GLPX - BACSU - GREMLIN Contacts

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GLPX - Fructose-1,6-bisphosphatase class 2

UniProt:	Q03224	Sequences: MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVFDTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALTVIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVATILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSAVALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGELLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	321 (312)
Sequences:	1120 (518)
Seq/√Len:	29.3

ECOLI - GLPX GLPX2
BACSU - GLPX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
161_I	174_L	6.245	1.00
143_L	157_V	4.171	1.00
50_K	79_R	4.134	1.00
28_K	31_E	4.009	1.00
140_I	173_E	3.903	1.00
136_E	231_K	3.310	1.00
34_E	38_S	3.219	1.00
139_V	206_F	3.217	1.00
171_I	183_L	3.210	1.00
159_A	204_I	3.206	1.00
146_V	204_I	3.172	1.00
222_K	257_E	3.129	1.00
192_A	217_S	3.062	1.00
87_L	272_V	2.985	1.00
79_R	109_H	2.973	1.00
174_L	179_A	2.956	1.00
235_Q	239_E	2.878	1.00
21_A	283_F	2.864	1.00
10_V	292_S	2.790	1.00
124_A	221_L	2.770	1.00
50_K	71_K	2.759	1.00
52_T	71_K	2.677	1.00
228_I	256_M	2.637	1.00
134_D	253_V	2.551	0.99
121_Q	231_K	2.479	0.99
135_I	253_V	2.478	0.99
131_G	227_E	2.446	0.99
241_T	245_K	2.416	0.99
169_K	173_E	2.377	0.99
136_E	253_V	2.355	0.99
52_T	109_H	2.298	0.99
291_E	306_D	2.268	0.99
208_S	233_L	2.212	0.98
196_A	221_L	2.091	0.98
128_E	150_K	2.077	0.97
291_E	304_F	2.030	0.97
135_I	231_K	1.968	0.97
289_T	306_D	1.914	0.96
129_A	146_V	1.898	0.96
170_I	206_F	1.891	0.96
18_L	288_G	1.873	0.95
137_A	145_A	1.841	0.95
143_L	177_A	1.835	0.95
123_I	133_I	1.812	0.94
146_V	157_V	1.806	0.94
172_S	176_E	1.783	0.94
143_L	154_V	1.758	0.93
143_L	204_I	1.748	0.93
3_R	296_R	1.744	0.93
271_G	275_G	1.684	0.92
162_L	184_I	1.675	0.92
125_V	204_I	1.672	0.92
9_L	106_V	1.664	0.91
137_A	141_D	1.609	0.90
222_K	260_V	1.590	0.89
108_D	264_D	1.580	0.89
24_M	273_T	1.577	0.89
82_V	106_V	1.558	0.88
133_I	146_V	1.557	0.88
165_E	168_A	1.537	0.88
160_T	184_I	1.533	0.88
296_R	301_T	1.511	0.87
300_G	313_K	1.492	0.86
140_I	176_E	1.488	0.86
20_S	102_T	1.483	0.86
168_A	172_S	1.481	0.86
227_E	256_M	1.473	0.85
281_V	290_T	1.471	0.85
274_D	279_K	1.469	0.85
160_T	191_G	1.467	0.85
159_A	206_F	1.461	0.85
284_K	287_V	1.460	0.85
112_L	260_V	1.453	0.85
240_I	244_H	1.440	0.84
41_R	70_E	1.440	0.84
29_K	60_M	1.410	0.83
47_V	109_H	1.381	0.81
59_E	65_M	1.374	0.81
249_D	252_K	1.339	0.79
161_I	171_I	1.320	0.78
134_D	229_I	1.307	0.78
115_A	211_A	1.307	0.78
279_K	306_D	1.304	0.77
234_P	239_E	1.296	0.77
44_F	104_I	1.294	0.77
287_V	311_L	1.285	0.76
11_R	296_R	1.282	0.76
219_V	265_A	1.273	0.76
140_I	144_K	1.253	0.75
68_I	114_N	1.249	0.74
154_V	179_A	1.242	0.74
296_R	299_S	1.240	0.74
91_N	95_S	1.232	0.73
114_N	118_M	1.228	0.73
61_D	90_T	1.223	0.73
68_I	211_A	1.221	0.73
254_L	258_D	1.218	0.72
288_G	311_L	1.210	0.72
105_A	219_V	1.210	0.72
153_D	156_D	1.209	0.72
107_A	111_T	1.209	0.72
63_A	90_T	1.208	0.72
117_D	211_A	1.207	0.72
71_K	109_H	1.201	0.71
92_I	185_N	1.199	0.71
60_M	235_Q	1.197	0.71
64_P	90_T	1.191	0.71
141_D	145_A	1.188	0.70
121_Q	208_S	1.180	0.70
113_L	211_A	1.174	0.70
289_T	308_R	1.167	0.69
138_P	142_N	1.163	0.69
130_V	227_E	1.157	0.68
142_N	145_A	1.151	0.68
68_I	117_D	1.148	0.68
135_I	229_I	1.144	0.68
61_D	65_M	1.142	0.67
182_K	276_E	1.141	0.67
124_A	228_I	1.140	0.67
58_G	61_D	1.133	0.67
29_K	84_V	1.128	0.66
125_V	227_E	1.121	0.66
60_M	118_M	1.107	0.65
68_I	115_A	1.099	0.64
161_I	207_G	1.091	0.64
169_K	172_S	1.090	0.64
57_E	61_D	1.087	0.63
108_D	262_G	1.085	0.63
23_W	35_A	1.082	0.63
229_I	253_V	1.082	0.63
129_A	205_L	1.080	0.63
152_K	203_D	1.075	0.63
168_A	171_I	1.074	0.63
296_R	303_R	1.056	0.61
238_E	241_T	1.055	0.61
211_A	214_G	1.053	0.61
115_A	242_R	1.053	0.61
48_P	74_N	1.049	0.61
123_I	307_G	1.047	0.60
3_R	8_E	1.047	0.60
143_L	174_L	1.045	0.60
99_N	191_G	1.032	0.59
223_A	295_I	1.031	0.59
114_N	246_M	1.027	0.59
248_L	252_K	1.026	0.59
252_K	258_D	1.025	0.59
61_D	64_P	1.022	0.59
90_T	212_P	1.016	0.58
300_G	310_S	1.015	0.58
138_P	141_D	1.005	0.57
111_T	261_K	0.996	0.57
52_T	114_N	0.992	0.56
262_G	297_A	0.986	0.56
118_M	239_E	0.980	0.55
59_E	242_R	0.980	0.55
86_P	212_P	0.974	0.55
20_S	306_D	0.971	0.55
143_L	146_V	0.969	0.55
290_T	309_H	0.962	0.54
91_N	186_D	0.957	0.54
240_I	251_S	0.952	0.53
32_A	93_L	0.952	0.53
11_R	303_R	0.951	0.53
133_I	142_N	0.951	0.53
30_D	87_L	0.946	0.53
270_T	290_T	0.944	0.53
115_A	248_L	0.943	0.52
117_D	246_M	0.940	0.52
95_S	223_A	0.939	0.52
205_L	216_L	0.937	0.52
242_R	246_M	0.934	0.52
32_A	87_L	0.932	0.52
33_D	57_E	0.921	0.51
4_S	266_I	0.920	0.51
117_D	242_R	0.919	0.51
113_L	117_D	0.911	0.50
85_D	90_T	0.905	0.50
3_R	11_R	0.894	0.49
228_I	259_L	0.891	0.48
65_M	90_T	0.886	0.48
60_M	87_L	0.884	0.48
16_A	40_M	0.872	0.47
59_E	64_P	0.870	0.47
95_S	163_N	0.865	0.46
214_G	230_G	0.864	0.46
216_L	227_E	0.861	0.46
68_I	118_M	0.856	0.46
99_N	160_T	0.856	0.46
87_L	93_L	0.849	0.45
124_A	192_A	0.848	0.45
9_L	190_A	0.848	0.45
152_K	297_A	0.837	0.44
237_E	241_T	0.837	0.44
118_M	211_A	0.836	0.44
241_T	244_H	0.835	0.44
60_M	117_D	0.833	0.44
11_R	301_T	0.831	0.44
116_P	215_V	0.829	0.44
142_N	229_I	0.829	0.44
238_E	307_G	0.829	0.44
132_C	145_A	0.829	0.44
58_G	64_P	0.828	0.44
125_V	129_A	0.826	0.43
265_A	297_A	0.821	0.43
138_P	145_A	0.819	0.43
98_W	274_D	0.818	0.43
60_M	211_A	0.816	0.43
121_Q	135_I	0.816	0.43
88_E	171_I	0.812	0.42
86_P	90_T	0.808	0.42
217_S	221_L	0.804	0.42
13_T	270_T	0.803	0.42
65_M	68_I	0.801	0.41
59_E	90_T	0.800	0.41
230_G	259_L	0.800	0.41
60_M	84_V	0.789	0.41
4_S	292_S	0.787	0.40
236_S	239_E	0.782	0.40
132_C	227_E	0.779	0.40
58_G	65_M	0.776	0.40
246_M	250_L	0.774	0.39
227_E	243_C	0.774	0.39
37_T	59_E	0.772	0.39
37_T	61_D	0.768	0.39
29_K	90_T	0.768	0.39
282_Q	289_T	0.767	0.39
12_V	44_F	0.767	0.39
10_V	305_V	0.760	0.38
223_A	265_A	0.760	0.38
98_W	194_N	0.754	0.38
68_I	246_M	0.753	0.38
97_G	185_N	0.751	0.38
137_A	142_N	0.749	0.38
8_E	47_V	0.744	0.37
182_K	202_V	0.743	0.37
23_W	31_E	0.743	0.37
37_T	63_A	0.740	0.37
59_E	68_I	0.738	0.37
264_D	297_A	0.733	0.36
211_A	248_L	0.733	0.36
33_D	58_G	0.729	0.36
59_E	63_A	0.727	0.36
101_L	160_T	0.726	0.36
13_T	53_V	0.723	0.36
55_I	63_A	0.719	0.35
133_I	158_V	0.718	0.35
118_M	246_M	0.718	0.35
8_E	108_D	0.717	0.35
125_V	228_I	0.717	0.35
117_D	243_C	0.717	0.35
88_E	190_A	0.716	0.35
133_I	149_A	0.715	0.35
33_D	61_D	0.714	0.35
107_A	112_L	0.709	0.35
10_V	106_V	0.708	0.35
104_I	185_N	0.706	0.34
96_G	288_G	0.705	0.34
76_Y	289_T	0.705	0.34
51_G	72_L	0.703	0.34
96_G	100_A	0.702	0.34
240_I	250_L	0.701	0.34
48_P	76_Y	0.697	0.34
68_I	242_R	0.697	0.34
152_K	284_K	0.696	0.34
269_A	278_L	0.695	0.34
65_M	242_R	0.694	0.34
63_A	103_V	0.692	0.33
22_R	223_A	0.691	0.33
22_R	283_F	0.688	0.33
174_L	177_A	0.685	0.33
161_I	170_I	0.684	0.33
55_I	83_A	0.681	0.33
198_D	304_F	0.680	0.33
4_S	9_L	0.676	0.32
6_S	266_I	0.675	0.32
222_K	258_D	0.675	0.32
24_M	96_G	0.675	0.32
97_G	292_S	0.672	0.32
97_G	102_T	0.672	0.32
93_L	100_A	0.668	0.32
11_R	14_E	0.666	0.32
3_R	299_S	0.666	0.32
221_L	256_M	0.666	0.32
156_D	258_D	0.665	0.32
129_A	149_A	0.661	0.31
163_N	168_A	0.661	0.31
89_G	210_G	0.659	0.31
193_I	277_L	0.656	0.31
161_I	181_I	0.650	0.31
263_D	298_K	0.650	0.31
97_G	104_I	0.650	0.31
101_L	269_A	0.649	0.31
151_N	154_V	0.646	0.30
44_F	91_N	0.646	0.30
114_N	117_D	0.644	0.30
296_R	309_H	0.643	0.30
22_R	288_G	0.640	0.30
132_C	148_K	0.636	0.30
60_M	68_I	0.636	0.30
102_T	292_S	0.635	0.30
184_I	191_G	0.631	0.29
197_F	224_L	0.631	0.29
124_A	159_A	0.631	0.29
164_R	223_A	0.625	0.29
152_K	243_C	0.625	0.29
237_E	246_M	0.623	0.29
225_G	247_G	0.622	0.29
58_G	63_A	0.620	0.29
59_E	212_P	0.620	0.29
144_K	153_D	0.617	0.28
231_K	253_V	0.617	0.28
88_E	233_L	0.617	0.28
106_V	307_G	0.616	0.28
65_M	212_P	0.615	0.28
234_P	250_L	0.612	0.28
31_E	35_A	0.612	0.28
18_L	49_M	0.610	0.28
208_S	216_L	0.609	0.28
57_E	119_Y	0.609	0.28
114_N	211_A	0.609	0.28
123_I	146_V	0.605	0.28
21_A	93_L	0.605	0.28
184_I	233_L	0.605	0.28
60_M	114_N	0.603	0.28
268_A	296_R	0.601	0.27
18_L	309_H	0.599	0.27
48_P	272_V	0.599	0.27
7_M	10_V	0.596	0.27
33_D	119_Y	0.593	0.27
194_N	276_E	0.592	0.27
46_T	274_D	0.592	0.27
83_A	212_P	0.592	0.27
24_M	93_L	0.591	0.27
133_I	197_F	0.590	0.27
44_F	93_L	0.586	0.26
3_R	301_T	0.586	0.26
101_L	151_N	0.585	0.26
127_P	201_G	0.585	0.26
175_R	290_T	0.583	0.26
123_I	142_N	0.582	0.26
118_M	243_C	0.582	0.26
3_R	189_V	0.581	0.26
61_D	212_P	0.578	0.26
237_E	240_I	0.577	0.26
139_V	170_I	0.576	0.26
14_E	290_T	0.575	0.26
45_D	74_N	0.575	0.26
163_N	185_N	0.574	0.26
63_A	83_A	0.574	0.26
282_Q	287_V	0.573	0.26
87_L	243_C	0.572	0.26
286_S	312_K	0.572	0.26
9_L	300_G	0.572	0.26
177_A	292_S	0.571	0.26
91_N	185_N	0.571	0.26
120_M	230_G	0.571	0.26
204_I	312_K	0.570	0.26
38_S	87_L	0.570	0.26
63_A	212_P	0.570	0.26
96_G	180_R	0.569	0.25
268_A	292_S	0.568	0.25
58_G	90_T	0.567	0.25
286_S	293_L	0.567	0.25
141_D	144_K	0.567	0.25
108_D	111_T	0.567	0.25
8_E	11_R	0.566	0.25
94_A	191_G	0.566	0.25
161_I	173_E	0.563	0.25
57_E	63_A	0.562	0.25
152_K	157_V	0.561	0.25
53_V	72_L	0.561	0.25
112_L	219_V	0.561	0.25
165_E	305_V	0.561	0.25
121_Q	233_L	0.560	0.25
115_A	254_L	0.560	0.25
139_V	173_E	0.560	0.25
192_A	205_L	0.560	0.25
22_R	156_D	0.560	0.25
248_L	254_L	0.559	0.25
30_D	60_M	0.559	0.25
123_I	149_A	0.558	0.25
203_D	306_D	0.557	0.25
9_L	101_L	0.553	0.25
134_D	221_L	0.552	0.24
150_K	297_A	0.551	0.24
194_N	292_S	0.551	0.24
63_A	85_D	0.550	0.24
8_E	301_T	0.549	0.24
55_I	61_D	0.547	0.24
222_K	265_A	0.547	0.24
138_P	195_T	0.546	0.24
310_S	313_K	0.546	0.24
72_L	193_I	0.545	0.24
32_A	231_K	0.545	0.24
173_E	206_F	0.544	0.24
33_D	86_P	0.542	0.24
222_K	261_K	0.542	0.24
198_D	203_D	0.541	0.24
88_E	189_V	0.541	0.24
19_A	39_A	0.541	0.24
65_M	84_V	0.541	0.24
146_V	159_A	0.541	0.24
243_C	250_L	0.540	0.24
37_T	86_P	0.539	0.24
37_T	65_M	0.538	0.24
61_D	86_P	0.537	0.24
63_A	84_V	0.535	0.23
30_D	62_E	0.535	0.23
250_L	254_L	0.535	0.23
31_E	266_I	0.535	0.23
37_T	90_T	0.534	0.23
105_A	229_I	0.534	0.23
221_L	228_I	0.534	0.23
124_A	195_T	0.534	0.23
115_A	246_M	0.533	0.23
116_P	125_V	0.533	0.23
201_G	281_V	0.532	0.23
52_T	245_K	0.527	0.23
131_G	246_M	0.526	0.23
10_V	13_T	0.526	0.23
12_V	49_M	0.526	0.23
24_M	283_F	0.526	0.23
84_V	245_K	0.526	0.23
133_I	145_A	0.525	0.23
111_T	262_G	0.525	0.23
40_M	84_V	0.525	0.23
197_F	304_F	0.524	0.23
119_Y	188_D	0.524	0.23
181_I	284_K	0.520	0.23
203_D	289_T	0.518	0.23
116_P	211_A	0.518	0.23
299_S	303_R	0.518	0.23
203_D	284_K	0.518	0.23
28_K	32_A	0.518	0.23
138_P	173_E	0.517	0.22
184_I	243_C	0.517	0.22
47_V	189_V	0.517	0.22
143_L	216_L	0.517	0.22
29_K	63_A	0.516	0.22
103_V	216_L	0.516	0.22
230_G	275_G	0.516	0.22
134_D	137_A	0.516	0.22
116_P	217_S	0.515	0.22
135_I	266_I	0.515	0.22
84_V	90_T	0.515	0.22
175_R	292_S	0.515	0.22
37_T	57_E	0.514	0.22
196_A	264_D	0.513	0.22
304_F	308_R	0.513	0.22
154_V	168_A	0.512	0.22
67_Y	217_S	0.512	0.22
125_V	132_C	0.511	0.22
99_N	193_I	0.511	0.22
154_V	157_V	0.510	0.22
37_T	92_I	0.510	0.22
23_W	32_A	0.509	0.22
88_E	117_D	0.509	0.22
21_A	181_I	0.509	0.22
88_E	91_N	0.507	0.22
59_E	66_L	0.507	0.22
121_Q	162_L	0.507	0.22
118_M	233_L	0.506	0.22
6_S	309_H	0.503	0.22
47_V	80_V	0.503	0.22
76_Y	305_V	0.501	0.22
33_D	90_T	0.501	0.22
199_H	307_G	0.501	0.22
154_V	204_I	0.500	0.22

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bigA	1	0.9657	100	0.004	Contact Map
3rojA	3	0.9969	100	0.014	Contact Map
3b8bA	1	0.7227	95.8	0.953	Contact Map
1ka1A	1	0.785	94.3	0.957	Contact Map
2pcrA	3	0.6947	94.2	0.957	Contact Map
4n81A	2	0.7134	94	0.958	Contact Map
4i3yA	2	0.757	94	0.958	Contact Map
3lv0A	2	0.7196	93.8	0.958	Contact Map
1inpA	1	0.8629	93.2	0.959	Contact Map
4o7iA	1	0.8162	93.2	0.959	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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