GREMLIN Database
DINB - Protein DinB
UniProt: Q02886 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (153)
Sequences: 1364 (1078)
Seq/√Len: 87.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_Y43_S4.2881.00
24_K88_E3.6481.00
42_I144_I3.6301.00
113_Q123_K3.5831.00
135_N138_T3.5601.00
83_E86_E2.6231.00
32_H43_S2.5291.00
37_S147_M2.4731.00
60_F129_L2.3811.00
7_K160_Y2.2211.00
27_P30_I2.2071.00
30_I33_Q2.1951.00
98_Y133_V2.1761.00
96_E100_L2.0811.00
88_E92_L2.0361.00
35_I151_A2.0011.00
6_F103_Q1.9771.00
16_N95_S1.9611.00
60_F126_V1.9001.00
110_K126_V1.8661.00
59_V114_I1.8431.00
115_Q121_I1.7731.00
9_Y134_V1.6201.00
113_Q121_I1.6171.00
29_E33_Q1.6061.00
12_N137_G1.5821.00
28_K32_H1.5741.00
50_Y90_L1.5381.00
11_Y135_N1.4840.99
111_P123_K1.4840.99
91_F95_S1.4790.99
22_R153_Y1.4600.99
25_E153_Y1.4280.99
99_I103_Q1.4170.99
23_L46_L1.3980.99
147_M150_Q1.3890.99
107_Q110_K1.3840.99
146_A150_Q1.3490.99
145_T155_S1.3430.99
38_V139_Y1.3400.99
15_A158_T1.3380.99
46_L144_I1.3130.99
91_F137_G1.3060.99
30_I35_I1.2990.99
57_I94_L1.2980.99
24_K85_E1.2980.99
51_L75_L1.2900.99
26_L148_L1.2870.99
16_N91_F1.2850.99
10_E99_I1.2550.98
13_V99_I1.2360.98
28_K43_S1.2250.98
19_I46_L1.1880.97
76_K80_E1.1680.97
116_N122_M1.1640.97
7_K128_E1.1000.96
82_K86_E1.0980.96
114_I161_G1.0970.96
145_T156_A1.0900.96
23_L42_I1.0880.96
59_V117_P1.0870.96
31_Y84_I1.0800.96
24_K27_P1.0730.95
21_N88_E1.0670.95
129_L161_G1.0580.95
17_Q92_L1.0510.95
40_P44_H1.0390.95
114_I117_P1.0290.94
14_W163_Y1.0040.93
143_N159_D1.0030.93
90_L93_R0.9980.93
86_E89_D0.9910.93
17_Q21_N0.9820.93
12_N16_N0.9740.92
112_L126_V0.9730.92
12_N98_Y0.9690.92
136_H140_H0.9600.92
21_N25_E0.9580.92
85_E89_D0.9450.91
9_Y95_S0.9430.91
116_N119_S0.9390.91
61_S97_R0.9390.91
134_V137_G0.9370.91
21_N24_K0.9360.91
109_N127_S0.9310.91
43_S84_I0.9130.90
15_A163_Y0.9120.90
91_F98_Y0.9100.90
53_D137_G0.9060.89
61_S64_T0.9050.89
100_L104_Q0.9030.89
128_E160_Y0.8990.89
118_S161_G0.8990.89
11_Y138_T0.8810.88
30_I151_A0.8790.88
35_I150_Q0.8780.88
83_E89_D0.8740.88
20_F87_M0.8740.88
54_L94_L0.8740.88
147_M154_A0.8720.88
149_R155_S0.8700.87
51_L55_G0.8680.87
56_W132_H0.8620.87
13_V96_E0.8610.87
60_F101_F0.8570.87
50_Y94_L0.8550.87
15_A156_A0.8450.86
89_D93_R0.8410.86
16_N137_G0.8370.85
37_S146_A0.8250.85
81_A90_L0.8240.84
125_T128_E0.8210.84
23_L139_Y0.8150.84
129_L133_V0.8120.84
127_S131_P0.8090.83
5_A101_F0.8090.83
148_L153_Y0.8090.83
26_L30_I0.8060.83
15_A18_Q0.8060.83
139_Y143_N0.8030.83
55_G117_P0.8020.83
58_E66_S0.8010.83
139_Y158_T0.8010.83
124_T161_G0.7940.82
53_D91_F0.7830.81
13_V95_S0.7820.81
20_F91_F0.7800.81
118_S121_I0.7750.81
12_N53_D0.7720.80
145_T158_T0.7710.80
95_S137_G0.7700.80
60_F133_V0.7690.80
50_Y143_N0.7680.80
96_E99_I0.7610.79
22_R148_L0.7570.79
157_P162_L0.7570.79
56_W161_G0.7530.79
101_F130_L0.7430.78
92_L103_Q0.7380.77
118_S122_M0.7260.76
54_L90_L0.7240.76
93_R96_E0.7180.75
30_I153_Y0.7170.75
9_Y12_N0.7140.75
95_S98_Y0.7110.75
30_I42_I0.7050.74
45_V156_A0.7050.74
25_E109_N0.7030.74
102_L130_L0.6990.73
132_H160_Y0.6990.73
20_F88_E0.6970.73
52_S60_F0.6930.73
19_I144_I0.6810.71
35_I40_P0.6790.71
47_S87_M0.6710.70
14_W141_R0.6710.70
59_V116_N0.6700.70
92_L96_E0.6670.70
32_H83_E0.6640.70
53_D95_S0.6610.69
32_H104_Q0.6580.69
107_Q126_V0.6560.69
48_H140_H0.6550.68
20_F46_L0.6530.68
52_S129_L0.6490.68
139_Y145_T0.6480.68
17_Q106_E0.6440.67
39_F141_R0.6440.67
7_K84_I0.6310.66
45_V143_N0.6300.66
42_I151_A0.6300.66
145_T149_R0.6240.65
60_F98_Y0.6220.65
55_G161_G0.6180.64
5_A8_L0.6150.64
39_F142_G0.6140.64
114_I119_S0.6130.63
114_I122_M0.6100.63
38_V146_A0.6080.63
38_V143_N0.6040.62
101_F126_V0.6040.62
25_E104_Q0.6030.62
38_V149_R0.6000.62
137_G145_T0.5990.62
98_Y137_G0.5940.61
56_W157_P0.5900.60
16_N57_I0.5870.60
143_N146_A0.5860.60
27_P31_Y0.5850.60
20_F23_L0.5840.60
28_K31_Y0.5830.60
59_V119_S0.5790.59
63_K97_R0.5780.59
46_L132_H0.5720.58
142_G147_M0.5710.58
129_L132_H0.5710.58
144_I147_M0.5610.57
9_Y137_G0.5580.56
15_A147_M0.5560.56
86_E106_E0.5560.56
92_L100_L0.5530.56
122_M161_G0.5510.55
76_K130_L0.5470.55
25_E133_V0.5440.54
119_S122_M0.5420.54
29_E83_E0.5400.54
5_A102_L0.5390.54
112_L118_S0.5380.54
7_K96_E0.5350.53
135_N158_T0.5320.53
44_H51_L0.5300.52
37_S150_Q0.5270.52
19_I156_A0.5260.52
8_L30_I0.5240.52
33_Q150_Q0.5240.52
137_G143_N0.5230.52
28_K88_E0.5210.51
9_Y102_L0.5210.51
7_K163_Y0.5200.51
38_V95_S0.5200.51
9_Y91_F0.5190.51
8_L134_V0.5180.51
12_N91_F0.5160.51
115_Q118_S0.5150.50
138_T141_R0.5110.50
17_Q88_E0.5110.50
39_F140_H0.5070.49
111_P125_T0.5070.49
23_L84_I0.5010.49
22_R26_L0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qe9A 2 0.936 99.9 0.482 Contact Map
3di5A 1 0.8547 99.8 0.592 Contact Map
2rd9A 4 0.9419 99.8 0.597 Contact Map
2p1aA 2 0.8198 99.8 0.599 Contact Map
2ou6A 2 0.8314 99.8 0.603 Contact Map
3gorA 2 0.8721 99.8 0.608 Contact Map
2hkvA 2 0.843 99.8 0.608 Contact Map
3dkaA 2 0.8547 99.8 0.619 Contact Map
2f22A 2 0.8314 99.8 0.619 Contact Map
3cexA 2 0.8721 99.7 0.636 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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