GREMLIN Database
KITH - Thymidine kinase
UniProt: Q03221 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 195 (180)
Sequences: 2056 (1130)
Seq/√Len: 84.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_C183_C4.0061.00
156_Q182_R3.1801.00
183_C186_H2.9361.00
54_A62_S2.7551.00
9_W137_S2.7521.00
148_C186_H2.6541.00
33_T63_M2.6141.00
99_E130_N2.3851.00
172_L178_S2.3191.00
41_V55_V2.2521.00
119_D170_V2.1671.00
23_E27_R2.1581.00
75_W103_S2.1571.00
10_L105_A2.1531.00
51_S54_A2.1491.00
24_E27_R2.1481.00
29_V39_V2.1061.00
90_V113_A2.1021.00
49_R174_G2.0821.00
29_V86_A2.0771.00
45_V69_S2.0671.00
73_D76_D2.0161.00
42_F77_H1.9661.00
26_I41_V1.9411.00
101_L113_A1.8761.00
102_S134_I1.7751.00
15_G19_S1.7721.00
25_L86_A1.7591.00
103_S107_K1.7191.00
87_V101_L1.7111.00
95_Q126_G1.6951.00
106_D184_R1.6911.00
95_Q130_N1.6811.00
13_I139_T1.6791.00
48_N52_E1.6711.00
71_A94_D1.6701.00
102_S184_R1.6121.00
20_G27_R1.5891.00
103_S188_E1.5881.00
90_V97_I1.5801.00
54_A64_T1.5521.00
50_Y56_V1.5501.00
20_G23_E1.5100.99
129_P133_A1.4970.99
13_I112_I1.4870.99
73_D100_V1.4730.99
159_I163_P1.4650.99
117_D140_K1.4580.99
126_G129_P1.3910.99
102_S188_E1.3740.99
96_E100_V1.3510.99
28_R112_I1.3410.99
40_R66_Y1.3370.99
156_Q164_A1.3310.99
71_A96_E1.3290.99
78_I104_L1.3250.99
50_Y58_H1.3200.99
72_A77_H1.3170.99
122_G187_H1.2880.98
11_E110_R1.2800.98
40_R82_T1.2780.98
99_E134_I1.2710.98
13_I28_R1.2710.98
123_E130_N1.2280.98
185_H189_V1.2010.97
102_S106_D1.1970.97
38_E81_S1.1950.97
19_S142_Q1.1890.97
43_K47_D1.1880.97
84_V112_I1.1850.97
95_Q123_E1.1790.97
105_A184_R1.1500.97
26_I63_M1.1420.96
158_L178_S1.1310.96
71_A100_V1.1110.96
90_V131_I1.0920.95
87_V93_F1.0920.95
58_H175_A1.0910.95
29_V63_M1.0880.95
146_S181_A1.0880.95
38_E83_D1.0810.95
143_A152_A1.0740.95
41_V63_M1.0720.95
16_S155_T1.0640.95
51_S56_V1.0600.95
122_G154_R1.0560.95
26_I59_N1.0470.94
43_K53_A1.0230.94
42_F66_Y1.0170.93
157_R172_L1.0040.93
27_R31_R1.0030.93
56_V62_S0.9990.93
76_D79_S0.9920.92
82_T109_Y0.9890.92
117_D132_M0.9870.92
75_W100_V0.9790.92
22_S65_S0.9710.92
120_F157_R0.9700.92
40_R77_H0.9690.92
90_V115_G0.9680.92
31_R34_Y0.9680.92
169_P172_L0.9670.91
11_E28_R0.9610.91
24_E141_L0.9480.91
69_S73_D0.9410.90
126_G170_V0.9360.90
105_A136_E0.9330.90
38_E82_T0.9290.90
12_L135_A0.9160.89
145_C148_C0.9150.89
31_R144_V0.9110.89
13_I24_E0.9050.89
22_S58_H0.9040.88
35_A144_V0.8840.87
32_A37_Q0.8760.87
80_E83_D0.8720.87
142_Q151_P0.8710.87
113_A128_V0.8660.86
124_P129_P0.8620.86
55_V158_L0.8610.86
70_S73_D0.8610.86
69_S76_D0.8580.86
32_A84_V0.8510.85
113_A131_I0.8510.85
145_C183_C0.8480.85
130_N133_A0.8450.85
119_D123_E0.8430.85
146_S186_H0.8390.84
130_N134_I0.8300.84
32_A110_R0.8290.84
134_I188_E0.8280.84
70_S94_D0.8250.83
20_G24_E0.8120.82
122_G133_A0.8050.82
136_E184_R0.7990.81
118_M133_A0.7970.81
78_I109_Y0.7960.81
24_E28_R0.7960.81
29_V33_T0.7910.81
139_T142_Q0.7780.80
69_S72_A0.7590.78
164_A169_P0.7580.78
28_R86_A0.7580.78
175_A178_S0.7560.78
37_Q110_R0.7550.78
17_M21_K0.7530.77
123_E166_Y0.7510.77
16_S142_Q0.7480.77
46_I171_I0.7340.76
48_N173_V0.7330.76
158_L180_E0.7310.75
16_S118_M0.7300.75
31_R143_A0.7260.75
32_A39_V0.7250.75
161_G164_A0.7200.74
120_F170_V0.7170.74
38_E80_E0.7150.74
85_V111_V0.7150.74
17_M20_G0.7150.74
157_R170_V0.7150.74
16_S143_A0.7090.73
101_L127_V0.7080.73
43_K50_Y0.7010.72
23_E57_S0.6930.71
100_V104_L0.6880.71
42_F74_I0.6880.71
10_L101_L0.6880.71
169_P189_V0.6760.70
186_H189_V0.6730.69
143_A181_A0.6720.69
52_E64_T0.6700.69
101_L105_A0.6690.69
80_E107_K0.6670.69
136_E153_S0.6660.68
85_V109_Y0.6660.68
26_I114_A0.6610.68
106_D136_E0.6600.68
152_A181_A0.6580.67
164_A182_R0.6570.67
43_K65_S0.6560.67
52_E67_A0.6550.67
84_V110_R0.6500.67
16_S22_S0.6440.66
95_Q129_P0.6410.65
77_H108_G0.6390.65
19_S34_Y0.6380.65
11_E140_K0.6370.65
40_R78_I0.6340.65
22_S175_A0.6280.64
91_Q171_I0.6260.64
75_W107_K0.6250.64
108_G185_H0.6220.63
112_I152_A0.6200.63
49_R175_A0.6180.63
62_S150_S0.6170.63
53_A64_T0.6160.62
86_A112_I0.6150.62
33_T38_E0.6130.62
90_V128_V0.6130.62
31_R35_A0.6110.62
111_V144_V0.6080.61
174_G184_R0.6050.61
13_I141_L0.6040.61
44_P68_I0.6020.61
38_E160_D0.6000.60
142_Q153_S0.5990.60
118_M155_T0.5980.60
34_Y181_A0.5970.60
141_L153_S0.5970.60
110_R151_P0.5930.59
137_S142_Q0.5870.59
62_S96_E0.5850.58
121_R168_D0.5840.58
72_A176_A0.5820.58
106_D188_E0.5810.58
76_D80_E0.5790.58
98_V131_I0.5790.58
18_F22_S0.5790.58
14_C132_M0.5770.57
15_G143_A0.5770.57
25_L114_A0.5770.57
110_R140_K0.5770.57
10_L127_V0.5740.57
84_V109_Y0.5720.57
8_G105_A0.5690.56
76_D103_S0.5680.56
18_F34_Y0.5660.56
45_V48_N0.5570.55
161_G165_S0.5560.55
126_G130_N0.5550.55
150_S185_H0.5550.55
48_N51_S0.5540.54
64_T123_E0.5530.54
50_Y54_A0.5530.54
14_C181_A0.5530.54
69_S185_H0.5530.54
32_A144_V0.5510.54
73_D79_S0.5480.54
97_I127_V0.5440.53
120_F187_H0.5430.53
23_E58_H0.5430.53
99_E188_E0.5390.52
74_I77_H0.5380.52
182_R187_H0.5370.52
57_S151_P0.5370.52
18_F181_A0.5330.52
75_W79_S0.5320.51
91_Q173_V0.5300.51
172_L177_E0.5300.51
18_F25_L0.5270.51
15_G68_I0.5270.51
108_G111_V0.5270.51
118_M142_Q0.5260.51
45_V67_A0.5240.50
52_E76_D0.5220.50
60_G168_D0.5210.50
26_I57_S0.5200.50
43_K48_N0.5190.50
19_S37_Q0.5160.49
98_V127_V0.5150.49
19_S32_A0.5150.49
144_V151_P0.5120.49
9_W136_E0.5080.48
47_D173_V0.5070.48
96_E99_E0.5070.48
33_T39_V0.5060.48
28_R139_T0.5040.48
19_S174_G0.5010.47
149_G182_R0.5000.47
143_A187_H0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w4rA 3 0.8923 100 0.18 Contact Map
2orvA 3 0.8359 100 0.23 Contact Map
2j9rA 3 0.9026 100 0.361 Contact Map
3e2iA 3 0.8923 100 0.371 Contact Map
2b8tA 3 0.9641 100 0.412 Contact Map
1xx6A 4 0.9128 100 0.433 Contact Map
2orwA 3 0.8923 100 0.548 Contact Map
4uxhA 3 0.8872 100 0.587 Contact Map
3upuA 1 0.9744 98.4 0.846 Contact Map
1w36D 1 0.9641 98.4 0.847 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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