GREMLIN Database
GLPX - Fructose-1,6-bisphosphatase class 2
UniProt: Q03224 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 321 (312)
Sequences: 1120 (518)
Seq/√Len: 29.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_I174_L6.2451.00
143_L157_V4.1711.00
50_K79_R4.1341.00
28_K31_E4.0091.00
140_I173_E3.9031.00
136_E231_K3.3101.00
34_E38_S3.2191.00
139_V206_F3.2171.00
171_I183_L3.2101.00
159_A204_I3.2061.00
146_V204_I3.1721.00
222_K257_E3.1291.00
192_A217_S3.0621.00
87_L272_V2.9851.00
79_R109_H2.9731.00
174_L179_A2.9561.00
235_Q239_E2.8781.00
21_A283_F2.8641.00
10_V292_S2.7901.00
124_A221_L2.7701.00
50_K71_K2.7591.00
52_T71_K2.6771.00
228_I256_M2.6371.00
134_D253_V2.5510.99
121_Q231_K2.4790.99
135_I253_V2.4780.99
131_G227_E2.4460.99
241_T245_K2.4160.99
169_K173_E2.3770.99
136_E253_V2.3550.99
52_T109_H2.2980.99
291_E306_D2.2680.99
208_S233_L2.2120.98
196_A221_L2.0910.98
128_E150_K2.0770.97
291_E304_F2.0300.97
135_I231_K1.9680.97
289_T306_D1.9140.96
129_A146_V1.8980.96
170_I206_F1.8910.96
18_L288_G1.8730.95
137_A145_A1.8410.95
143_L177_A1.8350.95
123_I133_I1.8120.94
146_V157_V1.8060.94
172_S176_E1.7830.94
143_L154_V1.7580.93
143_L204_I1.7480.93
3_R296_R1.7440.93
271_G275_G1.6840.92
162_L184_I1.6750.92
125_V204_I1.6720.92
9_L106_V1.6640.91
137_A141_D1.6090.90
222_K260_V1.5900.89
108_D264_D1.5800.89
24_M273_T1.5770.89
82_V106_V1.5580.88
133_I146_V1.5570.88
165_E168_A1.5370.88
160_T184_I1.5330.88
296_R301_T1.5110.87
300_G313_K1.4920.86
140_I176_E1.4880.86
20_S102_T1.4830.86
168_A172_S1.4810.86
227_E256_M1.4730.85
281_V290_T1.4710.85
274_D279_K1.4690.85
160_T191_G1.4670.85
159_A206_F1.4610.85
284_K287_V1.4600.85
112_L260_V1.4530.85
240_I244_H1.4400.84
41_R70_E1.4400.84
29_K60_M1.4100.83
47_V109_H1.3810.81
59_E65_M1.3740.81
249_D252_K1.3390.79
161_I171_I1.3200.78
134_D229_I1.3070.78
115_A211_A1.3070.78
279_K306_D1.3040.77
234_P239_E1.2960.77
44_F104_I1.2940.77
287_V311_L1.2850.76
11_R296_R1.2820.76
219_V265_A1.2730.76
140_I144_K1.2530.75
68_I114_N1.2490.74
154_V179_A1.2420.74
296_R299_S1.2400.74
91_N95_S1.2320.73
114_N118_M1.2280.73
61_D90_T1.2230.73
68_I211_A1.2210.73
254_L258_D1.2180.72
288_G311_L1.2100.72
105_A219_V1.2100.72
153_D156_D1.2090.72
107_A111_T1.2090.72
63_A90_T1.2080.72
117_D211_A1.2070.72
71_K109_H1.2010.71
92_I185_N1.1990.71
60_M235_Q1.1970.71
64_P90_T1.1910.71
141_D145_A1.1880.70
121_Q208_S1.1800.70
113_L211_A1.1740.70
289_T308_R1.1670.69
138_P142_N1.1630.69
130_V227_E1.1570.68
142_N145_A1.1510.68
68_I117_D1.1480.68
135_I229_I1.1440.68
61_D65_M1.1420.67
182_K276_E1.1410.67
124_A228_I1.1400.67
58_G61_D1.1330.67
29_K84_V1.1280.66
125_V227_E1.1210.66
60_M118_M1.1070.65
68_I115_A1.0990.64
161_I207_G1.0910.64
169_K172_S1.0900.64
57_E61_D1.0870.63
108_D262_G1.0850.63
23_W35_A1.0820.63
229_I253_V1.0820.63
129_A205_L1.0800.63
152_K203_D1.0750.63
168_A171_I1.0740.63
296_R303_R1.0560.61
238_E241_T1.0550.61
211_A214_G1.0530.61
115_A242_R1.0530.61
48_P74_N1.0490.61
123_I307_G1.0470.60
3_R8_E1.0470.60
143_L174_L1.0450.60
99_N191_G1.0320.59
223_A295_I1.0310.59
114_N246_M1.0270.59
248_L252_K1.0260.59
252_K258_D1.0250.59
61_D64_P1.0220.59
90_T212_P1.0160.58
300_G310_S1.0150.58
138_P141_D1.0050.57
111_T261_K0.9960.57
52_T114_N0.9920.56
262_G297_A0.9860.56
118_M239_E0.9800.55
59_E242_R0.9800.55
86_P212_P0.9740.55
20_S306_D0.9710.55
143_L146_V0.9690.55
290_T309_H0.9620.54
91_N186_D0.9570.54
240_I251_S0.9520.53
32_A93_L0.9520.53
11_R303_R0.9510.53
133_I142_N0.9510.53
30_D87_L0.9460.53
270_T290_T0.9440.53
115_A248_L0.9430.52
117_D246_M0.9400.52
95_S223_A0.9390.52
205_L216_L0.9370.52
242_R246_M0.9340.52
32_A87_L0.9320.52
33_D57_E0.9210.51
4_S266_I0.9200.51
117_D242_R0.9190.51
113_L117_D0.9110.50
85_D90_T0.9050.50
3_R11_R0.8940.49
228_I259_L0.8910.48
65_M90_T0.8860.48
60_M87_L0.8840.48
16_A40_M0.8720.47
59_E64_P0.8700.47
95_S163_N0.8650.46
214_G230_G0.8640.46
216_L227_E0.8610.46
68_I118_M0.8560.46
99_N160_T0.8560.46
87_L93_L0.8490.45
124_A192_A0.8480.45
9_L190_A0.8480.45
152_K297_A0.8370.44
237_E241_T0.8370.44
118_M211_A0.8360.44
241_T244_H0.8350.44
60_M117_D0.8330.44
11_R301_T0.8310.44
116_P215_V0.8290.44
142_N229_I0.8290.44
238_E307_G0.8290.44
132_C145_A0.8290.44
58_G64_P0.8280.44
125_V129_A0.8260.43
265_A297_A0.8210.43
138_P145_A0.8190.43
98_W274_D0.8180.43
60_M211_A0.8160.43
121_Q135_I0.8160.43
88_E171_I0.8120.42
86_P90_T0.8080.42
217_S221_L0.8040.42
13_T270_T0.8030.42
65_M68_I0.8010.41
59_E90_T0.8000.41
230_G259_L0.8000.41
60_M84_V0.7890.41
4_S292_S0.7870.40
236_S239_E0.7820.40
132_C227_E0.7790.40
58_G65_M0.7760.40
246_M250_L0.7740.39
227_E243_C0.7740.39
37_T59_E0.7720.39
37_T61_D0.7680.39
29_K90_T0.7680.39
282_Q289_T0.7670.39
12_V44_F0.7670.39
10_V305_V0.7600.38
223_A265_A0.7600.38
98_W194_N0.7540.38
68_I246_M0.7530.38
97_G185_N0.7510.38
137_A142_N0.7490.38
8_E47_V0.7440.37
182_K202_V0.7430.37
23_W31_E0.7430.37
37_T63_A0.7400.37
59_E68_I0.7380.37
264_D297_A0.7330.36
211_A248_L0.7330.36
33_D58_G0.7290.36
59_E63_A0.7270.36
101_L160_T0.7260.36
13_T53_V0.7230.36
55_I63_A0.7190.35
133_I158_V0.7180.35
118_M246_M0.7180.35
8_E108_D0.7170.35
125_V228_I0.7170.35
117_D243_C0.7170.35
88_E190_A0.7160.35
133_I149_A0.7150.35
33_D61_D0.7140.35
107_A112_L0.7090.35
10_V106_V0.7080.35
104_I185_N0.7060.34
96_G288_G0.7050.34
76_Y289_T0.7050.34
51_G72_L0.7030.34
96_G100_A0.7020.34
240_I250_L0.7010.34
48_P76_Y0.6970.34
68_I242_R0.6970.34
152_K284_K0.6960.34
269_A278_L0.6950.34
65_M242_R0.6940.34
63_A103_V0.6920.33
22_R223_A0.6910.33
22_R283_F0.6880.33
174_L177_A0.6850.33
161_I170_I0.6840.33
55_I83_A0.6810.33
198_D304_F0.6800.33
4_S9_L0.6760.32
6_S266_I0.6750.32
222_K258_D0.6750.32
24_M96_G0.6750.32
97_G292_S0.6720.32
97_G102_T0.6720.32
93_L100_A0.6680.32
11_R14_E0.6660.32
3_R299_S0.6660.32
221_L256_M0.6660.32
156_D258_D0.6650.32
129_A149_A0.6610.31
163_N168_A0.6610.31
89_G210_G0.6590.31
193_I277_L0.6560.31
161_I181_I0.6500.31
263_D298_K0.6500.31
97_G104_I0.6500.31
101_L269_A0.6490.31
151_N154_V0.6460.30
44_F91_N0.6460.30
114_N117_D0.6440.30
296_R309_H0.6430.30
22_R288_G0.6400.30
132_C148_K0.6360.30
60_M68_I0.6360.30
102_T292_S0.6350.30
184_I191_G0.6310.29
197_F224_L0.6310.29
124_A159_A0.6310.29
164_R223_A0.6250.29
152_K243_C0.6250.29
237_E246_M0.6230.29
225_G247_G0.6220.29
58_G63_A0.6200.29
59_E212_P0.6200.29
144_K153_D0.6170.28
231_K253_V0.6170.28
88_E233_L0.6170.28
106_V307_G0.6160.28
65_M212_P0.6150.28
234_P250_L0.6120.28
31_E35_A0.6120.28
18_L49_M0.6100.28
208_S216_L0.6090.28
57_E119_Y0.6090.28
114_N211_A0.6090.28
123_I146_V0.6050.28
21_A93_L0.6050.28
184_I233_L0.6050.28
60_M114_N0.6030.28
268_A296_R0.6010.27
18_L309_H0.5990.27
48_P272_V0.5990.27
7_M10_V0.5960.27
33_D119_Y0.5930.27
194_N276_E0.5920.27
46_T274_D0.5920.27
83_A212_P0.5920.27
24_M93_L0.5910.27
133_I197_F0.5900.27
44_F93_L0.5860.26
3_R301_T0.5860.26
101_L151_N0.5850.26
127_P201_G0.5850.26
175_R290_T0.5830.26
123_I142_N0.5820.26
118_M243_C0.5820.26
3_R189_V0.5810.26
61_D212_P0.5780.26
237_E240_I0.5770.26
139_V170_I0.5760.26
14_E290_T0.5750.26
45_D74_N0.5750.26
163_N185_N0.5740.26
63_A83_A0.5740.26
282_Q287_V0.5730.26
87_L243_C0.5720.26
286_S312_K0.5720.26
9_L300_G0.5720.26
177_A292_S0.5710.26
91_N185_N0.5710.26
120_M230_G0.5710.26
204_I312_K0.5700.26
38_S87_L0.5700.26
63_A212_P0.5700.26
96_G180_R0.5690.25
268_A292_S0.5680.25
58_G90_T0.5670.25
286_S293_L0.5670.25
141_D144_K0.5670.25
108_D111_T0.5670.25
8_E11_R0.5660.25
94_A191_G0.5660.25
161_I173_E0.5630.25
57_E63_A0.5620.25
152_K157_V0.5610.25
53_V72_L0.5610.25
112_L219_V0.5610.25
165_E305_V0.5610.25
121_Q233_L0.5600.25
115_A254_L0.5600.25
139_V173_E0.5600.25
192_A205_L0.5600.25
22_R156_D0.5600.25
248_L254_L0.5590.25
30_D60_M0.5590.25
123_I149_A0.5580.25
203_D306_D0.5570.25
9_L101_L0.5530.25
134_D221_L0.5520.24
150_K297_A0.5510.24
194_N292_S0.5510.24
63_A85_D0.5500.24
8_E301_T0.5490.24
55_I61_D0.5470.24
222_K265_A0.5470.24
138_P195_T0.5460.24
310_S313_K0.5460.24
72_L193_I0.5450.24
32_A231_K0.5450.24
173_E206_F0.5440.24
33_D86_P0.5420.24
222_K261_K0.5420.24
198_D203_D0.5410.24
88_E189_V0.5410.24
19_A39_A0.5410.24
65_M84_V0.5410.24
146_V159_A0.5410.24
243_C250_L0.5400.24
37_T86_P0.5390.24
37_T65_M0.5380.24
61_D86_P0.5370.24
63_A84_V0.5350.23
30_D62_E0.5350.23
250_L254_L0.5350.23
31_E266_I0.5350.23
37_T90_T0.5340.23
105_A229_I0.5340.23
221_L228_I0.5340.23
124_A195_T0.5340.23
115_A246_M0.5330.23
116_P125_V0.5330.23
201_G281_V0.5320.23
52_T245_K0.5270.23
131_G246_M0.5260.23
10_V13_T0.5260.23
12_V49_M0.5260.23
24_M283_F0.5260.23
84_V245_K0.5260.23
133_I145_A0.5250.23
111_T262_G0.5250.23
40_M84_V0.5250.23
197_F304_F0.5240.23
119_Y188_D0.5240.23
181_I284_K0.5200.23
203_D289_T0.5180.23
116_P211_A0.5180.23
299_S303_R0.5180.23
203_D284_K0.5180.23
28_K32_A0.5180.23
138_P173_E0.5170.22
184_I243_C0.5170.22
47_V189_V0.5170.22
143_L216_L0.5170.22
29_K63_A0.5160.22
103_V216_L0.5160.22
230_G275_G0.5160.22
134_D137_A0.5160.22
116_P217_S0.5150.22
135_I266_I0.5150.22
84_V90_T0.5150.22
175_R292_S0.5150.22
37_T57_E0.5140.22
196_A264_D0.5130.22
304_F308_R0.5130.22
154_V168_A0.5120.22
67_Y217_S0.5120.22
125_V132_C0.5110.22
99_N193_I0.5110.22
154_V157_V0.5100.22
37_T92_I0.5100.22
23_W32_A0.5090.22
88_E117_D0.5090.22
21_A181_I0.5090.22
88_E91_N0.5070.22
59_E66_L0.5070.22
121_Q162_L0.5070.22
118_M233_L0.5060.22
6_S309_H0.5030.22
47_V80_V0.5030.22
76_Y305_V0.5010.22
33_D90_T0.5010.22
199_H307_G0.5010.22
154_V204_I0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bigA 1 0.9657 100 0.004 Contact Map
3rojA 3 0.9969 100 0.014 Contact Map
3b8bA 1 0.7227 95.8 0.953 Contact Map
1ka1A 1 0.785 94.3 0.957 Contact Map
2pcrA 3 0.6947 94.2 0.957 Contact Map
4n81A 2 0.7134 94 0.958 Contact Map
4i3yA 2 0.757 94 0.958 Contact Map
3lv0A 2 0.7196 93.8 0.958 Contact Map
1inpA 1 0.8629 93.2 0.959 Contact Map
4o7iA 1 0.8162 93.2 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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