H68_E0.6561.00
118_H122_E0.6551.00
348_V454_V0.6551.00
44_K48_V0.6551.00
127_A313_C0.6541.00
106_G221_L0.6531.00
323_I326_A0.6491.00
165_M170_V0.6491.00
238_V312_T0.6481.00
51_H83_S0.6481.00
360_E391_K0.6471.00
182_L217_A0.6471.00
353_A362_V0.6431.00
262_I273_I0.6411.00
345_E451_G0.6411.00
58_V63_A0.6411.00
299_G302_N0.6401.00
49_D53_F0.6381.00
82_Q85_R0.6371.00
301_F361_N0.6361.00
289_G320_F0.6341.00
120_V174_I0.6331.00
88_S93_A0.6331.00
401_D449_K0.6281.00
42_C65_I0.6261.00
267_D287_N0.6251.00
377_V444_A0.6251.00
307_L311_A0.6241.00
274_S292_H0.6241.00
233_H254_A0.6221.00
362_V457_A0.6221.00
42_C51_H0.6211.00
303_V307_L0.6211.00
321_E324_T0.6201.00
144_E168_K0.6191.00
406_T434_I0.6191.00
355_T358_S0.6191.00
121_D132_G0.6181.00
131_T165_M0.6171.00
250_E257_I0.6171.00
165_M173_A0.6141.00
91_S95_Y0.6131.00
387_T390_P0.6131.00
389_R393_A0.6121.00
344_Q450_K0.6111.00
405_F423_E0.6081.00
359_L395_I0.6071.00
50_G53_F0.6071.00
43_V84_L0.6051.00
198_T260_Y0.6051.00
293_I306_V0.6041.00
437_R441_I0.6031.00
408_D414_D0.6031.00
205_L209_K0.6021.00
43_V57_A0.6011.00
377_V454_V0.6001.00
366_C455_L0.5991.00
246_S250_E0.5991.00
131_T174_I0.5991.00
107_I196_V0.5981.00
272_N275_I0.5961.00
121_D174_I0.5961.00
197_F215_R0.5961.00
349_I453_V0.5951.00
310_V327_V0.5951.00
118_H334_R0.5941.00
124_L313_C0.5931.00
115_S330_L0.5931.00
375_F444_A0.5931.00
258_S268_V0.5931.00
202_Q391_K0.5931.00
144_E164_K0.5931.00
441_I445_I0.5921.00
88_S91_S0.5901.00
372_G453_V0.5901.00
286_T320_F0.5891.00
282_F285_V0.5891.00
246_S249_F0.5891.00
378_V405_F0.5891.00
247_A250_E0.5881.00
393_A421_D0.5881.00
273_I282_F0.5871.00
395_I398_E0.5871.00
275_I300_Q0.5861.00
253_T257_I0.5831.00
463_T466_Q0.5831.00
407_S415_P0.5821.00
384_R387_T0.5821.00
337_F362_V0.5811.00
356_P391_K0.5811.00
353_A359_L0.5791.00
139_M142_G0.5771.00
273_I303_V0.5761.00
92_D191_D0.5751.00
203_D218_K0.5731.00
105_I124_L0.5711.00
262_I307_L0.5711.00
377_V440_A0.5701.00
388_K414_D0.5671.00
407_S419_L0.5671.00
437_R464_Y0.5671.00
195_A234_P0.5661.00
117_T174_I0.5641.00
205_L210_T0.5631.00
206_D214_Y0.5631.00
406_T437_R0.5631.00
341_N347_P0.5631.00
291_K321_E0.5621.00
85_R90_L0.5601.00
138_Y142_G0.5601.00
216_H219_S0.5581.00
135_G145_T0.5571.00
272_N292_H0.5571.00
132_G170_V0.5550.99
102_L173_A0.5550.99
308_A312_T0.5550.99
438_E466_Q0.5540.99
276_T294_T0.5530.99
123_I127_A0.5490.99
261_G269_M0.5490.99
212_D215_R0.5490.99
186_R190_C0.5480.99
389_R392_M0.5480.99
415_P419_L0.5450.99
87_L92_D0.5440.99
47_T50_G0.5420.99
114_T137_M0.5420.99
264_N269_M0.5410.99
386_K417_A0.5410.99
238_V258_S0.5400.99
118_H138_Y0.5390.99
376_V396_A0.5380.99
94_F97_Q0.5370.99
226_G235_K0.5350.99
376_V403_P0.5340.99
211_M214_Y0.5310.99
45_G48_V0.5310.99
50_G58_V0.5300.99
268_V287_N0.5300.99
394_K425_G0.5280.99
135_G138_Y0.5280.99
40_F53_F0.5270.99
343_Q346_F0.5250.99
246_S253_T0.5240.99
88_S189_G0.5230.99
110_T201_T0.5220.99
265_D269_M0.5220.99
312_T315_A0.5220.99
123_I318_I0.5210.99
300_Q303_V0.5210.99
441_I456_I0.5200.99
54_A64_A0.5200.99
295_M327_V0.5200.99
65_I77_V0.5190.99
359_L376_V0.5180.99
86_A89_V0.5170.99
57_A61_G0.5170.99
44_K47_T0.5170.99
216_H223_S0.5160.99
100_K191_D0.5150.99
187_V192_Y0.5150.99
391_K395_I0.5140.99
344_Q445_I0.5140.99
43_V47_T0.5130.99
55_Q58_V0.5130.99
125_K130_R0.5120.99
107_I116_T0.5120.99
394_K397_V0.5110.99
47_T52_D0.5090.99
181_A216_H0.5080.99
143_D175_M0.5070.99
115_S119_M0.5060.99
415_P433_S0.5060.99
87_L91_S0.5050.99
180_H206_D0.5050.99
322_I326_A0.5030.99
405_F418_I0.5020.99
178_S181_A0.5010.99
367_R370_T0.5010.99
320_F323_I0.5000.99
100_K103_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c12A 2 0.9838 100 0.167 Contact Map
4bubA 1 0.9636 100 0.185 Contact Map
2wtzA 1 0.9757 100 0.207 Contact Map
1e8cA 1 0.9717 100 0.218 Contact Map
4qdiA 1 0.8846 100 0.271 Contact Map
4cvkA 1 0.8543 100 0.273 Contact Map
3zm6A 1 0.8826 100 0.284 Contact Map
1gg4A 1 0.8603 100 0.289 Contact Map
3zl8A 1 0.8462 100 0.318 Contact Map
2x5oA 1 0.8441 100 0.41 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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