GREMLIN Database
YSXA - UPF0758 protein YsxA
UniProt: Q02170 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (220)
Sequences: 3118 (2313)
Seq/√Len: 155.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_E56_R5.5131.00
61_F70_A3.1871.00
147_R167_E3.0451.00
223_V228_K3.0001.00
138_N142_Q2.9671.00
165_F204_G2.7681.00
201_F211_L2.7581.00
120_V179_V2.7451.00
178_C211_L2.7291.00
194_I225_L2.6321.00
145_H171_R2.4151.00
135_L143_V2.2651.00
110_I143_V2.2561.00
191_R195_E2.1691.00
52_D55_N2.1341.00
71_S74_E2.1081.00
139_T155_N2.0781.00
111_R115_D2.0611.00
129_Q151_I2.0471.00
187_P221_K2.0131.00
178_C200_L2.0081.00
154_L174_A1.9661.00
49_S52_D1.9591.00
133_V148_T1.9201.00
198_R202_E1.8901.00
114_E118_N1.8851.00
148_T151_I1.8361.00
132_F159_V1.8031.00
127_L131_H1.7921.00
34_H55_N1.7631.00
124_M127_L1.7591.00
116_G177_I1.7451.00
131_H151_I1.7201.00
63_G66_L1.7111.00
123_D146_K1.6741.00
202_E205_N1.6711.00
164_V200_L1.6661.00
129_Q150_F1.6611.00
141_N175_S1.6601.00
131_H148_T1.6351.00
194_I230_Y1.6121.00
136_Y167_E1.6021.00
201_F205_N1.5911.00
150_F157_S1.5881.00
168_A209_I1.5861.00
117_A121_M1.5821.00
113_P227_E1.5711.00
92_A96_G1.5601.00
166_K172_S1.5551.00
81_I86_A1.5241.00
133_V146_K1.4951.00
23_L28_A1.4801.00
47_H79_P1.4781.00
136_Y171_R1.4691.00
140_K186_D1.4551.00
159_V196_V1.4011.00
132_F211_L1.3991.00
20_R84_V1.3931.00
76_S83_M1.3921.00
72_V76_S1.3741.00
75_L86_A1.3681.00
167_E171_R1.3571.00
23_L31_L1.3551.00
23_L87_I1.3531.00
165_F207_I1.3511.00
167_E170_K1.3461.00
38_A51_L1.3421.00
136_Y147_R1.3321.00
225_L230_Y1.3211.00
26_V30_N1.3191.00
42_R88_Q1.3041.00
40_L88_Q1.2791.00
50_V54_S1.2601.00
22_R35_E1.2551.00
132_F157_S1.2541.00
76_S86_A1.2531.00
23_L39_I1.2491.00
64_L95_L1.2291.00
124_M133_V1.2291.00
197_T214_H1.2241.00
60_S77_S1.2161.00
125_R219_D1.2121.00
15_M18_K1.2081.00
60_S78_I1.2021.00
121_M125_R1.1981.00
137_L175_S1.1841.00
153_S158_I1.1771.00
110_I116_G1.1721.00
223_V230_Y1.1371.00
40_L92_A1.1241.00
187_P223_V1.1131.00
34_H51_L1.1091.00
191_R194_I1.1060.99
22_R26_V1.1050.99
198_R201_F1.1040.99
204_G207_I1.1030.99
215_L222_F1.1030.99
24_L83_M1.1010.99
203_C206_L1.0980.99
135_L146_K1.0830.99
41_L50_V1.0710.99
153_S160_H1.0620.99
44_G85_K1.0550.99
203_C207_I1.0540.99
141_N212_L1.0430.99
43_T88_Q1.0420.99
168_A176_F1.0380.99
110_I115_D1.0350.99
136_Y168_A1.0280.99
187_P218_G1.0280.99
116_G215_L1.0260.99
157_S196_V1.0230.99
188_T228_K1.0220.99
125_R218_G1.0160.99
117_A222_F1.0060.99
57_L78_I1.0020.99
114_E227_E0.9960.99
117_A227_E0.9940.99
216_V223_V0.9800.99
94_E98_R0.9760.99
24_L87_I0.9740.99
204_G211_L0.9710.99
83_M87_I0.9680.99
218_G221_K0.9630.99
153_S163_E0.9580.99
72_V90_L0.9550.99
112_S115_D0.9520.98
119_L146_K0.9440.98
72_V83_M0.9420.98
166_K170_K0.9400.98
150_F158_I0.9380.98
154_L162_R0.9370.98
72_V86_A0.9360.98
127_L148_T0.9360.98
43_T85_K0.9360.98
48_E52_D0.9250.98
74_E170_K0.9090.98
159_V164_V0.9040.98
29_E97_S0.8980.98
134_C178_C0.8970.98
145_H167_E0.8920.98
121_M220_K0.8890.98
132_F196_V0.8890.98
129_Q147_R0.8860.98
81_I85_K0.8830.98
225_L228_K0.8820.98
75_L89_I0.8820.98
128_T166_K0.8740.97
121_M219_D0.8730.97
120_V135_L0.8660.97
110_I119_L0.8630.97
18_K50_V0.8620.97
147_R171_R0.8470.97
213_D224_S0.8460.97
139_T174_A0.8440.97
51_L55_N0.8420.97
217_I222_F0.8400.97
108_F143_V0.8360.97
33_N102_L0.8230.96
19_P44_G0.8190.96
163_E166_K0.8190.96
127_L151_I0.8170.96
84_V87_I0.8160.96
60_S74_E0.8130.96
101_K123_D0.8100.96
69_E99_I0.8070.96
72_V87_I0.8050.96
120_V146_K0.8040.96
132_F178_C0.8030.96
19_P42_R0.7940.95
65_R102_L0.7910.95
123_D133_V0.7900.95
175_S212_L0.7870.95
117_A215_L0.7840.95
136_Y149_V0.7820.95
222_F227_E0.7820.95
187_P216_V0.7810.95
22_R28_A0.7810.95
93_V96_G0.7680.94
74_E77_S0.7680.94
39_I43_T0.7640.94
116_G179_V0.7520.94
19_P39_I0.7510.94
129_Q163_E0.7430.93
68_K93_V0.7410.93
109_V142_Q0.7410.93
115_D143_V0.7340.93
37_L162_R0.7330.93
86_A90_L0.7310.93
44_G88_Q0.7280.93
195_E198_R0.7240.93
19_P38_A0.7230.93
94_E97_S0.7160.92
14_P17_E0.7090.92
176_F204_G0.7050.92
192_E195_E0.7020.91
202_E206_L0.6990.91
108_F115_D0.6980.91
33_N98_R0.6920.91
199_R208_G0.6910.91
107_H142_Q0.6900.91
134_C149_V0.6900.91
136_Y173_A0.6870.91
152_G181_N0.6860.90
194_I198_R0.6850.90
165_F211_L0.6830.90
100_H122_E0.6810.90
88_Q92_A0.6760.90
113_P117_A0.6750.90
38_A42_R0.6710.89
69_E128_T0.6710.89
23_L90_L0.6710.89
182_H193_D0.6710.89
41_L53_L0.6640.89
155_N174_A0.6590.89
23_L94_E0.6580.89
216_V230_Y0.6570.88
194_I223_V0.6530.88
216_V225_L0.6510.88
123_D148_T0.6490.88
134_C176_F0.6480.88
182_H190_S0.6460.88
164_V178_C0.6460.88
189_P223_V0.6400.87
56_R60_S0.6390.87
164_V176_F0.6360.87
154_L172_S0.6360.87
13_F51_L0.6360.87
120_V215_L0.6350.87
149_V164_V0.6320.86
144_I173_A0.6290.86
34_H50_V0.6290.86
118_N121_M0.6290.86
127_L133_V0.6270.86
14_P18_K0.6240.86
130_E183_P0.6200.85
160_H163_E0.6200.85
60_S79_P0.6170.85
31_L35_E0.6160.85
28_A39_I0.6140.85
99_I126_F0.6140.85
124_M217_I0.6110.85
61_F78_I0.6020.84
66_L102_L0.6010.84
169_F203_C0.6010.84
137_L177_I0.6010.84
45_T79_P0.6000.84
45_T48_E0.6000.84
180_H190_S0.5990.83
216_V228_K0.5980.83
13_F55_N0.5950.83
75_L81_I0.5940.83
116_G135_L0.5940.83
140_K184_S0.5920.83
57_L81_I0.5890.82
49_S55_N0.5890.82
22_R32_A0.5770.81
210_E226_K0.5770.81
130_E182_H0.5750.81
48_E53_L0.5730.81
122_E125_R0.5720.81
39_I50_V0.5720.81
38_A85_K0.5720.81
68_K99_I0.5710.80
62_D66_L0.5710.80
130_E180_H0.5690.80
152_G182_H0.5670.80
162_R174_A0.5660.80
195_E199_R0.5650.80
204_G209_I0.5640.80
170_K207_I0.5640.80
176_F211_L0.5630.80
38_A44_G0.5630.80
29_E94_E0.5620.79
53_L56_R0.5600.79
139_T154_L0.5590.79
130_E152_G0.5590.79
48_E79_P0.5580.79
18_K49_S0.5550.79
21_E25_K0.5540.78
15_M25_K0.5530.78
221_K228_K0.5530.78
111_R143_V0.5530.78
132_F161_P0.5500.78
104_N118_N0.5500.78
190_S193_D0.5500.78
136_Y145_H0.5490.78
195_E202_E0.5480.78
66_L69_E0.5470.78
36_L95_L0.5460.77
152_G193_D0.5430.77
136_Y176_F0.5420.77
19_P85_K0.5400.77
190_S197_T0.5390.77
180_H183_P0.5370.76
175_S210_E0.5370.76
20_R50_V0.5370.76
96_G99_I0.5370.76
28_A36_L0.5340.76
69_E93_V0.5330.76
199_R203_C0.5330.76
163_E184_S0.5330.76
154_L160_H0.5310.75
130_E190_S0.5310.75
181_N193_D0.5300.75
24_L72_V0.5300.75
20_R23_L0.5270.75
154_L161_P0.5270.75
93_V99_I0.5260.75
185_G197_T0.5220.74
28_A31_L0.5220.74
132_F164_V0.5190.74
137_L141_N0.5160.73
57_L67_L0.5160.73
166_K169_F0.5130.73
152_G180_H0.5100.73
57_L75_L0.5100.73
36_L44_G0.5090.72
113_P226_K0.5080.72
205_N210_E0.5080.72
73_E171_R0.5080.72
18_K51_L0.5060.72
199_R202_E0.5050.72
143_V158_I0.5040.72
19_P50_V0.5040.72
205_N208_G0.5030.72
39_I91_A0.5030.72
139_T210_E0.5020.71
108_F142_Q0.5010.71
199_R205_N0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qlcA 1 0.5455 100 0.429 Contact Map
1x2iA 2 0.2944 98.6 0.854 Contact Map
3c1yA 5 0.4199 98.1 0.875 Contact Map
4bxoA 1 0.4069 97 0.899 Contact Map
1dgsA 1 0.4935 96.9 0.899 Contact Map
2owoA 1 0.4935 96.6 0.903 Contact Map
2a1jB 2 0.3377 96.5 0.905 Contact Map
1z00A 1 0.3636 96.4 0.906 Contact Map
1kftA 1 0.2424 96.3 0.906 Contact Map
2bgwA 2 0.3983 96.1 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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