GREMLIN Database
MRAY - Phospho-N-acetylmuramoyl-pentapeptide-transferase
UniProt: Q03521 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (296)
Sequences: 6688 (4383)
Seq/√Len: 254.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
270_L282_I4.4841.00
190_A314_A4.1831.00
182_G307_W3.9691.00
192_A208_V3.5141.00
207_S244_I3.5041.00
284_K295_V3.4811.00
112_T115_Q3.3971.00
90_G123_I2.7641.00
185_A211_V2.7441.00
59_I229_M2.6321.00
127_F243_T2.5361.00
88_T236_A2.5081.00
163_L242_V2.4781.00
189_G211_V2.3951.00
97_L101_I2.3931.00
60_I92_G2.3861.00
298_S301_R2.2191.00
60_I89_L2.1831.00
274_S278_T2.1481.00
87_V239_G2.1321.00
181_S214_V2.1271.00
42_P45_H2.1091.00
259_G313_L2.0861.00
62_S66_T2.0631.00
170_V184_A2.0181.00
181_S218_L2.0041.00
210_V240_A1.9621.00
94_L119_G1.9481.00
275_F279_G1.9341.00
64_I89_L1.9021.00
206_F240_A1.9001.00
63_I210_V1.8401.00
274_S277_T1.8341.00
273_I277_T1.8281.00
125_V129_A1.8271.00
29_R33_F1.7751.00
121_I160_L1.7691.00
210_V237_L1.7621.00
116_K120_Q1.7381.00
276_K282_I1.7331.00
184_A188_F1.7191.00
128_Y160_L1.6981.00
188_F210_V1.6861.00
195_A248_T1.6711.00
125_V160_L1.6391.00
192_A207_S1.6321.00
128_Y159_V1.6291.00
288_L292_Y1.6101.00
154_A157_I1.6081.00
183_T310_G1.6021.00
96_F100_Y1.5751.00
59_I213_A1.5621.00
274_S282_I1.5581.00
153_W157_I1.5521.00
87_V127_F1.5511.00
116_K235_L1.5461.00
222_A304_V1.5381.00
297_W305_T1.5311.00
185_A215_L1.5131.00
117_L120_Q1.5101.00
187_A310_G1.5101.00
27_F30_R1.4951.00
181_S185_A1.4681.00
187_A241_I1.4671.00
196_W204_A1.4641.00
121_I164_V1.4411.00
159_V246_I1.4281.00
140_I143_P1.4271.00
266_L270_L1.4201.00
128_Y156_F1.4181.00
175_G289_H1.4051.00
287_P291_H1.4001.00
188_F211_V1.3941.00
60_I236_A1.3721.00
184_A237_L1.3721.00
93_L97_L1.3691.00
186_I307_W1.3551.00
287_P290_H1.3491.00
177_D224_P1.3481.00
21_S62_S1.3311.00
271_Q274_S1.3231.00
188_F241_I1.3131.00
92_G232_T1.3081.00
171_N231_D1.2971.00
66_T209_A1.2941.00
142_I145_T1.2911.00
301_R305_T1.2891.00
124_A160_L1.2871.00
214_V237_L1.2841.00
287_P292_Y1.2831.00
304_V308_A1.2531.00
223_H300_W1.2441.00
59_I214_V1.2301.00
24_L58_M1.2251.00
38_R41_G1.2221.00
18_V216_G1.2201.00
64_I85_L1.2061.00
26_P29_R1.2031.00
263_I288_L1.2031.00
209_A212_G1.1961.00
186_I314_A1.1951.00
162_M166_G1.1871.00
310_G314_A1.1821.00
121_I125_V1.1771.00
124_A163_L1.1751.00
21_S58_M1.1541.00
168_N171_N1.1531.00
94_L123_I1.1481.00
17_S216_G1.1461.00
83_L130_V1.1431.00
163_L243_T1.1401.00
16_I62_S1.1401.00
167_S235_L1.1361.00
117_L164_V1.1261.00
216_G220_F1.1261.00
124_A164_V1.1241.00
91_Y124_A1.1201.00
51_T228_F1.1191.00
188_F207_S1.1151.00
41_G44_S1.1111.00
127_F163_L1.1111.00
187_A257_I1.1111.00
170_V180_L1.1091.00
86_F126_V1.1061.00
268_V272_V1.1041.00
155_Y159_V1.1031.00
26_P30_R1.0981.00
172_L268_V1.0941.00
192_A211_V1.0941.00
181_S229_M1.0851.00
23_I27_F1.0841.00
162_M245_A1.0821.00
84_L203_V1.0801.00
51_T225_A1.0731.00
120_Q235_L1.0691.00
27_F31_L1.0681.00
22_P26_P1.0661.00
184_A214_V1.0631.00
25_I227_V1.0521.00
86_F90_G1.0481.00
88_T240_A1.0411.00
62_S65_V1.0371.00
267_S275_F1.0371.00
184_A241_I1.0351.00
120_Q167_S1.0301.00
95_G235_L1.0291.00
91_Y123_I1.0231.00
91_Y239_G1.0221.00
212_G216_G1.0191.00
47_K228_F1.0161.00
257_I317_G1.0111.00
44_S47_K1.0111.00
186_I310_G1.0081.00
90_G119_G1.0061.00
24_L61_L1.0021.00
236_A240_A0.9981.00
159_V163_L0.9921.00
297_W301_R0.9901.00
173_T183_T0.9871.00
195_A203_V0.9841.00
192_A195_A0.9831.00
120_Q164_V0.9811.00
18_V219_V0.9801.00
12_M70_M0.9721.00
218_L222_A0.9721.00
117_L121_I0.9701.00
29_R226_K0.9671.00
192_A196_W0.9551.00
188_F214_V0.9521.00
264_E289_H0.9511.00
63_I88_T0.9501.00
87_V123_I0.9501.00
116_K167_S0.9471.00
219_V305_T0.9441.00
22_P220_F0.9401.00
190_A318_I0.9391.00
195_A204_A0.9341.00
215_L219_V0.9341.00
129_A133_Y0.9301.00
281_R284_K0.9251.00
138_T150_D0.9251.00
287_P294_L0.9231.00
150_D154_A0.9201.00
165_G265_T0.9201.00
63_I213_A0.9181.00
165_G269_I0.9181.00
190_A257_I0.9181.00
189_G193_I0.9171.00
176_L303_V0.9081.00
116_K119_G0.9041.00
87_V243_T0.9021.00
154_A158_L0.9011.00
53_T232_T0.9011.00
101_I112_T0.9001.00
120_Q168_N0.8971.00
67_T81_M0.8951.00
101_I110_G0.8911.00
274_S280_K0.8911.00
91_Y167_S0.8901.00
165_G268_V0.8861.00
60_I88_T0.8841.00
40_E50_G0.8841.00
185_A214_V0.8831.00
290_H293_E0.8821.00
192_A204_A0.8811.00
39_E45_H0.8811.00
114_K118_I0.8651.00
309_A313_L0.8590.99
291_H294_L0.8580.99
116_K172_L0.8580.99
280_K284_K0.8560.99
101_I111_L0.8540.99
172_L265_T0.8530.99
131_Y134_Y0.8500.99
191_F245_A0.8500.99
303_V307_W0.8460.99
223_H299_E0.8450.99
30_R34_G0.8440.99
258_G261_F0.8410.99
187_A314_A0.8400.99
228_F231_D0.8310.99
186_I311_L0.8080.99
297_W302_V0.8070.99
63_I236_A0.8060.99
9_T209_A0.8060.99
84_L88_T0.8040.99
180_L237_L0.7970.99
272_V282_I0.7920.99
292_Y306_F0.7910.99
38_R50_G0.7900.99
40_E43_K0.7890.99
12_M69_V0.7880.99
91_Y119_G0.7850.99
284_K294_L0.7840.99
139_D148_S0.7780.99
40_E46_Q0.7780.99
181_S217_F0.7770.99
124_A128_Y0.7770.99
14_F18_V0.7770.99
308_A312_L0.7770.99
17_S21_S0.7760.99
299_E303_V0.7750.99
89_L93_L0.7750.99
280_K288_L0.7740.99
67_T71_T0.7730.99
279_G282_I0.7710.99
20_L66_T0.7690.99
171_N228_F0.7690.99
127_F131_Y0.7690.99
18_V22_P0.7650.99
21_S216_G0.7630.99
269_I272_V0.7620.99
223_H303_V0.7620.99
260_V310_G0.7610.99
263_I306_F0.7610.99
84_L240_A0.7590.99
313_L317_G0.7560.99
222_A300_W0.7520.99
91_Y120_Q0.7520.99
20_L62_S0.7500.99
170_V187_A0.7500.99
26_P220_F0.7480.99
206_F244_I0.7470.99
161_F165_G0.7460.99
166_G242_V0.7420.99
158_L162_M0.7380.98
139_D150_D0.7350.98
28_L227_V0.7310.98
115_Q118_I0.7310.98
168_N231_D0.7260.98
96_F232_T0.7240.98
183_T260_V0.7220.98
44_S285_M0.7210.98
90_G94_L0.7200.98
302_V306_F0.7160.98
97_L100_Y0.7150.98
264_E267_S0.7130.98
217_F229_M0.7120.98
25_I216_G0.7110.98
186_I190_A0.7110.98
84_L243_T0.7100.98
57_V232_T0.7090.98
43_K46_Q0.7080.98
169_A265_T0.7060.98
79_P130_V0.7050.98
176_L302_V0.7050.98
29_R32_K0.7040.98
140_I145_T0.7020.98
54_M96_F0.7010.98
14_F212_G0.7010.98
263_I309_A0.7010.98
275_F281_R0.7000.98
130_V134_Y0.7000.98
193_I197_N0.7000.98
67_T206_F0.6990.98
298_S302_V0.6990.98
239_G243_T0.6960.98
11_L15_L0.6900.98
286_S291_H0.6870.98
54_M100_Y0.6850.97
45_H51_T0.6850.97
17_S212_G0.6830.97
180_L229_M0.6810.97
166_G245_A0.6790.97
23_I26_P0.6740.97
116_K231_D0.6740.97
92_G236_A0.6740.97
152_G157_I0.6730.97
16_I19_L0.6720.97
273_I286_S0.6700.97
312_L316_L0.6700.97
13_G209_A0.6700.97
188_F240_A0.6690.97
172_L271_Q0.6650.97
315_V319_Y0.6610.97
10_I208_V0.6610.97
191_F207_S0.6570.97
62_S213_A0.6550.97
41_G45_H0.6520.97
204_A208_V0.6500.97
32_K38_R0.6470.96
203_V247_L0.6470.96
267_S271_Q0.6460.96
88_T206_F0.6450.96
63_I188_F0.6450.96
41_G50_G0.6440.96
273_I276_K0.6440.96
151_L155_Y0.6430.96
205_I209_A0.6390.96
20_L24_L0.6390.96
94_L235_L0.6390.96
174_D229_M0.6360.96
46_Q299_E0.6320.96
267_S286_S0.6300.96
183_T261_F0.6280.96
272_V276_K0.6270.96
112_T116_K0.6260.96
229_M237_L0.6250.96
63_I67_T0.6210.96
127_F239_G0.6200.96
275_F278_T0.6190.95
182_G303_V0.6190.95
191_F248_T0.6180.95
173_T271_Q0.6170.95
167_S239_G0.6150.95
26_P31_L0.6140.95
177_D229_M0.6130.95
165_G169_A0.6100.95
265_T269_I0.6090.95
92_G96_F0.6070.95
194_L250_L0.6050.95
157_I160_L0.6040.95
42_P46_Q0.5990.95
151_L154_A0.5970.95
300_W304_V0.5940.94
16_I66_T0.5930.94
172_L286_S0.5930.94
185_A189_G0.5920.94
53_T285_M0.5920.94
24_L28_L0.5890.94
169_A268_V0.5880.94
193_I318_I0.5880.94
180_L217_F0.5870.94
219_V226_K0.5870.94
66_T69_V0.5850.94
187_A261_F0.5830.94
314_A317_G0.5800.94
47_K275_F0.5780.94
258_G262_V0.5700.93
174_D180_L0.5700.93
174_D233_G0.5690.93
132_H156_F0.5680.93
124_A242_V0.5670.93
305_T308_A0.5640.93
299_E302_V0.5630.93
21_S25_I0.5630.93
69_V72_Q0.5630.93
60_I64_I0.5620.93
138_T141_R0.5620.93
120_Q234_S0.5610.92
259_G262_V0.5590.92
126_V130_V0.5580.92
55_G217_F0.5560.92
68_I72_Q0.5530.92
71_T81_M0.5510.92
259_G317_G0.5510.92
113_S172_L0.5500.92
265_T272_V0.5490.92
219_V308_A0.5490.92
150_D157_I0.5470.92
66_T70_M0.5470.92
113_S283_F0.5460.91
22_P25_I0.5440.91
91_Y235_L0.5430.91
31_L34_G0.5420.91
167_S234_S0.5410.91
28_L58_M0.5410.91
22_P216_G0.5390.91
182_G186_I0.5390.91
22_P219_V0.5390.91
13_G205_I0.5390.91
35_Q100_Y0.5370.91
156_F160_L0.5360.91
264_E286_S0.5350.91
34_G37_I0.5340.91
288_L291_H0.5330.90
207_S240_A0.5320.90
78_S202_D0.5310.90
282_I286_S0.5300.90
141_R144_G0.5290.90
41_G46_Q0.5290.90
265_T268_V0.5280.90
167_S242_V0.5280.90
297_W306_F0.5280.90
188_F192_A0.5250.90
57_V92_G0.5250.90
146_D149_F0.5240.90
232_T235_L0.5230.90
25_I28_L0.5200.89
217_F228_F0.5200.89
111_L119_G0.5200.89
268_V286_S0.5190.89
13_G17_S0.5180.89
220_F226_K0.5180.89
273_I278_T0.5160.89
177_D290_H0.5160.89
59_I63_I0.5160.89
139_D143_P0.5150.89
45_H285_M0.5140.89
270_L273_I0.5140.89
271_Q286_S0.5130.89
205_I212_G0.5130.89
257_I261_F0.5110.89
242_V245_A0.5100.88
125_V156_F0.5090.88
128_Y132_H0.5080.88
122_I129_A0.5070.88
60_I63_I0.5060.88
110_G283_F0.5050.88
163_L167_S0.5020.88
43_K294_L0.5020.88
276_K281_R0.5020.88
145_T149_F0.5000.88
260_V264_E0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j72A 2 0.9198 100 0.164 Contact Map
4dx5A 3 0.1451 11 0.964 Contact Map
2ls4A 1 0.0741 8.9 0.965 Contact Map
2i68A 2 0.2284 6.8 0.967 Contact Map
3ux4A 3 0.213 5.4 0.969 Contact Map
1vryA 1 0.1636 5.3 0.969 Contact Map
2xq2A 2 0.2932 4.7 0.969 Contact Map
2mmuA 1 0.0741 3.8 0.971 Contact Map
2lzrA 1 0.1512 3.8 0.971 Contact Map
2mfrA 1 0.1451 3.5 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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